Nannospalax galili (Upper Galilee mountains blind mole rat): 103751450
Help
Entry
103751450 CDS
T03372
Gene name
Raf1
Definition
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi01521
EGFR tyrosine kinase inhibitor resistance
ngi01522
Endocrine resistance
ngi04010
MAPK signaling pathway
ngi04012
ErbB signaling pathway
ngi04014
Ras signaling pathway
ngi04015
Rap1 signaling pathway
ngi04022
cGMP-PKG signaling pathway
ngi04024
cAMP signaling pathway
ngi04062
Chemokine signaling pathway
ngi04068
FoxO signaling pathway
ngi04071
Sphingolipid signaling pathway
ngi04072
Phospholipase D signaling pathway
ngi04140
Autophagy - animal
ngi04150
mTOR signaling pathway
ngi04151
PI3K-Akt signaling pathway
ngi04210
Apoptosis
ngi04218
Cellular senescence
ngi04270
Vascular smooth muscle contraction
ngi04360
Axon guidance
ngi04370
VEGF signaling pathway
ngi04371
Apelin signaling pathway
ngi04510
Focal adhesion
ngi04540
Gap junction
ngi04550
Signaling pathways regulating pluripotency of stem cells
ngi04625
C-type lectin receptor signaling pathway
ngi04630
JAK-STAT signaling pathway
ngi04650
Natural killer cell mediated cytotoxicity
ngi04660
T cell receptor signaling pathway
ngi04662
B cell receptor signaling pathway
ngi04664
Fc epsilon RI signaling pathway
ngi04666
Fc gamma R-mediated phagocytosis
ngi04720
Long-term potentiation
ngi04722
Neurotrophin signaling pathway
ngi04726
Serotonergic synapse
ngi04730
Long-term depression
ngi04810
Regulation of actin cytoskeleton
ngi04910
Insulin signaling pathway
ngi04912
GnRH signaling pathway
ngi04914
Progesterone-mediated oocyte maturation
ngi04915
Estrogen signaling pathway
ngi04916
Melanogenesis
ngi04917
Prolactin signaling pathway
ngi04919
Thyroid hormone signaling pathway
ngi04921
Oxytocin signaling pathway
ngi04926
Relaxin signaling pathway
ngi04928
Parathyroid hormone synthesis, secretion and action
ngi04929
GnRH secretion
ngi04935
Growth hormone synthesis, secretion and action
ngi05010
Alzheimer disease
ngi05022
Pathways of neurodegeneration - multiple diseases
ngi05034
Alcoholism
ngi05132
Salmonella infection
ngi05152
Tuberculosis
ngi05160
Hepatitis C
ngi05161
Hepatitis B
ngi05163
Human cytomegalovirus infection
ngi05164
Influenza A
ngi05165
Human papillomavirus infection
ngi05167
Kaposi sarcoma-associated herpesvirus infection
ngi05170
Human immunodeficiency virus 1 infection
ngi05200
Pathways in cancer
ngi05205
Proteoglycans in cancer
ngi05206
MicroRNAs in cancer
ngi05210
Colorectal cancer
ngi05211
Renal cell carcinoma
ngi05212
Pancreatic cancer
ngi05213
Endometrial cancer
ngi05214
Glioma
ngi05215
Prostate cancer
ngi05218
Melanoma
ngi05219
Bladder cancer
ngi05220
Chronic myeloid leukemia
ngi05221
Acute myeloid leukemia
ngi05223
Non-small cell lung cancer
ngi05224
Breast cancer
ngi05225
Hepatocellular carcinoma
ngi05226
Gastric cancer
ngi05230
Central carbon metabolism in cancer
ngi05231
Choline metabolism in cancer
ngi05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
103751450 (Raf1)
04012 ErbB signaling pathway
103751450 (Raf1)
04014 Ras signaling pathway
103751450 (Raf1)
04015 Rap1 signaling pathway
103751450 (Raf1)
04370 VEGF signaling pathway
103751450 (Raf1)
04371 Apelin signaling pathway
103751450 (Raf1)
04630 JAK-STAT signaling pathway
103751450 (Raf1)
04068 FoxO signaling pathway
103751450 (Raf1)
04072 Phospholipase D signaling pathway
103751450 (Raf1)
04071 Sphingolipid signaling pathway
103751450 (Raf1)
04024 cAMP signaling pathway
103751450 (Raf1)
04022 cGMP-PKG signaling pathway
103751450 (Raf1)
04151 PI3K-Akt signaling pathway
103751450 (Raf1)
04150 mTOR signaling pathway
103751450 (Raf1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
103751450 (Raf1)
09143 Cell growth and death
04210 Apoptosis
103751450 (Raf1)
04218 Cellular senescence
103751450 (Raf1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
103751450 (Raf1)
04540 Gap junction
103751450 (Raf1)
04550 Signaling pathways regulating pluripotency of stem cells
103751450 (Raf1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
103751450 (Raf1)
09150 Organismal Systems
09151 Immune system
04625 C-type lectin receptor signaling pathway
103751450 (Raf1)
04650 Natural killer cell mediated cytotoxicity
103751450 (Raf1)
04660 T cell receptor signaling pathway
103751450 (Raf1)
04662 B cell receptor signaling pathway
103751450 (Raf1)
04664 Fc epsilon RI signaling pathway
103751450 (Raf1)
04666 Fc gamma R-mediated phagocytosis
103751450 (Raf1)
04062 Chemokine signaling pathway
103751450 (Raf1)
09152 Endocrine system
04910 Insulin signaling pathway
103751450 (Raf1)
04929 GnRH secretion
103751450 (Raf1)
04912 GnRH signaling pathway
103751450 (Raf1)
04915 Estrogen signaling pathway
103751450 (Raf1)
04914 Progesterone-mediated oocyte maturation
103751450 (Raf1)
04917 Prolactin signaling pathway
103751450 (Raf1)
04921 Oxytocin signaling pathway
103751450 (Raf1)
04926 Relaxin signaling pathway
103751450 (Raf1)
04935 Growth hormone synthesis, secretion and action
103751450 (Raf1)
04919 Thyroid hormone signaling pathway
103751450 (Raf1)
04928 Parathyroid hormone synthesis, secretion and action
103751450 (Raf1)
04916 Melanogenesis
103751450 (Raf1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
103751450 (Raf1)
09156 Nervous system
04726 Serotonergic synapse
103751450 (Raf1)
04720 Long-term potentiation
103751450 (Raf1)
04730 Long-term depression
103751450 (Raf1)
04722 Neurotrophin signaling pathway
103751450 (Raf1)
09158 Development and regeneration
04360 Axon guidance
103751450 (Raf1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103751450 (Raf1)
05206 MicroRNAs in cancer
103751450 (Raf1)
05205 Proteoglycans in cancer
103751450 (Raf1)
05230 Central carbon metabolism in cancer
103751450 (Raf1)
05231 Choline metabolism in cancer
103751450 (Raf1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
103751450 (Raf1)
09162 Cancer: specific types
05210 Colorectal cancer
103751450 (Raf1)
05212 Pancreatic cancer
103751450 (Raf1)
05225 Hepatocellular carcinoma
103751450 (Raf1)
05226 Gastric cancer
103751450 (Raf1)
05214 Glioma
103751450 (Raf1)
05221 Acute myeloid leukemia
103751450 (Raf1)
05220 Chronic myeloid leukemia
103751450 (Raf1)
05218 Melanoma
103751450 (Raf1)
05211 Renal cell carcinoma
103751450 (Raf1)
05219 Bladder cancer
103751450 (Raf1)
05215 Prostate cancer
103751450 (Raf1)
05213 Endometrial cancer
103751450 (Raf1)
05224 Breast cancer
103751450 (Raf1)
05223 Non-small cell lung cancer
103751450 (Raf1)
09164 Neurodegenerative disease
05010 Alzheimer disease
103751450 (Raf1)
05022 Pathways of neurodegeneration - multiple diseases
103751450 (Raf1)
09165 Substance dependence
05034 Alcoholism
103751450 (Raf1)
09171 Infectious disease: bacterial
05132 Salmonella infection
103751450 (Raf1)
05152 Tuberculosis
103751450 (Raf1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
103751450 (Raf1)
05161 Hepatitis B
103751450 (Raf1)
05160 Hepatitis C
103751450 (Raf1)
05164 Influenza A
103751450 (Raf1)
05163 Human cytomegalovirus infection
103751450 (Raf1)
05167 Kaposi sarcoma-associated herpesvirus infection
103751450 (Raf1)
05165 Human papillomavirus infection
103751450 (Raf1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103751450 (Raf1)
01522 Endocrine resistance
103751450 (Raf1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ngi01001
]
103751450 (Raf1)
Enzymes [BR:
ngi01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
103751450 (Raf1)
Protein kinases [BR:
ngi01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
103751450 (Raf1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
103751450
NCBI-ProteinID:
XP_008853131
LinkDB
All DBs
Position
Un
AA seq
668 aa
AA seq
DB search
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDTGVPALPSLTMRRMRESVPRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq
2007 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggagcttggaagacgatcagcaatggttttggactcaaagatgcg
gtatttgatggctccagctgtatctcccctacaattgttcagcagtttggctatcagcgt
cgggcctcagatgatggcaaactcacagattcctcgaagacaagcaacactatccgtgtt
ttcttgccgaataagcaaagaactgtggtcaatgtgcggaatggaatgagcttacatgac
tgccttatgaaagctctcaaggtgagaggcttacagccggagtgctgtgcagtgttcaga
cttctccaggagcacaaaggtaaaaaagcacgcttagattggaatactgatgccgcctca
ttgattggagaagaacttcaagtagatttcctggatcatgttcctctcacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcaaaagttcctgcta
aatggatttcgatgtcagacctgtggctacaaatttcatgagcactgtagcaccaaagta
cccactatgtgtgtggattggagtaatatcagacaacttttgctctttccaaactctact
gttggtgatactggagtcccagcactaccttctttgacaatgcgtcggatgcgagaatct
gttccccgtatgcctgctagttcccagcacagatactccacaccccatgccttcactttc
aacacctccagtccttcttctgaaggctccctctcccagaggcagaggtcaacgtccact
cccaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagtcacagtgaatcagcttcaccttcagccttgtccagcagccctaacaacctg
agcccaacaggctggtcacagcccaaaacccctgtgccagcacaaagagagagggcacca
ggatctgggacccaggagaaaaacaaaattaggcctcgaggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctccttc
ggcactgtgtataagggcaagtggcatggagatgttgcagtaaagattctaaaggtcgtt
gacccaaccccagagcagttccaggccttcaggaatgaggtggctgtcctgcgcaaaact
cggcatgtcaacatcctattatttatggggtacatgacaaaggacaacttggcaattgtg
actcagtggtgtgaaggtagcagtctctacaaacacctgcatgtccaggagaccaaattc
cagatgttccagttaattgacattgcccggcagacagctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaagtccaacaatatattcctccatgaaggcctc
acggtgaaaattggagattttggtttggcaacagtgaaatcacgctggagtggttctcag
caggttgaacagcccaccggctccgtactgtggatggccccagaagtgatcaggatgcag
gataacaacccattcagcttccagtctgatgtctattcctatggcatcgtgctgtacgag
ctgatgacaggggagcttccctactctcacatcaacaaccgtgatcagatcatcttcatg
gtgggtcgcgggtatgcctccccagatcttagtaggctgtacaagaactgccctaaagca
atgaagaggctggtggctgactgtgtaaagaaagtaaaagaagagaggcctctgtttccc
cagattctgtcttctattgagctgctccagcactctctgccgaagatcaaccggagcgcc
tctgagccgtccctgcaccgggcggcccatactgaggacatcaatgcttgcacgctgacc
acatccccaaggctgcctgtcttctag
DBGET
integrated database retrieval system
