KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103751450
Entry
103751450         CDS       T03372                                 

Gene name
Raf1
Definition
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi01521  EGFR tyrosine kinase inhibitor resistance
ngi01522  Endocrine resistance
ngi04010  MAPK signaling pathway
ngi04012  ErbB signaling pathway
ngi04014  Ras signaling pathway
ngi04015  Rap1 signaling pathway
ngi04022  cGMP-PKG signaling pathway
ngi04024  cAMP signaling pathway
ngi04062  Chemokine signaling pathway
ngi04068  FoxO signaling pathway
ngi04071  Sphingolipid signaling pathway
ngi04072  Phospholipase D signaling pathway
ngi04140  Autophagy - animal
ngi04150  mTOR signaling pathway
ngi04151  PI3K-Akt signaling pathway
ngi04210  Apoptosis
ngi04218  Cellular senescence
ngi04270  Vascular smooth muscle contraction
ngi04360  Axon guidance
ngi04370  VEGF signaling pathway
ngi04371  Apelin signaling pathway
ngi04510  Focal adhesion
ngi04540  Gap junction
ngi04550  Signaling pathways regulating pluripotency of stem cells
ngi04625  C-type lectin receptor signaling pathway
ngi04630  JAK-STAT signaling pathway
ngi04650  Natural killer cell mediated cytotoxicity
ngi04660  T cell receptor signaling pathway
ngi04662  B cell receptor signaling pathway
ngi04664  Fc epsilon RI signaling pathway
ngi04666  Fc gamma R-mediated phagocytosis
ngi04720  Long-term potentiation
ngi04722  Neurotrophin signaling pathway
ngi04726  Serotonergic synapse
ngi04730  Long-term depression
ngi04810  Regulation of actin cytoskeleton
ngi04910  Insulin signaling pathway
ngi04912  GnRH signaling pathway
ngi04914  Progesterone-mediated oocyte maturation
ngi04915  Estrogen signaling pathway
ngi04916  Melanogenesis
ngi04917  Prolactin signaling pathway
ngi04919  Thyroid hormone signaling pathway
ngi04921  Oxytocin signaling pathway
ngi04926  Relaxin signaling pathway
ngi04928  Parathyroid hormone synthesis, secretion and action
ngi04929  GnRH secretion
ngi04935  Growth hormone synthesis, secretion and action
ngi05010  Alzheimer disease
ngi05022  Pathways of neurodegeneration - multiple diseases
ngi05034  Alcoholism
ngi05132  Salmonella infection
ngi05152  Tuberculosis
ngi05160  Hepatitis C
ngi05161  Hepatitis B
ngi05163  Human cytomegalovirus infection
ngi05164  Influenza A
ngi05165  Human papillomavirus infection
ngi05167  Kaposi sarcoma-associated herpesvirus infection
ngi05170  Human immunodeficiency virus 1 infection
ngi05200  Pathways in cancer
ngi05205  Proteoglycans in cancer
ngi05206  MicroRNAs in cancer
ngi05210  Colorectal cancer
ngi05211  Renal cell carcinoma
ngi05212  Pancreatic cancer
ngi05213  Endometrial cancer
ngi05214  Glioma
ngi05215  Prostate cancer
ngi05218  Melanoma
ngi05219  Bladder cancer
ngi05220  Chronic myeloid leukemia
ngi05221  Acute myeloid leukemia
ngi05223  Non-small cell lung cancer
ngi05224  Breast cancer
ngi05225  Hepatocellular carcinoma
ngi05226  Gastric cancer
ngi05230  Central carbon metabolism in cancer
ngi05231  Choline metabolism in cancer
ngi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103751450 (Raf1)
   04012 ErbB signaling pathway
    103751450 (Raf1)
   04014 Ras signaling pathway
    103751450 (Raf1)
   04015 Rap1 signaling pathway
    103751450 (Raf1)
   04370 VEGF signaling pathway
    103751450 (Raf1)
   04371 Apelin signaling pathway
    103751450 (Raf1)
   04630 JAK-STAT signaling pathway
    103751450 (Raf1)
   04068 FoxO signaling pathway
    103751450 (Raf1)
   04072 Phospholipase D signaling pathway
    103751450 (Raf1)
   04071 Sphingolipid signaling pathway
    103751450 (Raf1)
   04024 cAMP signaling pathway
    103751450 (Raf1)
   04022 cGMP-PKG signaling pathway
    103751450 (Raf1)
   04151 PI3K-Akt signaling pathway
    103751450 (Raf1)
   04150 mTOR signaling pathway
    103751450 (Raf1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103751450 (Raf1)
  09143 Cell growth and death
   04210 Apoptosis
    103751450 (Raf1)
   04218 Cellular senescence
    103751450 (Raf1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103751450 (Raf1)
   04540 Gap junction
    103751450 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    103751450 (Raf1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103751450 (Raf1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    103751450 (Raf1)
   04650 Natural killer cell mediated cytotoxicity
    103751450 (Raf1)
   04660 T cell receptor signaling pathway
    103751450 (Raf1)
   04662 B cell receptor signaling pathway
    103751450 (Raf1)
   04664 Fc epsilon RI signaling pathway
    103751450 (Raf1)
   04666 Fc gamma R-mediated phagocytosis
    103751450 (Raf1)
   04062 Chemokine signaling pathway
    103751450 (Raf1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103751450 (Raf1)
   04929 GnRH secretion
    103751450 (Raf1)
   04912 GnRH signaling pathway
    103751450 (Raf1)
   04915 Estrogen signaling pathway
    103751450 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    103751450 (Raf1)
   04917 Prolactin signaling pathway
    103751450 (Raf1)
   04921 Oxytocin signaling pathway
    103751450 (Raf1)
   04926 Relaxin signaling pathway
    103751450 (Raf1)
   04935 Growth hormone synthesis, secretion and action
    103751450 (Raf1)
   04919 Thyroid hormone signaling pathway
    103751450 (Raf1)
   04928 Parathyroid hormone synthesis, secretion and action
    103751450 (Raf1)
   04916 Melanogenesis
    103751450 (Raf1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103751450 (Raf1)
  09156 Nervous system
   04726 Serotonergic synapse
    103751450 (Raf1)
   04720 Long-term potentiation
    103751450 (Raf1)
   04730 Long-term depression
    103751450 (Raf1)
   04722 Neurotrophin signaling pathway
    103751450 (Raf1)
  09158 Development and regeneration
   04360 Axon guidance
    103751450 (Raf1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103751450 (Raf1)
   05206 MicroRNAs in cancer
    103751450 (Raf1)
   05205 Proteoglycans in cancer
    103751450 (Raf1)
   05230 Central carbon metabolism in cancer
    103751450 (Raf1)
   05231 Choline metabolism in cancer
    103751450 (Raf1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103751450 (Raf1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103751450 (Raf1)
   05212 Pancreatic cancer
    103751450 (Raf1)
   05225 Hepatocellular carcinoma
    103751450 (Raf1)
   05226 Gastric cancer
    103751450 (Raf1)
   05214 Glioma
    103751450 (Raf1)
   05221 Acute myeloid leukemia
    103751450 (Raf1)
   05220 Chronic myeloid leukemia
    103751450 (Raf1)
   05218 Melanoma
    103751450 (Raf1)
   05211 Renal cell carcinoma
    103751450 (Raf1)
   05219 Bladder cancer
    103751450 (Raf1)
   05215 Prostate cancer
    103751450 (Raf1)
   05213 Endometrial cancer
    103751450 (Raf1)
   05224 Breast cancer
    103751450 (Raf1)
   05223 Non-small cell lung cancer
    103751450 (Raf1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103751450 (Raf1)
   05022 Pathways of neurodegeneration - multiple diseases
    103751450 (Raf1)
  09165 Substance dependence
   05034 Alcoholism
    103751450 (Raf1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103751450 (Raf1)
   05152 Tuberculosis
    103751450 (Raf1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103751450 (Raf1)
   05161 Hepatitis B
    103751450 (Raf1)
   05160 Hepatitis C
    103751450 (Raf1)
   05164 Influenza A
    103751450 (Raf1)
   05163 Human cytomegalovirus infection
    103751450 (Raf1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103751450 (Raf1)
   05165 Human papillomavirus infection
    103751450 (Raf1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103751450 (Raf1)
   01522 Endocrine resistance
    103751450 (Raf1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ngi01001]
    103751450 (Raf1)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103751450 (Raf1)
Protein kinases [BR:ngi01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   103751450 (Raf1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 103751450
NCBI-ProteinID: XP_008853131
LinkDB
Position
Un
AA seq 668 aa
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDTGVPALPSLTMRRMRESVPRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggactcaaagatgcg
gtatttgatggctccagctgtatctcccctacaattgttcagcagtttggctatcagcgt
cgggcctcagatgatggcaaactcacagattcctcgaagacaagcaacactatccgtgtt
ttcttgccgaataagcaaagaactgtggtcaatgtgcggaatggaatgagcttacatgac
tgccttatgaaagctctcaaggtgagaggcttacagccggagtgctgtgcagtgttcaga
cttctccaggagcacaaaggtaaaaaagcacgcttagattggaatactgatgccgcctca
ttgattggagaagaacttcaagtagatttcctggatcatgttcctctcacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcaaaagttcctgcta
aatggatttcgatgtcagacctgtggctacaaatttcatgagcactgtagcaccaaagta
cccactatgtgtgtggattggagtaatatcagacaacttttgctctttccaaactctact
gttggtgatactggagtcccagcactaccttctttgacaatgcgtcggatgcgagaatct
gttccccgtatgcctgctagttcccagcacagatactccacaccccatgccttcactttc
aacacctccagtccttcttctgaaggctccctctcccagaggcagaggtcaacgtccact
cccaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagtcacagtgaatcagcttcaccttcagccttgtccagcagccctaacaacctg
agcccaacaggctggtcacagcccaaaacccctgtgccagcacaaagagagagggcacca
ggatctgggacccaggagaaaaacaaaattaggcctcgaggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctccttc
ggcactgtgtataagggcaagtggcatggagatgttgcagtaaagattctaaaggtcgtt
gacccaaccccagagcagttccaggccttcaggaatgaggtggctgtcctgcgcaaaact
cggcatgtcaacatcctattatttatggggtacatgacaaaggacaacttggcaattgtg
actcagtggtgtgaaggtagcagtctctacaaacacctgcatgtccaggagaccaaattc
cagatgttccagttaattgacattgcccggcagacagctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaagtccaacaatatattcctccatgaaggcctc
acggtgaaaattggagattttggtttggcaacagtgaaatcacgctggagtggttctcag
caggttgaacagcccaccggctccgtactgtggatggccccagaagtgatcaggatgcag
gataacaacccattcagcttccagtctgatgtctattcctatggcatcgtgctgtacgag
ctgatgacaggggagcttccctactctcacatcaacaaccgtgatcagatcatcttcatg
gtgggtcgcgggtatgcctccccagatcttagtaggctgtacaagaactgccctaaagca
atgaagaggctggtggctgactgtgtaaagaaagtaaaagaagagaggcctctgtttccc
cagattctgtcttctattgagctgctccagcactctctgccgaagatcaaccggagcgcc
tctgagccgtccctgcaccgggcggcccatactgaggacatcaatgcttgcacgctgacc
acatccccaaggctgcctgtcttctag

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