KEGG   PATHWAY: nle05213
Entry
nle05213                    Pathway                                

Name
Endometrial cancer - Nomascus leucogenys (northern white-cheeked gibbon)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
nle05213  Endometrial cancer
nle05213

Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100588963  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100597255  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100588218  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100580872  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100584384  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100605788  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100591270  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100599301  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100605147  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100593010  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
115831277  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
100598379  ILK; integrin-linked protein kinase isoform X2 [KO:K06272] [EC:2.7.11.1]
100604331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587864  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587109  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100597173  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101178725  BAD; bcl2-associated agonist of cell death [KO:K02158]
100600519  FOXO3; forkhead box protein O3 [KO:K09408]
100588468  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100590165  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100600495  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100595274  HRAS; GTPase HRas isoform X1 [KO:K02833]
100593773  KRAS; GTPase KRas isoform X1 [KO:K07827]
100592103  NRAS; GTPase NRas [KO:K07828]
100595311  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100582848  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100582599  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100579506  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100591827  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100600574  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100584480  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100596002  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100593390  MLH1; DNA mismatch repair protein Mlh1 isoform X2 [KO:K08734]
100596627  CDH1; cadherin-1 isoform X1 [KO:K05689]
100583002  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100606736  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
100599144  CTNNA2; catenin alpha-2 isoform X5 [KO:K05691]
100593453  CTNNA1; catenin alpha-1 isoform X1 [KO:K05691]
101179424  AXIN1; axin-1 isoform X1 [KO:K02157]
100589482  AXIN2; axin-2 isoform X1 [KO:K04385]
100602025  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100585467  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
100606885  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100595737  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
100601518  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100605701  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100593051  LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
100589322  MYC; myc proto-oncogene protein [KO:K04377]
100605736  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100583326  TP53; cellular tumor antigen p53 [KO:K04451]
100599083  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100593432  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100583800  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
115830865  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100593013  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100588483  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100605065  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100598341  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
100601700  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
nle04010  MAPK signaling pathway
nle04012  ErbB signaling pathway
nle04060  Cytokine-cytokine receptor interaction
nle04110  Cell cycle
nle04115  p53 signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04310  Wnt signaling pathway
nle04520  Adherens junction
KO pathway
ko05213   
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