KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100580599
Entry
100580599         CDS       T03265                                 
Symbol
MAPK11
Name
(RefSeq) mitogen-activated protein kinase 11 isoform X5
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01522  Endocrine resistance
nle04010  MAPK signaling pathway
nle04015  Rap1 signaling pathway
nle04068  FoxO signaling pathway
nle04071  Sphingolipid signaling pathway
nle04114  Oocyte meiosis
nle04148  Efferocytosis
nle04218  Cellular senescence
nle04261  Adrenergic signaling in cardiomyocytes
nle04370  VEGF signaling pathway
nle04380  Osteoclast differentiation
nle04550  Signaling pathways regulating pluripotency of stem cells
nle04611  Platelet activation
nle04613  Neutrophil extracellular trap formation
nle04620  Toll-like receptor signaling pathway
nle04621  NOD-like receptor signaling pathway
nle04622  RIG-I-like receptor signaling pathway
nle04625  C-type lectin receptor signaling pathway
nle04657  IL-17 signaling pathway
nle04658  Th1 and Th2 cell differentiation
nle04659  Th17 cell differentiation
nle04660  T cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04668  TNF signaling pathway
nle04670  Leukocyte transendothelial migration
nle04714  Thermogenesis
nle04722  Neurotrophin signaling pathway
nle04723  Retrograde endocannabinoid signaling
nle04728  Dopaminergic synapse
nle04750  Inflammatory mediator regulation of TRP channels
nle04912  GnRH signaling pathway
nle04914  Progesterone-mediated oocyte maturation
nle04917  Prolactin signaling pathway
nle04926  Relaxin signaling pathway
nle04932  Non-alcoholic fatty liver disease
nle04933  AGE-RAGE signaling pathway in diabetic complications
nle04935  Growth hormone synthesis, secretion and action
nle04936  Alcoholic liver disease
nle05014  Amyotrophic lateral sclerosis
nle05020  Prion disease
nle05022  Pathways of neurodegeneration - multiple diseases
nle05132  Salmonella infection
nle05133  Pertussis
nle05135  Yersinia infection
nle05140  Leishmaniasis
nle05142  Chagas disease
nle05145  Toxoplasmosis
nle05152  Tuberculosis
nle05161  Hepatitis B
nle05163  Human cytomegalovirus infection
nle05167  Kaposi sarcoma-associated herpesvirus infection
nle05169  Epstein-Barr virus infection
nle05170  Human immunodeficiency virus 1 infection
nle05171  Coronavirus disease - COVID-19
nle05205  Proteoglycans in cancer
nle05208  Chemical carcinogenesis - reactive oxygen species
nle05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nle05415  Diabetic cardiomyopathy
nle05417  Lipid and atherosclerosis
nle05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100580599 (MAPK11)
   04015 Rap1 signaling pathway
    100580599 (MAPK11)
   04370 VEGF signaling pathway
    100580599 (MAPK11)
   04668 TNF signaling pathway
    100580599 (MAPK11)
   04068 FoxO signaling pathway
    100580599 (MAPK11)
   04071 Sphingolipid signaling pathway
    100580599 (MAPK11)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    100580599 (MAPK11)
  09143 Cell growth and death
   04114 Oocyte meiosis
    100580599 (MAPK11)
   04218 Cellular senescence
    100580599 (MAPK11)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100580599 (MAPK11)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100580599 (MAPK11)
   04613 Neutrophil extracellular trap formation
    100580599 (MAPK11)
   04620 Toll-like receptor signaling pathway
    100580599 (MAPK11)
   04621 NOD-like receptor signaling pathway
    100580599 (MAPK11)
   04622 RIG-I-like receptor signaling pathway
    100580599 (MAPK11)
   04625 C-type lectin receptor signaling pathway
    100580599 (MAPK11)
   04660 T cell receptor signaling pathway
    100580599 (MAPK11)
   04658 Th1 and Th2 cell differentiation
    100580599 (MAPK11)
   04659 Th17 cell differentiation
    100580599 (MAPK11)
   04657 IL-17 signaling pathway
    100580599 (MAPK11)
   04664 Fc epsilon RI signaling pathway
    100580599 (MAPK11)
   04670 Leukocyte transendothelial migration
    100580599 (MAPK11)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100580599 (MAPK11)
   04914 Progesterone-mediated oocyte maturation
    100580599 (MAPK11)
   04917 Prolactin signaling pathway
    100580599 (MAPK11)
   04926 Relaxin signaling pathway
    100580599 (MAPK11)
   04935 Growth hormone synthesis, secretion and action
    100580599 (MAPK11)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100580599 (MAPK11)
  09156 Nervous system
   04728 Dopaminergic synapse
    100580599 (MAPK11)
   04723 Retrograde endocannabinoid signaling
    100580599 (MAPK11)
   04722 Neurotrophin signaling pathway
    100580599 (MAPK11)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100580599 (MAPK11)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100580599 (MAPK11)
  09159 Environmental adaptation
   04714 Thermogenesis
    100580599 (MAPK11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    100580599 (MAPK11)
   05208 Chemical carcinogenesis - reactive oxygen species
    100580599 (MAPK11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100580599 (MAPK11)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100580599 (MAPK11)
   05161 Hepatitis B
    100580599 (MAPK11)
   05171 Coronavirus disease - COVID-19
    100580599 (MAPK11)
   05163 Human cytomegalovirus infection
    100580599 (MAPK11)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100580599 (MAPK11)
   05169 Epstein-Barr virus infection
    100580599 (MAPK11)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100580599 (MAPK11)
   05135 Yersinia infection
    100580599 (MAPK11)
   05133 Pertussis
    100580599 (MAPK11)
   05152 Tuberculosis
    100580599 (MAPK11)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100580599 (MAPK11)
   05140 Leishmaniasis
    100580599 (MAPK11)
   05142 Chagas disease
    100580599 (MAPK11)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    100580599 (MAPK11)
   05020 Prion disease
    100580599 (MAPK11)
   05022 Pathways of neurodegeneration - multiple diseases
    100580599 (MAPK11)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100580599 (MAPK11)
   05418 Fluid shear stress and atherosclerosis
    100580599 (MAPK11)
   05415 Diabetic cardiomyopathy
    100580599 (MAPK11)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100580599 (MAPK11)
   04932 Non-alcoholic fatty liver disease
    100580599 (MAPK11)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100580599 (MAPK11)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100580599 (MAPK11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nle01001]
    100580599 (MAPK11)
Enzymes [BR:nle01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     100580599 (MAPK11)
Protein kinases [BR:nle01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   100580599 (MAPK11)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Kinase-like
Other DBs
NCBI-GeneID: 100580599
NCBI-ProteinID: XP_003281508
Ensembl: ENSNLEG00000000606 ENSNLEG00000000628
UniProt: G1QII1
LinkDB
Position
7b:513764..531233
AA seq 367 aa
MSSPSPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDGFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAAEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccgtcgcccgcccgcagtggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccgcaccggcgctaaggtggccatcaagaagctgtatcgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccacgagaacgtgatcgggctgctggacgtattcactcctgatgagaccctggat
ggcttcacagacttttacctggtgatgccgttcatgggcactgacctgggcaagctcatg
aaacatgagaagctaggcgaggaccggatccagttcctcgtgtaccagatgctgaagggg
ctgaggtatatccacgctgccggcatcatccacagagacctgaagcctggcaacctggct
gtgaacgaagactgtgagctgaagatcctggactttggcctggccaggcaggcagacagt
gagatgactgggtacgtggtgacccggtggtaccgagctcccgaggtcatcttgaattgg
atgcgctacacgcagacggtggacatctggtctgtgggctgcatcatggcggagatgatc
acaggcaagacgctgttcaagggcagcgaccacctggaccagctgaaagagatcatgaag
gtgacagggacgcctccggctgagtttgtgcagcggctgcagagcgatgaggccaagaac
tacatgaagggcctccccgaattggagaagaaggattttgcctccatcctgaccaatgca
agccctctggctgtgaacctcctggagaagatgctggtgctggatgcggagcagcgggtg
acggcggccgaggcgctggcccatccctacttcgagtccctgcacgacacggaagatgag
ccccaggtccagaagtatgatgactcctttgacgacgtggaccgcacactggatgaatgg
aagcgtgttacttacaaagaggtgctcagcttcaagcctccccggcagctgggggccagg
gtctccaaggagacggctctgtga

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