KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100582599
Entry
100582599         CDS       T03265                                 

Gene name
RAF1
Definition
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521  EGFR tyrosine kinase inhibitor resistance
nle01522  Endocrine resistance
nle04010  MAPK signaling pathway
nle04012  ErbB signaling pathway
nle04014  Ras signaling pathway
nle04015  Rap1 signaling pathway
nle04022  cGMP-PKG signaling pathway
nle04024  cAMP signaling pathway
nle04062  Chemokine signaling pathway
nle04068  FoxO signaling pathway
nle04071  Sphingolipid signaling pathway
nle04072  Phospholipase D signaling pathway
nle04140  Autophagy - animal
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04210  Apoptosis
nle04218  Cellular senescence
nle04270  Vascular smooth muscle contraction
nle04360  Axon guidance
nle04370  VEGF signaling pathway
nle04371  Apelin signaling pathway
nle04510  Focal adhesion
nle04540  Gap junction
nle04550  Signaling pathways regulating pluripotency of stem cells
nle04625  C-type lectin receptor signaling pathway
nle04630  JAK-STAT signaling pathway
nle04650  Natural killer cell mediated cytotoxicity
nle04660  T cell receptor signaling pathway
nle04662  B cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04666  Fc gamma R-mediated phagocytosis
nle04720  Long-term potentiation
nle04722  Neurotrophin signaling pathway
nle04726  Serotonergic synapse
nle04730  Long-term depression
nle04810  Regulation of actin cytoskeleton
nle04910  Insulin signaling pathway
nle04912  GnRH signaling pathway
nle04914  Progesterone-mediated oocyte maturation
nle04915  Estrogen signaling pathway
nle04916  Melanogenesis
nle04917  Prolactin signaling pathway
nle04919  Thyroid hormone signaling pathway
nle04921  Oxytocin signaling pathway
nle04926  Relaxin signaling pathway
nle04928  Parathyroid hormone synthesis, secretion and action
nle04929  GnRH secretion
nle04935  Growth hormone synthesis, secretion and action
nle05010  Alzheimer disease
nle05022  Pathways of neurodegeneration - multiple diseases
nle05034  Alcoholism
nle05132  Salmonella infection
nle05152  Tuberculosis
nle05160  Hepatitis C
nle05161  Hepatitis B
nle05163  Human cytomegalovirus infection
nle05164  Influenza A
nle05165  Human papillomavirus infection
nle05167  Kaposi sarcoma-associated herpesvirus infection
nle05170  Human immunodeficiency virus 1 infection
nle05200  Pathways in cancer
nle05205  Proteoglycans in cancer
nle05206  MicroRNAs in cancer
nle05210  Colorectal cancer
nle05211  Renal cell carcinoma
nle05212  Pancreatic cancer
nle05213  Endometrial cancer
nle05214  Glioma
nle05215  Prostate cancer
nle05218  Melanoma
nle05219  Bladder cancer
nle05220  Chronic myeloid leukemia
nle05221  Acute myeloid leukemia
nle05223  Non-small cell lung cancer
nle05224  Breast cancer
nle05225  Hepatocellular carcinoma
nle05226  Gastric cancer
nle05230  Central carbon metabolism in cancer
nle05231  Choline metabolism in cancer
nle05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100582599 (RAF1)
   04012 ErbB signaling pathway
    100582599 (RAF1)
   04014 Ras signaling pathway
    100582599 (RAF1)
   04015 Rap1 signaling pathway
    100582599 (RAF1)
   04370 VEGF signaling pathway
    100582599 (RAF1)
   04371 Apelin signaling pathway
    100582599 (RAF1)
   04630 JAK-STAT signaling pathway
    100582599 (RAF1)
   04068 FoxO signaling pathway
    100582599 (RAF1)
   04072 Phospholipase D signaling pathway
    100582599 (RAF1)
   04071 Sphingolipid signaling pathway
    100582599 (RAF1)
   04024 cAMP signaling pathway
    100582599 (RAF1)
   04022 cGMP-PKG signaling pathway
    100582599 (RAF1)
   04151 PI3K-Akt signaling pathway
    100582599 (RAF1)
   04150 mTOR signaling pathway
    100582599 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100582599 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    100582599 (RAF1)
   04218 Cellular senescence
    100582599 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100582599 (RAF1)
   04540 Gap junction
    100582599 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100582599 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100582599 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100582599 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    100582599 (RAF1)
   04660 T cell receptor signaling pathway
    100582599 (RAF1)
   04662 B cell receptor signaling pathway
    100582599 (RAF1)
   04664 Fc epsilon RI signaling pathway
    100582599 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    100582599 (RAF1)
   04062 Chemokine signaling pathway
    100582599 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100582599 (RAF1)
   04929 GnRH secretion
    100582599 (RAF1)
   04912 GnRH signaling pathway
    100582599 (RAF1)
   04915 Estrogen signaling pathway
    100582599 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    100582599 (RAF1)
   04917 Prolactin signaling pathway
    100582599 (RAF1)
   04921 Oxytocin signaling pathway
    100582599 (RAF1)
   04926 Relaxin signaling pathway
    100582599 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    100582599 (RAF1)
   04919 Thyroid hormone signaling pathway
    100582599 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    100582599 (RAF1)
   04916 Melanogenesis
    100582599 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100582599 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    100582599 (RAF1)
   04720 Long-term potentiation
    100582599 (RAF1)
   04730 Long-term depression
    100582599 (RAF1)
   04722 Neurotrophin signaling pathway
    100582599 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    100582599 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100582599 (RAF1)
   05206 MicroRNAs in cancer
    100582599 (RAF1)
   05205 Proteoglycans in cancer
    100582599 (RAF1)
   05230 Central carbon metabolism in cancer
    100582599 (RAF1)
   05231 Choline metabolism in cancer
    100582599 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100582599 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100582599 (RAF1)
   05212 Pancreatic cancer
    100582599 (RAF1)
   05225 Hepatocellular carcinoma
    100582599 (RAF1)
   05226 Gastric cancer
    100582599 (RAF1)
   05214 Glioma
    100582599 (RAF1)
   05221 Acute myeloid leukemia
    100582599 (RAF1)
   05220 Chronic myeloid leukemia
    100582599 (RAF1)
   05218 Melanoma
    100582599 (RAF1)
   05211 Renal cell carcinoma
    100582599 (RAF1)
   05219 Bladder cancer
    100582599 (RAF1)
   05215 Prostate cancer
    100582599 (RAF1)
   05213 Endometrial cancer
    100582599 (RAF1)
   05224 Breast cancer
    100582599 (RAF1)
   05223 Non-small cell lung cancer
    100582599 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100582599 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    100582599 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    100582599 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100582599 (RAF1)
   05152 Tuberculosis
    100582599 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100582599 (RAF1)
   05161 Hepatitis B
    100582599 (RAF1)
   05160 Hepatitis C
    100582599 (RAF1)
   05164 Influenza A
    100582599 (RAF1)
   05163 Human cytomegalovirus infection
    100582599 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100582599 (RAF1)
   05165 Human papillomavirus infection
    100582599 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100582599 (RAF1)
   01522 Endocrine resistance
    100582599 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nle01001]
    100582599 (RAF1)
Enzymes [BR:nle01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100582599 (RAF1)
Protein kinases [BR:nle01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100582599 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 100582599
NCBI-ProteinID: XP_003265042
Ensembl: ENSNLEG00000004732
UniProt: G1QXT4
LinkDB
Position
21
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaacttacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttgattggagaagaacttcaagtagatttcctggatcatgttccgctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctg
aacggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacagctcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacccccgtgccggcacaaagagagcgggcacca
gtatccgggacccaggagaaaaacaaaattaggcctcggggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaaccgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtt
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgtgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggctta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctgtggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcatcgtattgtatgag
ctgatgacaggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagtgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaacgcttgcacgctgacc
acgtccccgaggctgcctgtcttctag

KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100582848
Entry
100582848         CDS       T03265                                 

Gene name
BRAF
Definition
(RefSeq) serine/threonine-protein kinase B-raf isoform X2
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521  EGFR tyrosine kinase inhibitor resistance
nle01522  Endocrine resistance
nle04010  MAPK signaling pathway
nle04012  ErbB signaling pathway
nle04015  Rap1 signaling pathway
nle04024  cAMP signaling pathway
nle04062  Chemokine signaling pathway
nle04068  FoxO signaling pathway
nle04150  mTOR signaling pathway
nle04270  Vascular smooth muscle contraction
nle04510  Focal adhesion
nle04650  Natural killer cell mediated cytotoxicity
nle04720  Long-term potentiation
nle04722  Neurotrophin signaling pathway
nle04726  Serotonergic synapse
nle04730  Long-term depression
nle04810  Regulation of actin cytoskeleton
nle04910  Insulin signaling pathway
nle04914  Progesterone-mediated oocyte maturation
nle04928  Parathyroid hormone synthesis, secretion and action
nle04934  Cushing syndrome
nle05010  Alzheimer disease
nle05022  Pathways of neurodegeneration - multiple diseases
nle05034  Alcoholism
nle05160  Hepatitis C
nle05161  Hepatitis B
nle05200  Pathways in cancer
nle05205  Proteoglycans in cancer
nle05210  Colorectal cancer
nle05211  Renal cell carcinoma
nle05212  Pancreatic cancer
nle05213  Endometrial cancer
nle05214  Glioma
nle05215  Prostate cancer
nle05216  Thyroid cancer
nle05218  Melanoma
nle05219  Bladder cancer
nle05220  Chronic myeloid leukemia
nle05221  Acute myeloid leukemia
nle05223  Non-small cell lung cancer
nle05224  Breast cancer
nle05225  Hepatocellular carcinoma
nle05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100582848 (BRAF)
   04012 ErbB signaling pathway
    100582848 (BRAF)
   04015 Rap1 signaling pathway
    100582848 (BRAF)
   04068 FoxO signaling pathway
    100582848 (BRAF)
   04024 cAMP signaling pathway
    100582848 (BRAF)
   04150 mTOR signaling pathway
    100582848 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100582848 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100582848 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100582848 (BRAF)
   04062 Chemokine signaling pathway
    100582848 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100582848 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    100582848 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100582848 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100582848 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100582848 (BRAF)
   04720 Long-term potentiation
    100582848 (BRAF)
   04730 Long-term depression
    100582848 (BRAF)
   04722 Neurotrophin signaling pathway
    100582848 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100582848 (BRAF)
   05205 Proteoglycans in cancer
    100582848 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100582848 (BRAF)
   05212 Pancreatic cancer
    100582848 (BRAF)
   05225 Hepatocellular carcinoma
    100582848 (BRAF)
   05226 Gastric cancer
    100582848 (BRAF)
   05214 Glioma
    100582848 (BRAF)
   05216 Thyroid cancer
    100582848 (BRAF)
   05221 Acute myeloid leukemia
    100582848 (BRAF)
   05220 Chronic myeloid leukemia
    100582848 (BRAF)
   05218 Melanoma
    100582848 (BRAF)
   05211 Renal cell carcinoma
    100582848 (BRAF)
   05219 Bladder cancer
    100582848 (BRAF)
   05215 Prostate cancer
    100582848 (BRAF)
   05213 Endometrial cancer
    100582848 (BRAF)
   05224 Breast cancer
    100582848 (BRAF)
   05223 Non-small cell lung cancer
    100582848 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100582848 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100582848 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    100582848 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100582848 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100582848 (BRAF)
   05160 Hepatitis C
    100582848 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100582848 (BRAF)
   01522 Endocrine resistance
    100582848 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nle01001]
    100582848 (BRAF)
Enzymes [BR:nle01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100582848 (BRAF)
Protein kinases [BR:nle01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100582848 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like C1_2 Pkinase_fungal APH Kdo
Other DBs
NCBI-GeneID: 100582848
NCBI-ProteinID: XP_004090289
Ensembl: ENSNLEG00000002139
LinkDB
Position
13
AA seq 765 aa
MAALSGGGGSGAEPGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIE
ALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTS
SSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLK
KALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTF
FTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQ
EEASLAETALTSGSSPSAPASDSVGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDR
SSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGP
QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAV
KMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS
RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNR
DQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP
KIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2298 nt   +upstreamnt  +downstreamnt
atggcggcgttgagcggtggcggtggtagcggcgcggagccgggccaggctctgttcaac
ggggacatggagcccgaggccggcgccggcgccgcggcctcttcggctgcggaccctgcc
attccggaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagag
gccctattggacaaatttggtggggagcataatccaccatcaatatatctggaggcctat
gaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattggaatct
ctggggaacggaactgatttttctgtttctagctctgcatcaatggacaccgttacatct
tcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaatcctaca
gatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttcctgccc
aacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagtctaaag
aaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggat
ggagagaagaaaccaattggctgggacactgatatttcctggcttactggagaagaattg
catgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaaacgttt
ttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaa
acatgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaat
tatgaccaacttgatttgctgtttgtctccaagttttttgaacaccacccaataccacag
gaagaggcctccttagcagagactgccctaacatctggatcatccccttctgcacccgcc
tcagactctgttgggccccaaattctcaccagtccgtctccttcaaaatccattccaatt
ccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacgagaccgg
tcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgatgacttg
attagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgccaccccc
cctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctccaggacct
cagcgagaaaggaagtcatcttcatcctcagaagataggaatcgaatgaaaacacttggt
agacgggactcaagtgatgattgggagattcctgatgggcagattacagtgggacaaaga
attggatctggatcatttggaacagtctacaagggaaaatggcatggtgatgtggcagtg
aaaatgttgaatgtaacagcacctacacctcagcagttacaagccttcaaaaatgaagta
ggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattccacaaag
ccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccatctccat
atcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagactgcacag
ggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatata
tttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtgaaatct
cgatggagtgggtcccatcagtttgaacaattgtctggatccattttgtggatggcacca
gaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatatgcattt
gggattgttctgtatgaattgatgactggacaattaccttattcaaacatcaacaacagg
gaccagataatttttatggtgggacgaggatacctatctccagatctcagtaaggtacgg
agtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagat
gagagaccactctttccccaaattctcgcctctattgagctgctggcccgctcattgcca
aaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaacagaggat
tttagtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatatggagaa
tttgcagccttcaagtag

KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100595311
Entry
100595311         CDS       T03265                                 

Gene name
ARAF
Definition
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521  EGFR tyrosine kinase inhibitor resistance
nle01522  Endocrine resistance
nle04010  MAPK signaling pathway
nle04012  ErbB signaling pathway
nle04068  FoxO signaling pathway
nle04270  Vascular smooth muscle contraction
nle04650  Natural killer cell mediated cytotoxicity
nle04720  Long-term potentiation
nle04726  Serotonergic synapse
nle04730  Long-term depression
nle04810  Regulation of actin cytoskeleton
nle04910  Insulin signaling pathway
nle04914  Progesterone-mediated oocyte maturation
nle04928  Parathyroid hormone synthesis, secretion and action
nle05010  Alzheimer disease
nle05022  Pathways of neurodegeneration - multiple diseases
nle05034  Alcoholism
nle05160  Hepatitis C
nle05161  Hepatitis B
nle05200  Pathways in cancer
nle05205  Proteoglycans in cancer
nle05210  Colorectal cancer
nle05211  Renal cell carcinoma
nle05212  Pancreatic cancer
nle05213  Endometrial cancer
nle05214  Glioma
nle05215  Prostate cancer
nle05218  Melanoma
nle05219  Bladder cancer
nle05220  Chronic myeloid leukemia
nle05221  Acute myeloid leukemia
nle05223  Non-small cell lung cancer
nle05224  Breast cancer
nle05225  Hepatocellular carcinoma
nle05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100595311 (ARAF)
   04012 ErbB signaling pathway
    100595311 (ARAF)
   04068 FoxO signaling pathway
    100595311 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100595311 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100595311 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100595311 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    100595311 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100595311 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100595311 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100595311 (ARAF)
   04720 Long-term potentiation
    100595311 (ARAF)
   04730 Long-term depression
    100595311 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100595311 (ARAF)
   05205 Proteoglycans in cancer
    100595311 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100595311 (ARAF)
   05212 Pancreatic cancer
    100595311 (ARAF)
   05225 Hepatocellular carcinoma
    100595311 (ARAF)
   05226 Gastric cancer
    100595311 (ARAF)
   05214 Glioma
    100595311 (ARAF)
   05221 Acute myeloid leukemia
    100595311 (ARAF)
   05220 Chronic myeloid leukemia
    100595311 (ARAF)
   05218 Melanoma
    100595311 (ARAF)
   05211 Renal cell carcinoma
    100595311 (ARAF)
   05219 Bladder cancer
    100595311 (ARAF)
   05215 Prostate cancer
    100595311 (ARAF)
   05213 Endometrial cancer
    100595311 (ARAF)
   05224 Breast cancer
    100595311 (ARAF)
   05223 Non-small cell lung cancer
    100595311 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100595311 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100595311 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    100595311 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100595311 (ARAF)
   05160 Hepatitis C
    100595311 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100595311 (ARAF)
   01522 Endocrine resistance
    100595311 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nle01001]
    100595311 (ARAF)
Enzymes [BR:nle01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100595311 (ARAF)
Protein kinases [BR:nle01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100595311 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal APH TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 100595311
NCBI-ProteinID: XP_030663397
Ensembl: ENSNLEG00000036307
LinkDB
Position
X
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTSRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAACSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcacc
gtcaaagtgtacctgcctaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagaccgtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagcaccagccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacaacatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcccccgcacccagcactgtgacccggagcacttccccttccct
gccccagccaatgcccccctacagcgcatccgttccacgtccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgcctgtagtagaggaggtagtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcagggaggaagtccccacattccaagtcaccagcagagcagcgcgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaggctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccaggatttgccatc
atcacacagtggtgtgagggctcgagcctctaccatcacctgcatgtggccgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccatcgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagattggtgactttggcttggccacagtgaagactcgatggagtggggcc
cagcccttggagcagccctcaggctctgtgctgtggatggcagctgaggtgatccgtatg
caggacccaaacccctacagcttccagtcagacgtctatgcctacggggttgtgctctac
gagcttatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgagaggagcggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagaggagt
gcctcggaaccctccttgcaccgcacccaggccgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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