KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100605147Help
Entry
100605147         CDS       T03265                                 

Gene name
PTEN
Definition
(RefSeq) phosphatase and tensin homolog
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle00562  Inositol phosphate metabolism
nle01100  Metabolic pathways
nle01521  EGFR tyrosine kinase inhibitor resistance
nle04068  FoxO signaling pathway
nle04070  Phosphatidylinositol signaling system
nle04071  Sphingolipid signaling pathway
nle04115  p53 signaling pathway
nle04140  Autophagy - animal
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04218  Cellular senescence
nle04510  Focal adhesion
nle04931  Insulin resistance
nle05165  Human papillomavirus infection
nle05166  Human T-cell leukemia virus 1 infection
nle05200  Pathways in cancer
nle05206  MicroRNAs in cancer
nle05213  Endometrial cancer
nle05214  Glioma
nle05215  Prostate cancer
nle05218  Melanoma
nle05222  Small cell lung cancer
nle05224  Breast cancer
nle05225  Hepatocellular carcinoma
nle05230  Central carbon metabolism in cancer
nle05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:nle00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100605147 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100605147 (PTEN)
   04070 Phosphatidylinositol signaling system
    100605147 (PTEN)
   04071 Sphingolipid signaling pathway
    100605147 (PTEN)
   04151 PI3K-Akt signaling pathway
    100605147 (PTEN)
   04150 mTOR signaling pathway
    100605147 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100605147 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    100605147 (PTEN)
   04218 Cellular senescence
    100605147 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100605147 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100605147 (PTEN)
   05206 MicroRNAs in cancer
    100605147 (PTEN)
   05230 Central carbon metabolism in cancer
    100605147 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100605147 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100605147 (PTEN)
   05214 Glioma
    100605147 (PTEN)
   05218 Melanoma
    100605147 (PTEN)
   05215 Prostate cancer
    100605147 (PTEN)
   05213 Endometrial cancer
    100605147 (PTEN)
   05224 Breast cancer
    100605147 (PTEN)
   05222 Small cell lung cancer
    100605147 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    100605147 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100605147 (PTEN)
   05165 Human papillomavirus infection
    100605147 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100605147 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:nle01009]
    100605147 (PTEN)
Enzymes [BR:nle01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     100605147 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     100605147 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     100605147 (PTEN)
Protein phosphatases and associated proteins [BR:nle01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    100605147 (PTEN)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PTEN_C2 DSPc Y_phosphatase Y_phosphatase3 PTPlike_phytase DUF3256
Motif
Other DBs
NCBI-GeneID: 100605147
NCBI-ProteinID: XP_003255221
UniProt: G1RNC7
LinkDB All DBs
Position
3
AA seq 403 aa AA seqDB search
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1212 nt NT seq  +upstreamnt  +downstreamnt
atgacagccatcatcaaagagatcgttagcagaaacaaaaggagataccaagaggatgga
ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag
cataaaaaccattacaagatatacaatctttgtgctgaaagacattatgacaccgccaaa
tttaattgcagagttgcacaatatccttttgaagaccataacccaccacagctagaactt
atcaaacccttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca
gcaattcactgtaaagctggaaagggacgaactggtgtaatgatttgtgcatatttatta
catcggggcaaatttttaaaggcacaagaggccctagatttctatggggaagtaaggacc
agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac
ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt
gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta
aaggtgaagatatattcctccaattcaggacccacacgacgggaagacaagttcatgtac
tttgagttccctcagccgttacctgtgtgtggtgatatcaaagtagagttcttccacaaa
cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacattcttcata
ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatt
gatagcatttgcagtatagagcgtgcagataatgacaaggaatatctagtacttacttta
acaaaaaatgatcttgacaaagcaaataaagacaaagccaaccgatacttttctccaaat
tttaaggtgaagctgtacttcacaaaaacagtagaggagccgtcaaatccagaggctagc
agttcaacttctgtaacaccagatgttagtgacaatgaacctgatcattatagatattct
gacaccactgactctgatccagagaatgaaccttttgatgaagatcagcatacacaaatt
acaaaagtctga

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