Ornithorhynchus anatinus (platypus): 114811232 Help Entry 114811232         CDS       T01045                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism oaa  Ornithorhynchus anatinus (platypus) Pathway oaa00230   Purine metabolism oaa01100   Metabolic pathways oaa01522   Endocrine resistance oaa04015   Rap1 signaling pathway oaa04022   cGMP-PKG signaling pathway oaa04024   cAMP signaling pathway oaa04062   Chemokine signaling pathway oaa04072   Phospholipase D signaling pathway oaa04114   Oocyte meiosis oaa04211   Longevity regulating pathway oaa04213   Longevity regulating pathway - multiple species oaa04261   Adrenergic signaling in cardiomyocytes oaa04270   Vascular smooth muscle contraction oaa04371   Apelin signaling pathway oaa04540   Gap junction oaa04611   Platelet activation oaa04713   Circadian entrainment oaa04714   Thermogenesis oaa04723   Retrograde endocannabinoid signaling oaa04724   Glutamatergic synapse oaa04725   Cholinergic synapse oaa04726   Serotonergic synapse oaa04727   GABAergic synapse oaa04728   Dopaminergic synapse oaa04750   Inflammatory mediator regulation of TRP channels oaa04911   Insulin secretion oaa04912   GnRH signaling pathway oaa04913   Ovarian steroidogenesis oaa04914   Progesterone-mediated oocyte maturation oaa04915   Estrogen signaling pathway oaa04916   Melanogenesis oaa04918   Thyroid hormone synthesis oaa04921   Oxytocin signaling pathway oaa04923   Regulation of lipolysis in adipocytes oaa04924   Renin secretion oaa04925   Aldosterone synthesis and secretion oaa04926   Relaxin signaling pathway oaa04927   Cortisol synthesis and secretion oaa04928   Parathyroid hormone synthesis, secretion and action oaa04934   Cushing syndrome oaa04935   Growth hormone synthesis, secretion and action oaa04970   Salivary secretion oaa04971   Gastric acid secretion oaa04972   Pancreatic secretion oaa04976   Bile secretion oaa05012   Parkinson disease oaa05030   Cocaine addiction oaa05031   Amphetamine addiction oaa05032   Morphine addiction oaa05034   Alcoholism oaa05163   Human cytomegalovirus infection oaa05166   Human T-cell leukemia virus 1 infection oaa05200   Pathways in cancer oaa05207   Chemical carcinogenesis - receptor activation oaa05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:oaa00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     114811232 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     114811232 (ADCY5)    04371 Apelin signaling pathway     114811232 (ADCY5)    04072 Phospholipase D signaling pathway     114811232 (ADCY5)    04024 cAMP signaling pathway     114811232 (ADCY5)    04022 cGMP-PKG signaling pathway     114811232 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     114811232 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     114811232 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     114811232 (ADCY5)    04062 Chemokine signaling pathway     114811232 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     114811232 (ADCY5)    04923 Regulation of lipolysis in adipocytes     114811232 (ADCY5)    04912 GnRH signaling pathway     114811232 (ADCY5)    04913 Ovarian steroidogenesis     114811232 (ADCY5)    04915 Estrogen signaling pathway     114811232 (ADCY5)    04914 Progesterone-mediated oocyte maturation     114811232 (ADCY5)    04921 Oxytocin signaling pathway     114811232 (ADCY5)    04926 Relaxin signaling pathway     114811232 (ADCY5)    04935 Growth hormone synthesis, secretion and action     114811232 (ADCY5)    04918 Thyroid hormone synthesis     114811232 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     114811232 (ADCY5)    04916 Melanogenesis     114811232 (ADCY5)    04924 Renin secretion     114811232 (ADCY5)    04925 Aldosterone synthesis and secretion     114811232 (ADCY5)    04927 Cortisol synthesis and secretion     114811232 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     114811232 (ADCY5)    04270 Vascular smooth muscle contraction     114811232 (ADCY5)   09154 Digestive system    04970 Salivary secretion     114811232 (ADCY5)    04971 Gastric acid secretion     114811232 (ADCY5)    04972 Pancreatic secretion     114811232 (ADCY5)    04976 Bile secretion     114811232 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     114811232 (ADCY5)    04727 GABAergic synapse     114811232 (ADCY5)    04725 Cholinergic synapse     114811232 (ADCY5)    04728 Dopaminergic synapse     114811232 (ADCY5)    04726 Serotonergic synapse     114811232 (ADCY5)    04723 Retrograde endocannabinoid signaling     114811232 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     114811232 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     114811232 (ADCY5)    04213 Longevity regulating pathway - multiple species     114811232 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     114811232 (ADCY5)    04714 Thermogenesis     114811232 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     114811232 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     114811232 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     114811232 (ADCY5)    05163 Human cytomegalovirus infection     114811232 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     114811232 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     114811232 (ADCY5)    05031 Amphetamine addiction     114811232 (ADCY5)    05032 Morphine addiction     114811232 (ADCY5)    05034 Alcoholism     114811232 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     114811232 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     114811232 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     114811232 (ADCY5) Enzymes [BR:oaa01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      114811232 (ADCY5) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom Bax1-I TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  114811232 NCBI-ProteinID:  XP_039765988 LinkDB All DBs Position 1:185744464..185807499 Genome browser AA seq 1134 aa AA seqDB search MSRPSSVSPPGLGNPLRGGAELRSAWAEAESRANGFPCPPGPGPAEPGGPDGAGGGEDAD SRGSPAGPGAAPSTHARCCRGLAHIFRSKKFRSEKLERLYQRYFFRLNQSSLTMLAGALA VVGLVLLGLHAARGRDHLPFAAVLAGAVVAVLVLAVLCNRADFHQDQLGLACYALMAVLL AVQAAGILLPPPPPHSASDGLWWTVFCVYTVYTLLPVRMRAAVLSGLLLSAIHLGLALRA RAHDRALLRQLVSNVLIFSCTNLVGACAHYPAEGSQRQAFQETRQCIQARLHSQRENQQQ ERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAI SLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANQMEAGGAAGRIHITK ATLNYLNGDYEVEPGSGGERNAYLKDHNIETFLIVRCSQKRKEEKAMIARMNRQRANSIG HNPPPWAADRPFYSHRGGGHQVSKEMKRMGFEDPKDKNTQENMNPEDEVDEFLGRAIDAR SIDRLRSEHVRKFLLTFREPDLEQKYSKQVDGRFGAYVACASIVFLFICLVQMTVVPHSR FMLGAYLAAALMLTAVVFVSGVYTCTTLCPAPLQSLSRKIVQSRRNSTAVGVCTISLVFL SAFVNMFTCSRVDLLSCLAAEHNVSRNEVNACHVLASEFNFTLGAELTSCGSSQPQCHFP EYFTYSVLLSLLACSGFLQMSCPGKLALLLVAEAVYVLIVEGPAAALFDNADLLNAAADV LDFQNGTMECHPQETKVSLKIVTPLVISVFVLALYLHAQQMESTARLDFLWKLQATEEKE EMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVEL EANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTH IKALADFAMKLMDQMKHINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVAS RMDSTGVPNRIQVTTDMYQVLAASTYQLECRGVVKVKGKGEMMTYFLNGGPPPS NT seq 3405 nt NT seq  +upstreamnt  +downstreamnt atgtctcggcccagcagcgtgagcccccccggcctcgggaaccccctccgcgggggcgcg gagctccgctcggcctgggccgaggccgagtcccgggccaacgggttcccctgcccgccg gggccgggaccggccgagcccgggggccccgacggggcggggggcggcgaggacgcggac tcgcgcgggagccccgcgggcccgggggcggcgccgtcgacccacgcgcgctgctgccgg ggcctggcgcacatcttccgctccaagaagttccgctcggagaagctggagcggctgtac cagcgctacttcttccgactgaaccagagcagcttgaccatgctggccggggccctggcc gtcgtgggcctcgtgctgctgggcctacacgccgcccgcgggcgcgaccacctgcccttc gccgccgtcctggccggcgccgtggtcgccgtgctggtcctggccgtgctgtgcaaccgg gcggacttccaccaggaccagctgggcctggcctgctacgcgctcatggccgtgctgctg gccgtgcaggcggccgggatcctcctgccgccgccgccgccgcacagcgcgtcggacggg ctctggtggaccgtgttctgcgtctacaccgtctacaccctcctgcccgtccgcatgcgg gccgccgtgctcagcggactcctgctctccgccatccacctgggcctcgccctgcgcgcc cgcgcccacgaccgggccctgctccggcagctcgtctccaacgtcctgatcttctcgtgc accaacctggtgggcgcctgtgctcattacccggccgagggctcgcagcgccaggccttc caggagacgcgccagtgcatccaggcccgcctgcactcgcaacgggagaaccagcagcag gagcggctgctgctgtcggtgctgccccggcacgtcgccatggagatgaaagccgacatc aacgccaagcaggaggatatgatgttccacaagatttacatccagaaacacgacaacgtc agcatcctcttcgccgacatcgagggcttcactagcctcgcctcgcagtgcacggcgcag gagctggtgatgaccctcaacgagctgttcgcccgcttcgacaagctggccgccgagaac cactgtttacggatcaagatcctgggcgactgttactactgcgtgtcggggctcccggag gcccgtgccgaccacgcccactgctgcgtggagatgggcatggacatgatcgaggccatc tcgctggtgcgggaggtgaccggtgtgaacgtgaacatgcgtgtgggcatccacagtggc cgtgtgcactgcggcgtgcttggcctacgcaagtggcagtttgacgtctggtccaacgat gtcaccctcgccaatcaaatggaggcaggtggtgcagcagggcgcattcacatcacaaag gccacgctcaactacctgaacggagactatgaggtggaaccggggtccgggggcgagcgc aacgcttacctcaaagatcacaacatcgaaacctttctcatcgttcgttgcagccagaag cggaaagaggaaaaagccatgatcgccaggatgaaccgacaacgtgccaattccatcggc cacaacccgcccccctgggctgctgaccgccccttctacagccaccggggcggcggccat caggtctccaaggaaatgaagaggatgggtttcgaagaccccaaggacaagaacactcag gaaaacatgaaccccgaggatgaggtggacgagtttctgggccgagccattgacgcccga agcattgaccggctgcgatctgagcacgtgcggaaattcctgctgaccttccgggagccc gacctggagcagaagtactccaagcaggtggatggccggttcggagcttacgtggcctgc gcctccatcgtctttctgttcatctgcctcgtccagatgaccgtcgtgccccactccagg ttcatgctgggcgcctacctggccgctgccctgatgctcacagctgtggtgtttgtgtcc ggggtctacacctgcaccacgctgtgcccggcgcccttgcagtcgctgtcccggaagatc gtccagtcccgcaggaacagcacggcggtcggtgtctgcaccatctccctcgtgttcctg tccgccttcgtcaacatgttcacatgcagccgcgtggacctgctcagctgtctggcggcc gagcacaacgtttcacggaacgaggtcaacgcctgccacgtgcttgcgtctgagttcaac ttcaccctgggcgctgagctgacctcctgcggaagctctcagcctcagtgccactttcct gagtacttcacgtacagcgtgctgctgagcctgctggcctgctcggggttcctgcagatg agctgcccggggaagctggcgctgctgctggtggccgaggcggtctacgtactgatcgtc gagggccccgccgccgccctcttcgacaatgccgacctgctcaacgccgccgccgacgtc ctggatttccaaaacgggaccatggaatgccacccccaggaaaccaaggtgtccctgaag atcgtgaccccgctggtgatcagcgtcttcgtcctggccctctaccttcacgcgcagcag atggagtccacagccaggctcgacttcctctggaagctgcaggccacggaggagaaggaa gagatggaggagctgcaggcgtacaaccgtcggctgctgcacaacatccttcccaaggac gtggccgcgcacttcttggcccgtgagcggcgcaacgacgagctgtactaccagtcctgt gagtgcgtggccgtcatgttcgcctccatcgccaacttctctgaattctacgtagaactg gaggccaacaatgagggcgtcgagtgtctgcgcctgctcaacgagatcatcgcagacttc gacgagatcatcagcgaggaccggttccggcagctggagaagatcaagaccatcggcagc acgtacatggcggcgtcgggcctcaacgactccacctacgacaaggcggggaagacccac atcaaggccctggccgacttcgccatgaagctcatggaccagatgaaacacatcaacgag cactccttcaacaacttccagatgaagatcgggctgaacatcgggccggtggtcgccggg gtgatcggggcacggaagccccagtatgacatctggggaaacaccgtgaacgtggccagc cgcatggacagcactggcgtccctaacaggatccaggtgaccacggacatgtaccaggta ctggcggccagtacgtaccagctggagtgccgcggcgtcgtcaaggtcaagggcaaaggg gagatgatgacctactttctcaacggcggacccccgcccagttag

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