KEGG   Ovis aries (sheep): 100036759Help
Entry
100036759         CDS       T03117                                 

Gene name
HK1
Definition
(RefSeq) hexokinase-1 isoform X3
  KO
K00844  hexokinase [EC:2.7.1.1]
Organism
oas  Ovis aries (sheep)
Pathway
oas00010  Glycolysis / Gluconeogenesis
oas00051  Fructose and mannose metabolism
oas00052  Galactose metabolism
oas00500  Starch and sucrose metabolism
oas00520  Amino sugar and nucleotide sugar metabolism
oas00524  Neomycin, kanamycin and gentamicin biosynthesis
oas01100  Metabolic pathways
oas01200  Carbon metabolism
oas04066  HIF-1 signaling pathway
oas04910  Insulin signaling pathway
oas04930  Type II diabetes mellitus
oas04973  Carbohydrate digestion and absorption
oas05230  Central carbon metabolism in cancer
Module
oas_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
oas_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
Brite
KEGG Orthology (KO) [BR:oas00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    100036759 (HK1)
   00051 Fructose and mannose metabolism
    100036759 (HK1)
   00052 Galactose metabolism
    100036759 (HK1)
   00500 Starch and sucrose metabolism
    100036759 (HK1)
   00520 Amino sugar and nucleotide sugar metabolism
    100036759 (HK1)
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    100036759 (HK1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    100036759 (HK1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100036759 (HK1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100036759 (HK1)
 09160 Human Diseases
  09161 Cancers: Overview
   05230 Central carbon metabolism in cancer
    100036759 (HK1)
  09167 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100036759 (HK1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    100036759 (HK1)
Enzymes [BR:oas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     100036759 (HK1)
Membrane trafficking [BR:oas04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    100036759 (HK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Hexokinase_2 Hexokinase_1 CSD UvrD-helicase
Motif
Other DBs
NCBI-GeneID: 100036759
NCBI-ProteinID: XP_011960600
Ensembl: ENSOARG00000005491
UniProt: W5P655
LinkDB All DBs
Position
25
AA seq 921 aa AA seqDB search
MGQTCQRGWCTETENSIRPPLTESKIDKYLYAMRLSDETLLDIMNRFKKEMKNGLSRDFN
PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEQNQAVHMESEVYDTPE
NIMHGSGSQLFDHVAECLGDFMEKKKIKDKKLPVGFTFSFPCRQSRIDEAILITWTKRFK
ASGVEGTDVVKLLDKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQLCEVGLIIGTGTNA
CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDREIDRGSLNPGKQLFEKM
VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL
TRLGVEPSNDDCVSVQHVCTIVSFRSANLVAATLGAILSRLRDNKGTPRLRTTVGVDGSL
YKTHPQYSRRFHKTLRRLVPDCDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH
FSLTKEMLLEVKKRMRAEMELGLGKQTHDKAVVKMLPSFVRSIPDGTENGDFLALDLGGT
NFRVLLVKIRSGKKRSVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPKM
PLGFTFSFPCKQTSLDAGILITWTKGFKATDCVGHDVATLLREAIKRREEFDLDVVAVVN
DTVGTMMTCAYEEPSCEVGLIVGTGSNACYMEEMKNVETLEGNQGQMCINMEWGAFGDNG
CLDDIRTIYDKLVDEFSLNSGKQRYEKMISGMYLGEIVRNILIDFAKRGFLFRGQISEPL
KTRGLFQTKYLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGA
GMAAVGDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG
SGKGAALITAVGVRLRQEMSS
NT seq 2766 nt NT seq  +upstreamnt  +downstreamnt
atggggcagacctgccagcgaggatggtgtacagaaactgaaaattcaatccggcccccg
ctcactgaaagtaagattgacaagtatctctatgccatgcggctctctgatgaaactctg
ttagatatcatgaatcgtttcaaaaaggagatgaagaatggcctctcccgggattttaat
ccgacagccacagtcaagatgttgccaacatttgtaaggtctattcccgatggctcagaa
aaaggagatttcatcgccctggatcttggtgggtcttcctttcgaattctgcgggtgcag
gtgaatcatgagcagaaccaggctgttcatatggagtctgaggtttatgacaccccagag
aacatcatgcatggcagtggaagccagctttttgatcacgtcgctgagtgcctgggagac
ttcatggagaaaaaaaaaatcaaggacaagaaattacctgtgggattcacattttctttc
ccttgtcggcaatccagaatagacgaggccatcctgatcacctggacaaagagattcaaa
gcaagcggcgtggagggaactgatgtggtgaagctgcttgacaaagccatcaaaaagcgt
ggggactatgatgccaacattgtggctgtggtgaacgacacggtggggaccatgatgacc
tgtggctacgacgaccagctgtgtgaagtcggcctcatcattggtactggcaccaacgcg
tgctacatggaggagctgaggcacatcgacctggtggagggcgacgaggggaggatgtgc
atcaacaccgagtggggggcctttggggacgacggggccctggaggacatccgcactgag
ttcgaccgggagatagaccgggggtcgctcaaccccgggaagcagctgttcgagaagatg
gtcagtggcatgtacctgggtgagctggtccgactgatcctggtcaagatggccaaggag
ggcctcttatttgaagggcggatcactcccgagctgctcaccagagggaagtttaacacc
agtgacgtgtcggccatcgaaaagaataaggaaggcctccacaatgccaaagaaatcctg
acccgcctgggagtggagccgtctaatgacgactgtgtttcggttcagcacgtgtgcacc
atcgtctcatttcgctctgccaacctggtggcggcgaccctgggcgccatcttgagccgc
ctccgagataacaagggcacgcccaggctgcggaccacggttggtgtcgacgggtccctt
tacaagacgcacccacagtattctcggcgtttccacaagactctgcggcgcttggtaccc
gactgcgatgtgcgtttcctcctctccgagagcggcagtggcaagggggccgccatggtg
actgctgtggcctaccgcctggctgagcagcaccggcagatagaagaaaccctggcccac
ttcagtcttaccaaggaaatgctgctggaggtgaaaaagaggatgcgggctgagatggaa
ttggggctgggcaagcagacgcatgacaaggctgtggtcaagatgctgccctccttcgtc
cggagcattcctgatgggactgagaatggtgacttcttggccctggatcttggaggaacg
aatttccgcgtcctgctggtgaaaatccgtagtgggaaaaagagatcggtggaaatgcac
aataagatctatgccattcccattgaaatcatgcagggcactggggaggagctgtttgac
cacatcgtttcctgcatctctgacttcctggactacatgggcatcaagggccctaaaatg
cctctgggcttcacattttcgtttccctgcaagcagacgagcttagatgcgggtatctta
atcacctggaccaaaggttttaaggcaaccgactgcgtggggcacgacgtagcaacctta
ctgagggaggcgataaaaaggagagaggaatttgacctggacgtggtggctgtggtcaat
gacacggtgggcaccatgatgacctgtgcttatgaggagcccagctgcgaggttggactc
attgtagggactggcagcaatgcctgctacatggaggaaatgaaaaacgtcgagacgcta
gaaggaaaccagggacaaatgtgtatcaacatggagtggggggcctttggggacaacggg
tgtctggatgatatcagaacaatctatgacaaactggtggatgagttttctctaaactct
gggaagcaaaggtatgagaagatgatcagcggtatgtacctgggtgagattgtccgcaac
atcttgatcgactttgccaagaggggcttcctcttccgggggcagatctctgagccgctg
aagacccggggcctctttcagaccaagtatctctctcagatcgagagcgaccgattagcg
ctactgcaggtccgggccatcctccagcagctgggtctgaacagcacatgcgacgacagt
atcctcgtgaagaccgtgtgtggggtggtgtccaagagggcagcgcagctgtgtggcgca
ggcatggctgctgtgggggataagatccgcgaaaacagggggctggaccgcctcaacgtg
actgtgggcgtggacggcacgctctacaagcttcatccgcacttctccagaatcatgcac
caaaccgtgaaggaactgtcaccaaagtgtaacgtgtccttcctcttatccgaagacggc
agcggcaagggagccgccctcatcacagcagtgggcgttcggctccggcaagaaatgagc
agctaa

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