Ovis aries (sheep): 100305131
Help
Entry
100305131 CDS
T03117
Gene name
ARAF
Definition
(RefSeq) serine/threonine-protein kinase A-Raf
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
oas
Ovis aries (sheep)
Pathway
oas01521
EGFR tyrosine kinase inhibitor resistance
oas01522
Endocrine resistance
oas04010
MAPK signaling pathway
oas04012
ErbB signaling pathway
oas04068
FoxO signaling pathway
oas04270
Vascular smooth muscle contraction
oas04650
Natural killer cell mediated cytotoxicity
oas04720
Long-term potentiation
oas04726
Serotonergic synapse
oas04730
Long-term depression
oas04810
Regulation of actin cytoskeleton
oas04910
Insulin signaling pathway
oas04914
Progesterone-mediated oocyte maturation
oas04928
Parathyroid hormone synthesis, secretion and action
oas05010
Alzheimer disease
oas05022
Pathways of neurodegeneration - multiple diseases
oas05034
Alcoholism
oas05160
Hepatitis C
oas05161
Hepatitis B
oas05200
Pathways in cancer
oas05205
Proteoglycans in cancer
oas05210
Colorectal cancer
oas05211
Renal cell carcinoma
oas05212
Pancreatic cancer
oas05213
Endometrial cancer
oas05214
Glioma
oas05215
Prostate cancer
oas05218
Melanoma
oas05219
Bladder cancer
oas05220
Chronic myeloid leukemia
oas05221
Acute myeloid leukemia
oas05223
Non-small cell lung cancer
oas05224
Breast cancer
oas05225
Hepatocellular carcinoma
oas05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
oas00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100305131 (ARAF)
04012 ErbB signaling pathway
100305131 (ARAF)
04068 FoxO signaling pathway
100305131 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100305131 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100305131 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
100305131 (ARAF)
04914 Progesterone-mediated oocyte maturation
100305131 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
100305131 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100305131 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
100305131 (ARAF)
04720 Long-term potentiation
100305131 (ARAF)
04730 Long-term depression
100305131 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100305131 (ARAF)
05205 Proteoglycans in cancer
100305131 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
100305131 (ARAF)
05212 Pancreatic cancer
100305131 (ARAF)
05225 Hepatocellular carcinoma
100305131 (ARAF)
05226 Gastric cancer
100305131 (ARAF)
05214 Glioma
100305131 (ARAF)
05221 Acute myeloid leukemia
100305131 (ARAF)
05220 Chronic myeloid leukemia
100305131 (ARAF)
05218 Melanoma
100305131 (ARAF)
05211 Renal cell carcinoma
100305131 (ARAF)
05219 Bladder cancer
100305131 (ARAF)
05215 Prostate cancer
100305131 (ARAF)
05213 Endometrial cancer
100305131 (ARAF)
05224 Breast cancer
100305131 (ARAF)
05223 Non-small cell lung cancer
100305131 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100305131 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
100305131 (ARAF)
09165 Substance dependence
05034 Alcoholism
100305131 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
100305131 (ARAF)
05160 Hepatitis C
100305131 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100305131 (ARAF)
01522 Endocrine resistance
100305131 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oas01001
]
100305131 (ARAF)
Enzymes [BR:
oas01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100305131 (ARAF)
Protein kinases [BR:
oas01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100305131 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
APH
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
100305131
NCBI-ProteinID:
NP_001159362
Ensembl:
ENSOARG00000013254
UniProt:
A0A6P3CXM2
C7BDX3
LinkDB
All DBs
Position
X
AA seq
606 aa
AA seq
DB search
MEPPRGPPANGAEPSRSVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGSSRQHEVPSNRPLNEPL
TPQSPSSCTQHRDPEHFSFPAQANTPLQRIRSTSTPNVHMVSTTAPMDSGLIQLTGQNFN
TDAAGNRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq
1821 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgctaacggggccgagccctcccggtcagtgggcacc
gtcaaagtgtacctgcccaacaagcagcgcacggtggtgactgtccgggacggcatgagt
gtctatgactctctagacaaggccctcaaggtgcggggtctcaatcaagattgctgtgtg
gtttaccggctcatcaaggggcgaaagacagtcactgcctgggacacagccattgccccg
ctggatggcgaggagctcattgtggaggtcctcgaagacgtccccctgaccatgcacaat
tttgtacggaagacattcttcagcctggccttttgtgacttctgccttaagtttctgttc
catggtttccgctgccaaacctgtggatacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtgtccaggat
ttgtccggaagctccagacagcacgaggttccctcaaaccgccccctgaatgagccgctc
acccctcagagtcccagctcctgcacccagcaccgcgaccccgagcacttctccttccct
gcccaggccaacacccccctccagcgcatccgctccacatccacccccaatgtccacatg
gtcagcaccacagcccccatggactccggcctcatccagctcactggccagaacttcaac
actgatgctgctgggaatagaggtggtggcgatggagccccccgggggagccccagccca
gccagcgtgtcctcgggaaggaagtccccacattccaagtccccatcagagcagcgggaa
cggaagtccttggctgatgacaagaagaaagtgaagaatttggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagttgctgaagaggatcgggacgggctcg
tttggcacggtgtttcgcgggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcacgtcaacatcttgctgttcatgggcttcatgacccggccaggatttgccatc
atcacacagtggtgtgagggctccagtctctaccaccacctgcatgtggctgacacacgc
ttcgacatggtccagctcattgatgtggcccgccagactgctcagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctgcacgagggg
ctcacggtgaagatcggggattttggcctggccacagtaaagacgcggtggagtggggcc
cagcccttggagcaaccctcaggctctgtgctatggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctacgcctatggggttgtgctctat
gagctcatgaccggctcactgccttacagccacattggcagccgagaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaattgccccaag
gccatgaggcgcctgctgtctgactgcctgaagttccagcgagaggagcggccccttttt
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgtacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag
Ovis aries (sheep): 101103190
Help
Entry
101103190 CDS
T03117
Gene name
RAF1
Definition
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
oas
Ovis aries (sheep)
Pathway
oas01521
EGFR tyrosine kinase inhibitor resistance
oas01522
Endocrine resistance
oas04010
MAPK signaling pathway
oas04012
ErbB signaling pathway
oas04014
Ras signaling pathway
oas04015
Rap1 signaling pathway
oas04022
cGMP-PKG signaling pathway
oas04024
cAMP signaling pathway
oas04062
Chemokine signaling pathway
oas04068
FoxO signaling pathway
oas04071
Sphingolipid signaling pathway
oas04072
Phospholipase D signaling pathway
oas04140
Autophagy - animal
oas04150
mTOR signaling pathway
oas04151
PI3K-Akt signaling pathway
oas04210
Apoptosis
oas04218
Cellular senescence
oas04270
Vascular smooth muscle contraction
oas04360
Axon guidance
oas04370
VEGF signaling pathway
oas04371
Apelin signaling pathway
oas04510
Focal adhesion
oas04540
Gap junction
oas04550
Signaling pathways regulating pluripotency of stem cells
oas04613
Neutrophil extracellular trap formation
oas04625
C-type lectin receptor signaling pathway
oas04630
JAK-STAT signaling pathway
oas04650
Natural killer cell mediated cytotoxicity
oas04660
T cell receptor signaling pathway
oas04662
B cell receptor signaling pathway
oas04664
Fc epsilon RI signaling pathway
oas04666
Fc gamma R-mediated phagocytosis
oas04720
Long-term potentiation
oas04722
Neurotrophin signaling pathway
oas04726
Serotonergic synapse
oas04730
Long-term depression
oas04810
Regulation of actin cytoskeleton
oas04910
Insulin signaling pathway
oas04912
GnRH signaling pathway
oas04914
Progesterone-mediated oocyte maturation
oas04915
Estrogen signaling pathway
oas04916
Melanogenesis
oas04917
Prolactin signaling pathway
oas04919
Thyroid hormone signaling pathway
oas04921
Oxytocin signaling pathway
oas04926
Relaxin signaling pathway
oas04928
Parathyroid hormone synthesis, secretion and action
oas04929
GnRH secretion
oas04935
Growth hormone synthesis, secretion and action
oas05010
Alzheimer disease
oas05022
Pathways of neurodegeneration - multiple diseases
oas05034
Alcoholism
oas05132
Salmonella infection
oas05152
Tuberculosis
oas05160
Hepatitis C
oas05161
Hepatitis B
oas05163
Human cytomegalovirus infection
oas05164
Influenza A
oas05165
Human papillomavirus infection
oas05167
Kaposi sarcoma-associated herpesvirus infection
oas05170
Human immunodeficiency virus 1 infection
oas05200
Pathways in cancer
oas05205
Proteoglycans in cancer
oas05206
MicroRNAs in cancer
oas05210
Colorectal cancer
oas05211
Renal cell carcinoma
oas05212
Pancreatic cancer
oas05213
Endometrial cancer
oas05214
Glioma
oas05215
Prostate cancer
oas05218
Melanoma
oas05219
Bladder cancer
oas05220
Chronic myeloid leukemia
oas05221
Acute myeloid leukemia
oas05223
Non-small cell lung cancer
oas05224
Breast cancer
oas05225
Hepatocellular carcinoma
oas05226
Gastric cancer
oas05230
Central carbon metabolism in cancer
oas05231
Choline metabolism in cancer
oas05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
oas00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101103190 (RAF1)
04012 ErbB signaling pathway
101103190 (RAF1)
04014 Ras signaling pathway
101103190 (RAF1)
04015 Rap1 signaling pathway
101103190 (RAF1)
04370 VEGF signaling pathway
101103190 (RAF1)
04371 Apelin signaling pathway
101103190 (RAF1)
04630 JAK-STAT signaling pathway
101103190 (RAF1)
04068 FoxO signaling pathway
101103190 (RAF1)
04072 Phospholipase D signaling pathway
101103190 (RAF1)
04071 Sphingolipid signaling pathway
101103190 (RAF1)
04024 cAMP signaling pathway
101103190 (RAF1)
04022 cGMP-PKG signaling pathway
101103190 (RAF1)
04151 PI3K-Akt signaling pathway
101103190 (RAF1)
04150 mTOR signaling pathway
101103190 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
101103190 (RAF1)
09143 Cell growth and death
04210 Apoptosis
101103190 (RAF1)
04218 Cellular senescence
101103190 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
101103190 (RAF1)
04540 Gap junction
101103190 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
101103190 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101103190 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
101103190 (RAF1)
04625 C-type lectin receptor signaling pathway
101103190 (RAF1)
04650 Natural killer cell mediated cytotoxicity
101103190 (RAF1)
04660 T cell receptor signaling pathway
101103190 (RAF1)
04662 B cell receptor signaling pathway
101103190 (RAF1)
04664 Fc epsilon RI signaling pathway
101103190 (RAF1)
04666 Fc gamma R-mediated phagocytosis
101103190 (RAF1)
04062 Chemokine signaling pathway
101103190 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
101103190 (RAF1)
04929 GnRH secretion
101103190 (RAF1)
04912 GnRH signaling pathway
101103190 (RAF1)
04915 Estrogen signaling pathway
101103190 (RAF1)
04914 Progesterone-mediated oocyte maturation
101103190 (RAF1)
04917 Prolactin signaling pathway
101103190 (RAF1)
04921 Oxytocin signaling pathway
101103190 (RAF1)
04926 Relaxin signaling pathway
101103190 (RAF1)
04935 Growth hormone synthesis, secretion and action
101103190 (RAF1)
04919 Thyroid hormone signaling pathway
101103190 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
101103190 (RAF1)
04916 Melanogenesis
101103190 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
101103190 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
101103190 (RAF1)
04720 Long-term potentiation
101103190 (RAF1)
04730 Long-term depression
101103190 (RAF1)
04722 Neurotrophin signaling pathway
101103190 (RAF1)
09158 Development and regeneration
04360 Axon guidance
101103190 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101103190 (RAF1)
05206 MicroRNAs in cancer
101103190 (RAF1)
05205 Proteoglycans in cancer
101103190 (RAF1)
05230 Central carbon metabolism in cancer
101103190 (RAF1)
05231 Choline metabolism in cancer
101103190 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
101103190 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
101103190 (RAF1)
05212 Pancreatic cancer
101103190 (RAF1)
05225 Hepatocellular carcinoma
101103190 (RAF1)
05226 Gastric cancer
101103190 (RAF1)
05214 Glioma
101103190 (RAF1)
05221 Acute myeloid leukemia
101103190 (RAF1)
05220 Chronic myeloid leukemia
101103190 (RAF1)
05218 Melanoma
101103190 (RAF1)
05211 Renal cell carcinoma
101103190 (RAF1)
05219 Bladder cancer
101103190 (RAF1)
05215 Prostate cancer
101103190 (RAF1)
05213 Endometrial cancer
101103190 (RAF1)
05224 Breast cancer
101103190 (RAF1)
05223 Non-small cell lung cancer
101103190 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
101103190 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
101103190 (RAF1)
09165 Substance dependence
05034 Alcoholism
101103190 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
101103190 (RAF1)
05152 Tuberculosis
101103190 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
101103190 (RAF1)
05161 Hepatitis B
101103190 (RAF1)
05160 Hepatitis C
101103190 (RAF1)
05164 Influenza A
101103190 (RAF1)
05163 Human cytomegalovirus infection
101103190 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
101103190 (RAF1)
05165 Human papillomavirus infection
101103190 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101103190 (RAF1)
01522 Endocrine resistance
101103190 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oas01001
]
101103190 (RAF1)
Enzymes [BR:
oas01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
101103190 (RAF1)
Protein kinases [BR:
oas01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
101103190 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
101103190
NCBI-ProteinID:
XP_004018591
Ensembl:
ENSOARG00000015630
UniProt:
A0A6P3EIX5
W5Q234
LinkDB
All DBs
Position
19
AA seq
648 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDTVFDGASCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDGGVPALPSLTMRRMRESVSRIPPGSQHRYSTPHAFTF
STSSPSSEGSLSQRQRSTSTPNVHMVSAALPVDSRMIEDAIRSHSESGSPSALSSSPNNL
SPTGWSQPKTPAPAQRERAPGSSTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq
1947 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggcgcctggaagacgatcagcaacggttttggattcaaagacacg
gtgtttgacggcgccagctgcatctcccctacaatagttcagcagtttggctatcagcgt
cgggcgtcagatgatggcaagcttacggacccttctaagacaagcaacactatccgtgtg
tttttgccaaacaagcaaagaacagtggtcaacgtacggaatggaatgagcttgcatgac
tgccttatgaaagctctcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaagggtaaaaaagcacggttagattggaatactgatgctgcctcg
ttgattggagaggaacttcaagtggatttcctggatcatgttcccctcacaacacacaac
tttgctcggaaaaccttcctgaagcttgccttctgtgacatctgtcagaagttcttgctg
aatggatttagatgtcagacttgtggctacaagtttcacgagcattgtagcaccaaagta
cccactatgtgtgtggactggagtaatatcagacagctcttattgttcccaaattccact
gttggtgatggcggggtcccagcgctgccttctttgacgatgcgtcggatgcgagagtct
gtttcccggatacctcctggttcccagcacagatactccacaccccacgctttcacattc
agcacctccagcccctcctctgaaggctccctctcccagaggcagaggtcgacgtctacg
ccaaacgtgcacatggtcagcgccgctctgcccgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcaggctccccttcagccttgtccagcagccccaacaatctg
agcccgacaggctggtcacagcccaaaacccctgcgcctgcgcagagagagcgggcgcca
ggctccagcacccaggagaagaacaaaattaggcctcgtggacaaagagattcgagctat
tactgggagatagaagccagtgaagtgatgctgtccactcggattggatcaggctccttc
gggactgtttataagggcaagtggcatggagatgttgcagtaaagattctgaaggttgtt
gaccccactccagagcagttccaggccttcaggaacgaggtggctgtcctccgcaaaacc
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggacaacctggcgatcgtg
acgcagtggtgcgagggcagcagcctctacaagcacctgcatgtccaggagaccaagttc
cagatgttccagctgatcgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaataatatatttctccacgaaggccta
acggtgaaaatcggcgattttggattggccacggtgaagtcgcgctggagtggttctcag
caggtcgagcagcccaccggctccatcctgtggatggccccagaggtgatccggatgcag
gataataacccgttcagcttccagtctgacgtctactcctacggcatcgtgctgtatgag
ctcatgacgggggagctcccttactcccacatcaacaaccgcgaccagatcatcttcatg
gtgggccgcgggtacgcctccccagacctcagcaagctgtacaagaactgccccaaagcc
atgaagaggctggtagccgactgtgtgaagaaagtgaaggaagagaggcctctttttccc
cagatcctgtcttccatcgagctgctccagcactctctgcccaagatcaaccggagcgcc
tcggagccctccctgcaccgggcggcccacaccgaggacatcaacgcctgcacgctgacc
acgtcccctcggctgcccgtcttttag
Ovis aries (sheep): 101107438
Help
Entry
101107438 CDS
T03117
Gene name
BRAF
Definition
(RefSeq) serine/threonine-protein kinase B-raf isoform X2
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
oas
Ovis aries (sheep)
Pathway
oas01521
EGFR tyrosine kinase inhibitor resistance
oas01522
Endocrine resistance
oas04010
MAPK signaling pathway
oas04012
ErbB signaling pathway
oas04015
Rap1 signaling pathway
oas04024
cAMP signaling pathway
oas04062
Chemokine signaling pathway
oas04068
FoxO signaling pathway
oas04150
mTOR signaling pathway
oas04270
Vascular smooth muscle contraction
oas04510
Focal adhesion
oas04650
Natural killer cell mediated cytotoxicity
oas04720
Long-term potentiation
oas04722
Neurotrophin signaling pathway
oas04726
Serotonergic synapse
oas04730
Long-term depression
oas04810
Regulation of actin cytoskeleton
oas04910
Insulin signaling pathway
oas04914
Progesterone-mediated oocyte maturation
oas04928
Parathyroid hormone synthesis, secretion and action
oas04934
Cushing syndrome
oas05010
Alzheimer disease
oas05022
Pathways of neurodegeneration - multiple diseases
oas05034
Alcoholism
oas05160
Hepatitis C
oas05161
Hepatitis B
oas05200
Pathways in cancer
oas05205
Proteoglycans in cancer
oas05210
Colorectal cancer
oas05211
Renal cell carcinoma
oas05212
Pancreatic cancer
oas05213
Endometrial cancer
oas05214
Glioma
oas05215
Prostate cancer
oas05216
Thyroid cancer
oas05218
Melanoma
oas05219
Bladder cancer
oas05220
Chronic myeloid leukemia
oas05221
Acute myeloid leukemia
oas05223
Non-small cell lung cancer
oas05224
Breast cancer
oas05225
Hepatocellular carcinoma
oas05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
oas00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101107438 (BRAF)
04012 ErbB signaling pathway
101107438 (BRAF)
04015 Rap1 signaling pathway
101107438 (BRAF)
04068 FoxO signaling pathway
101107438 (BRAF)
04024 cAMP signaling pathway
101107438 (BRAF)
04150 mTOR signaling pathway
101107438 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
101107438 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101107438 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
101107438 (BRAF)
04062 Chemokine signaling pathway
101107438 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
101107438 (BRAF)
04914 Progesterone-mediated oocyte maturation
101107438 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
101107438 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
101107438 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
101107438 (BRAF)
04720 Long-term potentiation
101107438 (BRAF)
04730 Long-term depression
101107438 (BRAF)
04722 Neurotrophin signaling pathway
101107438 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101107438 (BRAF)
05205 Proteoglycans in cancer
101107438 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
101107438 (BRAF)
05212 Pancreatic cancer
101107438 (BRAF)
05225 Hepatocellular carcinoma
101107438 (BRAF)
05226 Gastric cancer
101107438 (BRAF)
05214 Glioma
101107438 (BRAF)
05216 Thyroid cancer
101107438 (BRAF)
05221 Acute myeloid leukemia
101107438 (BRAF)
05220 Chronic myeloid leukemia
101107438 (BRAF)
05218 Melanoma
101107438 (BRAF)
05211 Renal cell carcinoma
101107438 (BRAF)
05219 Bladder cancer
101107438 (BRAF)
05215 Prostate cancer
101107438 (BRAF)
05213 Endometrial cancer
101107438 (BRAF)
05224 Breast cancer
101107438 (BRAF)
05223 Non-small cell lung cancer
101107438 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
101107438 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
101107438 (BRAF)
09165 Substance dependence
05034 Alcoholism
101107438 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
101107438 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
101107438 (BRAF)
05160 Hepatitis C
101107438 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101107438 (BRAF)
01522 Endocrine resistance
101107438 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oas01001
]
101107438 (BRAF)
Enzymes [BR:
oas01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
101107438 (BRAF)
Protein kinases [BR:
oas01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
101107438 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
101107438
NCBI-ProteinID:
XP_012032633
Ensembl:
ENSOARG00000013581
UniProt:
W5PVT2
A0A6P3TLH8
LinkDB
All DBs
Position
4
AA seq
763 aa
AA seq
DB search
MAALSGGGGGGAEQGQALFNGDMEPEAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEAL
LDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSSS
SSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKA
LMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFT
LAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEE
ASLAETTLPCGSSPSAPPSDSIGPPILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSS
SAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLSNVKALQKSPGPQR
ERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKM
LNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHII
ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW
SGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ
IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI
HRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2292 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagcggcggcggcggcggcggcgcggagcagggccaggctctgttcaac
ggggacatggagcccgaggccggcgccgcggcctcttcggctgcggaccccgccattccc
gaggaggtgtggaatatcaaacaaatgattaagttgacacaggagcatatagaggcccta
ttggacaaatttggtggggagcataatccaccatcaatatatctggaggcctatgaagaa
tacaccagcaagctagacgccctccaacaaagagaacaacagttattggaatccctgggg
aatggaactgatttttctgtttctagctctgcatcaacggacaccgttacatcttcttcc
tcttctagcctttcagtgctgccttcatctctttcagtttttcaaaatcccacagatgtg
tcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttcctgcccaataaa
cagaggacagtggtacctgcacggtgtggagtcacagtccgggacagcctgaagaaggca
ctgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggatggggag
aagaaaccaattggctgggacactgatatttcctggcttactggagaggaattgcatgta
gaagtgttggagaatgttccacttacaacacacaactttgtacggaaaacttttttcacc
ttagcattttgtgacttctgtagaaagctgcttttccaggggttccgctgtcaaacatgt
ggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattatgac
caactagatttgctgtttgtctccaagttctttgaacaccacccaataccacaggaggag
gcctccttagcagagactacccttccatgtggctcatccccttctgcacccccctccgat
tctattgggcccccaattctcaccagtccatctccttcaaaatccattccaattccacag
cctttccgaccagcagatgaagatcatcgaaatcagtttggacaacgagaccggtcctca
tcagctccaaatgtgcatataaacacaatagaacctgtcaatattgatgacttgattaga
gaccaagggtttcgtagtgatggaggatcaaccacaggtttatctgccacaccccctgcc
tcattacctggctcactctctaatgtgaaagcattgcagaaatctccaggacctcagcga
gaaaggaagtcctcttcatcctcagaagacaggaatcgaatgaaaacgcttggtagacgg
gactcaagtgacgattgggagattcctgatggacagatcacagtgggacaaagaattgga
tcagggtcatttgggacagtctacaagggaaagtggcatggtgatgtggcagtgaaaatg
ttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtaggagta
ctcaggaaaacacgacatgtgaatatcctcctcttcatgggttattcaacaaagccacaa
ctggctattgttacccagtggtgtgagggctccagtttatatcatcatctccacatcatt
gagaccaaattcgagatgatcaaacttatagatattgcacggcagactgcacagggcatg
gattacttacacgccaagtcaatcatccacagagacctcaagagtaataatatttttctt
catgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcgatgg
agtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaagta
atcagaatgcaagataaaaacccatatagctttcagtcagatgtgtatgcatttgggatt
gttctgtatgaattgatgaccggacagttaccttattcaaatatcaacaacagggaccag
ataatttttatggtgggacgaggatatctgtctccagatctcagtaaggtacggagtaac
tgtccaaaagccatgaagagattaatggcagagtgcctaaaaaagaaaagagatgaaaga
ccactctttccccaaattctcgcctctattgagctgctggcccgctcattgccaaaaatt
caccgcagtgcatcagaaccctccttgaatcgggctggcttccaaacagaggattttagt
ctatatgcttgtgcttctccaaaaacacccattcaggcagggggatatggagaatttgca
gccttcaagtag
DBGET
integrated database retrieval system
