KEGG   Ovis aries (sheep): 101102438
Entry
101102438         CDS       T03117                                 

Gene name
NRAS
Definition
(RefSeq) GTPase NRas
  KO
K07828  GTPase NRas
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04015  Rap1 signaling pathway
oas04062  Chemokine signaling pathway
oas04068  FoxO signaling pathway
oas04071  Sphingolipid signaling pathway
oas04072  Phospholipase D signaling pathway
oas04137  Mitophagy - animal
oas04140  Autophagy - animal
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04210  Apoptosis
oas04211  Longevity regulating pathway
oas04213  Longevity regulating pathway - multiple species
oas04218  Cellular senescence
oas04360  Axon guidance
oas04370  VEGF signaling pathway
oas04371  Apelin signaling pathway
oas04540  Gap junction
oas04550  Signaling pathways regulating pluripotency of stem cells
oas04625  C-type lectin receptor signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04660  T cell receptor signaling pathway
oas04662  B cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04714  Thermogenesis
oas04720  Long-term potentiation
oas04722  Neurotrophin signaling pathway
oas04725  Cholinergic synapse
oas04726  Serotonergic synapse
oas04730  Long-term depression
oas04810  Regulation of actin cytoskeleton
oas04910  Insulin signaling pathway
oas04912  GnRH signaling pathway
oas04915  Estrogen signaling pathway
oas04916  Melanogenesis
oas04917  Prolactin signaling pathway
oas04919  Thyroid hormone signaling pathway
oas04921  Oxytocin signaling pathway
oas04926  Relaxin signaling pathway
oas04929  GnRH secretion
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas04935  Growth hormone synthesis, secretion and action
oas05010  Alzheimer disease
oas05022  Pathways of neurodegeneration - multiple diseases
oas05034  Alcoholism
oas05160  Hepatitis C
oas05161  Hepatitis B
oas05163  Human cytomegalovirus infection
oas05165  Human papillomavirus infection
oas05166  Human T-cell leukemia virus 1 infection
oas05167  Kaposi sarcoma-associated herpesvirus infection
oas05170  Human immunodeficiency virus 1 infection
oas05200  Pathways in cancer
oas05203  Viral carcinogenesis
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05210  Colorectal cancer
oas05211  Renal cell carcinoma
oas05213  Endometrial cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05216  Thyroid cancer
oas05218  Melanoma
oas05219  Bladder cancer
oas05220  Chronic myeloid leukemia
oas05221  Acute myeloid leukemia
oas05223  Non-small cell lung cancer
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
oas05230  Central carbon metabolism in cancer
oas05231  Choline metabolism in cancer
oas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101102438 (NRAS)
   04012 ErbB signaling pathway
    101102438 (NRAS)
   04014 Ras signaling pathway
    101102438 (NRAS)
   04015 Rap1 signaling pathway
    101102438 (NRAS)
   04370 VEGF signaling pathway
    101102438 (NRAS)
   04371 Apelin signaling pathway
    101102438 (NRAS)
   04068 FoxO signaling pathway
    101102438 (NRAS)
   04072 Phospholipase D signaling pathway
    101102438 (NRAS)
   04071 Sphingolipid signaling pathway
    101102438 (NRAS)
   04151 PI3K-Akt signaling pathway
    101102438 (NRAS)
   04150 mTOR signaling pathway
    101102438 (NRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101102438 (NRAS)
   04137 Mitophagy - animal
    101102438 (NRAS)
  09143 Cell growth and death
   04210 Apoptosis
    101102438 (NRAS)
   04218 Cellular senescence
    101102438 (NRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101102438 (NRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    101102438 (NRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101102438 (NRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    101102438 (NRAS)
   04650 Natural killer cell mediated cytotoxicity
    101102438 (NRAS)
   04660 T cell receptor signaling pathway
    101102438 (NRAS)
   04662 B cell receptor signaling pathway
    101102438 (NRAS)
   04664 Fc epsilon RI signaling pathway
    101102438 (NRAS)
   04062 Chemokine signaling pathway
    101102438 (NRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101102438 (NRAS)
   04929 GnRH secretion
    101102438 (NRAS)
   04912 GnRH signaling pathway
    101102438 (NRAS)
   04915 Estrogen signaling pathway
    101102438 (NRAS)
   04917 Prolactin signaling pathway
    101102438 (NRAS)
   04921 Oxytocin signaling pathway
    101102438 (NRAS)
   04926 Relaxin signaling pathway
    101102438 (NRAS)
   04935 Growth hormone synthesis, secretion and action
    101102438 (NRAS)
   04919 Thyroid hormone signaling pathway
    101102438 (NRAS)
   04916 Melanogenesis
    101102438 (NRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    101102438 (NRAS)
   04726 Serotonergic synapse
    101102438 (NRAS)
   04720 Long-term potentiation
    101102438 (NRAS)
   04730 Long-term depression
    101102438 (NRAS)
   04722 Neurotrophin signaling pathway
    101102438 (NRAS)
  09158 Development and regeneration
   04360 Axon guidance
    101102438 (NRAS)
  09149 Aging
   04211 Longevity regulating pathway
    101102438 (NRAS)
   04213 Longevity regulating pathway - multiple species
    101102438 (NRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    101102438 (NRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101102438 (NRAS)
   05206 MicroRNAs in cancer
    101102438 (NRAS)
   05205 Proteoglycans in cancer
    101102438 (NRAS)
   05203 Viral carcinogenesis
    101102438 (NRAS)
   05230 Central carbon metabolism in cancer
    101102438 (NRAS)
   05231 Choline metabolism in cancer
    101102438 (NRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101102438 (NRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101102438 (NRAS)
   05225 Hepatocellular carcinoma
    101102438 (NRAS)
   05226 Gastric cancer
    101102438 (NRAS)
   05214 Glioma
    101102438 (NRAS)
   05216 Thyroid cancer
    101102438 (NRAS)
   05221 Acute myeloid leukemia
    101102438 (NRAS)
   05220 Chronic myeloid leukemia
    101102438 (NRAS)
   05218 Melanoma
    101102438 (NRAS)
   05211 Renal cell carcinoma
    101102438 (NRAS)
   05219 Bladder cancer
    101102438 (NRAS)
   05215 Prostate cancer
    101102438 (NRAS)
   05213 Endometrial cancer
    101102438 (NRAS)
   05224 Breast cancer
    101102438 (NRAS)
   05223 Non-small cell lung cancer
    101102438 (NRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101102438 (NRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    101102438 (NRAS)
  09165 Substance dependence
   05034 Alcoholism
    101102438 (NRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101102438 (NRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101102438 (NRAS)
   05170 Human immunodeficiency virus 1 infection
    101102438 (NRAS)
   05161 Hepatitis B
    101102438 (NRAS)
   05160 Hepatitis C
    101102438 (NRAS)
   05163 Human cytomegalovirus infection
    101102438 (NRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101102438 (NRAS)
   05165 Human papillomavirus infection
    101102438 (NRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101102438 (NRAS)
   01522 Endocrine resistance
    101102438 (NRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    101102438 (NRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:oas04147]
    101102438 (NRAS)
   04031 GTP-binding proteins [BR:oas04031]
    101102438 (NRAS)
Membrane trafficking [BR:oas04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    101102438 (NRAS)
Exosome [BR:oas04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   101102438 (NRAS)
  Exosomal proteins of other body fluids (saliva and urine)
   101102438 (NRAS)
  Exosomal proteins of breast cancer cells
   101102438 (NRAS)
  Exosomal proteins of colorectal cancer cells
   101102438 (NRAS)
GTP-binding proteins [BR:oas04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    101102438 (NRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Septin ParA Ldh_1_N
Other DBs
NCBI-GeneID: 101102438
NCBI-ProteinID: XP_004002408
Ensembl: ENSOARG00000020027
UniProt: A0A6P3DZC2 W5QFK5
LinkDB
Position
1
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM
NT seq 570 nt   +upstreamnt  +downstreamnt
atgactgagtacaaactggtggtggttggagcaggtggtgttgggaaaagtgcactgaca
atccagctaatccagaaccactttgtagatgaatatgatcccaccatagaggattcctac
cgaaaacaggtggttatagatggtgaaacctgtctgttggacatactggatacagctgga
caagaggagtacagtgccatgagagaccaatacatgaggacaggcgaaggcttcctttgt
gtatttgccatcaataatagcaaatcatttgcagatattaacctctacagggaacagatt
aagcgtgtaaaggactcggatgatgtacctatggtgctagtaggaaacaagtgtgacttg
ccaacaaggacagttgacacaaaacaagcccatgaactggccaaaagctatgggattcca
ttcattgaaacctcagccaagaccagacagggtgttgaagatgccttttacacactggta
agagaaatacgtcagtaccgaatgaaaaaactcaacagcagtgatgatggcactcaaggt
tgtatggggttgccatgtgtggtaatgtaa

KEGG   Ovis aries (sheep): 101104357
Entry
101104357         CDS       T03117                                 

Gene name
HRAS
Definition
(RefSeq) GTPase HRas isoform X1
  KO
K02833  GTPase HRas
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04015  Rap1 signaling pathway
oas04062  Chemokine signaling pathway
oas04068  FoxO signaling pathway
oas04071  Sphingolipid signaling pathway
oas04072  Phospholipase D signaling pathway
oas04137  Mitophagy - animal
oas04140  Autophagy - animal
oas04144  Endocytosis
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04210  Apoptosis
oas04211  Longevity regulating pathway
oas04213  Longevity regulating pathway - multiple species
oas04218  Cellular senescence
oas04360  Axon guidance
oas04370  VEGF signaling pathway
oas04371  Apelin signaling pathway
oas04510  Focal adhesion
oas04540  Gap junction
oas04550  Signaling pathways regulating pluripotency of stem cells
oas04625  C-type lectin receptor signaling pathway
oas04630  JAK-STAT signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04660  T cell receptor signaling pathway
oas04662  B cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04714  Thermogenesis
oas04720  Long-term potentiation
oas04722  Neurotrophin signaling pathway
oas04725  Cholinergic synapse
oas04726  Serotonergic synapse
oas04730  Long-term depression
oas04810  Regulation of actin cytoskeleton
oas04910  Insulin signaling pathway
oas04912  GnRH signaling pathway
oas04915  Estrogen signaling pathway
oas04916  Melanogenesis
oas04917  Prolactin signaling pathway
oas04919  Thyroid hormone signaling pathway
oas04921  Oxytocin signaling pathway
oas04926  Relaxin signaling pathway
oas04929  GnRH secretion
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas04935  Growth hormone synthesis, secretion and action
oas05010  Alzheimer disease
oas05022  Pathways of neurodegeneration - multiple diseases
oas05034  Alcoholism
oas05132  Salmonella infection
oas05160  Hepatitis C
oas05161  Hepatitis B
oas05163  Human cytomegalovirus infection
oas05165  Human papillomavirus infection
oas05166  Human T-cell leukemia virus 1 infection
oas05167  Kaposi sarcoma-associated herpesvirus infection
oas05170  Human immunodeficiency virus 1 infection
oas05200  Pathways in cancer
oas05203  Viral carcinogenesis
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05210  Colorectal cancer
oas05211  Renal cell carcinoma
oas05213  Endometrial cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05216  Thyroid cancer
oas05218  Melanoma
oas05219  Bladder cancer
oas05220  Chronic myeloid leukemia
oas05221  Acute myeloid leukemia
oas05223  Non-small cell lung cancer
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
oas05230  Central carbon metabolism in cancer
oas05231  Choline metabolism in cancer
oas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101104357 (HRAS)
   04012 ErbB signaling pathway
    101104357 (HRAS)
   04014 Ras signaling pathway
    101104357 (HRAS)
   04015 Rap1 signaling pathway
    101104357 (HRAS)
   04370 VEGF signaling pathway
    101104357 (HRAS)
   04371 Apelin signaling pathway
    101104357 (HRAS)
   04630 JAK-STAT signaling pathway
    101104357 (HRAS)
   04068 FoxO signaling pathway
    101104357 (HRAS)
   04072 Phospholipase D signaling pathway
    101104357 (HRAS)
   04071 Sphingolipid signaling pathway
    101104357 (HRAS)
   04151 PI3K-Akt signaling pathway
    101104357 (HRAS)
   04150 mTOR signaling pathway
    101104357 (HRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    101104357 (HRAS)
   04140 Autophagy - animal
    101104357 (HRAS)
   04137 Mitophagy - animal
    101104357 (HRAS)
  09143 Cell growth and death
   04210 Apoptosis
    101104357 (HRAS)
   04218 Cellular senescence
    101104357 (HRAS)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101104357 (HRAS)
   04540 Gap junction
    101104357 (HRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    101104357 (HRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101104357 (HRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    101104357 (HRAS)
   04650 Natural killer cell mediated cytotoxicity
    101104357 (HRAS)
   04660 T cell receptor signaling pathway
    101104357 (HRAS)
   04662 B cell receptor signaling pathway
    101104357 (HRAS)
   04664 Fc epsilon RI signaling pathway
    101104357 (HRAS)
   04062 Chemokine signaling pathway
    101104357 (HRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101104357 (HRAS)
   04929 GnRH secretion
    101104357 (HRAS)
   04912 GnRH signaling pathway
    101104357 (HRAS)
   04915 Estrogen signaling pathway
    101104357 (HRAS)
   04917 Prolactin signaling pathway
    101104357 (HRAS)
   04921 Oxytocin signaling pathway
    101104357 (HRAS)
   04926 Relaxin signaling pathway
    101104357 (HRAS)
   04935 Growth hormone synthesis, secretion and action
    101104357 (HRAS)
   04919 Thyroid hormone signaling pathway
    101104357 (HRAS)
   04916 Melanogenesis
    101104357 (HRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    101104357 (HRAS)
   04726 Serotonergic synapse
    101104357 (HRAS)
   04720 Long-term potentiation
    101104357 (HRAS)
   04730 Long-term depression
    101104357 (HRAS)
   04722 Neurotrophin signaling pathway
    101104357 (HRAS)
  09158 Development and regeneration
   04360 Axon guidance
    101104357 (HRAS)
  09149 Aging
   04211 Longevity regulating pathway
    101104357 (HRAS)
   04213 Longevity regulating pathway - multiple species
    101104357 (HRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    101104357 (HRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101104357 (HRAS)
   05206 MicroRNAs in cancer
    101104357 (HRAS)
   05205 Proteoglycans in cancer
    101104357 (HRAS)
   05203 Viral carcinogenesis
    101104357 (HRAS)
   05230 Central carbon metabolism in cancer
    101104357 (HRAS)
   05231 Choline metabolism in cancer
    101104357 (HRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101104357 (HRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101104357 (HRAS)
   05225 Hepatocellular carcinoma
    101104357 (HRAS)
   05226 Gastric cancer
    101104357 (HRAS)
   05214 Glioma
    101104357 (HRAS)
   05216 Thyroid cancer
    101104357 (HRAS)
   05221 Acute myeloid leukemia
    101104357 (HRAS)
   05220 Chronic myeloid leukemia
    101104357 (HRAS)
   05218 Melanoma
    101104357 (HRAS)
   05211 Renal cell carcinoma
    101104357 (HRAS)
   05219 Bladder cancer
    101104357 (HRAS)
   05215 Prostate cancer
    101104357 (HRAS)
   05213 Endometrial cancer
    101104357 (HRAS)
   05224 Breast cancer
    101104357 (HRAS)
   05223 Non-small cell lung cancer
    101104357 (HRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101104357 (HRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    101104357 (HRAS)
  09165 Substance dependence
   05034 Alcoholism
    101104357 (HRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101104357 (HRAS)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101104357 (HRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101104357 (HRAS)
   05170 Human immunodeficiency virus 1 infection
    101104357 (HRAS)
   05161 Hepatitis B
    101104357 (HRAS)
   05160 Hepatitis C
    101104357 (HRAS)
   05163 Human cytomegalovirus infection
    101104357 (HRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101104357 (HRAS)
   05165 Human papillomavirus infection
    101104357 (HRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101104357 (HRAS)
   01522 Endocrine resistance
    101104357 (HRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    101104357 (HRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:oas04147]
    101104357 (HRAS)
   04031 GTP-binding proteins [BR:oas04031]
    101104357 (HRAS)
Membrane trafficking [BR:oas04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    101104357 (HRAS)
Exosome [BR:oas04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   101104357 (HRAS)
  Exosomal proteins of colorectal cancer cells
   101104357 (HRAS)
GTP-binding proteins [BR:oas04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    101104357 (HRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Gtr1_RagA ATP_bind_1 Septin Ldh_1_N AAA_25
Other DBs
NCBI-GeneID: 101104357
NCBI-ProteinID: XP_027815796
Ensembl: ENSOARG00000007365
UniProt: A0A6P7DAM5
LinkDB
Position
21
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINHTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKMRKLSPPDEGGPG
CLSCRCLLS
NT seq 570 nt   +upstreamnt  +downstreamnt
atgacggagtataagctcgtggtggtgggcgccggcggcgtggggaagagcgccctgacc
atccagctcattcagaaccacttcgtggacgagtacgaccccaccatcgaggactcctac
cggaagcaagtggtcatcgatggggagacgtgcctgctggacatcctggacacggcgggc
caggaggagtacagcgccatgcgggaccagtacatgcgcaccggggagggcttcctctgc
gtgtttgccatcaaccacaccaagtccttcgaggacatccatcagtaccgggagcagatc
aagagggtgaaggactcggacgacgtgcccatggtgttggtcgggaacaagtgcgacctg
gccgcgcgcaccgtggagtctcggcaggcccaggacctcgcccgcagctacggcattccg
tacatcgagacctccgccaagacccgccagggcgtggaggacgccttctacactctggtg
cgcgagatccggcagcacaagatgcgcaagctgagcccaccggacgaggggggccccggc
tgcctgagctgcaggtgcctgctctcctga

KEGG   Ovis aries (sheep): 101114005
Entry
101114005         CDS       T03117                                 

Gene name
KRAS
Definition
(RefSeq) GTPase KRas isoform X1
  KO
K07827  GTPase KRas
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04015  Rap1 signaling pathway
oas04062  Chemokine signaling pathway
oas04068  FoxO signaling pathway
oas04071  Sphingolipid signaling pathway
oas04072  Phospholipase D signaling pathway
oas04137  Mitophagy - animal
oas04140  Autophagy - animal
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04210  Apoptosis
oas04211  Longevity regulating pathway
oas04213  Longevity regulating pathway - multiple species
oas04218  Cellular senescence
oas04360  Axon guidance
oas04370  VEGF signaling pathway
oas04371  Apelin signaling pathway
oas04540  Gap junction
oas04550  Signaling pathways regulating pluripotency of stem cells
oas04625  C-type lectin receptor signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04660  T cell receptor signaling pathway
oas04662  B cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04714  Thermogenesis
oas04720  Long-term potentiation
oas04722  Neurotrophin signaling pathway
oas04725  Cholinergic synapse
oas04726  Serotonergic synapse
oas04730  Long-term depression
oas04810  Regulation of actin cytoskeleton
oas04910  Insulin signaling pathway
oas04912  GnRH signaling pathway
oas04914  Progesterone-mediated oocyte maturation
oas04915  Estrogen signaling pathway
oas04916  Melanogenesis
oas04917  Prolactin signaling pathway
oas04919  Thyroid hormone signaling pathway
oas04921  Oxytocin signaling pathway
oas04926  Relaxin signaling pathway
oas04929  GnRH secretion
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas04935  Growth hormone synthesis, secretion and action
oas04960  Aldosterone-regulated sodium reabsorption
oas05010  Alzheimer disease
oas05022  Pathways of neurodegeneration - multiple diseases
oas05034  Alcoholism
oas05160  Hepatitis C
oas05161  Hepatitis B
oas05163  Human cytomegalovirus infection
oas05165  Human papillomavirus infection
oas05166  Human T-cell leukemia virus 1 infection
oas05167  Kaposi sarcoma-associated herpesvirus infection
oas05170  Human immunodeficiency virus 1 infection
oas05200  Pathways in cancer
oas05203  Viral carcinogenesis
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05210  Colorectal cancer
oas05211  Renal cell carcinoma
oas05212  Pancreatic cancer
oas05213  Endometrial cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05216  Thyroid cancer
oas05218  Melanoma
oas05219  Bladder cancer
oas05220  Chronic myeloid leukemia
oas05221  Acute myeloid leukemia
oas05223  Non-small cell lung cancer
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
oas05230  Central carbon metabolism in cancer
oas05231  Choline metabolism in cancer
oas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101114005 (KRAS)
   04012 ErbB signaling pathway
    101114005 (KRAS)
   04014 Ras signaling pathway
    101114005 (KRAS)
   04015 Rap1 signaling pathway
    101114005 (KRAS)
   04370 VEGF signaling pathway
    101114005 (KRAS)
   04371 Apelin signaling pathway
    101114005 (KRAS)
   04068 FoxO signaling pathway
    101114005 (KRAS)
   04072 Phospholipase D signaling pathway
    101114005 (KRAS)
   04071 Sphingolipid signaling pathway
    101114005 (KRAS)
   04151 PI3K-Akt signaling pathway
    101114005 (KRAS)
   04150 mTOR signaling pathway
    101114005 (KRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101114005 (KRAS)
   04137 Mitophagy - animal
    101114005 (KRAS)
  09143 Cell growth and death
   04210 Apoptosis
    101114005 (KRAS)
   04218 Cellular senescence
    101114005 (KRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101114005 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    101114005 (KRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101114005 (KRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    101114005 (KRAS)
   04650 Natural killer cell mediated cytotoxicity
    101114005 (KRAS)
   04660 T cell receptor signaling pathway
    101114005 (KRAS)
   04662 B cell receptor signaling pathway
    101114005 (KRAS)
   04664 Fc epsilon RI signaling pathway
    101114005 (KRAS)
   04062 Chemokine signaling pathway
    101114005 (KRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101114005 (KRAS)
   04929 GnRH secretion
    101114005 (KRAS)
   04912 GnRH signaling pathway
    101114005 (KRAS)
   04915 Estrogen signaling pathway
    101114005 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    101114005 (KRAS)
   04917 Prolactin signaling pathway
    101114005 (KRAS)
   04921 Oxytocin signaling pathway
    101114005 (KRAS)
   04926 Relaxin signaling pathway
    101114005 (KRAS)
   04935 Growth hormone synthesis, secretion and action
    101114005 (KRAS)
   04919 Thyroid hormone signaling pathway
    101114005 (KRAS)
   04916 Melanogenesis
    101114005 (KRAS)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101114005 (KRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    101114005 (KRAS)
   04726 Serotonergic synapse
    101114005 (KRAS)
   04720 Long-term potentiation
    101114005 (KRAS)
   04730 Long-term depression
    101114005 (KRAS)
   04722 Neurotrophin signaling pathway
    101114005 (KRAS)
  09158 Development and regeneration
   04360 Axon guidance
    101114005 (KRAS)
  09149 Aging
   04211 Longevity regulating pathway
    101114005 (KRAS)
   04213 Longevity regulating pathway - multiple species
    101114005 (KRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    101114005 (KRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101114005 (KRAS)
   05206 MicroRNAs in cancer
    101114005 (KRAS)
   05205 Proteoglycans in cancer
    101114005 (KRAS)
   05203 Viral carcinogenesis
    101114005 (KRAS)
   05230 Central carbon metabolism in cancer
    101114005 (KRAS)
   05231 Choline metabolism in cancer
    101114005 (KRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101114005 (KRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101114005 (KRAS)
   05212 Pancreatic cancer
    101114005 (KRAS)
   05225 Hepatocellular carcinoma
    101114005 (KRAS)
   05226 Gastric cancer
    101114005 (KRAS)
   05214 Glioma
    101114005 (KRAS)
   05216 Thyroid cancer
    101114005 (KRAS)
   05221 Acute myeloid leukemia
    101114005 (KRAS)
   05220 Chronic myeloid leukemia
    101114005 (KRAS)
   05218 Melanoma
    101114005 (KRAS)
   05211 Renal cell carcinoma
    101114005 (KRAS)
   05219 Bladder cancer
    101114005 (KRAS)
   05215 Prostate cancer
    101114005 (KRAS)
   05213 Endometrial cancer
    101114005 (KRAS)
   05224 Breast cancer
    101114005 (KRAS)
   05223 Non-small cell lung cancer
    101114005 (KRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101114005 (KRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    101114005 (KRAS)
  09165 Substance dependence
   05034 Alcoholism
    101114005 (KRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101114005 (KRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101114005 (KRAS)
   05170 Human immunodeficiency virus 1 infection
    101114005 (KRAS)
   05161 Hepatitis B
    101114005 (KRAS)
   05160 Hepatitis C
    101114005 (KRAS)
   05163 Human cytomegalovirus infection
    101114005 (KRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101114005 (KRAS)
   05165 Human papillomavirus infection
    101114005 (KRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101114005 (KRAS)
   01522 Endocrine resistance
    101114005 (KRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    101114005 (KRAS)
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:oas04031]
    101114005 (KRAS)
Membrane trafficking [BR:oas04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    101114005 (KRAS)
GTP-binding proteins [BR:oas04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    101114005 (KRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 G-alpha FeoB_N ATP_bind_1 Gtr1_RagA Septin AAA_25 CbiA
Other DBs
NCBI-GeneID: 101114005
NCBI-ProteinID: XP_014950382
Ensembl: ENSOARG00000019999
UniProt: A0A6P7DY74 W5QFH7
LinkDB
Position
3
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIVM
NT seq 570 nt   +upstreamnt  +downstreamnt
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcactttgtggatgaatatgatcctacgatagaggattcctac
aggaaacaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggaatacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaata
aaaagagttaaagactctgaagatgtacctatggttctagtaggaaataaatgtgatttg
ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttatggaattcct
tttattgaaacatcagcaaagacaagacagagagtggaggatgctttttatacattggtg
agagagatccgacaatacagattgaaaaaaatcagcaaagaagaaaagactcctggctgt
gtgaaaattaaaaaatgcattgttatgtaa

KEGG   Ovis aries (sheep): 114114919
Entry
114114919         CDS       T03117                                 

Definition
(RefSeq) GTPase HRas-like
  KO
K02833  GTPase HRas
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04015  Rap1 signaling pathway
oas04062  Chemokine signaling pathway
oas04068  FoxO signaling pathway
oas04071  Sphingolipid signaling pathway
oas04072  Phospholipase D signaling pathway
oas04137  Mitophagy - animal
oas04140  Autophagy - animal
oas04144  Endocytosis
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04210  Apoptosis
oas04211  Longevity regulating pathway
oas04213  Longevity regulating pathway - multiple species
oas04218  Cellular senescence
oas04360  Axon guidance
oas04370  VEGF signaling pathway
oas04371  Apelin signaling pathway
oas04510  Focal adhesion
oas04540  Gap junction
oas04550  Signaling pathways regulating pluripotency of stem cells
oas04625  C-type lectin receptor signaling pathway
oas04630  JAK-STAT signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04660  T cell receptor signaling pathway
oas04662  B cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04714  Thermogenesis
oas04720  Long-term potentiation
oas04722  Neurotrophin signaling pathway
oas04725  Cholinergic synapse
oas04726  Serotonergic synapse
oas04730  Long-term depression
oas04810  Regulation of actin cytoskeleton
oas04910  Insulin signaling pathway
oas04912  GnRH signaling pathway
oas04915  Estrogen signaling pathway
oas04916  Melanogenesis
oas04917  Prolactin signaling pathway
oas04919  Thyroid hormone signaling pathway
oas04921  Oxytocin signaling pathway
oas04926  Relaxin signaling pathway
oas04929  GnRH secretion
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas04935  Growth hormone synthesis, secretion and action
oas05010  Alzheimer disease
oas05022  Pathways of neurodegeneration - multiple diseases
oas05034  Alcoholism
oas05132  Salmonella infection
oas05160  Hepatitis C
oas05161  Hepatitis B
oas05163  Human cytomegalovirus infection
oas05165  Human papillomavirus infection
oas05166  Human T-cell leukemia virus 1 infection
oas05167  Kaposi sarcoma-associated herpesvirus infection
oas05170  Human immunodeficiency virus 1 infection
oas05200  Pathways in cancer
oas05203  Viral carcinogenesis
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05210  Colorectal cancer
oas05211  Renal cell carcinoma
oas05213  Endometrial cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05216  Thyroid cancer
oas05218  Melanoma
oas05219  Bladder cancer
oas05220  Chronic myeloid leukemia
oas05221  Acute myeloid leukemia
oas05223  Non-small cell lung cancer
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
oas05230  Central carbon metabolism in cancer
oas05231  Choline metabolism in cancer
oas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114114919
   04012 ErbB signaling pathway
    114114919
   04014 Ras signaling pathway
    114114919
   04015 Rap1 signaling pathway
    114114919
   04370 VEGF signaling pathway
    114114919
   04371 Apelin signaling pathway
    114114919
   04630 JAK-STAT signaling pathway
    114114919
   04068 FoxO signaling pathway
    114114919
   04072 Phospholipase D signaling pathway
    114114919
   04071 Sphingolipid signaling pathway
    114114919
   04151 PI3K-Akt signaling pathway
    114114919
   04150 mTOR signaling pathway
    114114919
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    114114919
   04140 Autophagy - animal
    114114919
   04137 Mitophagy - animal
    114114919
  09143 Cell growth and death
   04210 Apoptosis
    114114919
   04218 Cellular senescence
    114114919
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114114919
   04540 Gap junction
    114114919
   04550 Signaling pathways regulating pluripotency of stem cells
    114114919
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114114919
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    114114919
   04650 Natural killer cell mediated cytotoxicity
    114114919
   04660 T cell receptor signaling pathway
    114114919
   04662 B cell receptor signaling pathway
    114114919
   04664 Fc epsilon RI signaling pathway
    114114919
   04062 Chemokine signaling pathway
    114114919
  09152 Endocrine system
   04910 Insulin signaling pathway
    114114919
   04929 GnRH secretion
    114114919
   04912 GnRH signaling pathway
    114114919
   04915 Estrogen signaling pathway
    114114919
   04917 Prolactin signaling pathway
    114114919
   04921 Oxytocin signaling pathway
    114114919
   04926 Relaxin signaling pathway
    114114919
   04935 Growth hormone synthesis, secretion and action
    114114919
   04919 Thyroid hormone signaling pathway
    114114919
   04916 Melanogenesis
    114114919
  09156 Nervous system
   04725 Cholinergic synapse
    114114919
   04726 Serotonergic synapse
    114114919
   04720 Long-term potentiation
    114114919
   04730 Long-term depression
    114114919
   04722 Neurotrophin signaling pathway
    114114919
  09158 Development and regeneration
   04360 Axon guidance
    114114919
  09149 Aging
   04211 Longevity regulating pathway
    114114919
   04213 Longevity regulating pathway - multiple species
    114114919
  09159 Environmental adaptation
   04714 Thermogenesis
    114114919
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114114919
   05206 MicroRNAs in cancer
    114114919
   05205 Proteoglycans in cancer
    114114919
   05203 Viral carcinogenesis
    114114919
   05230 Central carbon metabolism in cancer
    114114919
   05231 Choline metabolism in cancer
    114114919
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114114919
  09162 Cancer: specific types
   05210 Colorectal cancer
    114114919
   05225 Hepatocellular carcinoma
    114114919
   05226 Gastric cancer
    114114919
   05214 Glioma
    114114919
   05216 Thyroid cancer
    114114919
   05221 Acute myeloid leukemia
    114114919
   05220 Chronic myeloid leukemia
    114114919
   05218 Melanoma
    114114919
   05211 Renal cell carcinoma
    114114919
   05219 Bladder cancer
    114114919
   05215 Prostate cancer
    114114919
   05213 Endometrial cancer
    114114919
   05224 Breast cancer
    114114919
   05223 Non-small cell lung cancer
    114114919
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114114919
   05022 Pathways of neurodegeneration - multiple diseases
    114114919
  09165 Substance dependence
   05034 Alcoholism
    114114919
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    114114919
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114114919
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114114919
   05170 Human immunodeficiency virus 1 infection
    114114919
   05161 Hepatitis B
    114114919
   05160 Hepatitis C
    114114919
   05163 Human cytomegalovirus infection
    114114919
   05167 Kaposi sarcoma-associated herpesvirus infection
    114114919
   05165 Human papillomavirus infection
    114114919
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114114919
   01522 Endocrine resistance
    114114919
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    114114919
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:oas04147]
    114114919
   04031 GTP-binding proteins [BR:oas04031]
    114114919
Membrane trafficking [BR:oas04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    114114919
Exosome [BR:oas04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   114114919
  Exosomal proteins of colorectal cancer cells
   114114919
GTP-binding proteins [BR:oas04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    114114919
SSDB
Motif
Pfam: Ras Roc
Other DBs
NCBI-GeneID: 114114919
NCBI-ProteinID: XP_027826364
UniProt: A0A6P7E6Q6
LinkDB
Position
5
AA seq 144 aa
MTGDKLVVVGAMVRKSALTIQLIENHPVDDNVPSYEGWLPLSSYWKQVVTDGETCLLDTA
GQESQRHGDQYMSTREGFPLGACISDTESFKGIHQPWEQIKWVKASDGIPVVLVGTRQLL
DLWLQLREPLEPTAIPVNQQPLKL
NT seq 435 nt   +upstreamnt  +downstreamnt
atgacgggggataagctcgtggtggtgggcgccatggtgaggaagagcgccctgaccatc
cagctcatcgagaaccaccctgtggacgacaatgtcccctcctacgaaggctggctgcct
ctaagctcctactggaagcaagtggtcactgatggggagacctgcctactggacacagca
ggccaggagagtcagcgtcatggagaccagtacatgagcaccagggagggctttcccctg
ggtgcttgcatcagcgatactgagtccttcaagggcatccaccagccctgggagcagatc
aagtgggtgaaggcctcagatggcatacctgtggtgctggtgggaacaaggcagctgctc
gacctctggctccagctaagggaacccctggaacccactgcgattcccgtgaaccagcag
cccctcaagctgtga

DBGET integrated database retrieval system