KEGG   Ovis aries (sheep): 101109893
Entry
101109893         CDS       T03117                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04062  Chemokine signaling pathway
oas04068  FoxO signaling pathway
oas04072  Phospholipase D signaling pathway
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04380  Osteoclast differentiation
oas04510  Focal adhesion
oas04540  Gap junction
oas04550  Signaling pathways regulating pluripotency of stem cells
oas04630  JAK-STAT signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04660  T cell receptor signaling pathway
oas04662  B cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04714  Thermogenesis
oas04722  Neurotrophin signaling pathway
oas04910  Insulin signaling pathway
oas04912  GnRH signaling pathway
oas04915  Estrogen signaling pathway
oas04917  Prolactin signaling pathway
oas04926  Relaxin signaling pathway
oas04935  Growth hormone synthesis, secretion and action
oas05034  Alcoholism
oas05160  Hepatitis C
oas05161  Hepatitis B
oas05163  Human cytomegalovirus infection
oas05165  Human papillomavirus infection
oas05200  Pathways in cancer
oas05203  Viral carcinogenesis
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05210  Colorectal cancer
oas05211  Renal cell carcinoma
oas05213  Endometrial cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05220  Chronic myeloid leukemia
oas05221  Acute myeloid leukemia
oas05223  Non-small cell lung cancer
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
oas05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101109893 (GRB2)
   04012 ErbB signaling pathway
    101109893 (GRB2)
   04014 Ras signaling pathway
    101109893 (GRB2)
   04630 JAK-STAT signaling pathway
    101109893 (GRB2)
   04068 FoxO signaling pathway
    101109893 (GRB2)
   04072 Phospholipase D signaling pathway
    101109893 (GRB2)
   04151 PI3K-Akt signaling pathway
    101109893 (GRB2)
   04150 mTOR signaling pathway
    101109893 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101109893 (GRB2)
   04540 Gap junction
    101109893 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101109893 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101109893 (GRB2)
   04660 T cell receptor signaling pathway
    101109893 (GRB2)
   04662 B cell receptor signaling pathway
    101109893 (GRB2)
   04664 Fc epsilon RI signaling pathway
    101109893 (GRB2)
   04062 Chemokine signaling pathway
    101109893 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101109893 (GRB2)
   04912 GnRH signaling pathway
    101109893 (GRB2)
   04915 Estrogen signaling pathway
    101109893 (GRB2)
   04917 Prolactin signaling pathway
    101109893 (GRB2)
   04926 Relaxin signaling pathway
    101109893 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    101109893 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101109893 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101109893 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    101109893 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101109893 (GRB2)
   05206 MicroRNAs in cancer
    101109893 (GRB2)
   05205 Proteoglycans in cancer
    101109893 (GRB2)
   05203 Viral carcinogenesis
    101109893 (GRB2)
   05231 Choline metabolism in cancer
    101109893 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101109893 (GRB2)
   05225 Hepatocellular carcinoma
    101109893 (GRB2)
   05226 Gastric cancer
    101109893 (GRB2)
   05214 Glioma
    101109893 (GRB2)
   05221 Acute myeloid leukemia
    101109893 (GRB2)
   05220 Chronic myeloid leukemia
    101109893 (GRB2)
   05211 Renal cell carcinoma
    101109893 (GRB2)
   05215 Prostate cancer
    101109893 (GRB2)
   05213 Endometrial cancer
    101109893 (GRB2)
   05224 Breast cancer
    101109893 (GRB2)
   05223 Non-small cell lung cancer
    101109893 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    101109893 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101109893 (GRB2)
   05160 Hepatitis C
    101109893 (GRB2)
   05163 Human cytomegalovirus infection
    101109893 (GRB2)
   05165 Human papillomavirus infection
    101109893 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101109893 (GRB2)
   01522 Endocrine resistance
    101109893 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    101109893 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:oas04990]
    101109893 (GRB2)
Membrane trafficking [BR:oas04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    101109893 (GRB2)
Domain-containing proteins not elsewhere classified [BR:oas04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   101109893 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 101109893
NCBI-ProteinID: XP_027829868
Ensembl: ENSOARG00000010626
UniProt: A0A6P7EFI9
LinkDB
Position
11
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccaccgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgaccagaactggtacaaggcagag
ctcaatgggaaagacggcttcatccccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaagcagaagaaatgctcagcaaacagcggcatgat
ggggcctttcttatccgagagagcgagagtgctcctggggatttctccctctccgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggggctggaaagtatttcctc
tgggtggtcaagttcaactctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatatttctccgggacatagagcaggtgccacagcagccgacatac
gtccaagccctctttgactttgacccccaggaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcttgccacggg
cagaccggcatgttcccacgcaattacgtcacccccgtgaaccggaacgtctaa

KEGG   Ovis aries (sheep): 114110058
Entry
114110058         CDS       T03117                                 

Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04062  Chemokine signaling pathway
oas04068  FoxO signaling pathway
oas04072  Phospholipase D signaling pathway
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04380  Osteoclast differentiation
oas04510  Focal adhesion
oas04540  Gap junction
oas04550  Signaling pathways regulating pluripotency of stem cells
oas04630  JAK-STAT signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04660  T cell receptor signaling pathway
oas04662  B cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04714  Thermogenesis
oas04722  Neurotrophin signaling pathway
oas04910  Insulin signaling pathway
oas04912  GnRH signaling pathway
oas04915  Estrogen signaling pathway
oas04917  Prolactin signaling pathway
oas04926  Relaxin signaling pathway
oas04935  Growth hormone synthesis, secretion and action
oas05034  Alcoholism
oas05160  Hepatitis C
oas05161  Hepatitis B
oas05163  Human cytomegalovirus infection
oas05165  Human papillomavirus infection
oas05200  Pathways in cancer
oas05203  Viral carcinogenesis
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05210  Colorectal cancer
oas05211  Renal cell carcinoma
oas05213  Endometrial cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05220  Chronic myeloid leukemia
oas05221  Acute myeloid leukemia
oas05223  Non-small cell lung cancer
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
oas05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114110058
   04012 ErbB signaling pathway
    114110058
   04014 Ras signaling pathway
    114110058
   04630 JAK-STAT signaling pathway
    114110058
   04068 FoxO signaling pathway
    114110058
   04072 Phospholipase D signaling pathway
    114110058
   04151 PI3K-Akt signaling pathway
    114110058
   04150 mTOR signaling pathway
    114110058
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114110058
   04540 Gap junction
    114110058
   04550 Signaling pathways regulating pluripotency of stem cells
    114110058
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    114110058
   04660 T cell receptor signaling pathway
    114110058
   04662 B cell receptor signaling pathway
    114110058
   04664 Fc epsilon RI signaling pathway
    114110058
   04062 Chemokine signaling pathway
    114110058
  09152 Endocrine system
   04910 Insulin signaling pathway
    114110058
   04912 GnRH signaling pathway
    114110058
   04915 Estrogen signaling pathway
    114110058
   04917 Prolactin signaling pathway
    114110058
   04926 Relaxin signaling pathway
    114110058
   04935 Growth hormone synthesis, secretion and action
    114110058
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    114110058
  09158 Development and regeneration
   04380 Osteoclast differentiation
    114110058
  09159 Environmental adaptation
   04714 Thermogenesis
    114110058
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114110058
   05206 MicroRNAs in cancer
    114110058
   05205 Proteoglycans in cancer
    114110058
   05203 Viral carcinogenesis
    114110058
   05231 Choline metabolism in cancer
    114110058
  09162 Cancer: specific types
   05210 Colorectal cancer
    114110058
   05225 Hepatocellular carcinoma
    114110058
   05226 Gastric cancer
    114110058
   05214 Glioma
    114110058
   05221 Acute myeloid leukemia
    114110058
   05220 Chronic myeloid leukemia
    114110058
   05211 Renal cell carcinoma
    114110058
   05215 Prostate cancer
    114110058
   05213 Endometrial cancer
    114110058
   05224 Breast cancer
    114110058
   05223 Non-small cell lung cancer
    114110058
  09165 Substance dependence
   05034 Alcoholism
    114110058
  09172 Infectious disease: viral
   05161 Hepatitis B
    114110058
   05160 Hepatitis C
    114110058
   05163 Human cytomegalovirus infection
    114110058
   05165 Human papillomavirus infection
    114110058
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114110058
   01522 Endocrine resistance
    114110058
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    114110058
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:oas04990]
    114110058
Membrane trafficking [BR:oas04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    114110058
Domain-containing proteins not elsewhere classified [BR:oas04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   114110058
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 114110058
NCBI-ProteinID: XP_027815423
UniProt: A0A6P7EFI9
LinkDB
Position
21
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccaccgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgaccagaactggtacaaggcagag
ctcaatgggaaagacggcttcatccccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaagcagaagaaatgctcagcaaacagcggcatgat
ggggcctttcttatccgagagagcgagagtgctcctggggatttctccctctccgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggggctggaaagtatttcctc
tgggtggtcaagttcaactctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatatttctccgggacatagagcaggtgccacagcagccgacatac
gtccaagccctctttgactttgacccccaggaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcttgccacggg
cagaccggcatgttcccacgcaattacgtcacccccgtgaaccggaacgtctaa

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