KEGG   PATHWAY: ocu03015
Entry
ocu03015                    Pathway                                

Name
mRNA surveillance pathway - Oryctolagus cuniculus (rabbit)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
ocu03015  mRNA surveillance pathway
ocu03015

Other DBs
GO: 0071028
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100357449  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
100339832  NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
103346328  UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
100341564  UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
100356723  RBM8A; RNA binding motif protein 8A [KO:K12876]
100344696  MAGOHB; mago homolog B, exon junction complex core component [KO:K12877]
100354873  MAGOH; mago homolog, exon junction complex core component [KO:K12877]
100344550  protein mago nashi homolog [KO:K12877]
100358381  CASC3; cancer susceptibility candidate 3 [KO:K14323]
100356364  SAP18; Sin3A associated protein 18 [KO:K14324]
100339760  PNN; pinin, desmosome associated protein [KO:K13114]
100338262  ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
100344881  RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
100339723  DDX19A; DEAD-box helicase 19A [KO:K18655] [EC:3.6.4.13]
100340393  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:3.6.4.13]
100351460  GLE1; GLE1, RNA export mediator [KO:K18723]
100347351  NXF1; nuclear RNA export factor 1 [KO:K14284]
100342837  nuclear RNA export factor 2 [KO:K14284]
103351963  nuclear RNA export factor 2 [KO:K14284]
100340535  NXF2; nuclear RNA export factor 2 [KO:K14284]
100339773  nuclear RNA export factor 2 [KO:K14284]
100338777  NXF3; nuclear RNA export factor 3 [KO:K14284]
100339936  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
100351903  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
100349333  DDX39B; DExD-box helicase 39B [KO:K12812] [EC:3.6.4.13]
100342436  PYM1; PYM homolog 1, exon junction complex associated factor [KO:K14294]
100342974  SRRM1; serine and arginine repetitive matrix 1 [KO:K13171]
100340242  RNGTT; RNA guanylyltransferase and 5'-phosphatase [KO:K13917] [EC:2.7.7.50 3.6.1.-]
100340576  RNMT; RNA guanine-7 methyltransferase [KO:K00565] [EC:2.1.1.56]
100352362  FUS; FUS RNA binding protein [KO:K13098]
100341393  polyadenylate-binding protein 2-like [KO:K14396]
100345355  PABPN1; poly(A) binding protein nuclear 1 [KO:K14396]
100342787  NUDT21; nudix hydrolase 21 [KO:K14397]
100353973  CPSF7; cleavage and polyadenylation specific factor 7 [KO:K14398]
100340648  CPSF6; cleavage and polyadenylation specific factor 6 [KO:K14398]
100338861  PAPOLA; poly(A) polymerase alpha [KO:K14376] [EC:2.7.7.19]
100352625  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
100344714  PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
100350312  CLP1; cleavage and polyadenylation factor I subunit 1 [KO:K14399] [EC:2.7.1.78]
100347292  PCF11; PCF11 cleavage and polyadenylation factor subunit [KO:K14400]
100346821  CPSF2; cleavage and polyadenylation specific factor 2 [KO:K14402]
100354833  CPSF3; cleavage and polyadenylation specific factor 3 [KO:K14403] [EC:3.1.27.-]
100346062  CPSF4; cleavage and polyadenylation specific factor 4 [KO:K14404]
100342324  CPSF4L; cleavage and polyadenylation specific factor 4 like [KO:K14404]
100341056  FIP1L1; factor interacting with PAPOLA and CPSF1 [KO:K14405]
100356036  WDR33; WD repeat domain 33 [KO:K15542]
100346627  WDR82; WD repeat domain 82 [KO:K14962]
100009587  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
100009298  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
100353054  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
103346471  SSU72; SSU72 homolog, RNA polymerase II CTD phosphatase [KO:K15544] [EC:3.1.3.16]
100349354  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
100342333  CSTF2; cleavage stimulation factor subunit 2 [KO:K14407]
100344475  cleavage stimulation factor subunit 2 tau variant-like [KO:K14407]
100357418  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
100339047  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
100348044  SYMPK; symplekin [KO:K06100]
100342991  MSI2; musashi RNA binding protein 2 [KO:K14411]
100352797  MSI1; musashi RNA binding protein 1 [KO:K14411]
100351201  PABPC1L; poly(A) binding protein cytoplasmic 1 like [KO:K13126]
100340846  PABPC4; poly(A) binding protein cytoplasmic 4 [KO:K13126]
100353191  PABPC4L; poly(A) binding protein cytoplasmic 4 like [KO:K13126]
100342434  PABPC1; poly(A) binding protein cytoplasmic 1 [KO:K13126]
100350595  PABPC5; poly(A) binding protein cytoplasmic 5 [KO:K13126]
100356494  PABPC1L2B; poly(A) binding protein cytoplasmic 1 like 2B [KO:K13126]
100009553  ETF1; eukaryotic translation termination factor 1 [KO:K03265]
100355660  GSPT2; G1 to S phase transition 2 [KO:K03267]
100008618  GSPT1; G1 to S phase transition 1 [KO:K03267]
100354055  UPF2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
100354937  SMG1; SMG1, nonsense mediated mRNA decay associated PI3K related kinase [KO:K08873] [EC:2.7.11.1]
100339791  SMG7; SMG7, nonsense mediated mRNA decay factor [KO:K14409]
100341361  SMG5; SMG5, nonsense mediated mRNA decay factor [KO:K11125]
100355820  SMG6; SMG6, nonsense mediated mRNA decay factor [KO:K11124] [EC:3.1.-.-]
100009252  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
100009300  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
100355092  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
100355758  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
100328617  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
100009139  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
100328616  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
100348286  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
100355159  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
100356580  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
100353545  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
100009434  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
100346997  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
100009533  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
100009216  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
100009215  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
100338746  HBS1L; HBS1 like translational GTPase [KO:K14416]
100344574  PELO; pelota homolog (Drosophila) [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
ocu03013  RNA transport
ocu03018  RNA degradation
ocu03040  Spliceosome
KO pathway
ko03015   
LinkDB

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