KEGG   PATHWAY: ocu04115
ocu04115                    Pathway                                

p53 signaling pathway - Oryctolagus cuniculus (rabbit)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
ocu04115  p53 signaling pathway

Oryctolagus cuniculus (rabbit) [GN:ocu]
100349299  ATM; ATM serine/threonine kinase [KO:K04728] [EC:]
100339430  CHEK2; checkpoint kinase 2 [KO:K06641] [EC:]
100359062  ATR; ATR serine/threonine kinase [KO:K06640] [EC:]
100345729  CHEK1; checkpoint kinase 1 [KO:K02216] [EC:]
100346548  GORAB; golgin, RAB6 interacting [KO:K19748]
100340625  CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
100340389  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:]
100351683  MDM4; MDM4, p53 regulator [KO:K10127]
100009292  TP53; tumor protein p53 [KO:K04451]
100348489  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100009036  CCND2; cyclin D2 [KO:K10151]
100009038  CCND3; cyclin D3 [KO:K10152]
100009039  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:]
100009040  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:]
100134864  CCNE1; cyclin E1 [KO:K06626]
100134867  CCNE2; cyclin E2 [KO:K06626]
100134865  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:]
100358179  SFN; stratifin [KO:K06644]
100350564  RPRM; reprimo, TP53 dependent G2 arrest mediator candidate [KO:K10128]
100338989  CCNB1; cyclin B1 [KO:K05868]
100357416  CCNB2; cyclin B2 [KO:K21770]
100352863  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:]
100353284  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
100353742  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
100357969  GTSE1; G2 and S-phase expressed 1 [KO:K10129]
100008609  FAS; Fas cell surface death receptor [KO:K04390]
108176138  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
100348477  CASP8; caspase 8 [KO:K04398] [EC:]
100355991  BID; BH3 interacting domain death agonist [KO:K04726]
100355675  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
103349392  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
100357703  BBC3; BCL2 binding component 3 [KO:K10132]
100008875  BCL2L1; BCL2 like 1 [KO:K04570]
103349397  BCL2; BCL2, apoptosis regulator [KO:K02161]
100342948  TP53I3; tumor protein p53 inducible protein 3 [KO:K10133] [EC:1.-.-.-]
100351308  EI24; EI24, autophagy associated transmembrane protein [KO:K10134]
100355793  SHISA5; shisa family member 5 [KO:K10135]
100350501  PERP; PERP, TP53 apoptosis effector [KO:K10136]
100358964  ZMAT3; zinc finger matrin-type 3 [KO:K10137]
100355829  SIAH1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:]
100357840  cytochrome c-like [KO:K08738]
100355084  cytochrome c [KO:K08738]
100341050  cytochrome c-like [KO:K08738]
100354468  cytochrome c-like [KO:K08738]
100357329  cytochrome c [KO:K08738]
100341515  cytochrome c-like [KO:K08738]
100353673  cytochrome c, testis-specific [KO:K08738]
100351037  cytochrome c-like [KO:K08738]
100341175  cytochrome c [KO:K08738]
103347723  cytochrome c-like [KO:K08738]
100354724  cytochrome c-like [KO:K08738]
103351673  cytochrome c-like [KO:K08738]
108178730  cytochrome c-like [KO:K08738]
108177422  cytochrome c-like [KO:K08738]
103348383  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
100101592  CASP9; caspase 9 [KO:K04399] [EC:]
100008840  CASP3; caspase 3 [KO:K02187] [EC:]
100343674  AIFM2; apoptosis inducing factor, mitochondria associated 2 [KO:K22745]
100008668  IGF1; insulin like growth factor 1 [KO:K05459]
100009588  SERPINE1; serpin family E member 1 [KO:K03982]
100343949  CD82; CD82 molecule [KO:K06509]
100350430  THBS1; thrombospondin 1 [KO:K16857]
100338403  SERPINB5; serpin family B member 5 [KO:K10139]
100352386  DDB2; damage specific DNA binding protein 2 [KO:K10140]
100346325  RRM2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:]
100337711  RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:]
100344328  SESN1; sestrin 1 [KO:K10141]
100354919  SESN3; sestrin 3 [KO:K10141]
100353543  SESN2; sestrin 2 [KO:K20394]
100358716  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:]
100351640  TSC2; tuberous sclerosis 2 [KO:K07207]
100354683  STEAP3; STEAP3 metalloreductase [KO:K10142] [EC:1.16.1.-]
100356568  RFWD2; ring finger and WD repeat domain 2 [KO:K10143] [EC:]
100342142  RCHY1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:]
100357563  CCNG1; cyclin G1 [KO:K10145]
100350583  CCNG2; cyclin G2 [KO:K10146]
100358554  PPM1D; protein phosphatase, Mg2+/Mn2+ dependent 1D [KO:K10147] [EC:]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
ocu04110  Cell cycle
ocu04210  Apoptosis
ocu04218  Cellular senescence
KO pathway

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