KEGG   PATHWAY: ocu05164
Entry
ocu05164                    Pathway                                

Name
Influenza A - Oryctolagus cuniculus (rabbit)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
ocu05164  Influenza A
ocu05164

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100357844  PLG; plasminogen [KO:K01315] [EC:3.4.21.7]
100339859  PRSS2; protease, serine 2 [KO:K01312] [EC:3.4.21.4]
100339606  cationic trypsin [KO:K01312] [EC:3.4.21.4]
100339353  cationic trypsin [KO:K01312] [EC:3.4.21.4]
100337870  TMPRSS2; transmembrane protease, serine 2 [KO:K09633] [EC:3.4.21.-]
100355162  TMPRSS4; transmembrane protease, serine 4 [KO:K09635] [EC:3.4.21.-]
100355883  TMPRSS11D; transmembrane protease, serine 11D [KO:K09641] [EC:3.4.21.-]
100037719  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
100340530  OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
100340787  OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
108178670  OAS1; 2'-5'-oligoadenylate synthetase 1 [KO:K14216] [EC:2.7.7.84]
100343787  RNASEL; ribonuclease L [KO:K01165]
100355543  DNAJC3; DnaJ heat shock protein family (Hsp40) member C3 [KO:K09523]
100009013  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
100339093  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
100343500  TRIM25; tripartite motif containing 25 [KO:K10652] [EC:2.3.2.27]
100347707  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:3.6.4.13]
100343560  IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
100341830  NLRX1; NLR family member X1 [KO:K12653]
100356540  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
100355888  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100356401  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100328905  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100359283  NFKBIB; NFKB inhibitor beta [KO:K02581]
100357341  NFKBIA; NFKB inhibitor alpha [KO:K04734]
100349426  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100351096  CALCOCO2; calcium binding and coiled-coil domain 2 [KO:K21348]
100009024  TLR3; toll like receptor 3 [KO:K05401]
100359083  TRAF3; TNF receptor associated factor 3 [KO:K03174]
100358771  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
100354455  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103346571  IRF3; interferon regulatory factor 3 [KO:K05411]
100354135  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
100340619  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
100009497  TLR4; toll like receptor 4 [KO:K10160]
100340811  MYD88; myeloid differentiation primary response 88 [KO:K04729]
100341605  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100358763  IRF7; interferon regulatory factor 7 [KO:K09447]
100009250  IL1A; interleukin 1 alpha [KO:K04383]
100008990  IL1B; interleukin 1 beta [KO:K04519]
100008733  IL6; interleukin 6 [KO:K05405]
100349007  IL12A; interleukin 12A [KO:K05406]
100354852  IL12B; interleukin 12B [KO:K05425]
100009088  TNF; tumor necrosis factor [KO:K03156]
100009129  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
100009130  CCL2; chemokine (C-C motif) ligand 2 [KO:K14624]
100348266  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
100353112  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
100345640  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100353390  interferon alpha-21-like [KO:K05414]
100355669  interferon alpha-21-like [KO:K05414]
100355912  interferon alpha-5-like [KO:K05414]
100357708  interferon alpha-21-like [KO:K05414]
100354654  interferon alpha-21-like [KO:K05414]
100356419  interferon alpha-14-like [KO:K05414]
100357194  interferon alpha-21-like [KO:K05414]
100356678  interferon alpha-1/13-like [KO:K05414]
100342931  IFNB1; interferon beta 1 [KO:K05415]
100338604  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
100338097  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
100352594  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
100344622  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
100343893  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
100344467  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100344432  IRF9; interferon regulatory factor 9 [KO:K04693]
100008606  interferon-induced GTP-binding protein Mx2 [KO:K14754]
100359014  MX1; MX dynamin like GTPase 1 [KO:K14754]
100009451  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
100346984  ADAR; adenosine deaminase, RNA specific [KO:K12968] [EC:3.5.4.37]
100351382  PML; promyelocytic leukemia [KO:K10054]
100008602  IFNG; interferon gamma [KO:K04687]
100341787  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100338854  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100358134  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
100338894  CIITA; class II major histocompatibility complex transactivator [KO:K08060] [EC:2.7.11.1]
100328929  RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha [KO:K06752]
100348904  RLA-DRB1; HLA class II histocompatibility antigen, DRB1-8 beta chain [KO:K06752]
100349408  HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752]
100349667  HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752]
100350656  RLA-DRB1; HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752]
100350168  Orcu-DRB; HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752]
100343144  Orcu-DQA; SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
100351163  RLA-DQB; HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
100351416  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100341358  RLA class II histocompatibility antigen, DP beta chain [KO:K06752]
100352927  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
100352672  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100355948  RLA-DMB; histocompatibility antigen DM heterodimer light chain-like [KO:K06752]
100352415  RLA-DMA; histocompatibility antigen DM heterodimer heavy chain-like [KO:K06752]
100351623  NLRP3; NLR family pyrin domain containing 3 [KO:K12800]
100352110  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100101588  CASP1; caspase 1 [KO:K01370] [EC:3.4.22.36]
100144338  IL18; interleukin 18 [KO:K05482]
100356081  IL33; interleukin 33 [KO:K12967]
100357841  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100345250  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100348663  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100345181  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100337822  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100342852  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100353706  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100009038  CCND3; cyclin D3 [KO:K10152]
100009039  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100009040  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100355808  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
108176138  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
100344073  FASLG; Fas ligand [KO:K04389]
100008609  FAS; Fas cell surface death receptor [KO:K04390]
100346106  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
100337888  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103346753  FADD; Fas associated via death domain [KO:K02373]
100348477  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
100355991  BID; BH3 interacting domain death agonist [KO:K04726]
100355675  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
100342046  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
100008751  VDAC1; voltage dependent anion channel 1 [KO:K05862]
100346477  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
100009414  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
100349768  ADP/ATP translocase 1 [KO:K05863]
100356326  ADP/ATP translocase 2 [KO:K05863]
100337764  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
100357840  cytochrome c-like [KO:K08738]
100355084  cytochrome c [KO:K08738]
100341050  cytochrome c-like [KO:K08738]
100354468  cytochrome c-like [KO:K08738]
100357329  cytochrome c [KO:K08738]
100341515  cytochrome c-like [KO:K08738]
100353673  cytochrome c, testis-specific [KO:K08738]
100351037  cytochrome c-like [KO:K08738]
100341175  cytochrome c [KO:K08738]
103347723  cytochrome c-like [KO:K08738]
100354724  cytochrome c-like [KO:K08738]
103351673  cytochrome c-like [KO:K08738]
108178730  cytochrome c-like [KO:K08738]
108177422  cytochrome c-like [KO:K08738]
103348383  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
100101592  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
100008840  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
100346062  CPSF4; cleavage and polyadenylation specific factor 4 [KO:K14404]
100342324  CPSF4L; cleavage and polyadenylation specific factor 4 like [KO:K14404]
100341393  polyadenylate-binding protein 2-like [KO:K14396]
100345355  PABPN1; poly(A) binding protein nuclear 1 [KO:K14396]
100347351  NXF1; nuclear RNA export factor 1 [KO:K14284]
100342837  nuclear RNA export factor 2 [KO:K14284]
103351963  nuclear RNA export factor 2 [KO:K14284]
100340535  NXF2; nuclear RNA export factor 2 [KO:K14284]
100339773  nuclear RNA export factor 2 [KO:K14284]
100338777  NXF3; nuclear RNA export factor 3 [KO:K14284]
100339936  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
100351903  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
100358566  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U like 1 [KO:K15047]
100359017  RAE1; ribonucleic acid export 1 [KO:K14298]
100343626  NUP98; nucleoporin 98 [KO:K14297]
100347276  RSAD2; radical S-adenosyl methionine domain containing 2 [KO:K15045]
103350044  FDPS; farnesyl diphosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
100037720  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100347407  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100009316  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100347345  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100009272  ACTB; actin beta [KO:K05692]
100009072  RAB11A; RAB11A, member RAS oncogene family [KO:K07904]
100358563  RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
100343451  XPO1; exportin 1 [KO:K14290]
100357334  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
100351853  KPNA2; karyopherin subunit alpha 2 [KO:K15043]
100353066  KPNA7; karyopherin subunit alpha 7 [KO:K15043]
100343572  KPNA5; karyopherin subunit alpha 5 [KO:K15042]
100350359  KPNA6; karyopherin subunit alpha 6 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
ocu00900  Terpenoid backbone biosynthesis
ocu03013  RNA transport
ocu03015  mRNA surveillance pathway
ocu04010  MAPK signaling pathway
ocu04110  Cell cycle
ocu04144  Endocytosis
ocu04210  Apoptosis
ocu04620  Toll-like receptor signaling pathway
ocu04621  NOD-like receptor signaling pathway
ocu04622  RIG-I-like receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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