Oryctolagus cuniculus (rabbit): 100340437
Help
Entry
100340437 CDS
T03373
Gene name
ARAF
Definition
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu01521
EGFR tyrosine kinase inhibitor resistance
ocu01522
Endocrine resistance
ocu04010
MAPK signaling pathway
ocu04012
ErbB signaling pathway
ocu04068
FoxO signaling pathway
ocu04270
Vascular smooth muscle contraction
ocu04650
Natural killer cell mediated cytotoxicity
ocu04720
Long-term potentiation
ocu04726
Serotonergic synapse
ocu04730
Long-term depression
ocu04810
Regulation of actin cytoskeleton
ocu04910
Insulin signaling pathway
ocu04914
Progesterone-mediated oocyte maturation
ocu04928
Parathyroid hormone synthesis, secretion and action
ocu05010
Alzheimer disease
ocu05022
Pathways of neurodegeneration - multiple diseases
ocu05034
Alcoholism
ocu05160
Hepatitis C
ocu05161
Hepatitis B
ocu05200
Pathways in cancer
ocu05205
Proteoglycans in cancer
ocu05210
Colorectal cancer
ocu05211
Renal cell carcinoma
ocu05212
Pancreatic cancer
ocu05213
Endometrial cancer
ocu05214
Glioma
ocu05215
Prostate cancer
ocu05218
Melanoma
ocu05219
Bladder cancer
ocu05220
Chronic myeloid leukemia
ocu05221
Acute myeloid leukemia
ocu05223
Non-small cell lung cancer
ocu05224
Breast cancer
ocu05225
Hepatocellular carcinoma
ocu05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100340437 (ARAF)
04012 ErbB signaling pathway
100340437 (ARAF)
04068 FoxO signaling pathway
100340437 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100340437 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100340437 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
100340437 (ARAF)
04914 Progesterone-mediated oocyte maturation
100340437 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
100340437 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100340437 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
100340437 (ARAF)
04720 Long-term potentiation
100340437 (ARAF)
04730 Long-term depression
100340437 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100340437 (ARAF)
05205 Proteoglycans in cancer
100340437 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
100340437 (ARAF)
05212 Pancreatic cancer
100340437 (ARAF)
05225 Hepatocellular carcinoma
100340437 (ARAF)
05226 Gastric cancer
100340437 (ARAF)
05214 Glioma
100340437 (ARAF)
05221 Acute myeloid leukemia
100340437 (ARAF)
05220 Chronic myeloid leukemia
100340437 (ARAF)
05218 Melanoma
100340437 (ARAF)
05211 Renal cell carcinoma
100340437 (ARAF)
05219 Bladder cancer
100340437 (ARAF)
05215 Prostate cancer
100340437 (ARAF)
05213 Endometrial cancer
100340437 (ARAF)
05224 Breast cancer
100340437 (ARAF)
05223 Non-small cell lung cancer
100340437 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100340437 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
100340437 (ARAF)
09165 Substance dependence
05034 Alcoholism
100340437 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
100340437 (ARAF)
05160 Hepatitis C
100340437 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100340437 (ARAF)
01522 Endocrine resistance
100340437 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ocu01001
]
100340437 (ARAF)
Enzymes [BR:
ocu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100340437 (ARAF)
Protein kinases [BR:
ocu01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100340437 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
APH
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
100340437
NCBI-ProteinID:
XP_008270774
Ensembl:
ENSOCUG00000016449
UniProt:
G1TBN2
LinkDB
All DBs
Position
X
AA seq
606 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVITVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTSRRQFYHSIQDLSGSSRQHEAPSSRPLNEPL
TPQGPSSCTQHHDPERFPFPAPANAPLQRIRSTSTPNVHMVSTAAPTDSSLMQLTAQSFG
TDAAGGRGGGDGAPRGSPSPASMSSGRKSPHSKSPSEQRERKSTADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq
1821 nt
NT seq
+upstream
nt +downstream
nt
atggagccgccacgaggtccccctgccaacggggccgagccgtcccgggcagtgggcacc
gtgaaagtgtacctgcccaacaagcaacgcacggtgataactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaagtgcggggtctcaatcaggactgctgtgtg
gtgtaccgactcatcaaggggcgaaagacagtcactgcctgggacacggccatcgccccc
ctggatggcgaggagctcattgttgaggtccttgaagacgtcccgctgaccatgcacaat
tttgtgcgcaagaccttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggtttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtt
cccacagtgtgtgtggacatgagtaccagccgccgacagttctaccacagcatccaggat
ttgtccggaagctccaggcagcatgaggctccctccagccgccccctgaatgagccactc
accccccagggtcccagctcctgcacccagcaccatgacccggagcggttccccttccct
gccccggccaacgccccccttcagcgcatccgctccacgtccactcccaatgtccacatg
gtcagcaccgcagcccccacggactccagcctcatgcagctcactgcccagagtttcggc
actgatgctgctggtggtagaggtggtggtgatggagccccccggggaagccccagcccg
gccagcatgtcctcggggaggaagtccccacattccaagtcaccatcagagcaacgagag
cggaagtccacggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccccccagtgaggtgcagctgctgaagaggatcgggactggctca
tttggcaccgtgtttcgtggacggtggcatggcgacgtggccgtgaaggtgctcaaggtg
gcccagcccacagccgagcaggcccaggccttcaagaatgagatgcaggtgctcaggaag
acacggcatgtcaacatcttgctattcatgggcttcatgacccgaccgggctttgccatc
atcacacagtggtgcgagggctccagcctctaccaccacctacatgtggccgacacgcgc
tttgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagacctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagatcggtgactttggcctggccaccgtgaagacgcggtggagcggggcc
cagcccttggagcagccttcaggctctgtgctttggatggcggctgaggtgatccgcatg
caggacccgaacccctacagcttccagtcggacgtctatgcctacggggttgtgctctac
gaactcatgaccggctcactgccttacagccacattggcagccgtgaccagatcatcttt
atggtgggccgtggctatctgtccccggacctcagtaaaatctccagcaactgccccaag
gccatgcggcgtctgctgtctgactgcctcaagttccagcgggaggagcggcctctcttc
ccccagatcctggccacgattgagctgctgcaacggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggctgacgagctgcctgcctgcctcctcagt
gcagcccgccttgtgccttag
Oryctolagus cuniculus (rabbit): 100347407
Help
Entry
100347407 CDS
T03373
Gene name
RAF1
Definition
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu01521
EGFR tyrosine kinase inhibitor resistance
ocu01522
Endocrine resistance
ocu04010
MAPK signaling pathway
ocu04012
ErbB signaling pathway
ocu04014
Ras signaling pathway
ocu04015
Rap1 signaling pathway
ocu04022
cGMP-PKG signaling pathway
ocu04024
cAMP signaling pathway
ocu04062
Chemokine signaling pathway
ocu04068
FoxO signaling pathway
ocu04071
Sphingolipid signaling pathway
ocu04072
Phospholipase D signaling pathway
ocu04140
Autophagy - animal
ocu04150
mTOR signaling pathway
ocu04151
PI3K-Akt signaling pathway
ocu04210
Apoptosis
ocu04218
Cellular senescence
ocu04270
Vascular smooth muscle contraction
ocu04360
Axon guidance
ocu04370
VEGF signaling pathway
ocu04371
Apelin signaling pathway
ocu04510
Focal adhesion
ocu04540
Gap junction
ocu04550
Signaling pathways regulating pluripotency of stem cells
ocu04613
Neutrophil extracellular trap formation
ocu04625
C-type lectin receptor signaling pathway
ocu04630
JAK-STAT signaling pathway
ocu04650
Natural killer cell mediated cytotoxicity
ocu04660
T cell receptor signaling pathway
ocu04662
B cell receptor signaling pathway
ocu04664
Fc epsilon RI signaling pathway
ocu04666
Fc gamma R-mediated phagocytosis
ocu04720
Long-term potentiation
ocu04722
Neurotrophin signaling pathway
ocu04726
Serotonergic synapse
ocu04730
Long-term depression
ocu04810
Regulation of actin cytoskeleton
ocu04910
Insulin signaling pathway
ocu04912
GnRH signaling pathway
ocu04914
Progesterone-mediated oocyte maturation
ocu04915
Estrogen signaling pathway
ocu04916
Melanogenesis
ocu04917
Prolactin signaling pathway
ocu04919
Thyroid hormone signaling pathway
ocu04921
Oxytocin signaling pathway
ocu04926
Relaxin signaling pathway
ocu04928
Parathyroid hormone synthesis, secretion and action
ocu04929
GnRH secretion
ocu04935
Growth hormone synthesis, secretion and action
ocu05010
Alzheimer disease
ocu05022
Pathways of neurodegeneration - multiple diseases
ocu05034
Alcoholism
ocu05132
Salmonella infection
ocu05152
Tuberculosis
ocu05160
Hepatitis C
ocu05161
Hepatitis B
ocu05163
Human cytomegalovirus infection
ocu05164
Influenza A
ocu05165
Human papillomavirus infection
ocu05167
Kaposi sarcoma-associated herpesvirus infection
ocu05170
Human immunodeficiency virus 1 infection
ocu05200
Pathways in cancer
ocu05205
Proteoglycans in cancer
ocu05206
MicroRNAs in cancer
ocu05210
Colorectal cancer
ocu05211
Renal cell carcinoma
ocu05212
Pancreatic cancer
ocu05213
Endometrial cancer
ocu05214
Glioma
ocu05215
Prostate cancer
ocu05218
Melanoma
ocu05219
Bladder cancer
ocu05220
Chronic myeloid leukemia
ocu05221
Acute myeloid leukemia
ocu05223
Non-small cell lung cancer
ocu05224
Breast cancer
ocu05225
Hepatocellular carcinoma
ocu05226
Gastric cancer
ocu05230
Central carbon metabolism in cancer
ocu05231
Choline metabolism in cancer
ocu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100347407 (RAF1)
04012 ErbB signaling pathway
100347407 (RAF1)
04014 Ras signaling pathway
100347407 (RAF1)
04015 Rap1 signaling pathway
100347407 (RAF1)
04370 VEGF signaling pathway
100347407 (RAF1)
04371 Apelin signaling pathway
100347407 (RAF1)
04630 JAK-STAT signaling pathway
100347407 (RAF1)
04068 FoxO signaling pathway
100347407 (RAF1)
04072 Phospholipase D signaling pathway
100347407 (RAF1)
04071 Sphingolipid signaling pathway
100347407 (RAF1)
04024 cAMP signaling pathway
100347407 (RAF1)
04022 cGMP-PKG signaling pathway
100347407 (RAF1)
04151 PI3K-Akt signaling pathway
100347407 (RAF1)
04150 mTOR signaling pathway
100347407 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100347407 (RAF1)
09143 Cell growth and death
04210 Apoptosis
100347407 (RAF1)
04218 Cellular senescence
100347407 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100347407 (RAF1)
04540 Gap junction
100347407 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
100347407 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100347407 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100347407 (RAF1)
04625 C-type lectin receptor signaling pathway
100347407 (RAF1)
04650 Natural killer cell mediated cytotoxicity
100347407 (RAF1)
04660 T cell receptor signaling pathway
100347407 (RAF1)
04662 B cell receptor signaling pathway
100347407 (RAF1)
04664 Fc epsilon RI signaling pathway
100347407 (RAF1)
04666 Fc gamma R-mediated phagocytosis
100347407 (RAF1)
04062 Chemokine signaling pathway
100347407 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
100347407 (RAF1)
04929 GnRH secretion
100347407 (RAF1)
04912 GnRH signaling pathway
100347407 (RAF1)
04915 Estrogen signaling pathway
100347407 (RAF1)
04914 Progesterone-mediated oocyte maturation
100347407 (RAF1)
04917 Prolactin signaling pathway
100347407 (RAF1)
04921 Oxytocin signaling pathway
100347407 (RAF1)
04926 Relaxin signaling pathway
100347407 (RAF1)
04935 Growth hormone synthesis, secretion and action
100347407 (RAF1)
04919 Thyroid hormone signaling pathway
100347407 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
100347407 (RAF1)
04916 Melanogenesis
100347407 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100347407 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
100347407 (RAF1)
04720 Long-term potentiation
100347407 (RAF1)
04730 Long-term depression
100347407 (RAF1)
04722 Neurotrophin signaling pathway
100347407 (RAF1)
09158 Development and regeneration
04360 Axon guidance
100347407 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100347407 (RAF1)
05206 MicroRNAs in cancer
100347407 (RAF1)
05205 Proteoglycans in cancer
100347407 (RAF1)
05230 Central carbon metabolism in cancer
100347407 (RAF1)
05231 Choline metabolism in cancer
100347407 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100347407 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
100347407 (RAF1)
05212 Pancreatic cancer
100347407 (RAF1)
05225 Hepatocellular carcinoma
100347407 (RAF1)
05226 Gastric cancer
100347407 (RAF1)
05214 Glioma
100347407 (RAF1)
05221 Acute myeloid leukemia
100347407 (RAF1)
05220 Chronic myeloid leukemia
100347407 (RAF1)
05218 Melanoma
100347407 (RAF1)
05211 Renal cell carcinoma
100347407 (RAF1)
05219 Bladder cancer
100347407 (RAF1)
05215 Prostate cancer
100347407 (RAF1)
05213 Endometrial cancer
100347407 (RAF1)
05224 Breast cancer
100347407 (RAF1)
05223 Non-small cell lung cancer
100347407 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100347407 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
100347407 (RAF1)
09165 Substance dependence
05034 Alcoholism
100347407 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
100347407 (RAF1)
05152 Tuberculosis
100347407 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100347407 (RAF1)
05161 Hepatitis B
100347407 (RAF1)
05160 Hepatitis C
100347407 (RAF1)
05164 Influenza A
100347407 (RAF1)
05163 Human cytomegalovirus infection
100347407 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
100347407 (RAF1)
05165 Human papillomavirus infection
100347407 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100347407 (RAF1)
01522 Endocrine resistance
100347407 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ocu01001
]
100347407 (RAF1)
Enzymes [BR:
ocu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100347407 (RAF1)
Protein kinases [BR:
ocu01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100347407 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
100347407
NCBI-ProteinID:
XP_008258643
Ensembl:
ENSOCUG00000014175
LinkDB
All DBs
Position
9
AA seq
621 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGAPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESGSPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
PDPVLHRAAPALSAEDQPERL
NT seq
1866 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggggcttggaagacgatcagcaatggttttggattcaaagatgca
gtgtttgatggctccagctgcatctcccccacgatagttcagcagtttggctatcagcgt
cgggcgtcagatgatggcaaactcacagattcttctaagacaagcaacactatccgtgtg
ttcttgccaaataagcaacgaacagtggtcaatgtgcgaaatgggatgagcttgcatgac
tgcctaatgaaagcgctcaaggtgaggggcctgcagccggagtgctgtgctgtgttcaga
ctcctccatgaacataaaggtaaaaaagcacgtttagattggaatacggatgccgcctcc
ttgattggagaagaacttcaagtagatttcctggatcacgttcccctcaccacacacaac
tttgcccgaaagacgttcctgaagcttgccttctgtgacatttgtcaaaagttcctcctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtcgactggagtaatatcagacagctcttattgtttccaaactccacc
attggtgatagtggggccccagcactaccttctttgacgatgcgtcggatgcgagaatct
gtttcccggatgcctgttagttcccagcacagatactccacaccccatgccttcacattc
aacacctccagtccctcctcagaaggctccctgtcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcaggctcaccttcagccctatccagcagccccaacaatttg
agcccaacaggctggtcacagcccaaaacccctgtgccagcacagagagaacgggcacca
ggatctggaacacaggagaaaaacaaaattaggccccgtggacagagagattccagctat
tactgggaaatagaagccagcgaagtgatgctctccactcggattggatctggctccttt
ggaactgtttataaaggcaaatggcatggagacgttgcagtgaagatccttaaggtcgtc
gacccaaccccagagcagctgcaggccttcaggaacgaggtggctgtcctgcgcaaaaca
cggcatgtgaacatcctactcttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgtgagggcagcagcctctataaacatctgcacgtccaggagaccaagttc
cagatgttccagttaattgacatcgcccgccagacagcacaaggcatggactacttgcat
gcaaagaatatcattcacagagacatgaaatccaacaatatattcctccatgaaggccta
acggtgaaaattggagatttcggtttggcaacagtaaaatcacggtggagtggttcccag
caggtcgaacaacctaccggctccgtcctgtggatggctccagaggtgatccgaatgcag
gataacaaccccttcagcttccagtctgacgtctactcgtacggcatcgtgttgtacgag
ctgatgacaggggagcttccctactcccacatcaacaaccgggatcagatcatcttcatg
gtgggccggggctatgcctccccggatctcagcaagctctacaagaactgcccgaaagcc
atgaagaggctggtggctgactgcgtgaagaaagttaaggaggagaggcctctttttccc
ccagatcctgtcctccatcgagctgctccagcactctctgccgaagatcaaccggagcgc
ctctga
Oryctolagus cuniculus (rabbit): 100351964
Help
Entry
100351964 CDS
T03373
Gene name
BRAF
Definition
(RefSeq) B-Raf proto-oncogene, serine/threonine kinase
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu01521
EGFR tyrosine kinase inhibitor resistance
ocu01522
Endocrine resistance
ocu04010
MAPK signaling pathway
ocu04012
ErbB signaling pathway
ocu04015
Rap1 signaling pathway
ocu04024
cAMP signaling pathway
ocu04062
Chemokine signaling pathway
ocu04068
FoxO signaling pathway
ocu04150
mTOR signaling pathway
ocu04270
Vascular smooth muscle contraction
ocu04510
Focal adhesion
ocu04650
Natural killer cell mediated cytotoxicity
ocu04720
Long-term potentiation
ocu04722
Neurotrophin signaling pathway
ocu04726
Serotonergic synapse
ocu04730
Long-term depression
ocu04810
Regulation of actin cytoskeleton
ocu04910
Insulin signaling pathway
ocu04914
Progesterone-mediated oocyte maturation
ocu04928
Parathyroid hormone synthesis, secretion and action
ocu04934
Cushing syndrome
ocu05010
Alzheimer disease
ocu05022
Pathways of neurodegeneration - multiple diseases
ocu05034
Alcoholism
ocu05160
Hepatitis C
ocu05161
Hepatitis B
ocu05200
Pathways in cancer
ocu05205
Proteoglycans in cancer
ocu05210
Colorectal cancer
ocu05211
Renal cell carcinoma
ocu05212
Pancreatic cancer
ocu05213
Endometrial cancer
ocu05214
Glioma
ocu05215
Prostate cancer
ocu05216
Thyroid cancer
ocu05218
Melanoma
ocu05219
Bladder cancer
ocu05220
Chronic myeloid leukemia
ocu05221
Acute myeloid leukemia
ocu05223
Non-small cell lung cancer
ocu05224
Breast cancer
ocu05225
Hepatocellular carcinoma
ocu05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100351964 (BRAF)
04012 ErbB signaling pathway
100351964 (BRAF)
04015 Rap1 signaling pathway
100351964 (BRAF)
04068 FoxO signaling pathway
100351964 (BRAF)
04024 cAMP signaling pathway
100351964 (BRAF)
04150 mTOR signaling pathway
100351964 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
100351964 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100351964 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100351964 (BRAF)
04062 Chemokine signaling pathway
100351964 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
100351964 (BRAF)
04914 Progesterone-mediated oocyte maturation
100351964 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
100351964 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100351964 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
100351964 (BRAF)
04720 Long-term potentiation
100351964 (BRAF)
04730 Long-term depression
100351964 (BRAF)
04722 Neurotrophin signaling pathway
100351964 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100351964 (BRAF)
05205 Proteoglycans in cancer
100351964 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
100351964 (BRAF)
05212 Pancreatic cancer
100351964 (BRAF)
05225 Hepatocellular carcinoma
100351964 (BRAF)
05226 Gastric cancer
100351964 (BRAF)
05214 Glioma
100351964 (BRAF)
05216 Thyroid cancer
100351964 (BRAF)
05221 Acute myeloid leukemia
100351964 (BRAF)
05220 Chronic myeloid leukemia
100351964 (BRAF)
05218 Melanoma
100351964 (BRAF)
05211 Renal cell carcinoma
100351964 (BRAF)
05219 Bladder cancer
100351964 (BRAF)
05215 Prostate cancer
100351964 (BRAF)
05213 Endometrial cancer
100351964 (BRAF)
05224 Breast cancer
100351964 (BRAF)
05223 Non-small cell lung cancer
100351964 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100351964 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
100351964 (BRAF)
09165 Substance dependence
05034 Alcoholism
100351964 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100351964 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
100351964 (BRAF)
05160 Hepatitis C
100351964 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100351964 (BRAF)
01522 Endocrine resistance
100351964 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ocu01001
]
100351964 (BRAF)
Enzymes [BR:
ocu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100351964 (BRAF)
Protein kinases [BR:
ocu01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100351964 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
100351964
NCBI-ProteinID:
XP_017194278
Ensembl:
ENSOCUG00000005487
UniProt:
A0A5F9CFV9
LinkDB
All DBs
Position
Un
AA seq
755 aa
AA seq
DB search
MIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVS
SSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPAR
CGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPL
TTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVS
KFFEHHPVPQEEASLAETALTSGSSPSAPPSDSIGHQILTSPSPSKSIPIPQSFRPADED
HRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSP
LLPSVPSDIVFDFEPGPVFRGSTTGLSATPPASLPGSLTSVKAVQRSPGPQRERKSSSSS
EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIK
LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQ
LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRG
YLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPS
LNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2268 nt
NT seq
+upstream
nt +downstream
nt
atgattaagttgacacaggagcatatagaggccctattggacaaatttggtggggagcat
aatccaccatcaatatatctggaggcctacgaagaatacaccagcaagctagatgccctc
caacaaagagaacagcagttattggaatccctggggaatggaactgatttttctgtttct
agctctgcgtcaatggacaccgttacgtcttcttcctcttctagcctttcagtgctacct
tcatctctttcagtttttcaaaatcccacagatgtgtcacggagcaaccccaagtcacca
caaaaacctattgttagagtcttcctgcccaacaaacagaggacagtggtacctgcaaga
tgtggagttacggttcgagacagtctaaagaaagcgctgatgatgagaggtctgatccca
gaatgctgtgctgtttacagaattcaggatggagagaagaagccaattggctgggacact
gatatttcctggctcactggagaagagctgcatgtggaagtgttagagaatgtcccactc
accacacataactttgtacggaaaacttttttcaccttagcattttgtgacttctgtaga
aagctgcttttccagggtttccgctgtcaaacatgtggctacaaatttcaccagcgttgt
agtacggaagttccactgatgtgtgttaattatgaccaacttgatttgctgtttgtctcc
aagttctttgaacaccacccagtaccacaggaggaggcctccttagcagagactgccctc
acatctgggtcatcgccttccgcacctccctcagactctattgggcaccaaattctcacc
agtccgtccccttcaaaatccattccgattccacagtccttccgaccagcagatgaagat
catcgaaatcagtttgggcaacgagaccggtcttcatcagcgcctaatgttcacattaac
acaatagaacctgtcaatattgatgacttgattagagaccaagggtttcgtggtgatgga
gcccctttgaaccagctgatgcgctgtcttcggaaataccaatcccggactcccagtccc
ctcctaccttctgtccccagtgacatagtgtttgattttgagcctggcccagtgttcaga
ggatcgaccacgggtttgtctgccactccccctgcctcattacctggctcactcactagt
gtgaaagctgtacagagatccccaggacctcagcgagagaggaagtcgtcttcctcctca
gaagacaggaatcgaatgaaaactcttggtagacgggattcaagtgatgattgggagatt
cctgatgggcagatcaccgtgggacagagaattggatctggatcatttggaaccgtctac
aagggaaaatggcacggtgatgtggcagtaaaaatgttgaatgtgacagcacctacacct
cagcagttacaggccttcaaaaatgaagtaggagtactcaggaaaacacgacatgtgaat
atcctacttttcatgggctattccacaaagccacagctggctattgttacccagtggtgt
gagggctccagtttatatcaccatctccacatcattgagaccaaattcgagatgatcaaa
cttatagatattgcacggcagactgcacagggcatggattacttacacgccaagtcaatc
atccacagagacctcaagagtaataatatatttcttcatgaagacctcacagtaaaaata
ggtgattttggtctagccacagtgaaatctcgatggagtgggtcccatcagtttgaacaa
ttgtctggatccattttgtggatggcaccagaagtaatcagaatgcaagacaaaaaccca
tatagctttcagtcagatgtatatgcatttgggattgttctgtatgaattgatgactggg
cagttaccttactcaaacatcaacaacagggaccagatcatttttatggtgggacgtggc
tacctgtctccagacctcagtaaggtacggagtaactgtccgaaagccatgaagagatta
atggcagagtgcctcaaaaagaaaagagatgagagaccactctttccccaaattctcgcc
tccattgagctgctggcccgctcattgccaaaaatccaccgcagtgcatcagaaccctcc
ttgaatcgggctggtttccagacagaggattttagtctatatgcttgtgcttctccaaaa
acacccatccaggcagggggatatggagaatttgcagccttcaagtag
DBGET
integrated database retrieval system
