KEGG   Oryctolagus cuniculus (rabbit): 100343958
Entry
100343958         CDS       T03373                                 

Gene name
ADCY3
Definition
(RefSeq) adenylate cyclase 3
  KO
K08043  adenylate cyclase 3 [EC:4.6.1.1]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00230  Purine metabolism
ocu01100  Metabolic pathways
ocu01522  Endocrine resistance
ocu04015  Rap1 signaling pathway
ocu04020  Calcium signaling pathway
ocu04022  cGMP-PKG signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04114  Oocyte meiosis
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04261  Adrenergic signaling in cardiomyocytes
ocu04270  Vascular smooth muscle contraction
ocu04371  Apelin signaling pathway
ocu04540  Gap junction
ocu04611  Platelet activation
ocu04713  Circadian entrainment
ocu04714  Thermogenesis
ocu04723  Retrograde endocannabinoid signaling
ocu04724  Glutamatergic synapse
ocu04725  Cholinergic synapse
ocu04727  GABAergic synapse
ocu04740  Olfactory transduction
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04911  Insulin secretion
ocu04912  GnRH signaling pathway
ocu04913  Ovarian steroidogenesis
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04916  Melanogenesis
ocu04918  Thyroid hormone synthesis
ocu04921  Oxytocin signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04925  Aldosterone synthesis and secretion
ocu04926  Relaxin signaling pathway
ocu04927  Cortisol synthesis and secretion
ocu04928  Parathyroid hormone synthesis, secretion and action
ocu04934  Cushing syndrome
ocu04935  Growth hormone synthesis, secretion and action
ocu04962  Vasopressin-regulated water reabsorption
ocu04970  Salivary secretion
ocu04971  Gastric acid secretion
ocu04972  Pancreatic secretion
ocu04976  Bile secretion
ocu05032  Morphine addiction
ocu05163  Human cytomegalovirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05200  Pathways in cancer
ocu05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    100343958 (ADCY3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100343958 (ADCY3)
   04371 Apelin signaling pathway
    100343958 (ADCY3)
   04020 Calcium signaling pathway
    100343958 (ADCY3)
   04072 Phospholipase D signaling pathway
    100343958 (ADCY3)
   04024 cAMP signaling pathway
    100343958 (ADCY3)
   04022 cGMP-PKG signaling pathway
    100343958 (ADCY3)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    100343958 (ADCY3)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100343958 (ADCY3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100343958 (ADCY3)
   04062 Chemokine signaling pathway
    100343958 (ADCY3)
  09152 Endocrine system
   04911 Insulin secretion
    100343958 (ADCY3)
   04923 Regulation of lipolysis in adipocytes
    100343958 (ADCY3)
   04912 GnRH signaling pathway
    100343958 (ADCY3)
   04913 Ovarian steroidogenesis
    100343958 (ADCY3)
   04915 Estrogen signaling pathway
    100343958 (ADCY3)
   04914 Progesterone-mediated oocyte maturation
    100343958 (ADCY3)
   04921 Oxytocin signaling pathway
    100343958 (ADCY3)
   04926 Relaxin signaling pathway
    100343958 (ADCY3)
   04935 Growth hormone synthesis, secretion and action
    100343958 (ADCY3)
   04918 Thyroid hormone synthesis
    100343958 (ADCY3)
   04928 Parathyroid hormone synthesis, secretion and action
    100343958 (ADCY3)
   04916 Melanogenesis
    100343958 (ADCY3)
   04925 Aldosterone synthesis and secretion
    100343958 (ADCY3)
   04927 Cortisol synthesis and secretion
    100343958 (ADCY3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100343958 (ADCY3)
   04270 Vascular smooth muscle contraction
    100343958 (ADCY3)
  09154 Digestive system
   04970 Salivary secretion
    100343958 (ADCY3)
   04971 Gastric acid secretion
    100343958 (ADCY3)
   04972 Pancreatic secretion
    100343958 (ADCY3)
   04976 Bile secretion
    100343958 (ADCY3)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    100343958 (ADCY3)
  09156 Nervous system
   04724 Glutamatergic synapse
    100343958 (ADCY3)
   04727 GABAergic synapse
    100343958 (ADCY3)
   04725 Cholinergic synapse
    100343958 (ADCY3)
   04723 Retrograde endocannabinoid signaling
    100343958 (ADCY3)
  09157 Sensory system
   04740 Olfactory transduction
    100343958 (ADCY3)
   04750 Inflammatory mediator regulation of TRP channels
    100343958 (ADCY3)
  09149 Aging
   04211 Longevity regulating pathway
    100343958 (ADCY3)
   04213 Longevity regulating pathway - multiple species
    100343958 (ADCY3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100343958 (ADCY3)
   04714 Thermogenesis
    100343958 (ADCY3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100343958 (ADCY3)
  09165 Substance dependence
   05032 Morphine addiction
    100343958 (ADCY3)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    100343958 (ADCY3)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100343958 (ADCY3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100343958 (ADCY3)
   05163 Human cytomegalovirus infection
    100343958 (ADCY3)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100343958 (ADCY3)
Enzymes [BR:ocu01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     100343958 (ADCY3)
SSDB
Motif
Pfam: Guanylate_cyc AC_N HNOBA fn3_4 Peptidase_S49_N
Other DBs
NCBI-GeneID: 100343958
NCBI-ProteinID: XP_017196407
Ensembl: ENSOCUG00000015443
LinkDB
Position
2
AA seq 1144 aa
MPRNQGFSEPEYSAEYSAEYSVSLPSDADRGVGRTHEISVRNSGACLCLPRFMRLTFVPE
SLENLYQTYFKRQRHETLLVLVGFAALFDCYVVVMCAVVFSSDKLAPLVVAGIGLLLDLV
LFVVCKKGLLPDRLTRKAVPYLLWLLITAQIFSYLGLNFAQAHAASDTVGWQAFFLFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELQGMQLLREILANIFLYLCVIIVG
VMSYYMADRKQRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES
QKDQQQFNTMYMYRHENVXXXXXXXVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV
LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTLDCLKGEFDVEPGEGGSRCD
YLEEKGIETYLIIASQPAVKAAAQNGLHGSALPNGAPASSKPSSPALIETKEPVGGSQAG
SSTWEEPEQQEAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQ
VVKKRNTFLLSMRFMDPDLESRYSEEKEKQSGAAFSCSCVVLLCTALVQILIDPWLMTNY
VTFVVGEVLLLILTVCSLAAIFPRAFPKKLVAFSTWIDQTRWARNTWAMLAIFILVMANV
VDMLSCLQDYAGPGNGTAGQELGGGCLENPKYYSYVAVLSLVATIMLVQVSHMVKLTLML
LVTGAVAAINLTAWSPVFDEYDHRRFQEHGFPLVALEKMQVVSAPGLNGTDRLPLMPSKY
SMTAMMLVMMLSFYYFSRHVEKLARTLFLWKMEVHDQKERVNEMRRWNEALVTNMLPEHV
ARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFD
SLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSNKEEKSDKERWQHLADLADFA
LAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM
GNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKPAAYPNGSSVTLPHQV
VDNP
NT seq 3435 nt   +upstreamnt  +downstreamnt
atgcccaggaaccagggcttctcggagcccgagtactcggccgagtactccgccgagtac
tcggtcagcctgccgtcggatgcggaccgcggcgtgggccggacgcacgagatctccgtg
cggaactcgggcgcctgcctgtgtctgccccgcttcatgcggctgaccttcgtgccggag
tccttggagaacctctaccagacctacttcaagcggcagcgccacgagaccctgctggtg
ctggtgggcttcgcggccctcttcgactgctacgtggtggtcatgtgcgccgtggtcttc
tcgagcgacaagctggcgccgctcgtcgtggctggcatcgggctgctgttggacctcgtg
ctcttcgtggtctgcaagaaggggctgctgcccgaccggctcacccggaaggcggtgccc
tacctgctgtggctgctgataacagcccagatcttctcctacctgggcctgaacttcgcg
caggcccacgcggccagcgacacggtgggctggcaggccttcttcctcttctccttcttc
atcacgctgccactcagcctcagccccatcgtcatcatctctgtggtctcctgtgtggtg
cacacgctcgtcctgggggtcactgtggcccagcagcagcaggacgagctgcaggggatg
cagctgctcagggagatcctggccaacatcttcctctacctgtgcgtcatcatcgtgggc
gtcatgtcctactacatggccgaccgcaagcagcgcaaggccttcctggaggcccgccag
tcgctggaggtgaagatgaacctggaggagcagagccagcagcaggagaacctcatgctg
tccatcctgcccaagcacgtggccgatgagatgttgaaggacatgaagaaggatgagagc
cagaaagaccagcagcagttcaacaccatgtacatgtaccgccacgagaatgtnnnnnnn
nnnnnnnnnnnnnnngtgggcttcactcagctctcctctgcctgcagcgcccaggagctc
gtgaagctgctcaacgagctctttgcccgcttcgacaagctggcggccaaataccaccag
ctgcggatcaagatcctgggcgactgctactactgcatctgcgggctgcccgactaccgg
gaggaccacgccgtgtgctccatcctcatggggctcgccatggtggaggccatctcgtat
gtgcgggagaagacgaagactggcgtggacatgcgtgtgggggtgcacacaggcactgta
ctggggggcgtcctgggccagaagcgctggcagtacgacgtgtggtccaccgacgtcacc
gtggccaacaagatggaggccggcggcatccccgggcgcgtgcacatctcccagagcacc
ctggactgcctgaagggagagttcgacgtggagcccggcgaggggggcagccgctgcgac
tacctggaggagaagggcatcgagacctacctcatcatcgcctcccagcccgccgtgaag
gccgccgcccagaacggcctccacggctcggccctgcccaacggagcgccagcttcctcc
aagcccagctcgcctgccctcattgagaccaaggagcccgtggggggcagccaggccggc
agttccacgtgggaggagcccgagcagcaggaggcgcaggcggacaacccctccttcccc
aaccctcgccggaggctgcgcctgcaggacctggccgaccgcgtggtggacgcctccgag
gacgagcacgagctcaaccagctgctcaacgaggccctgctggagcgcgagtccgcccag
gtggtgaagaagaggaacaccttcctcctgtccatgcggttcatggaccccgacctggag
tcccgctactcggaggagaaggagaagcagagcggggccgccttcagctgctcctgcgtc
gtcctgctgtgcacggccctggtgcagatcctcatcgacccctggctgatgacaaactac
gtgacctttgtggtcggggaggtcctgctcctgatcctgaccgtctgctcgctggctgcc
atctttccccgggcctttcctaagaagctggtagccttctccacgtggatcgaccagacc
cgctgggccaggaacacctgggccatgctggccatcttcatcctggtgatggcaaatgtc
gtggacatgctcagctgtctgcaggactacgcgggaccgggcaatggcacggcggggcag
gagctggggggcggctgcctggagaaccccaagtattacagctacgtggccgtgctgtcg
ctcgtcgccaccatcatgctggtgcaggtcagccacatggtgaagctcacgctcatgctg
ctcgtcacgggcgccgtggccgccatcaacctcaccgcctggagccccgtcttcgacgag
tacgaccacaggcgcttccaggagcacggcttccccctggtggccctggagaagatgcag
gtcgtttccgcccctgggctcaacggtaccgacaggctgccgctgatgccatccaagtac
tcgatgacagcgatgatgctggtcatgatgctgagcttttactacttctcgcgccacgtg
gaaaagctggcacggaccctgttcctgtggaagatggaggtccacgatcagaaggagcgt
gtcaatgagatgcggcgctggaacgaggccttggtcaccaacatgctgcctgagcacgtg
gcacgccatttcctggggtccaagaagagagacgaggagctgtacagccagtcctatgat
gagatcggagtcatgttcgcctccctgcccaacttcgccgacttctacaccgaggagagc
atcaacaatgggggcatcgagtgcctgcgcttcctcaacgagatcatctccgactttgac
tctctcctggacaatcccaaatttcgggtcatcacgaagatcaaaaccattggcagcacc
tatatggcggcttcgggagtcaccccagatgtcaacaccaacggctttaccagctccaac
aaggaagagaagtcagacaaggagcgctggcagcacctggccgacctggccgacttcgca
ctcgccatgaaggacacgctgaccaacatcaacaatcagtccttcaacaacttcatgctg
cgcataggcatgaacaaaggaggggttctggctggcgtcatcggagcccggaaaccacac
tatgacatctggggcaacactgtcaatgtggccagcagaatggagtccacaggggtcatg
ggcaacattcaggtggtggaggaaacgcaagtgatcctgagagagtacggcttccgcttc
gtgaggcgcggccccatctttgtgaaaggaaagggggaactgctgaccttcttcctgaag
gggcgggacaagcccgctgcctaccccaacggctcctcggtgaccctgccccaccaggtg
gtcgacaacccctga

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