Oryctolagus cuniculus (rabbit): 100358716
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Entry
100358716 CDS
T03373
Gene name
PTEN
Definition
(RefSeq) phosphatase and tensin homolog
KO
K01110
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:
3.1.3.16
3.1.3.48
3.1.3.67
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu00562
Inositol phosphate metabolism
ocu01100
Metabolic pathways
ocu01521
EGFR tyrosine kinase inhibitor resistance
ocu04068
FoxO signaling pathway
ocu04070
Phosphatidylinositol signaling system
ocu04071
Sphingolipid signaling pathway
ocu04115
p53 signaling pathway
ocu04140
Autophagy - animal
ocu04150
mTOR signaling pathway
ocu04151
PI3K-Akt signaling pathway
ocu04218
Cellular senescence
ocu04510
Focal adhesion
ocu04931
Insulin resistance
ocu05165
Human papillomavirus infection
ocu05166
Human T-cell leukemia virus 1 infection
ocu05200
Pathways in cancer
ocu05206
MicroRNAs in cancer
ocu05213
Endometrial cancer
ocu05214
Glioma
ocu05215
Prostate cancer
ocu05218
Melanoma
ocu05222
Small cell lung cancer
ocu05224
Breast cancer
ocu05225
Hepatocellular carcinoma
ocu05230
Central carbon metabolism in cancer
ocu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100358716 (PTEN)
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
100358716 (PTEN)
04070 Phosphatidylinositol signaling system
100358716 (PTEN)
04071 Sphingolipid signaling pathway
100358716 (PTEN)
04151 PI3K-Akt signaling pathway
100358716 (PTEN)
04150 mTOR signaling pathway
100358716 (PTEN)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100358716 (PTEN)
09143 Cell growth and death
04115 p53 signaling pathway
100358716 (PTEN)
04218 Cellular senescence
100358716 (PTEN)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100358716 (PTEN)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100358716 (PTEN)
05206 MicroRNAs in cancer
100358716 (PTEN)
05230 Central carbon metabolism in cancer
100358716 (PTEN)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100358716 (PTEN)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
100358716 (PTEN)
05214 Glioma
100358716 (PTEN)
05218 Melanoma
100358716 (PTEN)
05215 Prostate cancer
100358716 (PTEN)
05213 Endometrial cancer
100358716 (PTEN)
05224 Breast cancer
100358716 (PTEN)
05222 Small cell lung cancer
100358716 (PTEN)
09167 Endocrine and metabolic disease
04931 Insulin resistance
100358716 (PTEN)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100358716 (PTEN)
05165 Human papillomavirus infection
100358716 (PTEN)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100358716 (PTEN)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
ocu01009
]
100358716 (PTEN)
Enzymes [BR:
ocu01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.16 protein-serine/threonine phosphatase
100358716 (PTEN)
3.1.3.48 protein-tyrosine-phosphatase
100358716 (PTEN)
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
100358716 (PTEN)
Protein phosphatases and associated proteins [BR:
ocu01009
]
Protein tyrosine phosphatases (PTPs)
Class I PTPs (Dual specificity phosphatases)
Phosphatase and Tensin homologs (PTEN)
100358716 (PTEN)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PTEN_C2
DSPc
Y_phosphatase
Y_phosphatase3
PTPlike_phytase
DUF3256
Motif
Other DBs
NCBI-GeneID:
100358716
NCBI-ProteinID:
XP_008268354
Ensembl:
ENSOCUG00000008774
LinkDB
All DBs
Position
18
AA seq
431 aa
AA seq
DB search
MAGEGCPRGISLDTDPRGPPVHSHRLPDMTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNI
IAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFED
HNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEAL
DFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCN
PQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFH
FWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDK
ANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPF
DEDQHTQITKV
NT seq
1296 nt
NT seq
+upstream
nt +downstream
nt
atggcgggggaggggtgtcctcgcggcatttccctagatactgacccgcgcggtccacct
gtgcacagccacaggctcccagacatgacagccatcatcaaagagatcgttagcagaaac
aaaaggagatatcaagaggatggattcgacttagacttgacctatatttatccaaatatt
attgctatgggatttcctgcagaaagacttgaaggcgtatacaggaacaatattgatgat
gtagtaaggtttttggattcaaagcataaaaaccattacaagatatacaatctatgtgct
gaaaggcattatgacaccgccaaatttaactgcagagttgcacagtatccttttgaagac
cataacccaccacagctagaacttatcaaacccttttgtgaagatcttgaccaatggcta
agtgaagatgacaatcatgttgcagcaattcactgtaaagctggaaagggacgaactggt
gtaatgatttgtgcatatttattacatcggggcaaatttttaaaggcacaagaagcccta
gatttttatggagaagtaaggaccagagacaaaaagggagtaactattcccagtcagaga
cgctatgtgtattattatagctacctgttaaagaatcatctggattatagaccagtggca
ctgttgtttcacaagatgatgtttgaaactattccaatgttcagtggcggaacttgcaat
cctcagtttgtggtctgccagctaaaggtgaagatatattcctccaattcaggacccaca
cgacgggaagacaagttcatgtacttcgagttccctcagccgttgcctgtgtgtggtgac
atcaaagtagagttcttccacaaacagaacaagatgcttaaaaaggacaaaatgtttcac
ttttgggtaaatacgttctttataccaggaccagaggaaacctcagaaaaagtagaaaat
ggaagtctttgtgatcaagaaattgatagtatttgcagtatagaacgtgcagataacgac
aaagaatatctagtacttactttaacaaaaaatgatcttgataaagcaaataaagacaag
gcaaaccgatacttttctccaaattttaaggtgaagctgtatttcacaaaaacagtagag
gagccatcaaatccagaggctagcagttcaacttctgtaacgccagatgttagtgacaat
gaacctgatcattatagatattctgacaccactgactctgatccagagaatgaacctttt
gatgaagatcagcatacacaaattacaaaagtctga
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