Oryctolagus cuniculus (rabbit): 100358716 Entry 100358716         CDS       T03373                                  Gene name PTEN Definition (RefSeq) phosphatase and tensin homolog   KO K01110   phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67] Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu00562   Inositol phosphate metabolism ocu01100   Metabolic pathways ocu01521   EGFR tyrosine kinase inhibitor resistance ocu04068   FoxO signaling pathway ocu04070   Phosphatidylinositol signaling system ocu04071   Sphingolipid signaling pathway ocu04115   p53 signaling pathway ocu04140   Autophagy - animal ocu04150   mTOR signaling pathway ocu04151   PI3K-Akt signaling pathway ocu04218   Cellular senescence ocu04510   Focal adhesion ocu04931   Insulin resistance ocu05165   Human papillomavirus infection ocu05166   Human T-cell leukemia virus 1 infection ocu05200   Pathways in cancer ocu05206   MicroRNAs in cancer ocu05213   Endometrial cancer ocu05214   Glioma ocu05215   Prostate cancer ocu05218   Melanoma ocu05222   Small cell lung cancer ocu05224   Breast cancer ocu05225   Hepatocellular carcinoma ocu05230   Central carbon metabolism in cancer ocu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:ocu00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     100358716 (PTEN)  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     100358716 (PTEN)    04070 Phosphatidylinositol signaling system     100358716 (PTEN)    04071 Sphingolipid signaling pathway     100358716 (PTEN)    04151 PI3K-Akt signaling pathway     100358716 (PTEN)    04150 mTOR signaling pathway     100358716 (PTEN)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     100358716 (PTEN)   09143 Cell growth and death    04115 p53 signaling pathway     100358716 (PTEN)    04218 Cellular senescence     100358716 (PTEN)   09144 Cellular community - eukaryotes    04510 Focal adhesion     100358716 (PTEN)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100358716 (PTEN)    05206 MicroRNAs in cancer     100358716 (PTEN)    05230 Central carbon metabolism in cancer     100358716 (PTEN)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100358716 (PTEN)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     100358716 (PTEN)    05214 Glioma     100358716 (PTEN)    05218 Melanoma     100358716 (PTEN)    05215 Prostate cancer     100358716 (PTEN)    05213 Endometrial cancer     100358716 (PTEN)    05224 Breast cancer     100358716 (PTEN)    05222 Small cell lung cancer     100358716 (PTEN)   09167 Endocrine and metabolic disease    04931 Insulin resistance     100358716 (PTEN)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100358716 (PTEN)    05165 Human papillomavirus infection     100358716 (PTEN)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100358716 (PTEN)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:ocu01009]     100358716 (PTEN) Enzymes [BR:ocu01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.3  Phosphoric-monoester hydrolases     3.1.3.16  protein-serine/threonine phosphatase      100358716 (PTEN)     3.1.3.48  protein-tyrosine-phosphatase      100358716 (PTEN)     3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase      100358716 (PTEN) Protein phosphatases and associated proteins [BR:ocu01009]  Protein tyrosine phosphatases (PTPs)   Class I PTPs (Dual specificity phosphatases)    Phosphatase and Tensin homologs (PTEN)     100358716 (PTEN) SSDB Motif Pfam:  PTEN_C2 DSPc Y_phosphatase Y_phosphatase3 PTPlike_phytase DUF3256 Other DBs NCBI-GeneID:  100358716 NCBI-ProteinID:  XP_008268354 Ensembl:  ENSOCUG00000008774 LinkDB Position 18 AA seq 431 aa MAGEGCPRGISLDTDPRGPPVHSHRLPDMTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNI IAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFED HNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEAL DFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCN PQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFH FWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDK ANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPF DEDQHTQITKV NT seq 1296 nt   +upstreamnt  +downstreamnt atggcgggggaggggtgtcctcgcggcatttccctagatactgacccgcgcggtccacct gtgcacagccacaggctcccagacatgacagccatcatcaaagagatcgttagcagaaac aaaaggagatatcaagaggatggattcgacttagacttgacctatatttatccaaatatt attgctatgggatttcctgcagaaagacttgaaggcgtatacaggaacaatattgatgat gtagtaaggtttttggattcaaagcataaaaaccattacaagatatacaatctatgtgct gaaaggcattatgacaccgccaaatttaactgcagagttgcacagtatccttttgaagac cataacccaccacagctagaacttatcaaacccttttgtgaagatcttgaccaatggcta agtgaagatgacaatcatgttgcagcaattcactgtaaagctggaaagggacgaactggt gtaatgatttgtgcatatttattacatcggggcaaatttttaaaggcacaagaagcccta gatttttatggagaagtaaggaccagagacaaaaagggagtaactattcccagtcagaga cgctatgtgtattattatagctacctgttaaagaatcatctggattatagaccagtggca ctgttgtttcacaagatgatgtttgaaactattccaatgttcagtggcggaacttgcaat cctcagtttgtggtctgccagctaaaggtgaagatatattcctccaattcaggacccaca cgacgggaagacaagttcatgtacttcgagttccctcagccgttgcctgtgtgtggtgac atcaaagtagagttcttccacaaacagaacaagatgcttaaaaaggacaaaatgtttcac ttttgggtaaatacgttctttataccaggaccagaggaaacctcagaaaaagtagaaaat ggaagtctttgtgatcaagaaattgatagtatttgcagtatagaacgtgcagataacgac aaagaatatctagtacttactttaacaaaaaatgatcttgataaagcaaataaagacaag gcaaaccgatacttttctccaaattttaaggtgaagctgtatttcacaaaaacagtagag gagccatcaaatccagaggctagcagttcaacttctgtaacgccagatgttagtgacaat gaacctgatcattatagatattctgacaccactgactctgatccagagaatgaacctttt gatgaagatcagcatacacaaattacaaaagtctga

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