KEGG   Oryctolagus cuniculus (rabbit): 100358716Help
Entry
100358716         CDS       T03373                                 

Gene name
PTEN
Definition
(RefSeq) phosphatase and tensin homolog
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00562  Inositol phosphate metabolism
ocu01100  Metabolic pathways
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu04068  FoxO signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04071  Sphingolipid signaling pathway
ocu04115  p53 signaling pathway
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04218  Cellular senescence
ocu04510  Focal adhesion
ocu04931  Insulin resistance
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05200  Pathways in cancer
ocu05206  MicroRNAs in cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05222  Small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05230  Central carbon metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100358716 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100358716 (PTEN)
   04070 Phosphatidylinositol signaling system
    100358716 (PTEN)
   04071 Sphingolipid signaling pathway
    100358716 (PTEN)
   04151 PI3K-Akt signaling pathway
    100358716 (PTEN)
   04150 mTOR signaling pathway
    100358716 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100358716 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    100358716 (PTEN)
   04218 Cellular senescence
    100358716 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100358716 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100358716 (PTEN)
   05206 MicroRNAs in cancer
    100358716 (PTEN)
   05230 Central carbon metabolism in cancer
    100358716 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100358716 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100358716 (PTEN)
   05214 Glioma
    100358716 (PTEN)
   05218 Melanoma
    100358716 (PTEN)
   05215 Prostate cancer
    100358716 (PTEN)
   05213 Endometrial cancer
    100358716 (PTEN)
   05224 Breast cancer
    100358716 (PTEN)
   05222 Small cell lung cancer
    100358716 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    100358716 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100358716 (PTEN)
   05165 Human papillomavirus infection
    100358716 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100358716 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ocu01009]
    100358716 (PTEN)
Enzymes [BR:ocu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     100358716 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     100358716 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     100358716 (PTEN)
Protein phosphatases and associated proteins [BR:ocu01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    100358716 (PTEN)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PTEN_C2 DSPc Y_phosphatase Y_phosphatase3 PTPlike_phytase DUF3256
Motif
Other DBs
NCBI-GeneID: 100358716
NCBI-ProteinID: XP_008268354
Ensembl: ENSOCUG00000008774
LinkDB All DBs
Position
18
AA seq 431 aa AA seqDB search
MAGEGCPRGISLDTDPRGPPVHSHRLPDMTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNI
IAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFED
HNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEAL
DFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCN
PQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFH
FWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDK
ANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPF
DEDQHTQITKV
NT seq 1296 nt NT seq  +upstreamnt  +downstreamnt
atggcgggggaggggtgtcctcgcggcatttccctagatactgacccgcgcggtccacct
gtgcacagccacaggctcccagacatgacagccatcatcaaagagatcgttagcagaaac
aaaaggagatatcaagaggatggattcgacttagacttgacctatatttatccaaatatt
attgctatgggatttcctgcagaaagacttgaaggcgtatacaggaacaatattgatgat
gtagtaaggtttttggattcaaagcataaaaaccattacaagatatacaatctatgtgct
gaaaggcattatgacaccgccaaatttaactgcagagttgcacagtatccttttgaagac
cataacccaccacagctagaacttatcaaacccttttgtgaagatcttgaccaatggcta
agtgaagatgacaatcatgttgcagcaattcactgtaaagctggaaagggacgaactggt
gtaatgatttgtgcatatttattacatcggggcaaatttttaaaggcacaagaagcccta
gatttttatggagaagtaaggaccagagacaaaaagggagtaactattcccagtcagaga
cgctatgtgtattattatagctacctgttaaagaatcatctggattatagaccagtggca
ctgttgtttcacaagatgatgtttgaaactattccaatgttcagtggcggaacttgcaat
cctcagtttgtggtctgccagctaaaggtgaagatatattcctccaattcaggacccaca
cgacgggaagacaagttcatgtacttcgagttccctcagccgttgcctgtgtgtggtgac
atcaaagtagagttcttccacaaacagaacaagatgcttaaaaaggacaaaatgtttcac
ttttgggtaaatacgttctttataccaggaccagaggaaacctcagaaaaagtagaaaat
ggaagtctttgtgatcaagaaattgatagtatttgcagtatagaacgtgcagataacgac
aaagaatatctagtacttactttaacaaaaaatgatcttgataaagcaaataaagacaag
gcaaaccgatacttttctccaaattttaaggtgaagctgtatttcacaaaaacagtagag
gagccatcaaatccagaggctagcagttcaacttctgtaacgccagatgttagtgacaat
gaacctgatcattatagatattctgacaccactgactctgatccagagaatgaacctttt
gatgaagatcagcatacacaaattacaaaagtctga

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