KEGG   Orcinus orca (killer whale): 101271441
Entry
101271441         CDS       T05247                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
oor  Orcinus orca (killer whale)
Pathway
oor01521  EGFR tyrosine kinase inhibitor resistance
oor01522  Endocrine resistance
oor04010  MAPK signaling pathway
oor04012  ErbB signaling pathway
oor04014  Ras signaling pathway
oor04062  Chemokine signaling pathway
oor04068  FoxO signaling pathway
oor04072  Phospholipase D signaling pathway
oor04150  mTOR signaling pathway
oor04151  PI3K-Akt signaling pathway
oor04380  Osteoclast differentiation
oor04510  Focal adhesion
oor04540  Gap junction
oor04550  Signaling pathways regulating pluripotency of stem cells
oor04630  JAK-STAT signaling pathway
oor04650  Natural killer cell mediated cytotoxicity
oor04660  T cell receptor signaling pathway
oor04662  B cell receptor signaling pathway
oor04664  Fc epsilon RI signaling pathway
oor04714  Thermogenesis
oor04722  Neurotrophin signaling pathway
oor04910  Insulin signaling pathway
oor04912  GnRH signaling pathway
oor04915  Estrogen signaling pathway
oor04917  Prolactin signaling pathway
oor04926  Relaxin signaling pathway
oor04935  Growth hormone synthesis, secretion and action
oor05034  Alcoholism
oor05160  Hepatitis C
oor05161  Hepatitis B
oor05163  Human cytomegalovirus infection
oor05165  Human papillomavirus infection
oor05200  Pathways in cancer
oor05203  Viral carcinogenesis
oor05205  Proteoglycans in cancer
oor05206  MicroRNAs in cancer
oor05210  Colorectal cancer
oor05211  Renal cell carcinoma
oor05213  Endometrial cancer
oor05214  Glioma
oor05215  Prostate cancer
oor05220  Chronic myeloid leukemia
oor05221  Acute myeloid leukemia
oor05223  Non-small cell lung cancer
oor05224  Breast cancer
oor05225  Hepatocellular carcinoma
oor05226  Gastric cancer
oor05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:oor00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101271441 (GRB2)
   04012 ErbB signaling pathway
    101271441 (GRB2)
   04014 Ras signaling pathway
    101271441 (GRB2)
   04630 JAK-STAT signaling pathway
    101271441 (GRB2)
   04068 FoxO signaling pathway
    101271441 (GRB2)
   04072 Phospholipase D signaling pathway
    101271441 (GRB2)
   04151 PI3K-Akt signaling pathway
    101271441 (GRB2)
   04150 mTOR signaling pathway
    101271441 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101271441 (GRB2)
   04540 Gap junction
    101271441 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101271441 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101271441 (GRB2)
   04660 T cell receptor signaling pathway
    101271441 (GRB2)
   04662 B cell receptor signaling pathway
    101271441 (GRB2)
   04664 Fc epsilon RI signaling pathway
    101271441 (GRB2)
   04062 Chemokine signaling pathway
    101271441 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101271441 (GRB2)
   04912 GnRH signaling pathway
    101271441 (GRB2)
   04915 Estrogen signaling pathway
    101271441 (GRB2)
   04917 Prolactin signaling pathway
    101271441 (GRB2)
   04926 Relaxin signaling pathway
    101271441 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    101271441 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101271441 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101271441 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    101271441 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101271441 (GRB2)
   05206 MicroRNAs in cancer
    101271441 (GRB2)
   05205 Proteoglycans in cancer
    101271441 (GRB2)
   05203 Viral carcinogenesis
    101271441 (GRB2)
   05231 Choline metabolism in cancer
    101271441 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101271441 (GRB2)
   05225 Hepatocellular carcinoma
    101271441 (GRB2)
   05226 Gastric cancer
    101271441 (GRB2)
   05214 Glioma
    101271441 (GRB2)
   05221 Acute myeloid leukemia
    101271441 (GRB2)
   05220 Chronic myeloid leukemia
    101271441 (GRB2)
   05211 Renal cell carcinoma
    101271441 (GRB2)
   05215 Prostate cancer
    101271441 (GRB2)
   05213 Endometrial cancer
    101271441 (GRB2)
   05224 Breast cancer
    101271441 (GRB2)
   05223 Non-small cell lung cancer
    101271441 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    101271441 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101271441 (GRB2)
   05160 Hepatitis C
    101271441 (GRB2)
   05163 Human cytomegalovirus infection
    101271441 (GRB2)
   05165 Human papillomavirus infection
    101271441 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101271441 (GRB2)
   01522 Endocrine resistance
    101271441 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oor04131]
    101271441 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:oor04990]
    101271441 (GRB2)
Membrane trafficking [BR:oor04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    101271441 (GRB2)
Domain-containing proteins not elsewhere classified [BR:oor04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   101271441 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 101271441
NCBI-ProteinID: XP_004275521
LinkDB
Position
Unknown
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccaccgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgatcagaactggtacaaggcagag
ctcaatgggaaagacggcttcatccccaagaattacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagcgagagtgctcctggggatttctccctctctgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggggctggaaagtatttcctc
tgggtggtcaagttcaattctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatatttctccgggacatagagcaggtgccacagcaaccgacgtac
gtccaagccctctttgactttgatccccaagaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcttgccacggg
cagaccggcatgtttccacgcaattacgtcacccccgtgaaccggaacgtctaa

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