Orcinus orca (killer whale): 101275398
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Entry
101275398 CDS
T05247
Gene name
EGFR
Definition
(RefSeq) epidermal growth factor receptor
KO
K04361
epidermal growth factor receptor [EC:
2.7.10.1
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor01521
EGFR tyrosine kinase inhibitor resistance
oor01522
Endocrine resistance
oor04010
MAPK signaling pathway
oor04012
ErbB signaling pathway
oor04014
Ras signaling pathway
oor04015
Rap1 signaling pathway
oor04020
Calcium signaling pathway
oor04066
HIF-1 signaling pathway
oor04068
FoxO signaling pathway
oor04072
Phospholipase D signaling pathway
oor04144
Endocytosis
oor04151
PI3K-Akt signaling pathway
oor04510
Focal adhesion
oor04520
Adherens junction
oor04540
Gap junction
oor04630
JAK-STAT signaling pathway
oor04810
Regulation of actin cytoskeleton
oor04912
GnRH signaling pathway
oor04915
Estrogen signaling pathway
oor04921
Oxytocin signaling pathway
oor04926
Relaxin signaling pathway
oor04928
Parathyroid hormone synthesis, secretion and action
oor04934
Cushing syndrome
oor05160
Hepatitis C
oor05163
Human cytomegalovirus infection
oor05165
Human papillomavirus infection
oor05171
Coronavirus disease - COVID-19
oor05200
Pathways in cancer
oor05205
Proteoglycans in cancer
oor05206
MicroRNAs in cancer
oor05210
Colorectal cancer
oor05212
Pancreatic cancer
oor05213
Endometrial cancer
oor05214
Glioma
oor05215
Prostate cancer
oor05218
Melanoma
oor05219
Bladder cancer
oor05223
Non-small cell lung cancer
oor05224
Breast cancer
oor05225
Hepatocellular carcinoma
oor05226
Gastric cancer
oor05230
Central carbon metabolism in cancer
oor05231
Choline metabolism in cancer
oor05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101275398 (EGFR)
04012 ErbB signaling pathway
101275398 (EGFR)
04014 Ras signaling pathway
101275398 (EGFR)
04015 Rap1 signaling pathway
101275398 (EGFR)
04630 JAK-STAT signaling pathway
101275398 (EGFR)
04066 HIF-1 signaling pathway
101275398 (EGFR)
04068 FoxO signaling pathway
101275398 (EGFR)
04020 Calcium signaling pathway
101275398 (EGFR)
04072 Phospholipase D signaling pathway
101275398 (EGFR)
04151 PI3K-Akt signaling pathway
101275398 (EGFR)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
101275398 (EGFR)
09144 Cellular community - eukaryotes
04510 Focal adhesion
101275398 (EGFR)
04520 Adherens junction
101275398 (EGFR)
04540 Gap junction
101275398 (EGFR)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101275398 (EGFR)
09150 Organismal Systems
09152 Endocrine system
04912 GnRH signaling pathway
101275398 (EGFR)
04915 Estrogen signaling pathway
101275398 (EGFR)
04921 Oxytocin signaling pathway
101275398 (EGFR)
04926 Relaxin signaling pathway
101275398 (EGFR)
04928 Parathyroid hormone synthesis, secretion and action
101275398 (EGFR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101275398 (EGFR)
05206 MicroRNAs in cancer
101275398 (EGFR)
05205 Proteoglycans in cancer
101275398 (EGFR)
05230 Central carbon metabolism in cancer
101275398 (EGFR)
05231 Choline metabolism in cancer
101275398 (EGFR)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
101275398 (EGFR)
09162 Cancer: specific types
05210 Colorectal cancer
101275398 (EGFR)
05212 Pancreatic cancer
101275398 (EGFR)
05225 Hepatocellular carcinoma
101275398 (EGFR)
05226 Gastric cancer
101275398 (EGFR)
05214 Glioma
101275398 (EGFR)
05218 Melanoma
101275398 (EGFR)
05219 Bladder cancer
101275398 (EGFR)
05215 Prostate cancer
101275398 (EGFR)
05213 Endometrial cancer
101275398 (EGFR)
05224 Breast cancer
101275398 (EGFR)
05223 Non-small cell lung cancer
101275398 (EGFR)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
101275398 (EGFR)
09172 Infectious disease: viral
05160 Hepatitis C
101275398 (EGFR)
05171 Coronavirus disease - COVID-19
101275398 (EGFR)
05163 Human cytomegalovirus infection
101275398 (EGFR)
05165 Human papillomavirus infection
101275398 (EGFR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101275398 (EGFR)
01522 Endocrine resistance
101275398 (EGFR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oor01001
]
101275398 (EGFR)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
oor04147
]
101275398 (EGFR)
Enzymes [BR:
oor01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
101275398 (EGFR)
Protein kinases [BR:
oor01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
101275398 (EGFR)
Exosome [BR:
oor04147
]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
101275398 (EGFR)
Exosomal proteins of pancreatic cancer cells
101275398 (EGFR)
Exosomal proteins of bladder cancer cells
101275398 (EGFR)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
APH
Kinase-like
Borrelia_P83
Kdo
Motif
Other DBs
NCBI-GeneID:
101275398
NCBI-ProteinID:
XP_004283056
LinkDB
All DBs
Position
Unknown
AA seq
1209 aa
AA seq
DB search
MRRSEAGRAVLLALLAAHFQASPALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYMQSSYNLSFLKTIQEVAGYVLIALNTVETIPLEKLQIIRGNVLYENTHALA
VLSNYGANKTGLRELPMRNLQEILQGAVRFSNNPVLCNMDTVQWRDIVNADFLSNMSIEF
QSQLSRCPKCDPACLNGSCWGAGKENCQKLTKVICAQQCSGRCRGRSPSDCCHSQCAAGC
TGPRESDCLVCRRFRDGATCKDTCPPLMLYDPTTYEMKVNPLGKYSFGATCVRKCPRNYV
VTDHGSCVRACSSDSQEVEEDGVRKCKKCDGPCGKVCNGIGIGEFKDTLSINATNIKHFR
NCTSISGDLHILPVAFKGDSFTRTPPLDPKELDILKTVKEITGFLLIQAWPANRTGLHAF
ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNRKLCYADTINWKKL
FGTSSQKTKITNNRSEKECKAMGHVCNPLCSSEGCWGPKPEDCMSCRNFSRGRECVEKCN
ILKGEPREFVENSECVQCHPECLPQAMNVTCTGHGPGSCVKCAHNIDGPHCVKTCPAGVT
GENSTLIWKFADANHVCHLCHPSCTYGCAGPGSEGCAVSGPRIPSIATGMVGALLLALVL
ALGVGLFLRRRRIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETELKKVKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQHLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISTVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMQDVVDADEYLIPQ
QGFFHSPASSRTPLLSSLSSTSNTPTVACGDRNGQSYPLQEDSFLQRYSSDPTGTLTEDS
IDDAFLPAPEYVNQSIPKRPAGSVQNPVYHNQPLNPAPGRDPHYQNSHSNAVDSPEYLNT
THPACTNGVLDGPALWAQKGGHQINLDNPDYQQAFLPKEAKSNGIFKGSAAENAEYLRVA
PAGSDLTGA
NT seq
3630 nt
NT seq
+upstream
nt +downstream
nt
atgcgacgctccgaagcgggccgcgccgtgctcctggcgctgctggccgcgcacttccag
gcgagtccggcgctggaggagaagaaagtttgccaagggacaagtaacaagctcacccag
ttgggcacttttgaagaccactttctcagcctccagaggatgttcaataactgtgaggtg
gtccttgggaatttggaaattacctacatgcaaagtagttacaacctttctttcctaaag
accatccaggaggttgctggctatgtactcattgccctcaacacagtggagacgattcct
ttggaaaagctgcagatcatcagaggaaatgtgctctatgaaaacacccatgccttagcg
gtcttatccaactacggtgcaaataaaacgggactgagggagttgcccatgagaaactta
caggagatcctgcaaggcgccgtgcgattcagcaacaaccctgtcctctgcaacatggac
accgtccagtggagggacatcgtcaacgccgactttctaagcaatatgtcgattgaattt
cagagccagctgagcagatgcccaaagtgtgatccagcctgtcttaatggaagctgctgg
ggtgcagggaaggagaactgccagaaactgaccaaagtcatctgtgcccagcagtgttcc
gggcgctgccgcggcaggtcccccagcgactgctgccacagccagtgtgccgccggctgc
acggggccgcgggagagtgactgcctggtctgccgcaggttccgggacggagccacgtgc
aaggacacatgcccgccactcatgctgtacgaccccaccacctacgagatgaaagtcaac
ccgctggggaagtacagcttcggcgccacctgtgtcaggaagtgtccccgtaactacgtg
gtgacggaccacggctcgtgcgtccgcgcctgcagctctgacagccaggaggtggaggag
gacggcgtccgcaagtgtaaaaagtgtgacggaccttgtggcaaagtttgtaacggaata
ggaattggtgagtttaaagatacactttccataaatgctacaaatattaaacacttcaga
aattgcacctcgatcagtggagaccttcatatcctgccagtagcatttaagggtgattcc
ttcacacgtactccacctctggacccaaaggaactggacattctaaaaactgtaaaggaa
ataacagggtttttgctgattcaggcctggcctgcaaacaggactggcctccatgctttt
gagaacctggaaatcatacgtggcaggacgaagcaacatggtcagttttctctggcggtt
gttggcctggatataacgtccttgggattacgctccctcaaggagataagtgatggagat
gtgatcatttcaggaaaccgaaagttgtgctacgcagatacaataaactggaaaaaactc
tttgggacctcaagtcagaaaaccaaaattaccaacaacaggagtgaaaaagagtgcaag
gccatgggccacgtctgtaacccgctgtgttcgtcagagggctgctggggcccgaaaccc
gaagactgcatgtcctgccgaaacttcagccgtggcagggagtgtgtggagaagtgcaac
attctaaaaggagagcccagggagttcgttgaaaactccgagtgcgtgcagtgccatccg
gaatgcctgccccaggccatgaacgtgacctgcacgggacacggaccaggcagctgtgta
aagtgtgcccacaacatcgacggccctcactgcgtcaagacctgccctgctggagtcaca
ggagaaaacagcaccctgatctggaagtttgcagatgccaatcacgtgtgtcacctgtgc
caccccagctgcacctacggctgtgctgggcccggttctgaaggctgtgcagtgagtggg
cccaggattccgtccatcgccaccgggatggtgggcgccctgctgctggccctggtgctg
gccctgggggtcggcctctttctgcgcaggcgccgcatcgtccgcaagcgcacgctgcgc
cggctgctgcaggagcgcgagcttgtcgagcctctgacgcccagcggagaagctcccaac
caagctctcttgaggatcttaaaggagacggaattaaaaaaggtcaaggtgctgggctcc
ggagcattcggcacggtgtacaagggactctggatcccagaaggcgagaaggttaaaatt
cctgtggctatcaaggaattaagagaagccacatctccaaaagccaacaaggagattctt
gatgaagcctacgtgatggccagtgtggacaatccgcacgtgtgccgcctcctgggcatc
tgcctgacgtccacggtgcagctcatcacgcagctcatgcccttcggctgcctgctggac
tacgtccgcgagcacaaggacaacatcggttcccagcacctgctcaactggtgcgtgcag
atcgcaaagggcatgaactacctggaagaccggcgcctggtgcaccgagacctggcggcc
aggaatgtgctggtgaagacgccgcagcacgtcaagatcacggatttcggcctggccaaa
ctgctcggcgccgaggagaaagaataccacgcggaggggggcaaggtgcctatcaagtgg
atggctttggaatcaattctacaccgaatttatacccaccagagtgacgtctggagctac
ggagtcaccgtttgggagttgatgacctttgggtccaagccttacgacgggatccccgcg
agtgagatctcaaccgtcctggagaagggagaacgcctgcctcagccgcccatctgcacc
atcgacgtctacatgatcatggtcaagtgctggatgattgatgcagatagtcgcccgaag
ttccgtgagttgatcattgaattctccaaaatggcccgagacccccagcgctaccttgtc
atccagggggacgagaggatgcatttgccaagccccacggactccaacttctaccgcgcc
ctgatggacgaagaggacatgcaagatgtcgtggatgcggacgagtacctcatcccccag
cagggcttcttccacagccccgccagctcccggacgcccctcctcagttctctgagctcc
accagcaacacgcccactgtggcttgcggtgatagaaacgggcagagctatcccctccag
gaagatagcttcttgcagcggtacagctcagaccccactggcaccttgaccgaggacagc
atagatgacgccttccttccagcacccgaatacgtaaaccagtctattcccaaaaggccc
gcgggctctgtccagaaccccgtctatcacaatcagcctctaaacccggctccaggcaga
gaccctcactaccagaattcccacagcaatgccgtggacagccctgagtatctcaacacc
acccatcccgcctgcaccaacggtgtgctcgacggccctgccctctgggcacagaaaggt
ggtcaccaaattaacctggacaaccctgactaccagcaggccttccttcccaaggaagcc
aagtcaaatggcatctttaagggttctgccgctgaaaatgcagaatacctaagggtagca
ccagcgggcagcgaccttaccggggcctga
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integrated database retrieval system
