Orcinus orca (killer whale): 101275490
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Entry
101275490 CDS
T05247
Gene name
PTK2
Definition
(RefSeq) focal adhesion kinase 1
KO
K05725
focal adhesion kinase 1 [EC:
2.7.10.2
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor01522
Endocrine resistance
oor04012
ErbB signaling pathway
oor04062
Chemokine signaling pathway
oor04151
PI3K-Akt signaling pathway
oor04360
Axon guidance
oor04370
VEGF signaling pathway
oor04510
Focal adhesion
oor04670
Leukocyte transendothelial migration
oor04810
Regulation of actin cytoskeleton
oor04935
Growth hormone synthesis, secretion and action
oor05100
Bacterial invasion of epithelial cells
oor05135
Yersinia infection
oor05146
Amoebiasis
oor05163
Human cytomegalovirus infection
oor05165
Human papillomavirus infection
oor05170
Human immunodeficiency virus 1 infection
oor05200
Pathways in cancer
oor05202
Transcriptional misregulation in cancer
oor05205
Proteoglycans in cancer
oor05222
Small cell lung cancer
oor05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
101275490 (PTK2)
04370 VEGF signaling pathway
101275490 (PTK2)
04151 PI3K-Akt signaling pathway
101275490 (PTK2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
101275490 (PTK2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101275490 (PTK2)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
101275490 (PTK2)
04062 Chemokine signaling pathway
101275490 (PTK2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
101275490 (PTK2)
09158 Development and regeneration
04360 Axon guidance
101275490 (PTK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101275490 (PTK2)
05202 Transcriptional misregulation in cancer
101275490 (PTK2)
05205 Proteoglycans in cancer
101275490 (PTK2)
09162 Cancer: specific types
05222 Small cell lung cancer
101275490 (PTK2)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
101275490 (PTK2)
09171 Infectious disease: bacterial
05135 Yersinia infection
101275490 (PTK2)
05100 Bacterial invasion of epithelial cells
101275490 (PTK2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
101275490 (PTK2)
05163 Human cytomegalovirus infection
101275490 (PTK2)
05165 Human papillomavirus infection
101275490 (PTK2)
09174 Infectious disease: parasitic
05146 Amoebiasis
101275490 (PTK2)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
101275490 (PTK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oor01001
]
101275490 (PTK2)
01009 Protein phosphatases and associated proteins [BR:
oor01009
]
101275490 (PTK2)
Enzymes [BR:
oor01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
101275490 (PTK2)
Protein kinases [BR:
oor01001
]
Non-receptor tyrosine kinases
FAK family
101275490 (PTK2)
Protein phosphatases and associated proteins [BR:
oor01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
101275490 (PTK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Focal_AT
Pkinase
FERM_N_2
Kinase-like
Motif
Other DBs
NCBI-GeneID:
101275490
NCBI-ProteinID:
XP_012386845
LinkDB
All DBs
Position
Unknown
AA seq
1075 aa
AA seq
DB search
MAAAYLDPNLNHTPNSSTKTHLGTGVERSPGAMERVLKVFHYFESNSEPTTWASIIRHGD
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHLDMGVSNVREKYELAHPPEEW
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVQEDALITFFFFFAFGLPQGLGQILSLVEI
LPSQDPQHRPVSGSPAPPSRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPRSLLDSVKA
KTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPE
EGISYLTDKGCNPTHLADFNQVQTIQYSNSEDKDRKGTLQLKIAGAPEPLTVTAPSLTIA
ENMADLIDGYCRLVHGATQSFIIRPQKEGERALPSIPKLANSEKQGVRTHAVSVSETDDY
AEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGAYTSPENPALAVAIKTCK
NCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYS
LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY
KASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN
GERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRR
QVTVSWDSGGSDEAPPKPSRPGYPSPRSSEGFHPSPQHMLQTNHYQVSGYPGSHGITAVA
GSIYPGQASLLDQTDSWNHRPQEISMWQPNVEDSATLDLRGIGQVLPTHLMEERLIRQQQ
EMEEDQRWLEKEERFLKPDVRLSRGSIDREDGGPQGPTGNQHIYQPVGKPDPAAPPKKPP
RPGAPGHLSSLASLGSPGDNYNEGVKLQPQEISPPPTANLDRSNDRVYENVTGLVRAVIE
MSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPVLPASTHREIEMAQKLLNSDLGEL
INKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKALGQTRPH
NT seq
3228 nt
NT seq
+upstream
nt +downstream
nt
atggcagctgcctaccttgacccaaacttgaatcacacaccgaattcaagtaccaagact
cacctgggtaccggtgtggaacgttcccctggggccatggagcgagtgttgaaggtcttt
cattattttgaaagcaacagtgagccaaccacttgggccagtattatcaggcatggagac
gctactgacgtcaggggcatcattcagaagatagtggacagtcacaaagtaaagcacgtg
gcctgctatggatttcgcctcagtcacctgcggtcagaggaggttcactggctccatttg
gatatgggtgtctccaatgtgagggagaagtatgaacttgcacacccaccagaggagtgg
aaatatgaattgagaattcgttatttgccaaaaggatttctaaaccagtttactgaagac
aagccaactctgaatttcttctatcaacaggtacaggaggatgctttaataacatttttt
ttcttttttgcctttggtctacctcagggccttggacagattctttctttggtagaaatc
ctgccgtctcaggatccccagcaccgccccgtctcaggatccccagcaccgccctcaagg
cggtcgtactgggagatgcggggcaacgccctggagaagaagtctaactatgaagtatta
gaaaaagatgttggtttgaagcgattttttcctaggagtttactggactcagtcaaggcc
aaaacactaagaaaattgattcaacaaacatttagacagtttgccaaccttaatagagaa
gaaagtattttgaaattctttgagatcctctccccagtgtacagatttgataaagaatgc
ttcaagtgtgcccttggttcgagctggattatttcggtggagctggcgattggccccgaa
gaagggatcagttacctcacagacaagggctgcaaccccacacacctggccgacttcaat
caagtgcagaccattcagtattcaaacagcgaagacaaggacaggaaagggacgctgcag
ctgaagattgcaggagcgcctgagcctctgacggtgacagcaccgtccctgaccattgcc
gagaacatggccgacctgatagatgggtactgccggctggtgcacggggccacgcagtct
ttcatcatcaggcctcagaaagaaggtgaacgggctttgccatcaataccaaagctggcc
aacagcgagaagcagggtgttcggacccacgccgtctctgtgtcagaaacagatgactat
gctgagattatcgacgaggaagatacctacaccatgccctcgactagggactatgagatt
cagagagaaagaatagaactgggacggtgcatcggagagggccagttcggagacgtgcac
caaggcgcttacacgagcccggagaatccagctttggcggttgcaattaaaacatgtaaa
aactgtacttcggacagcgtgagagagaaattccttcaagaagccttaacaatgcgtcag
tttgaccaccctcacattgtgaagctgatcggagtcatcacagagaaccccgtctggatc
atcatggagctgtgcacgctcggagagctgaggtcatttctgcaagtaaggaaatacagt
ttggatctagcatctctgatcctctatgcctatcagcttagcacagcccttgcgtaccta
gagagcaaaagatttgtgcacagggacattgctgctcggaatgttctggtgtcctcaaac
gactgtgtaaaattaggagacttcggcttatcccgatacatggaagacagcacttactac
aaagcttccaaaggaaaattgcctattaaatggatggctccagagtcaatcaattttcgc
cgttttacctcagctagtgacgtatggatgtttggtgtgtgtatgtgggagatactgatg
cacggtgtgaagccctttcaaggcgtgaagaacaatgatgtgattggtcgcattgagaac
ggggagaggttgcccatgcctccaaactgccctcccaccctctacagcctcatgaccaag
tgctgggcctacgaccccagccggcggccccgcttcactgagctcaaagctcagctcagc
acaatcctggaggaagagaaggtccagcaagaagaacggatgaggatggagtccagaagg
caggtcacagtgtcctgggactctggagggtccgacgaagcaccacccaagcccagcaga
cctggttatcctagtccgaggtccagcgaagggtttcatcccagcccacagcacatgcta
cagaccaatcactaccaggtctctggctaccctggctcacatggaatcacagccgtggct
ggcagcatctacccaggtcaggcatctcttttggaccaaacggattcgtggaatcacaga
ccacaggagatatcgatgtggcagcccaacgtggaggactctgcaacactggacctgcgt
ggcatcgggcaggtgttgccgacccacctgatggaggagcggctgatccggcagcagcag
gagatggaagaggaccagcgctggctggagaaggaggagaggtttctgaaacctgacgtg
cggctctctcgaggcagcatcgacagggaggatggaggtcctcagggcccgactggaaac
cagcacatatatcagcctgtgggcaaaccagatcctgcagctccaccaaagaaaccaccg
cgtcccggagcccctgggcacctgagcagcctcgccagcctcggcagccccggggacaat
tacaacgagggtgtcaagcttcagccccaggaaatcagcccccctcccactgccaacctg
gaccggtccaatgacagggtgtacgagaacgtgacgggcctggtgagagcggtcatcgag
atgtccagcaagatccagccagccccgccagaggagtatgtccccatggtgaaggaagtc
ggcttggccctgaggacgctgttggccaccgtggatgagaccattcccgtcctgcccgcc
agcacccaccgagagattgagatggcccagaagctgctgaactccgacttgggggagctc
atcaacaagatgaagctggcccagcagtatgtcatgaccagcctgcagcaggagtacaag
aagcagatgctgacggccgcacacgccctggctgtggacgccaagaacctgctcgatgtc
atcgaccaggccagactgaaggccctggggcagacgaggccacactga
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