Orcinus orca (killer whale): 101281976
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Entry
101281976 CDS
T05247
Gene name
IGF1R
Definition
(RefSeq) insulin-like growth factor 1 receptor
KO
K05087
insulin-like growth factor 1 receptor [EC:
2.7.10.1
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor01521
EGFR tyrosine kinase inhibitor resistance
oor01522
Endocrine resistance
oor04010
MAPK signaling pathway
oor04014
Ras signaling pathway
oor04015
Rap1 signaling pathway
oor04066
HIF-1 signaling pathway
oor04068
FoxO signaling pathway
oor04114
Oocyte meiosis
oor04140
Autophagy - animal
oor04144
Endocytosis
oor04150
mTOR signaling pathway
oor04151
PI3K-Akt signaling pathway
oor04152
AMPK signaling pathway
oor04211
Longevity regulating pathway
oor04213
Longevity regulating pathway - multiple species
oor04510
Focal adhesion
oor04520
Adherens junction
oor04550
Signaling pathways regulating pluripotency of stem cells
oor04730
Long-term depression
oor04913
Ovarian steroidogenesis
oor04914
Progesterone-mediated oocyte maturation
oor05200
Pathways in cancer
oor05202
Transcriptional misregulation in cancer
oor05205
Proteoglycans in cancer
oor05214
Glioma
oor05215
Prostate cancer
oor05218
Melanoma
oor05224
Breast cancer
oor05225
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101281976 (IGF1R)
04014 Ras signaling pathway
101281976 (IGF1R)
04015 Rap1 signaling pathway
101281976 (IGF1R)
04066 HIF-1 signaling pathway
101281976 (IGF1R)
04068 FoxO signaling pathway
101281976 (IGF1R)
04151 PI3K-Akt signaling pathway
101281976 (IGF1R)
04152 AMPK signaling pathway
101281976 (IGF1R)
04150 mTOR signaling pathway
101281976 (IGF1R)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
101281976 (IGF1R)
04140 Autophagy - animal
101281976 (IGF1R)
09143 Cell growth and death
04114 Oocyte meiosis
101281976 (IGF1R)
09144 Cellular community - eukaryotes
04510 Focal adhesion
101281976 (IGF1R)
04520 Adherens junction
101281976 (IGF1R)
04550 Signaling pathways regulating pluripotency of stem cells
101281976 (IGF1R)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
101281976 (IGF1R)
04914 Progesterone-mediated oocyte maturation
101281976 (IGF1R)
09156 Nervous system
04730 Long-term depression
101281976 (IGF1R)
09149 Aging
04211 Longevity regulating pathway
101281976 (IGF1R)
04213 Longevity regulating pathway - multiple species
101281976 (IGF1R)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101281976 (IGF1R)
05202 Transcriptional misregulation in cancer
101281976 (IGF1R)
05205 Proteoglycans in cancer
101281976 (IGF1R)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
101281976 (IGF1R)
05214 Glioma
101281976 (IGF1R)
05218 Melanoma
101281976 (IGF1R)
05215 Prostate cancer
101281976 (IGF1R)
05224 Breast cancer
101281976 (IGF1R)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101281976 (IGF1R)
01522 Endocrine resistance
101281976 (IGF1R)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oor01001
]
101281976 (IGF1R)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
oor04090
]
101281976 (IGF1R)
Enzymes [BR:
oor01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
101281976 (IGF1R)
Protein kinases [BR:
oor01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
101281976 (IGF1R)
CD molecules [BR:
oor04090
]
Proteins
101281976 (IGF1R)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Pkinase
Furin-like
fn3
Kinase-like
Insulin_TMD
DUF4476
Motif
Other DBs
NCBI-GeneID:
101281976
NCBI-ProteinID:
XP_004271707
LinkDB
All DBs
Position
Unknown
AA seq
1367 aa
AA seq
DB search
MKSGSGGGSPTSLWGLLFFSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPLCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENHECCHPECLGSCS
APDNDTACVACRHYYYAGVCVPSCPPNTYRFEGWRCVDRDFCANIPNAESSDSEGFVIHD
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSF
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDAEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRH
NYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNAIFVPRPERKRREVMQVANTTMSSRNRNTTVVDTYNITDPEELETEYPFFES
RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTDPVFFYVQAKTTYENFIHLIIALPIAVLLIVGGLVIMLYVFHR
KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGV
VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
EIISSIKDEMEPGFREVSFYYSEENKPPEPEELDLEPENMESVPLDPSASSSSLPLPDRH
SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKKERALPLPQSSTC
NT seq
4104 nt
NT seq
+upstream
nt +downstream
nt
atgaagtctggctccggaggagggtccccgacctcgctgtgggggctcctatttttctcc
gccgcgctctcgctctggccgacgagtggagaaatctgtgggccaggcatcgacatccgc
aacgactaccagcagctgaagcggctggagaactgcacggtgatcgagggctacctccac
atcctgctcatttccaaggctgaggactaccgcagctaccgctttcccaagctcacggtc
atcactgagtacctgctgctgttccgcgtggccggcctcgagagcctcggtgacctcttc
cccaacctcacagtcatccgtggctggaagctcttctacaactacgccctggtcatcttc
gagatgaccaacctcaaggatattgggctctacaacctgcgaaacattacccgtggggcc
atccggatcgagaagaatgctgacctctgctacctctccacggtggactggtccctaatc
ctggatgctgtgtccaataactacatcgtggggaataagcccccaaaggagtgtggggac
ctgtgcccggggacgatggaggagaagccgctgtgcgagaagacgaccatcaacaacgag
tacaactaccgctgctggaccacgaaccgctgtcagaaaatgtgcccgagcacgtgcggg
aagcgggcgtgcacggagaaccacgagtgctgccaccccgagtgcctgggcagctgcagc
gcgcccgacaacgacacggcctgcgtggcctgccgccactactactatgccggtgtctgt
gtgcccagctgcccgcccaacacctaccgcttcgagggctggcgttgtgtggaccgtgac
ttctgcgccaacatccccaacgctgagagcagcgattccgagggcttcgtgatccacgac
ggcgagtgcatgcaggagtgcccgtcgggcttcatccgcaacggcagccagagcatgtac
tgcatcccttgcgaaggcccttgtcccaaagtgtgtgaggaagagaaaaagacaaagacc
attgattctgtcacttctgctcagatgctccaaggatgcaccatcttcaagggcaatcta
ctcattaatatccgacgcggcaacaacatcgcttcggaactggagaacttcatgggactc
atcgaggtcgtgacgggctacgtgaagatccgccactcccatgccttggtctccttgtcc
ttcctgaagaaccttcgccagatcctaggagaggagcaactagaggggaattactccttc
tacgtcctcgacaaccagaacttgcagcagctgtgggactgggaccaccgcaacctgacc
atcaaagccgggaaaatgtactttgctttcaatcccaaattgtgtgtctccgagatttac
cgcatggaggaagtgacggggactaaagggcgccagagcaaaggggacataaacaccagg
aacaacggagagagagcctcctgtgaaagtgacgtcctgcacttcacctccaccaccacg
tggaagaaccgcatcatcatcacctggcaccggtaccggccccctgactacagggacctc
atcagcttcaccgtctactacaaggaagcaccctttaaaaacgtcacagagtatgacggg
caggatgcctgtggctccaacagctggaacatggtagatgtggacctcccacccaacaag
gacgcggagcccggcattttactgcatggactgaagccctggacacagtatgccgtttac
gtcaaggctgtgaccctcaccatggtggagaatgaccacatccgtggagccaagagtgag
atcttgtacattcgcaccaacgcttcagttccttccatccccctggatgtactctcagca
tcaaactcctcctctcagctgatcgtgaagtggaaccctccttccctgcccaacggcaac
ctgagctactacatcgtaaggtggcagcgccagccccaggacagctacctttaccggcat
aattactgctccaaagacaaaatccccatcaggaagtacgccgatggcaccatcgacgtt
gaggaggtgacggagaatcccaagaccgaagtgtgtggtggggagaaagggccgtgctgc
gcttgccccaaaaccgaagccgagaagcaggccgagaaggaggaggccgagtaccgcaag
gtcttcgagaatttcctgcacaacgccatcttcgtgcccagacctgaacggaagcggagg
gaggtcatgcaggtcgccaacaccaccatgtccagccggaacaggaacaccacggtggtg
gacacctacaacatcacagacccggaagagctcgagaccgagtaccctttcttcgagagc
agagtggataacaaggagagaactgtcatctccaacctccggccttttactctgtaccga
atcgatatccacagctgtaaccacgaagctgagaagcttggctgcagtgcctccaacttt
gtctttgcaagaaccatgcctgcagaaggagcagatgacattcctgggccagtgacctgg
gagccaaggcctgagaactccatctttttaaaatggccagaacctgagaatcccaatgga
ttgattttaatgtacgaaataaaatatggatcacaagtcgaggatcagcgggaatgtgtg
tccagacaggagtacaggaagtatggaggggccaagctaaaccggctcaacccggggaac
tacacggcccggatccaggccacctctctctctgggaacgggtcgtggactgatcctgtg
ttcttctatgtccaggccaaaacaacgtatgaaaacttcatccatctgatcattgctctg
cccattgccgttctgctgatagtaggagggttggttataatgctgtacgtcttccataga
aaaagaaataacagcaggctggggaacggagtgctgtatgcctctgtgaacccggagtac
ttcagtgcagccgatgtgtacgtgcctgacgagtgggaggtcgcccgggagaagatcacc
atgagccgggagctgggacagggctcgttcgggatggtttacgaaggtgtcgccaagggc
gtggtcaaggatgagcctgagaccagggtggccattaagacggtgaacgaggccgccagc
atgcgcgagaggattgagtttctcaacgaggcctcggtgatgaaggagttcaactgtcac
cacgtggtgcgcttgctgggcgtggtatcccagggccagccgacgctggtcatcatggaa
ctgatgacccggggggacctcaaaagttatctccggtctctgaggccagaaatggagaat
aatccagtcctagcacctcccagcctaagcaaaatgatccagatggctggagagattgca
gatggcatggcatacctcaacgccaataagtttgtccacagagacctcgctgcccggaac
tgcatggtggccgaagatttcacagtcaaaatcggagattttgggatgacgagagacatc
tatgagaccgactattaccggaagggagggaaggggctgctgcccgtgcgctggatgtcc
cccgagtccctcaaggatggagtcttcaccacgcactctgacgtctggtccttcggggtc
gtcctctgggagatcgccacgctggccgagcagccataccagggcctgtccaatgagcaa
gtccttcgctttgtcatggagggcggccttctggacaagccggacaactgtcctgacatg
ctgtttgaactgatgcgcatgtgctggcagtacaaccccaagatgaggccttccttcctg
gaaatcatcagcagcatcaaggacgagatggagcccggcttccgggaggtctccttctac
tacagcgaggagaacaagccacctgagccagaggagctggacctagagccggagaacatg
gagagtgtccccttggacccctcggcatcctcgtcctccctgccactgcccgacagacac
tcaggacacaaggccgagaacggtccgggccctggcgtgctggtccttcgagccagcttc
gacgagagacagccttatgcgcacatgaacgggggccgcaagaaggagcgggccttgcct
ctgccccagtcctcgacctgctga
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integrated database retrieval system
