Orcinus orca (killer whale): 101284580
Help
Entry
101284580 CDS
T05247
Gene name
SOS2
Definition
(RefSeq) son of sevenless homolog 2 isoform X1
KO
K03099
son of sevenless
Organism
oor
Orcinus orca (killer whale)
Pathway
oor01521
EGFR tyrosine kinase inhibitor resistance
oor01522
Endocrine resistance
oor04010
MAPK signaling pathway
oor04012
ErbB signaling pathway
oor04014
Ras signaling pathway
oor04062
Chemokine signaling pathway
oor04068
FoxO signaling pathway
oor04072
Phospholipase D signaling pathway
oor04150
mTOR signaling pathway
oor04151
PI3K-Akt signaling pathway
oor04510
Focal adhesion
oor04540
Gap junction
oor04630
JAK-STAT signaling pathway
oor04650
Natural killer cell mediated cytotoxicity
oor04660
T cell receptor signaling pathway
oor04662
B cell receptor signaling pathway
oor04664
Fc epsilon RI signaling pathway
oor04714
Thermogenesis
oor04722
Neurotrophin signaling pathway
oor04810
Regulation of actin cytoskeleton
oor04910
Insulin signaling pathway
oor04912
GnRH signaling pathway
oor04915
Estrogen signaling pathway
oor04917
Prolactin signaling pathway
oor04926
Relaxin signaling pathway
oor04935
Growth hormone synthesis, secretion and action
oor05034
Alcoholism
oor05160
Hepatitis C
oor05161
Hepatitis B
oor05163
Human cytomegalovirus infection
oor05165
Human papillomavirus infection
oor05200
Pathways in cancer
oor05205
Proteoglycans in cancer
oor05206
MicroRNAs in cancer
oor05210
Colorectal cancer
oor05211
Renal cell carcinoma
oor05213
Endometrial cancer
oor05214
Glioma
oor05215
Prostate cancer
oor05220
Chronic myeloid leukemia
oor05221
Acute myeloid leukemia
oor05223
Non-small cell lung cancer
oor05224
Breast cancer
oor05225
Hepatocellular carcinoma
oor05226
Gastric cancer
oor05231
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101284580 (SOS2)
04012 ErbB signaling pathway
101284580 (SOS2)
04014 Ras signaling pathway
101284580 (SOS2)
04630 JAK-STAT signaling pathway
101284580 (SOS2)
04068 FoxO signaling pathway
101284580 (SOS2)
04072 Phospholipase D signaling pathway
101284580 (SOS2)
04151 PI3K-Akt signaling pathway
101284580 (SOS2)
04150 mTOR signaling pathway
101284580 (SOS2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
101284580 (SOS2)
04540 Gap junction
101284580 (SOS2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101284580 (SOS2)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
101284580 (SOS2)
04660 T cell receptor signaling pathway
101284580 (SOS2)
04662 B cell receptor signaling pathway
101284580 (SOS2)
04664 Fc epsilon RI signaling pathway
101284580 (SOS2)
04062 Chemokine signaling pathway
101284580 (SOS2)
09152 Endocrine system
04910 Insulin signaling pathway
101284580 (SOS2)
04912 GnRH signaling pathway
101284580 (SOS2)
04915 Estrogen signaling pathway
101284580 (SOS2)
04917 Prolactin signaling pathway
101284580 (SOS2)
04926 Relaxin signaling pathway
101284580 (SOS2)
04935 Growth hormone synthesis, secretion and action
101284580 (SOS2)
09156 Nervous system
04722 Neurotrophin signaling pathway
101284580 (SOS2)
09159 Environmental adaptation
04714 Thermogenesis
101284580 (SOS2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101284580 (SOS2)
05206 MicroRNAs in cancer
101284580 (SOS2)
05205 Proteoglycans in cancer
101284580 (SOS2)
05231 Choline metabolism in cancer
101284580 (SOS2)
09162 Cancer: specific types
05210 Colorectal cancer
101284580 (SOS2)
05225 Hepatocellular carcinoma
101284580 (SOS2)
05226 Gastric cancer
101284580 (SOS2)
05214 Glioma
101284580 (SOS2)
05221 Acute myeloid leukemia
101284580 (SOS2)
05220 Chronic myeloid leukemia
101284580 (SOS2)
05211 Renal cell carcinoma
101284580 (SOS2)
05215 Prostate cancer
101284580 (SOS2)
05213 Endometrial cancer
101284580 (SOS2)
05224 Breast cancer
101284580 (SOS2)
05223 Non-small cell lung cancer
101284580 (SOS2)
09165 Substance dependence
05034 Alcoholism
101284580 (SOS2)
09172 Infectious disease: viral
05161 Hepatitis B
101284580 (SOS2)
05160 Hepatitis C
101284580 (SOS2)
05163 Human cytomegalovirus infection
101284580 (SOS2)
05165 Human papillomavirus infection
101284580 (SOS2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101284580 (SOS2)
01522 Endocrine resistance
101284580 (SOS2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04990 Domain-containing proteins not elsewhere classified [BR:
oor04990
]
101284580 (SOS2)
Domain-containing proteins not elsewhere classified [BR:
oor04990
]
Pleckstrin homology (PH) domain-containing proteins
Dbl-Like RhoGEF family proteins
101284580 (SOS2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
RasGEF
RasGEF_N
RhoGEF
Histone
PH
IQ_SEC7_PH
PH_19
PH_13
Motif
Other DBs
NCBI-GeneID:
101284580
NCBI-ProteinID:
XP_004270083
LinkDB
All DBs
Position
Unknown
AA seq
1332 aa
AA seq
DB search
MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRDLFKPSDI
EKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPKFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEHEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA
VEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD
EAVELSQDHFKKYLLKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGNASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS
EEPLIPPPLPPRKKFDHDASNSKGTMKSDDDPPAIPPRQPPPPKVKPRVPAPSGAFDGLL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVSTCPNSPN
TPPSTPSPRVPRRCYVLSSSQNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY
RLPLLENAETTQ
NT seq
3999 nt
NT seq
+upstream
nt +downstream
nt
atgcagcaggcgccgcagccgtacgagttcttcagcgaagagaacagtccgaaatggcgg
ggactgttggtctcggccctgcggaaggttcaggagcaagtacatcccaatctctcagct
aatgaagagtctctctattatattgaagagctgatttttcagctgcttaataaattatgc
atggcccaaccaaggactgttcaagatgtggaggaacgagttcaaaagacctttcctcat
ccaattgataaatgggctattgctgatgcacagtctgccatagagaaacgaaaacgaaga
aatcctctcttactgcctgtggacaaaatccatccttcattgaaggaagttttagggtac
aaagtggactaccatgtgtccttatatattgtggctgtactagagtatatctcagctgat
attttgaaattggctggtaattatgtttttaatatccgacattatgaaatatcccaacag
gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac
ataggcttggtttctctttgtgaagatgaacctagttcttcaggtgaattaaactactat
gaccttgtcagaactgaaattgcagaagaaagacagtatctacgggaactaaatatgatc
ataaaagtgtttcgagaagcttttctttctgacagagacctgtttaaaccttctgatatt
gaaaagattttcagtaacattttagatatacatgaattgaccgtgaaacttttaggttta
attgaagacacagttgaaatgacagatgaaagcagccctcatcccttagctggaagctgt
tttgaagatttggcagaggaacaagcatttgatccttatgaaacattatcacaggatatt
ctttcaccaaaatttaatgaacatttcagtaagttgatggccagacctgcagtggctcta
cactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgcctt
atgctggtgccagtatatcattgttggcactattttgaattattaaagcaattgaaagca
tgtagtgaagagcatgaagacagagaatgtttgaaccaagctattactgctcttatgaat
ctccaaggtagtatggaccgaatttacaagcagtattcacctagacgccgacctggggat
cctgtttgccctttttataatcgtcaattaagaagcaagcacctggctattaaaaaaatg
aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgtaat
gaatttattatggaaggcccattgacaagaattggtgctaaacacgaacggcacattttt
ctctttgatggcttaatgattagctgcaaacccaatcatagccagtcacgccttccagga
tacagtagtgcagaatacagattaaaagaaaaatttgtcatgaggaaaatacaaatatgt
gataaagaagatacttgtgagtgcaaacatgcttttgaattagtatccaaagatgaaaac
agcataatatttgctgctaagtctgctgaagagaaaaataattggatggcagcacttatt
tctcttcattatcgtagtactctagatcgaatgctagattcagtattactgaaggaagaa
aatgaacaaccacttagattaccgagtcctgaagtgtatcgttttgtggtaaaagactct
gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggaatccccattattaaa
ggaggaactgtggtgaaattaattgaaaggttaacatatcacatgtatgcagatcccaat
tttgttcgcacttttcttactacgtatcgttcattttgtaaaccacaggaattgctaagc
ttactgattgaacgatttgaaattccagagccagaacctactgaagcagataaattggca
gtagagaaaggcgagcagccaatcagtgcagaccttaaaaggtttcgcaaggaatatgtc
caaccagtacaacttaggatcttaaatgtgtttcggcactgggttgaacaccatttttat
gactttgaaagagacttggagttgcttgaaagactagaatccttcatttcaagtgtaaga
gggaaagctatgaagaaatgggtagagtcaattgctaagatcatcaagaggaagaaacaa
gctcaggcaaatggaataagccataatattacctttgaaagtccacctccaccaattgaa
tggcatatcagcagaccaggacagtttgaaacgtttgatctcatgacacttcatccaata
gaaattgcacgtcagctgacacttttggaatctgatctctacaggaaagttcaaccttct
gaacttgtagggagtgtatggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccacaccacaaatctcactctctggtttgaaaagtgcattgtggaagca
gaaaattttgaggaacgggtggcagtactaagtagaataatagaaattctgcaagttttt
caagatttgaataatttcaatggtgtattagagatcgtcagtgcagtaaattcagtatca
gtctatagactagatcatacctttgaggcattgcaggaaagaaaaaggaaaattttggat
gaagctgtggaattaagtcaagatcattttaaaaaatatctattgaaacttaagtcaatc
aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaagaa
gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcaatatcagaatcaaccttactgtttacgg
atagaaccagaaatgaggaggttctttgaaaaccttaaccccatgggaaatgcttctgaa
aaagagtttacagattatctgttcaacaagtcactagaaattgaaccccggaactgcaaa
cagccacctcgatttcctaggaaatcaactttctctttaaaatctcctggaataaggcct
aatacaggccgacatggctctacctcaggtactttacgaggtcatccaacaccattagaa
agagaaccatgtaaaataagctttagtcggattgctgaaacagagcttgaatcaacagtg
tcagcaccaacctctccaaatacaccatctactccaccagtgtctgcttcttcagacctt
agtgtgtttttagatgtggatctcaacagttcctgtggaagcaatagcatctttgctcca
gtcctcttgcctcattcaaagtctttctttagttcgtgtggtagtttacataaactaagt
gaagagccactgattcctcctccacttcctcctcgaaaaaaatttgatcatgatgcttca
aattccaagggaactatgaaatctgatgatgacccccctgctattccgccaagacagcct
cctcctccaaaggtaaaacccagagttcctgctccttctggtgcatttgacgggcttctg
catagtccaccaccgccgccgccgagagatcctcttcccgatacccctccaccagttccc
cttcggcctccagaacactttataaactgtccgtttactcttcagccacctccactggga
catcttcacagagatccagactggttcagagacgttagtacgtgtccaaattctccaaac
actcctcctagcacaccctctccaagggtaccacgtcgatgctacgtgctcagttctagt
cagaataatcttgctcatcctcaagctccccctgttccaccaaggcagaattcaagccct
cacctaccaaaactgccaccaaagacttacaaacgggagctttcgcaccccccattgtat
agactgcctttgctagaaaatgcagaaactactcaatga
Orcinus orca (killer whale): 101286587
Help
Entry
101286587 CDS
T05247
Gene name
SOS1
Definition
(RefSeq) son of sevenless homolog 1 isoform X1
KO
K03099
son of sevenless
Organism
oor
Orcinus orca (killer whale)
Pathway
oor01521
EGFR tyrosine kinase inhibitor resistance
oor01522
Endocrine resistance
oor04010
MAPK signaling pathway
oor04012
ErbB signaling pathway
oor04014
Ras signaling pathway
oor04062
Chemokine signaling pathway
oor04068
FoxO signaling pathway
oor04072
Phospholipase D signaling pathway
oor04150
mTOR signaling pathway
oor04151
PI3K-Akt signaling pathway
oor04510
Focal adhesion
oor04540
Gap junction
oor04630
JAK-STAT signaling pathway
oor04650
Natural killer cell mediated cytotoxicity
oor04660
T cell receptor signaling pathway
oor04662
B cell receptor signaling pathway
oor04664
Fc epsilon RI signaling pathway
oor04714
Thermogenesis
oor04722
Neurotrophin signaling pathway
oor04810
Regulation of actin cytoskeleton
oor04910
Insulin signaling pathway
oor04912
GnRH signaling pathway
oor04915
Estrogen signaling pathway
oor04917
Prolactin signaling pathway
oor04926
Relaxin signaling pathway
oor04935
Growth hormone synthesis, secretion and action
oor05034
Alcoholism
oor05160
Hepatitis C
oor05161
Hepatitis B
oor05163
Human cytomegalovirus infection
oor05165
Human papillomavirus infection
oor05200
Pathways in cancer
oor05205
Proteoglycans in cancer
oor05206
MicroRNAs in cancer
oor05210
Colorectal cancer
oor05211
Renal cell carcinoma
oor05213
Endometrial cancer
oor05214
Glioma
oor05215
Prostate cancer
oor05220
Chronic myeloid leukemia
oor05221
Acute myeloid leukemia
oor05223
Non-small cell lung cancer
oor05224
Breast cancer
oor05225
Hepatocellular carcinoma
oor05226
Gastric cancer
oor05231
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101286587 (SOS1)
04012 ErbB signaling pathway
101286587 (SOS1)
04014 Ras signaling pathway
101286587 (SOS1)
04630 JAK-STAT signaling pathway
101286587 (SOS1)
04068 FoxO signaling pathway
101286587 (SOS1)
04072 Phospholipase D signaling pathway
101286587 (SOS1)
04151 PI3K-Akt signaling pathway
101286587 (SOS1)
04150 mTOR signaling pathway
101286587 (SOS1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
101286587 (SOS1)
04540 Gap junction
101286587 (SOS1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101286587 (SOS1)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
101286587 (SOS1)
04660 T cell receptor signaling pathway
101286587 (SOS1)
04662 B cell receptor signaling pathway
101286587 (SOS1)
04664 Fc epsilon RI signaling pathway
101286587 (SOS1)
04062 Chemokine signaling pathway
101286587 (SOS1)
09152 Endocrine system
04910 Insulin signaling pathway
101286587 (SOS1)
04912 GnRH signaling pathway
101286587 (SOS1)
04915 Estrogen signaling pathway
101286587 (SOS1)
04917 Prolactin signaling pathway
101286587 (SOS1)
04926 Relaxin signaling pathway
101286587 (SOS1)
04935 Growth hormone synthesis, secretion and action
101286587 (SOS1)
09156 Nervous system
04722 Neurotrophin signaling pathway
101286587 (SOS1)
09159 Environmental adaptation
04714 Thermogenesis
101286587 (SOS1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101286587 (SOS1)
05206 MicroRNAs in cancer
101286587 (SOS1)
05205 Proteoglycans in cancer
101286587 (SOS1)
05231 Choline metabolism in cancer
101286587 (SOS1)
09162 Cancer: specific types
05210 Colorectal cancer
101286587 (SOS1)
05225 Hepatocellular carcinoma
101286587 (SOS1)
05226 Gastric cancer
101286587 (SOS1)
05214 Glioma
101286587 (SOS1)
05221 Acute myeloid leukemia
101286587 (SOS1)
05220 Chronic myeloid leukemia
101286587 (SOS1)
05211 Renal cell carcinoma
101286587 (SOS1)
05215 Prostate cancer
101286587 (SOS1)
05213 Endometrial cancer
101286587 (SOS1)
05224 Breast cancer
101286587 (SOS1)
05223 Non-small cell lung cancer
101286587 (SOS1)
09165 Substance dependence
05034 Alcoholism
101286587 (SOS1)
09172 Infectious disease: viral
05161 Hepatitis B
101286587 (SOS1)
05160 Hepatitis C
101286587 (SOS1)
05163 Human cytomegalovirus infection
101286587 (SOS1)
05165 Human papillomavirus infection
101286587 (SOS1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101286587 (SOS1)
01522 Endocrine resistance
101286587 (SOS1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04990 Domain-containing proteins not elsewhere classified [BR:
oor04990
]
101286587 (SOS1)
Domain-containing proteins not elsewhere classified [BR:
oor04990
]
Pleckstrin homology (PH) domain-containing proteins
Dbl-Like RhoGEF family proteins
101286587 (SOS1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
RasGEF
RasGEF_N
RhoGEF
Histone
PH
PH_19
PH_10
IQ_SEC7_PH
PH_13
Motif
Other DBs
NCBI-GeneID:
101286587
NCBI-ProteinID:
XP_004265079
LinkDB
All DBs
Position
Unknown
AA seq
1333 aa
AA seq
DB search
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESSDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENVQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDADLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSSDTVFIQVTLPHGPRSASVSSISL
TKSTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSVSD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHSNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS
NT seq
4002 nt
NT seq
+upstream
nt +downstream
nt
atgcaggcgcagcagctgccgtacgagtttttcagcgaggagaacgcgcccaagtggcgg
gggctgctggtgcctgcgctgaaaaaggttcaggggcaagttcatcctactcttgagtct
agtgatgatgctcttcagtatgttgaagaattaattttgcagttactaaatatgctgtgc
caagctcagccccgaagtgcttcagatgtagaggaacgtgttcaaaaaagtttccctcat
ccaattgataagtgggcaatagctgatgcccagtcggctattgaaaagaggaagcgaaga
aaccctttatctctcccagtagaaaaaattcatcctttgttaaaggaggtcctaggttat
aaaattgaccaccaggtttctgtttacatagtagcagtattagaatacatttctgcagac
attttaaagctggtggggaattatgtgcgaaatatacggcattatgaaattacaaaacaa
gatattaaagtggcaatgtgtgctgataaggtattgatggatatgtttcatcaagatgta
gaagatataaatatattatctttaactgatgaagagccttccacctcaggagagcaaact
tattatgatttggtaaaagcatttatggcagaaattcgacaatacataagggaacttaat
ttaattataaaagtttttagagagccctttgtctccaattcaaaattgttttcagctaac
gatgtagaaaatatatttagccgtatagtggatatacatgaacttagtgtaaagttactg
ggccatatagaagatactgtagaaatgacagatgaaggcagtccccatccattagtagga
agttgctttgaagacttagcagaggaactggcatttgatccatatgaatcatatgctcga
gatattttacgacctggttttcatgatcgtttccttagtcagttatcaaagcctggagcg
gcactctatttgcagtcaataggcgaaggtttcaaagaagctgttcagtatgttttaccc
aggctacttctagcccctgtttaccactgtctacattactttgaacttctgaagcagtta
gaagaaaagagtgaagatcaagaagacaaggaatgtttgaaacaagcaataacagctttg
cttaatgttcagagtggtatggaaaaaatatgctctaaaagtcttgcaaaacgaagactg
agtgaatctgcatgtcggttttatagtcagcaaatgaaggggaaacaactagcaatcaag
aaaatgaacgagattcagaagaatattgatggttgggagggaaaagacattggacagtgt
tgcaatgagtttataatggaaggaactcttacacgtgtaggagccaaacatgagagacac
atatttctctttgatggcttaatgatttgctgtaaatcaaatcatgggcagccaagactt
cctggtgctagcaatgcagagtatcgtcttaaagaaaagttttttatgagaaaggtacaa
attaatgacaaagatgacaccaatgagtacaagcatgcttttgagataattttaaaagat
gaaaatagcgttatattttctgccaagtcagctgaagagaaaaacaattggatggcagca
ttgatatctttacagtaccggagtacactggaaaggatgcttgatgtgacaatgctacag
gaagaaaaggaggagcagatgaggctccctagtgctgatgtttatagatttgcagagcct
gactctgaagaaaatatcatatttgaagaaaacgtgcagcccaaagctggaattccaatt
atcaaagcaggaactgttattaaacttatagagaggctcacataccatatgtacgcagat
cccaattttgttcggacatttcttacaacatatagatccttttgtaaacctcaagaacta
ctgagtcttataatagaaaggtttgaaattccagagcctgagccaacagaagctgatcgc
atagctatagagaatggagatcagcccttgagtgcagaactaaaaaggtttagaaaagaa
tatatacagcctgtacaactgcgagtattaaatgtatgtcggcactgggtagagcaccac
ttctacgattttgaaagagatgcagatcttttgcagcgaatggaggaatttattggaaca
gtaagaggtaaagcgatgaaaaagtgggttgaatccatcactaaaataatccaaaggaaa
aaaattgcaagagacaatggaccaggtcataatattacatttcagagttcaccccctaca
gttgagtggcatataagcagacctgggcacatagagacttttgacctgctcaccttacac
ccaatagaaattgctcgacaactcactttacttgaatcagatctatatcgagctgtacag
ccatcagaattagttggaagtgtgtggacaaaggaagacaaagaaattaattctcctaat
cttctgaaaatgatccggcataccactaatctcactctgtggtttgagaaatgtattgta
gaaactgaaaacttagaagaaagagtagctgtggtgagtcgaataattgagattctgcaa
gtctttcaagagctgaacaacttcaatggtgtccttgaggttgtcagtgctatgaactca
tcacctgtatacagactagaccacacgtttgagcaaataccaagtcgccaaaagaaaatt
ttagaagaagctcatgaactaagtgaagatcactataagaaatatttggcaaaactcagg
tctattaatccaccatgtgtgcctttctttggaatttatctaactaatatcttgaaaaca
gaagaaggcaaccctgaggtcctaaaaaggcatggaaaagagcttataaactttagcaaa
aggaggaaagtagcagaaataacaggcgagatccagcagtaccaaaatcagccttattgt
ttacgagtagaatcagatatcaaaaggttctttgaaaacttgaatccaatgggaaatagt
atggaaaaagaatttacagattatcttttcaacaaatccctagaaatagaaccacgaaac
cctaagcctctcccaagatttccaaaaaaatatagctatcccctaaaatctcctggtgtt
cgtccatcaaacccaagaccaggtactatgagacatcccacacctctgcagcaagagcca
aggaaaattagttatagtaggatccctgaaagtgaaacagaaagtacagcatctgcacca
aattctccaagaacaccgttaacacctcctcctgcttctggtgcttctagtaccacagat
gtttgcagcgtatttgattctgatcattcaagcccttttcactcaagcagcgataccgtc
tttatccaagttacactgccccatggcccaagatctgcttcagtatcatctataagttta
accaagagcactgatgaagtgcctgtcccccctcctgttcctccacgaagacgaccagaa
tctgccccagcggaatcttcgccatctaagatcatgtctaagcatttggacagcccccca
gcaattcctcctaggcaacccacatcaaaagcctattcaccacgatattcagtatcagac
cggacctctatatcagatcctcctgaaagccctcccttattacctccacgagaacccgtg
aggacacctgatgttttctcaagctcaccactacatctccaacctccccctttgggcaaa
aaaagtgaccatagtaatgccttcttcccaaacagcccttccccctttacaccacctcct
cctcaaacaccttctcctcacggcacaagaaggcatctgccatcaccaccattgacacaa
gaagtggaccttcattccattgctgggccgcctgttcctccacgacaaagcacttctcaa
catatccctaaactccctccaaaaacttacaaaagggagcatacacacccatccatgcac
agagatggaccaccactgttggagaatgctcattcttcctga
Orcinus orca (killer whale): 105748221
Help
Entry
105748221 CDS
T05247
Definition
(RefSeq) LOW QUALITY PROTEIN: son of sevenless homolog 2-like
KO
K03099
son of sevenless
Organism
oor
Orcinus orca (killer whale)
Pathway
oor01521
EGFR tyrosine kinase inhibitor resistance
oor01522
Endocrine resistance
oor04010
MAPK signaling pathway
oor04012
ErbB signaling pathway
oor04014
Ras signaling pathway
oor04062
Chemokine signaling pathway
oor04068
FoxO signaling pathway
oor04072
Phospholipase D signaling pathway
oor04150
mTOR signaling pathway
oor04151
PI3K-Akt signaling pathway
oor04510
Focal adhesion
oor04540
Gap junction
oor04630
JAK-STAT signaling pathway
oor04650
Natural killer cell mediated cytotoxicity
oor04660
T cell receptor signaling pathway
oor04662
B cell receptor signaling pathway
oor04664
Fc epsilon RI signaling pathway
oor04714
Thermogenesis
oor04722
Neurotrophin signaling pathway
oor04810
Regulation of actin cytoskeleton
oor04910
Insulin signaling pathway
oor04912
GnRH signaling pathway
oor04915
Estrogen signaling pathway
oor04917
Prolactin signaling pathway
oor04926
Relaxin signaling pathway
oor04935
Growth hormone synthesis, secretion and action
oor05034
Alcoholism
oor05160
Hepatitis C
oor05161
Hepatitis B
oor05163
Human cytomegalovirus infection
oor05165
Human papillomavirus infection
oor05200
Pathways in cancer
oor05205
Proteoglycans in cancer
oor05206
MicroRNAs in cancer
oor05210
Colorectal cancer
oor05211
Renal cell carcinoma
oor05213
Endometrial cancer
oor05214
Glioma
oor05215
Prostate cancer
oor05220
Chronic myeloid leukemia
oor05221
Acute myeloid leukemia
oor05223
Non-small cell lung cancer
oor05224
Breast cancer
oor05225
Hepatocellular carcinoma
oor05226
Gastric cancer
oor05231
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
105748221
04012 ErbB signaling pathway
105748221
04014 Ras signaling pathway
105748221
04630 JAK-STAT signaling pathway
105748221
04068 FoxO signaling pathway
105748221
04072 Phospholipase D signaling pathway
105748221
04151 PI3K-Akt signaling pathway
105748221
04150 mTOR signaling pathway
105748221
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
105748221
04540 Gap junction
105748221
09142 Cell motility
04810 Regulation of actin cytoskeleton
105748221
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
105748221
04660 T cell receptor signaling pathway
105748221
04662 B cell receptor signaling pathway
105748221
04664 Fc epsilon RI signaling pathway
105748221
04062 Chemokine signaling pathway
105748221
09152 Endocrine system
04910 Insulin signaling pathway
105748221
04912 GnRH signaling pathway
105748221
04915 Estrogen signaling pathway
105748221
04917 Prolactin signaling pathway
105748221
04926 Relaxin signaling pathway
105748221
04935 Growth hormone synthesis, secretion and action
105748221
09156 Nervous system
04722 Neurotrophin signaling pathway
105748221
09159 Environmental adaptation
04714 Thermogenesis
105748221
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
105748221
05206 MicroRNAs in cancer
105748221
05205 Proteoglycans in cancer
105748221
05231 Choline metabolism in cancer
105748221
09162 Cancer: specific types
05210 Colorectal cancer
105748221
05225 Hepatocellular carcinoma
105748221
05226 Gastric cancer
105748221
05214 Glioma
105748221
05221 Acute myeloid leukemia
105748221
05220 Chronic myeloid leukemia
105748221
05211 Renal cell carcinoma
105748221
05215 Prostate cancer
105748221
05213 Endometrial cancer
105748221
05224 Breast cancer
105748221
05223 Non-small cell lung cancer
105748221
09165 Substance dependence
05034 Alcoholism
105748221
09172 Infectious disease: viral
05161 Hepatitis B
105748221
05160 Hepatitis C
105748221
05163 Human cytomegalovirus infection
105748221
05165 Human papillomavirus infection
105748221
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
105748221
01522 Endocrine resistance
105748221
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04990 Domain-containing proteins not elsewhere classified [BR:
oor04990
]
105748221
Domain-containing proteins not elsewhere classified [BR:
oor04990
]
Pleckstrin homology (PH) domain-containing proteins
Dbl-Like RhoGEF family proteins
105748221
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
RasGEF
RasGEF_N
RhoGEF
PH
Histone
IQ_SEC7_PH
Motif
Other DBs
NCBI-GeneID:
105748221
NCBI-ProteinID:
XP_012390150
LinkDB
All DBs
Position
Unknown
AA seq
1337 aa
AA seq
DB search
MPQAPQPYEFVSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNXCM
AQPRTVEDVEERVQKTFPHPMDKWAIADAXSAIEKRKRRNPLXLPVDKIHPSLKEVLGYE
VDYHVSLYIVAVLEYISADILKLADNYVFNIQHYEISQQDIKVSMCADKDKVLMDMFDQD
DIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFXEAFISDRKLSKLSD
IEKIFSNILAIHELTVKLLGLIEDTVEMTDESSPHPSAGSCFEDLAEEQAFDPYETLSQH
ILSPKFNEHFSKLMARPAVALPFQSIADGFKEALRYVLPRLMLVPVYHCWHYFELLKQLK
ACSEEHEDRECLNQAVTALMNLQGSVDRIYKQYSPRRXPGDPVCPFYNRQLRSKHLAIKK
MNEIQKNIDGWEDKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISHKPSHSQSHLP
GYSSTEYRLKEKFVMREIQICDKEDTCECKHAFELVSKDENSIIFAAKFAEEKNNWMAAL
ISLHYHSTLHRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPII
KGGTVVKLIERLTHHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPSEADKL
AVEKGEQPISADLKMFRKEYVQPVQLRILNVFRHRVEHHFYDFERGLELLERLESFISSV
RGKTMKNWVESVAKIIKRKKQAQANGISHNITFGSPPPPTEWHISRPGQFETFDLMTLHP
IEIAHQLILLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVE
AENFEERVAVLSRIIEILQVFQDLNNFSGVLEIVSAINSVSVCRLDHTFEERKRKFLDEA
VELSQDHFKKYLVKFKSISPPCVSFFGIYLTNIFXRLNIILKTEEGNNDFLKKKGKDLIN
FSKRKKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGNASENEFTDYLFNKSLEIE
PRNCKQPPQFPRKSTFSLKSPGIRPNTGXHGSTSGTLRGHPTPLEREPRKISFSRIAETE
LASTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGG
FHKRSEGPLIPPPLPPRKKFDHDASNSKGTMKSDDDPPAILPRQPPPPKVKPRVPAPSGA
FDGPLHSPPPPPPRDALPDTPPPVPLRPLERFINCLFTLQPPALGHLHRDPDWFRDVSTC
PNSPNTPPSTPSPRVPHRCYVLSSSQNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELS
HPPLCRLPLLENAETPQ
NT seq
4014 nt
NT seq
+upstream
nt +downstream
nt
atgccgcaggcgccgcagccgtacgagttcgtcagcgaagagaacagtccgaaatggcgg
ggactgttggtctcggccctgcggaaggttcaggagcaagtacatcccaatctctcagct
aatgaagagtctctctattatattgaagagctgatttttcagctgcttaatntatgcatg
gcccaaccaaggactgttgaagatgtggaggaacgagttcaaaagacctttcctcatcca
atggataaatgggctattgctgatgcatagtctgccatagagaaacgaaaacgaagaaat
cctcttnnactgcctgtggacaaaatccatccttcattgaaggaagttttagggtacgaa
gtggactaccatgtgtccctgtatattgtggctgtactagagtatatctcagctgatatt
ttgaaattggctgataattatgtatttaatatccaacattatgaaatatcccaacaggac
attaaagtgtcaatgtgtgcagataaggataaggttttgatggacatgtttgatcaggat
gacataggcttggtttctctttgtgaagatgaacctagttcttcaggtgaattaaactac
tatgaccttgtcagaactgaaattgcagaagaaagacagtatttacgggaactaaatatg
atcataaaagtgttttgagaagcttttatttctgacagaaagctgtctaaactttctgat
attgaaaagattttcagtaacattttagctatacatgaattgactgtgaaacttttaggt
ttaattgaagacacagttgaaatgactgatgaaagcagccctcatccctcagctggaagc
tgttttgaagatttggcagaggaacaagcatttgatccttacgaaacattatcacagcat
attctttcaccaaaatttaatgaacatttcagtaagttgatggccagacctgcagtggct
ctacccttccagtccattgctgatggttttaaagaggcacttcgttatgtccttccacgc
cttatgctggtgccagtatatcattgttggcactactttgaattattaaagcaattgaaa
gcatgtagtgaagagcatgaagacagagagtgtttgaaccaagctgttactgctctcatg
aatctccaaggtagtgtagaccgaatttacaagcagtattcacctagacgctgacctggg
gatcctgtttgccctttttataatcgtcaattaagaagcaagcacctggctattaaaaaa
atgaatgaaattcagaaaaacatagatggatgggaagacaaagatattggacagtgttgt
aatgaatttattatggaaggcccattgacaagaattggtgctaaacatgaacggcatatt
tttctctttgatggcttaatgattagccacaaacccagtcacagccagtcacaccttcca
ggatacagtagtacagaatacagattaaaagaaaaatttgtcatgagggaaatacaaata
tgtgacaaagaagatacttgtgagtgcaaacatgcttttgaattagtatccaaagatgaa
aacagcataatatttgctgctaagtttgctgaagagaaaaataactggatggcagcactt
atttctcttcattatcatagtactctacatcgaatgctagattcagtattattgaaggaa
gaaaatgagcaaccacttagattaccgagtcctgaagtgtatcgttttgtggtaaaagac
tctgaggaaaacattgtttttgaagacaacttgcaaagtagaagtggaatccccattatt
aaaggaggaactgtggtgaaattaattgaaaggttaacacatcacatgtatgcagatccc
aattttgttcgcacttttcttactacgtatcgttcattttgtaaaccacaggaattgcta
agcttactgattgaacgatttgaaattccagagccagaacctagtgaagcagataaattg
gcagtagagaaaggcgagcagccaatcagtgcagaccttaaaatgtttcgcaaggaatac
gtccagccagtacaacttaggatcttaaatgtgtttcggcacagggttgaacaccatttt
tatgattttgaaagaggcttggagttgcttgaaagactagaatccttcatttcaagtgta
agagggaaaactatgaagaactgggtagagtcagttgctaagatcatcaagaggaagaaa
caagctcaggcaaatggaataagccataatattacctttggaagtccacctccaccaact
gaatggcatatcagcagaccaggacagtttgaaacatttgatctcatgacacttcatcca
atagaaattgcacatcagctgatacttttggaatctgatctctacaggaaagttcaacct
tctgaacttgtagggagtgtatggaccaaagaagataaagaaataaattctccaaattta
ttaaaaatgattcgccacaccacaaatctcactctctggtttgaaaagtgcattgtggaa
gcagaaaattttgaggaacgggtggcagtactaagtagaattatagaaattctgcaagtt
tttcaagatttgaataatttcagtggtgtattagagatcgtcagtgcaataaattcagta
tcagtctgtagactagatcatacctttgaggaaagaaaaaggaaatttttggatgaagct
gtggaattaagtcaagatcattttaaaaaatatctagtgaaatttaagtcaatcagtcca
ccttgtgtgtctttttttggaatatatttaacaaatatattctgaagactgaatataatt
ctgaagactgaagaagggaataatgattttttaaaaaagaaagggaaagatttaatcaat
ttcagtaagaggaaaaaagtagctgaaattaccggagaaattcagcaatatcagaatcag
ccttactgtttacggatagaaccagaaatgaggaggttctttgaaaaccttaaccccatg
ggaaatgcttctgaaaacgagtttacagattatttgttcaacaagtcactagaaattgaa
ccccgaaactgcaaacagccacctcaatttcctaggaaatcaactttctctttaaaatct
cctggaataaggcctaatacaggctgacatggctctacctcaggtactttacgaggtcat
ccaacaccattagaaagagaaccacgtaaaataagctttagtcggattgctgaaacagag
cttgcatcaacagtgtcagcaccaacctctccgaatacaccgtctactccaccagtatct
gcttcttcagaccttagtgtgtttttagatgtggatctcaacagttcctgtggaagcaat
agcatctttgctccagtcctcttgcctcattcaaagtctttctttagttcgtgtggtggt
tttcataaacgaagtgaagggccactgattcctcctccacttcctcctcgaaaaaaattt
gatcatgatgcttcaaattccaaggggactatgaaatctgatgatgacccccctgctatt
ctgccaagacagcctcctcctccaaaggtaaaacccagagttcctgctccttctggtgca
tttgacgggcctctgcatagtccaccaccgccgccgccgagagatgctcttcctgatacc
cctccaccagttccccttcggcctctagaacgctttataaactgtctgtttactcttcag
ccacctgcactgggacatcttcatagagacccagactggttcagagacgttagtacatgt
cccaattctccaaacactcctcctagcacaccctctccaagggtaccacatcgatgctat
gtgctcagttctagtcaaaataatcttgctcatcctcaagcgccccccgttccaccgagg
cagaattcaagccctcacctgccaaaactgccaccaaagacttacaaacgggagctttcg
caccccccattgtgtagactgcctttgctagaaaatgcagaaactcctcaatga
DBGET
integrated database retrieval system
