KEGG   Pteropus alecto (black flying fox): 102878822
Entry
102878822         CDS       T02993                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2 isoform X1
  KO
K04364  growth factor receptor-bound protein 2
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale01521  EGFR tyrosine kinase inhibitor resistance
pale01522  Endocrine resistance
pale04010  MAPK signaling pathway
pale04012  ErbB signaling pathway
pale04014  Ras signaling pathway
pale04062  Chemokine signaling pathway
pale04068  FoxO signaling pathway
pale04072  Phospholipase D signaling pathway
pale04150  mTOR signaling pathway
pale04151  PI3K-Akt signaling pathway
pale04380  Osteoclast differentiation
pale04510  Focal adhesion
pale04540  Gap junction
pale04550  Signaling pathways regulating pluripotency of stem cells
pale04630  JAK-STAT signaling pathway
pale04650  Natural killer cell mediated cytotoxicity
pale04660  T cell receptor signaling pathway
pale04662  B cell receptor signaling pathway
pale04664  Fc epsilon RI signaling pathway
pale04714  Thermogenesis
pale04722  Neurotrophin signaling pathway
pale04910  Insulin signaling pathway
pale04912  GnRH signaling pathway
pale04915  Estrogen signaling pathway
pale04917  Prolactin signaling pathway
pale04926  Relaxin signaling pathway
pale04935  Growth hormone synthesis, secretion and action
pale05034  Alcoholism
pale05160  Hepatitis C
pale05161  Hepatitis B
pale05163  Human cytomegalovirus infection
pale05165  Human papillomavirus infection
pale05200  Pathways in cancer
pale05203  Viral carcinogenesis
pale05205  Proteoglycans in cancer
pale05206  MicroRNAs in cancer
pale05210  Colorectal cancer
pale05211  Renal cell carcinoma
pale05213  Endometrial cancer
pale05214  Glioma
pale05215  Prostate cancer
pale05220  Chronic myeloid leukemia
pale05221  Acute myeloid leukemia
pale05223  Non-small cell lung cancer
pale05224  Breast cancer
pale05225  Hepatocellular carcinoma
pale05226  Gastric cancer
pale05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:pale00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102878822 (GRB2)
   04012 ErbB signaling pathway
    102878822 (GRB2)
   04014 Ras signaling pathway
    102878822 (GRB2)
   04630 JAK-STAT signaling pathway
    102878822 (GRB2)
   04068 FoxO signaling pathway
    102878822 (GRB2)
   04072 Phospholipase D signaling pathway
    102878822 (GRB2)
   04151 PI3K-Akt signaling pathway
    102878822 (GRB2)
   04150 mTOR signaling pathway
    102878822 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102878822 (GRB2)
   04540 Gap junction
    102878822 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102878822 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    102878822 (GRB2)
   04660 T cell receptor signaling pathway
    102878822 (GRB2)
   04662 B cell receptor signaling pathway
    102878822 (GRB2)
   04664 Fc epsilon RI signaling pathway
    102878822 (GRB2)
   04062 Chemokine signaling pathway
    102878822 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102878822 (GRB2)
   04912 GnRH signaling pathway
    102878822 (GRB2)
   04915 Estrogen signaling pathway
    102878822 (GRB2)
   04917 Prolactin signaling pathway
    102878822 (GRB2)
   04926 Relaxin signaling pathway
    102878822 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    102878822 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102878822 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102878822 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    102878822 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102878822 (GRB2)
   05206 MicroRNAs in cancer
    102878822 (GRB2)
   05205 Proteoglycans in cancer
    102878822 (GRB2)
   05203 Viral carcinogenesis
    102878822 (GRB2)
   05231 Choline metabolism in cancer
    102878822 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102878822 (GRB2)
   05225 Hepatocellular carcinoma
    102878822 (GRB2)
   05226 Gastric cancer
    102878822 (GRB2)
   05214 Glioma
    102878822 (GRB2)
   05221 Acute myeloid leukemia
    102878822 (GRB2)
   05220 Chronic myeloid leukemia
    102878822 (GRB2)
   05211 Renal cell carcinoma
    102878822 (GRB2)
   05215 Prostate cancer
    102878822 (GRB2)
   05213 Endometrial cancer
    102878822 (GRB2)
   05224 Breast cancer
    102878822 (GRB2)
   05223 Non-small cell lung cancer
    102878822 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    102878822 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102878822 (GRB2)
   05160 Hepatitis C
    102878822 (GRB2)
   05163 Human cytomegalovirus infection
    102878822 (GRB2)
   05165 Human papillomavirus infection
    102878822 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102878822 (GRB2)
   01522 Endocrine resistance
    102878822 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pale04131]
    102878822 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:pale04990]
    102878822 (GRB2)
Membrane trafficking [BR:pale04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    102878822 (GRB2)
Domain-containing proteins not elsewhere classified [BR:pale04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   102878822 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 102878822
NCBI-ProteinID: XP_006912287
UniProt: L5KL61
LinkDB
Position
Unknown
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaagtatgacttcaaagccactgcagacgacgagctgagcttcaaa
agaggggacatcctcaaggttttgaatgaagaatgtgatcagaactggtacaaggcagaa
ctcaatgggaaagatggcttcattcccaagaattacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaagcagaagaaatgcttagcaaacagcggcatgat
ggagccttccttatccgagagagcgagagtgctcctggggatttctccctctcagtcaag
tttggaaacgacgtgcagcacttcaaggtgctccgggacggagccgggaagtatttcctc
tgggtggtgaagttcaattctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatattcctccgggacatagagcaggtgccacagcagccgacatac
gtccaagccctctttgacttcgacccccaggaggatggagagctggggttccgccgggga
gactttatccacgtcatggataactcagaccccaactggtggaagggggcgtgccacggg
cagaccggcatgttcccccgcaattacgtcacccctgtgaaccggaacgtgtag

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