KEGG T02993: 102879034

KEGG Orthology (KO) [BR:pale00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102879034 (MAP2K2)
   04012 ErbB signaling pathway
    102879034 (MAP2K2)
   04014 Ras signaling pathway
    102879034 (MAP2K2)
   04015 Rap1 signaling pathway
    102879034 (MAP2K2)
   04370 VEGF signaling pathway
    102879034 (MAP2K2)
   04371 Apelin signaling pathway
    102879034 (MAP2K2)
   04066 HIF-1 signaling pathway
    102879034 (MAP2K2)
   04068 FoxO signaling pathway
    102879034 (MAP2K2)
   04072 Phospholipase D signaling pathway
    102879034 (MAP2K2)
   04071 Sphingolipid signaling pathway
    102879034 (MAP2K2)
   04024 cAMP signaling pathway
    102879034 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    102879034 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    102879034 (MAP2K2)
   04150 mTOR signaling pathway
    102879034 (MAP2K2)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102879034 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    102879034 (MAP2K2)
   04218 Cellular senescence
    102879034 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102879034 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102879034 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102879034 (MAP2K2)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    102879034 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    102879034 (MAP2K2)
   04660 T cell receptor signaling pathway
    102879034 (MAP2K2)
   04662 B cell receptor signaling pathway
    102879034 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    102879034 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102879034 (MAP2K2)
   04929 GnRH secretion
    102879034 (MAP2K2)
   04912 GnRH signaling pathway
    102879034 (MAP2K2)
   04915 Estrogen signaling pathway
    102879034 (MAP2K2)
   04917 Prolactin signaling pathway
    102879034 (MAP2K2)
   04921 Oxytocin signaling pathway
    102879034 (MAP2K2)
   04926 Relaxin signaling pathway
    102879034 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    102879034 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    102879034 (MAP2K2)
   04916 Melanogenesis
    102879034 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102879034 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    102879034 (MAP2K2)
   04730 Long-term depression
    102879034 (MAP2K2)
   04722 Neurotrophin signaling pathway
    102879034 (MAP2K2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102879034 (MAP2K2)
   05206 MicroRNAs in cancer
    102879034 (MAP2K2)
   05205 Proteoglycans in cancer
    102879034 (MAP2K2)
   05230 Central carbon metabolism in cancer
    102879034 (MAP2K2)
   05231 Choline metabolism in cancer
    102879034 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102879034 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102879034 (MAP2K2)
   05225 Hepatocellular carcinoma
    102879034 (MAP2K2)
   05226 Gastric cancer
    102879034 (MAP2K2)
   05214 Glioma
    102879034 (MAP2K2)
   05216 Thyroid cancer
    102879034 (MAP2K2)
   05221 Acute myeloid leukemia
    102879034 (MAP2K2)
   05220 Chronic myeloid leukemia
    102879034 (MAP2K2)
   05218 Melanoma
    102879034 (MAP2K2)
   05211 Renal cell carcinoma
    102879034 (MAP2K2)
   05219 Bladder cancer
    102879034 (MAP2K2)
   05215 Prostate cancer
    102879034 (MAP2K2)
   05213 Endometrial cancer
    102879034 (MAP2K2)
   05224 Breast cancer
    102879034 (MAP2K2)
   05223 Non-small cell lung cancer
    102879034 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102879034 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    102879034 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102879034 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102879034 (MAP2K2)
   05135 Yersinia infection
    102879034 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102879034 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    102879034 (MAP2K2)
   05161 Hepatitis B
    102879034 (MAP2K2)
   05160 Hepatitis C
    102879034 (MAP2K2)
   05164 Influenza A
    102879034 (MAP2K2)
   05163 Human cytomegalovirus infection
    102879034 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102879034 (MAP2K2)
   05165 Human papillomavirus infection
    102879034 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102879034 (MAP2K2)
   01522 Endocrine resistance
    102879034 (MAP2K2)
Enzymes [BR:pale01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102879034 (MAP2K2)
Protein kinases [BR:pale01001]
Serine/threonine kinases: STE group
  STE7 family
   102879034 (MAP2K2)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like APH Seadorna_VP7 Kdo CAMSAP_CC1

Other DBs

NCBI-GeneID:

102879034

NCBI-ProteinID:

XP_024898867

LinkDB

Position

Unknown

AA seq 454 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKWVRVASPASSVH
GVEWAPNVTGETRTCCGLGAPPGTPWSGRHLVTRPGPDPGGAGTLPSLWKRQPLTVTENH
TFIKRSEVEEVDFAGWLCKTLRLDQPSTPTRTAV

NT seq 1365 nt +upstreamnt +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagaagagctagagcttgacgagcagcagaagaagcggctggaagccttcctcacccag
aaggccaaggtcggggagctcaaggacgatgacttcgaaaggatctcggagctgggagcc
gggaacggcggagtggtcaccaaggtccagcacagaccttctggtctcatcatggcaaga
aagctgattcacctggagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctgcatgagtgcaactcgccgtacatcgtgggcttctacggggccttctacagcgac
ggggagatcagcatctgcatggagcacatggacggcggctccctggaccaggtgctgaag
gaagccaagagaattccggaggagatcctggggaaggtcagcattgcggttctgcggggc
ctggcgtatctccgggagaagcaccagatcatgcaccgagatgtgaagccgtccaacatc
ctcgtcaactccagaggcgagatcaagctgtgcgacttcggggtgagcgggcagctcatc
gactccatggccaactccttcgtgggaactcggtcctacatgtctccggagcggttgcag
ggcacccactactcggtgcagtcggacatctggagcatgggcctgtccttggtggagctg
tccatcgggaggtaccccatccccccaccggacgccaaggagctggaggccatctttggt
cggcccatggtcgacggggcagaaggagagcctcatagcatctcgccgcggccgagaccc
cccggacgccccatcagcggtcacgggatggacagccggccggccatggccatcttcgaa
ctgctggactacattgtgaacgagcctcctcccaagctgcccagcggcgtcttcacccag
gacttccaggaatttgtgaataaatgggtgcgggtggcctcacctgcctccagcgtgcac
ggggtggaatgggcccccaacgtcactggggagactaggacctgctgtgggctcggggcc
ccgcccggcacgccctggtcaggaaggcatctggtcacccgacccggcccagacccagga
ggcgctggcactctgccgtccctgtggaagcgccagccactcacggtgactgagaatcac
accttcatcaaacggtccgaggtggaggaagtggattttgccggctggctgtgtaagacg
ctgcgtctggaccagcccagcacacccacgcggaccgccgtgtga

Pteropus alecto (black flying fox): 102897122

Entry

102897122 CDS T02993

Gene name

MAP2K1

Definition

(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1

K04368

mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]

Organism

pale Pteropus alecto (black flying fox)

Pathway

pale01521

EGFR tyrosine kinase inhibitor resistance

pale01522

Endocrine resistance

pale04010

MAPK signaling pathway

pale04012

ErbB signaling pathway

pale04014

Ras signaling pathway

pale04015

Rap1 signaling pathway

pale04022

cGMP-PKG signaling pathway

pale04024

cAMP signaling pathway

pale04062

Chemokine signaling pathway

pale04066

HIF-1 signaling pathway

pale04068

FoxO signaling pathway

pale04071

Sphingolipid signaling pathway

pale04072

Phospholipase D signaling pathway

pale04114

Oocyte meiosis

pale04140

Autophagy - animal

pale04150

mTOR signaling pathway

pale04151

PI3K-Akt signaling pathway

pale04210

Apoptosis

pale04218

Cellular senescence

pale04270

Vascular smooth muscle contraction

pale04370

VEGF signaling pathway

pale04371

Apelin signaling pathway

pale04380

Osteoclast differentiation

pale04510

Focal adhesion

pale04540

Gap junction

pale04550

Signaling pathways regulating pluripotency of stem cells

pale04620

Toll-like receptor signaling pathway

pale04650

Natural killer cell mediated cytotoxicity

pale04660

T cell receptor signaling pathway

pale04662

B cell receptor signaling pathway

pale04664

Fc epsilon RI signaling pathway

pale04666

Fc gamma R-mediated phagocytosis

pale04668

TNF signaling pathway

pale04720

Long-term potentiation

pale04722

Neurotrophin signaling pathway

pale04725

Cholinergic synapse

pale04726

Serotonergic synapse

pale04730

Long-term depression

pale04810

Regulation of actin cytoskeleton

pale04910

Insulin signaling pathway

pale04912

GnRH signaling pathway

pale04914

Progesterone-mediated oocyte maturation

pale04915

Estrogen signaling pathway

pale04916

Melanogenesis

pale04917

Prolactin signaling pathway

pale04919

Thyroid hormone signaling pathway

pale04921

Oxytocin signaling pathway

pale04926

Relaxin signaling pathway

pale04928

Parathyroid hormone synthesis, secretion and action

pale04929

GnRH secretion

pale04934

Cushing syndrome

pale04935

Growth hormone synthesis, secretion and action

pale05010

Alzheimer disease

pale05022

Pathways of neurodegeneration - multiple diseases

pale05034

Alcoholism

pale05132

Salmonella infection

pale05135

Yersinia infection

pale05160

Hepatitis C

pale05161

Hepatitis B

pale05163

Human cytomegalovirus infection

pale05164

Influenza A

pale05165

Human papillomavirus infection

pale05166

Human T-cell leukemia virus 1 infection

pale05167

Kaposi sarcoma-associated herpesvirus infection

pale05170

Human immunodeficiency virus 1 infection

pale05200

Pathways in cancer

pale05205

Proteoglycans in cancer

pale05206

MicroRNAs in cancer

pale05210

Colorectal cancer

pale05211

Renal cell carcinoma

pale05212

Pancreatic cancer

pale05213

Endometrial cancer

pale05214

Glioma

pale05215

Prostate cancer

pale05216

Thyroid cancer

pale05218

Melanoma

pale05219

Bladder cancer

pale05220

Chronic myeloid leukemia

pale05221

Acute myeloid leukemia

pale05223

Non-small cell lung cancer

pale05224

Breast cancer

pale05225

Hepatocellular carcinoma

pale05226

Gastric cancer

pale05230

Central carbon metabolism in cancer

pale05231

Choline metabolism in cancer

pale05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:pale00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102897122 (MAP2K1)
   04012 ErbB signaling pathway
    102897122 (MAP2K1)
   04014 Ras signaling pathway
    102897122 (MAP2K1)
   04015 Rap1 signaling pathway
    102897122 (MAP2K1)
   04370 VEGF signaling pathway
    102897122 (MAP2K1)
   04371 Apelin signaling pathway
    102897122 (MAP2K1)
   04668 TNF signaling pathway
    102897122 (MAP2K1)
   04066 HIF-1 signaling pathway
    102897122 (MAP2K1)
   04068 FoxO signaling pathway
    102897122 (MAP2K1)
   04072 Phospholipase D signaling pathway
    102897122 (MAP2K1)
   04071 Sphingolipid signaling pathway
    102897122 (MAP2K1)
   04024 cAMP signaling pathway
    102897122 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    102897122 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    102897122 (MAP2K1)
   04150 mTOR signaling pathway
    102897122 (MAP2K1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102897122 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102897122 (MAP2K1)
   04210 Apoptosis
    102897122 (MAP2K1)
   04218 Cellular senescence
    102897122 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102897122 (MAP2K1)
   04540 Gap junction
    102897122 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102897122 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102897122 (MAP2K1)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    102897122 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    102897122 (MAP2K1)
   04660 T cell receptor signaling pathway
    102897122 (MAP2K1)
   04662 B cell receptor signaling pathway
    102897122 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    102897122 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    102897122 (MAP2K1)
   04062 Chemokine signaling pathway
    102897122 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102897122 (MAP2K1)
   04929 GnRH secretion
    102897122 (MAP2K1)
   04912 GnRH signaling pathway
    102897122 (MAP2K1)
   04915 Estrogen signaling pathway
    102897122 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    102897122 (MAP2K1)
   04917 Prolactin signaling pathway
    102897122 (MAP2K1)
   04921 Oxytocin signaling pathway
    102897122 (MAP2K1)
   04926 Relaxin signaling pathway
    102897122 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    102897122 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    102897122 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    102897122 (MAP2K1)
   04916 Melanogenesis
    102897122 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102897122 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    102897122 (MAP2K1)
   04726 Serotonergic synapse
    102897122 (MAP2K1)
   04720 Long-term potentiation
    102897122 (MAP2K1)
   04730 Long-term depression
    102897122 (MAP2K1)
   04722 Neurotrophin signaling pathway
    102897122 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102897122 (MAP2K1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102897122 (MAP2K1)
   05206 MicroRNAs in cancer
    102897122 (MAP2K1)
   05205 Proteoglycans in cancer
    102897122 (MAP2K1)
   05230 Central carbon metabolism in cancer
    102897122 (MAP2K1)
   05231 Choline metabolism in cancer
    102897122 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102897122 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102897122 (MAP2K1)
   05212 Pancreatic cancer
    102897122 (MAP2K1)
   05225 Hepatocellular carcinoma
    102897122 (MAP2K1)
   05226 Gastric cancer
    102897122 (MAP2K1)
   05214 Glioma
    102897122 (MAP2K1)
   05216 Thyroid cancer
    102897122 (MAP2K1)
   05221 Acute myeloid leukemia
    102897122 (MAP2K1)
   05220 Chronic myeloid leukemia
    102897122 (MAP2K1)
   05218 Melanoma
    102897122 (MAP2K1)
   05211 Renal cell carcinoma
    102897122 (MAP2K1)
   05219 Bladder cancer
    102897122 (MAP2K1)
   05215 Prostate cancer
    102897122 (MAP2K1)
   05213 Endometrial cancer
    102897122 (MAP2K1)
   05224 Breast cancer
    102897122 (MAP2K1)
   05223 Non-small cell lung cancer
    102897122 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102897122 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    102897122 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    102897122 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102897122 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102897122 (MAP2K1)
   05135 Yersinia infection
    102897122 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102897122 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    102897122 (MAP2K1)
   05161 Hepatitis B
    102897122 (MAP2K1)
   05160 Hepatitis C
    102897122 (MAP2K1)
   05164 Influenza A
    102897122 (MAP2K1)
   05163 Human cytomegalovirus infection
    102897122 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102897122 (MAP2K1)
   05165 Human papillomavirus infection
    102897122 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102897122 (MAP2K1)
   01522 Endocrine resistance
    102897122 (MAP2K1)
Enzymes [BR:pale01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102897122 (MAP2K1)
Protein kinases [BR:pale01001]
Serine/threonine kinases: STE group
  STE7 family
   102897122 (MAP2K1)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like Seadorna_VP7 NAD_binding_6

Other DBs

NCBI-GeneID:

102897122

NCBI-ProteinID:

XP_006920300

UniProt:

L5K149

LinkDB

Position

Unknown

AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV

NT seq 1182 nt +upstreamnt +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaatccagccccagacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctggatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggatgacgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccacaagccatccggcctggtcatggctagaaagttaattcac
ctggaaatcaaacctgcaatccggaaccagatcataagagagctgcaagttctacatgag
tgtaactctccgtacatcgtgggcttctatggtgcattttacagtgatggcgagatcagc
atctgcatggagcatatggatgggggttccttggatcaagtgctgaagaaagctggacga
attcctgaacaaattttaggaaaagttagcattgctgtaattaaaggtctgacgtatctg
agggagaagcacaagattatgcatagagatgtcaagccttctaacatcctagtgaactct
cgtggggagatcaagctttgtgactttggggtcagcgggcagcttatcgactccatggcc
aattccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcactac
tcggtgcagtcggacatctggagtatggggctctctctggttgagatggcagttgggagg
tatcccatccctcctccagatgccaaggagctggaactgatgtttgggtgccaagtggag
ggagatgcagctgagacaccgcctaggccaaggacccctgggaggcccctcagctcttat
ggaatggatagccgacctcccatggcaattttcgaattgttggattatatagttaatgag
cctcctccaaaactacccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagaaagagctgatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtagattttgcaggttggctctgctctaccattggc
cttaaccagcccagcacaccaacccatgcagctggtgtctaa

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