Pteropus alecto (black flying fox): 102893495 Help Entry 102893495         CDS       T02993                                  Gene name EGFR Definition (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism pale  Pteropus alecto (black flying fox) Pathway pale01521   EGFR tyrosine kinase inhibitor resistance pale01522   Endocrine resistance pale04010   MAPK signaling pathway pale04012   ErbB signaling pathway pale04014   Ras signaling pathway pale04015   Rap1 signaling pathway pale04020   Calcium signaling pathway pale04066   HIF-1 signaling pathway pale04068   FoxO signaling pathway pale04072   Phospholipase D signaling pathway pale04144   Endocytosis pale04151   PI3K-Akt signaling pathway pale04510   Focal adhesion pale04520   Adherens junction pale04540   Gap junction pale04630   JAK-STAT signaling pathway pale04810   Regulation of actin cytoskeleton pale04912   GnRH signaling pathway pale04915   Estrogen signaling pathway pale04921   Oxytocin signaling pathway pale04926   Relaxin signaling pathway pale04928   Parathyroid hormone synthesis, secretion and action pale04934   Cushing syndrome pale05160   Hepatitis C pale05163   Human cytomegalovirus infection pale05165   Human papillomavirus infection pale05171   Coronavirus disease - COVID-19 pale05200   Pathways in cancer pale05205   Proteoglycans in cancer pale05206   MicroRNAs in cancer pale05210   Colorectal cancer pale05212   Pancreatic cancer pale05213   Endometrial cancer pale05214   Glioma pale05215   Prostate cancer pale05218   Melanoma pale05219   Bladder cancer pale05223   Non-small cell lung cancer pale05224   Breast cancer pale05225   Hepatocellular carcinoma pale05226   Gastric cancer pale05230   Central carbon metabolism in cancer pale05231   Choline metabolism in cancer pale05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:pale00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102893495 (EGFR)    04012 ErbB signaling pathway     102893495 (EGFR)    04014 Ras signaling pathway     102893495 (EGFR)    04015 Rap1 signaling pathway     102893495 (EGFR)    04630 JAK-STAT signaling pathway     102893495 (EGFR)    04066 HIF-1 signaling pathway     102893495 (EGFR)    04068 FoxO signaling pathway     102893495 (EGFR)    04020 Calcium signaling pathway     102893495 (EGFR)    04072 Phospholipase D signaling pathway     102893495 (EGFR)    04151 PI3K-Akt signaling pathway     102893495 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     102893495 (EGFR)   09144 Cellular community - eukaryotes    04510 Focal adhesion     102893495 (EGFR)    04520 Adherens junction     102893495 (EGFR)    04540 Gap junction     102893495 (EGFR)   09142 Cell motility    04810 Regulation of actin cytoskeleton     102893495 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     102893495 (EGFR)    04915 Estrogen signaling pathway     102893495 (EGFR)    04921 Oxytocin signaling pathway     102893495 (EGFR)    04926 Relaxin signaling pathway     102893495 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     102893495 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102893495 (EGFR)    05206 MicroRNAs in cancer     102893495 (EGFR)    05205 Proteoglycans in cancer     102893495 (EGFR)    05230 Central carbon metabolism in cancer     102893495 (EGFR)    05231 Choline metabolism in cancer     102893495 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102893495 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     102893495 (EGFR)    05212 Pancreatic cancer     102893495 (EGFR)    05225 Hepatocellular carcinoma     102893495 (EGFR)    05226 Gastric cancer     102893495 (EGFR)    05214 Glioma     102893495 (EGFR)    05218 Melanoma     102893495 (EGFR)    05219 Bladder cancer     102893495 (EGFR)    05215 Prostate cancer     102893495 (EGFR)    05213 Endometrial cancer     102893495 (EGFR)    05224 Breast cancer     102893495 (EGFR)    05223 Non-small cell lung cancer     102893495 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     102893495 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     102893495 (EGFR)    05171 Coronavirus disease - COVID-19     102893495 (EGFR)    05163 Human cytomegalovirus infection     102893495 (EGFR)    05165 Human papillomavirus infection     102893495 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102893495 (EGFR)    01522 Endocrine resistance     102893495 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pale01001]     102893495 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pale04147]     102893495 (EGFR) Enzymes [BR:pale01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      102893495 (EGFR) Protein kinases [BR:pale01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    102893495 (EGFR) Exosome [BR:pale04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    102893495 (EGFR)   Exosomal proteins of pancreatic cancer cells    102893495 (EGFR)   Exosomal proteins of bladder cancer cells    102893495 (EGFR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Furin-like Pkinase APH Motif Other DBs NCBI-GeneID:  102893495 NCBI-ProteinID:  XP_024902585 LinkDB All DBs Position Unknown AA seq 1219 aa AA seqDB search MLNNCEVVLGNLEITYMQRNYDLSFLKTIQEVAGYVLIALNVAETIPLENLQIIRGNVLF ENTHALSVLSNYGANKTGLRELPMRNLQEILQGAVRFNNNPLLCNVETIQWRDIVDSTFL SNMSLDFQNQMSSCPKCDPSCPNGSCWGAGQENCQKLTRIVCAQQCSRRCRGRSPSDCCH SQCAAGCTGPRESDCLVCHKFRDEATCKDTCPPLMLYNPTTYEMDVNPEGKYSFGATCVK KCPRNYVVTDHGSCVRACSSDSYEVEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINA TNIKHFKNCTSISGDLHILPVAFKGDSFTHTPPLDPKELDILKTVKEITGFLLIQAWPEN RTDLHAFENLEIIRGRTKQHGQFSLAVVGLHITSLGLRSLKEISDGDVVISGNQKLCYAD TIRWQNLFGTFSQKTKIINNRNGRDCQAAGHVCNPLCSSEGCWGPEPKDCVSCRNVSRDR ECVERCNLLEGEPREFVENSECVQCHPECLPQAMNVTCTGRGPDKCVKCAHYIDGPHCVK TCPSGIMGENNTLVWKFSDANHVCHLCHRNCTYGCAGPGLEGCTYGPRIPSIATGIVGGL LLVVVLALGVVLFLRRRYIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRVLKETEFKK IKVLGSGAFGTVYKGLWNPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHV CRLLGICLTSTVQLVTQLMPFGCLLDYVREHKDNMLPRMRKVMYRTKTFVGCSAGAKRHP GVYGPRDRRRVASSFSAKSLGLRMGFCHPSSWLPSASPCSPGGQLASVPSPHVPAFQGMN YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI LHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEVSALLEKGERLPQPPICTIDVYMI MVKCWMIDAESRPKFRELVLEFCKMARDPQRFLVIQGDERMDLPSPTDSNFYRALMEEED MEDVVDADEYLIPQHGFFHSPSTSRTPLLSSLSATSNTSAVACIDRNGQSCPLKEDSFLQ RYSSDPTGALTEENINDTFLPVPEYMNQSIPKRPAGSVQNPVYHSQPLSPAAGREPHYQH PHSSAVGNPEYLNTIRPASGDGPALWVQKGGHHISLDNPDYQQDFLPKEATSNGTFKGPA AENAEYLRVAPASREFTGA NT seq 3660 nt NT seq  +upstreamnt  +downstreamnt atgctgaacaactgtgaggtggtccttgggaacctggaaattacctatatgcaaaggaat tacgacctttccttcttaaagaccatccaggaggtggccggctacgtcctcatcgccctc aacgtggcggagacgatcccgctggaaaacctgcagatcatcagagggaacgtgctcttc gaaaacacgcacgccttgtcggtcctgtccaactacggggcaaacaaaacggggctgcgg gagctccccatgagaaacctgcaggaaatcctgcaaggcgccgtgcgattcaacaacaac cccctcctctgcaatgtggagaccatccagtggcgggacatcgtggacagcactttcctg agcaacatgtcgctggactttcagaaccagatgagcagctgcccaaagtgcgacccaagc tgtcccaacgggagctgctggggtgcgggacaggagaattgccagaaactgaccaggatc gtgtgtgcccagcagtgctccaggcgctgccgtggcaggtcgcccagcgactgctgccac agccagtgtgcggccggctgcaccgggccgcgggagagcgactgcctggtctgtcacaag ttccgggacgaagccacgtgcaaggacacctgcccgccgctcatgctgtacaaccccacc acgtacgagatggacgtcaacccggagggcaaatacagcttcggcgccacctgcgtgaag aaatgtccccgtaactatgtggtgacagaccacggctcgtgcgtccgcgcctgcagctct gacagctacgaggtggaggaggacggggttcgcaagtgtaagaagtgcgaagggccttgt cgcaaagtttgcaacggaataggaattggtgaatttaaagacacactttccataaatgct acgaatatcaaacacttcaaaaactgcacctccatcagtggggacctccacatcctgccg gtagctttcaagggtgactctttcactcacaccccgcctctggacccgaaggaactggac attctgaaaaccgtgaaggagataacagggtttttgctgattcaggcctggccagaaaac aggactgacctccatgctttcgagaacctggaaatcatacgtggcagaacaaagcaacat ggccagttttctctcgcggtcgtcggcctgcacatcacgtcgctgggactacgctccctc aaggagataagtgacggagacgtggtcatctcggggaaccagaagttgtgctacgcagac accatacgctggcaaaacctatttgggaccttcagccagaaaaccaagattataaacaat aggaatggacgagactgccaggccgcgggccatgtctgtaacccactctgctcgtcagag ggctgctggggcccggagccaaaggactgtgtgtcctgcaggaacgtcagccgtgaccgg gagtgcgtggagaggtgcaacctcctggagggcgagcccagggagtttgtggagaactct gagtgcgtgcagtgccatccagaatgcctgccccaggccatgaacgtaacctgcacggga cgcggaccagacaagtgtgtaaagtgtgcccactacatcgatggcccccactgtgtcaag acctgcccgtctgggatcatgggagaaaacaacacgctggtctggaagttctcagatgcc aatcacgtgtgtcacctgtgccaccgaaactgtacatacggctgcgctgggccgggtctc gaaggctgcacgtatgggcccaggatcccgtccatcgccaccggcatcgtgggcggcctg ctgctggtggtggtgctggccctcggggtcgtcctcttcctgcgcaggcgttacatcgtc cggaagcgcacgctgcgccggctgctgcaggagagagagctcgtggagcccctcacgccc agtggggaggcccccaaccaggctctcctgagggtcttgaaggagacggagttcaaaaag atcaaggtgctgggctctggcgcattcggcacggtgtacaagggtctctggaacccagaa ggcgagaaggtcaagatccccgtggctatcaaggagttgcgagaagccacgtctccaaaa gccaacaaggaaattcttgatgaagcctacgtgatggccagcgtggacaaccctcacgtg tgccgcctgctgggcatctgcctgacctccacagtccagctggtcacgcagctcatgccc ttcggctgcctcctggactatgtccgtgagcacaaggacaacatgctcccaaggatgcgg aaggtgatgtacaggacaaagacgtttgtgggctgctcggctggagcaaagcgccatcct ggcgtttatgggccacgcgaccgcagacgagtggcctcgtctttcagcgccaagtctctg gggctgcgcatgggcttctgccacccgtcttcctggctcccctcagccagtccatgctct cccgggggccagctggcgtccgtgccctcaccccatgttcccgcgtttcagggcatgaac tacctggaagaccggcgtttggtgcatcgtgacctggccgccaggaacgtcctggtgaag acgccacagcacgtcaagatcacagacttcgggctggccaagctgctgggcgccgaggag aaggaataccacgcggagggaggcaaggtgcctatcaagtggatggctttggaatcgatt ttacaccgaatttatacccaccaaagtgacgtctggagctatggtgtcaccgtgtgggag ctgatgacgttcgggtccaagccttatgatggcatcccggcgagcgaggtctcggccctg ctggagaagggagagcgcctcccgcagccgcccatatgcaccatcgacgtctacatgatc atggtcaagtgctggatgatagatgcagagagtcgccccaagttccgtgagttggtcctc gaattctgcaaaatggcccgagacccccagcgcttccttgtcatccagggggacgagaga atggacttgcccagccccacggactccaacttctaccgcgccctcatggaagaggaggac atggaggacgtggtggacgcggacgagtacctgatcccgcagcacggcttcttccacagc ccctccacgtcccgcacgcccctcctgagctccctgagtgccaccagcaacacttccgcc gtggcttgcatcgacagaaacgggcagagctgtcccctcaaggaagacagcttcttacag cgctacagctcagaccccaccggcgccttgaccgaggagaacatcaacgacactttcctc ccagtgcccgaatacatgaaccagtccatccccaaaaggcccgcgggctctgtgcagaac ccggtgtaccacagtcagcccctgagccccgccgccggcagagagccgcactaccagcac ccccacagcagcgccgtgggcaaccccgagtatctcaacaccatccgccccgccagcggc gacggccctgccctctgggtgcagaaaggaggccaccacattagcctggacaaccctgac taccagcaggacttcctgcccaaggaagccacgtcgaacggcacgttcaagggcccggcc gccgaaaacgcagagtacctgcgggtagccccggcgagccgcgagttcaccggcgcgtga

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