KEGG   Pteropus alecto (black flying fox): 102895982
Entry
102895982         CDS       T02993                                 

Gene name
BRCA1
Definition
(RefSeq) breast cancer type 1 susceptibility protein isoform X1
  KO
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale01524  Platinum drug resistance
pale03440  Homologous recombination
pale03460  Fanconi anemia pathway
pale04120  Ubiquitin mediated proteolysis
pale04151  PI3K-Akt signaling pathway
pale05206  MicroRNAs in cancer
pale05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:pale00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    102895982 (BRCA1)
  09124 Replication and repair
   03440 Homologous recombination
    102895982 (BRCA1)
   03460 Fanconi anemia pathway
    102895982 (BRCA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    102895982 (BRCA1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    102895982 (BRCA1)
  09162 Cancer: specific types
   05224 Breast cancer
    102895982 (BRCA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    102895982 (BRCA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:pale01009]
    102895982 (BRCA1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:pale04121]
    102895982 (BRCA1)
   03036 Chromosome and associated proteins [BR:pale03036]
    102895982 (BRCA1)
   03400 DNA repair and recombination proteins [BR:pale03400]
    102895982 (BRCA1)
Enzymes [BR:pale01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     102895982 (BRCA1)
Protein phosphatases and associated proteins [BR:pale01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     102895982 (BRCA1)
Ubiquitin system [BR:pale04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    102895982 (BRCA1)
  Multi subunit Ring-finger type E3
   BRCC complex
    102895982 (BRCA1)
Chromosome and associated proteins [BR:pale03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     102895982 (BRCA1)
DNA repair and recombination proteins [BR:pale03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     102895982 (BRCA1)
    BRCA1-A complex
     102895982 (BRCA1)
    BRCA1-B complex
     102895982 (BRCA1)
    BRCA1-C complex
     102895982 (BRCA1)
    BRCA complex
     102895982 (BRCA1)
   FA (Fanconi anemia) pathway
    Downstream FA components
     102895982 (BRCA1)
SSDB
Motif
Pfam: BRCT_assoc BRCT zf-C3HC4_2 zf-C3HC4 zf-C3HC4_4 zf-C3HC4_3 zf-RING_UBOX zf-RING_2 zf-RING_5 zf-Nse BRCT_2 zf-RING_6 zf-ANAPC11 zf-RING_10 Prok-RING_4 zf-rbx1
Other DBs
NCBI-GeneID: 102895982
NCBI-ProteinID: XP_006924625
LinkDB
Position
Unknown
AA seq 1836 aa
MDLCADRVEEVQNVLNAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQ
CPLCKNDITKRSLQESTRFSQLVEELLKIIHAFELDTGLQFANSYNFSKKENNSPEHLNE
EVSIIQSLGYRNRAKRLRQSELENSTLQETSLSVQLSNLGIVRSLRTKQQIQPQNKFVYI
ELGSDSSEETVNKASSCSVGDHELLQIIPQGAKAEASLNPAKKDNDACEFSEDITNIEHR
KSSNNDLTTTEKHAAEKHPEKYQGSSVSNLHVEPCGTNAHASSLQHENSLLYTKDRMNVE
KTDFCNKSKQPGLARSQQNRWVETKETCNDIQTSSTEKKVVLNADPLNGRIELNKQKPPC
SDSPRDSQDISWITRNSSIQKVNEWFSRRDEILTSDVSPDGRSESNVVEVPNEVDGYSGA
SEKIALKANDPHGALMCERVHSKLVESNIEDKIFGKTYRRKASLPNLSHITENLITGASA
IEPQITQEYPLTNKLKRKRRTTSGLHPEDFIKKIDLAVVQKTPENIIEETDQIEQNGHVM
NSTNNGHENETKGDYVQKKKNTNPTESLEKESTFKTKAEPICSSISNMELELNIHSSKAV
KKNRLRRKSSTRHIHALELVVNRNPSPPNHTELQIDSCSSSEELKEKNSDQMPVRHSKKL
QFIEDKESSTGAKKNNKPNETINKRLASDAFPELNVTNIPGFFTNGSSSNKLQEFVNPSL
QREEIKENLGTIQVSNSTKDPKILIFGEGRGSQTDRSTESTSILLVPETDYGTQDSISLL
EPDIPERVKTAPNHHAAIKNPRELIHGCSEDTRNDAEGFKDPLRCEVNYTQKTNIEIEEN
ELDTQYLQNTFKVSKRQSFALFSNPGNLEKECATGYAYSKSLRKQSPKVTLECDRKENQG
KKESNVKHVQAVYTTVGFPVVCEKEKKPGDYAKYGIKEVSRLCQSFQFRENETELTIANK
LGISQNPYHMPSISPIKSSVKTTCKKNLSEEKFEEHSISPERTIGNETIIQSTVGTISQN
NIRESTFKEGSSSSIYEAGSSTNELGSSVNEVGSSGENIQAELSRNRGPKLNAVLQLGLM
QPEVYKQSLPLSNCKHPEIKRQGENEGVVQAVNADVSLCQISDNLEQPMGNSNASQVCSE
TPDDLLNDDKIKENIGFDESGIKERSAVFSKSVQKGEFKRSPSPLAHTSLSQGRRRGARK
LESSEEDVSSEDEELPCFQHLLFGKVTKVPSSSTRYNAVATDGLSKKTEENLVSLKNSLN
DSSNRIASAKASQEHHLSEEARCSSSLFSSQHSASEDLIANPNTQDPFLMFDPPSKQVRH
QSENQEVLSDKELVSDDDERETGPEEYNQEEQSVDSNLDEAASEYENETSLSGECSRLSS
QSDILTTQQRDTMQDNLIKLQQEMAELEAVLEQHGSQPNMSPPLIADSCAPEELLNPEQN
TSEKAVLTSEKSSAYPVRQNPESLSANKSQESLGRSTNKNREPGVERSSPSKSQLLDDRW
YVHSHSQSLQNRNCPSQKELDKVAKVLEQQLIKPEAQEGTPYLESGVSLFSDDPQSDPSE
DRAPEPAYVCSMPASTSALKLPQFQVQESAKSPAAAHTNTVGYNVREESVSKKPEVISST
KRVNKRISMVASGLTHKEFMLVHKFARKHHITLTNLITEETTHVIMKTDTEFVCERTLKY
FLGIAGGKWVVSYFWVTQSVKERKILDEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRG
LEICCYGPFTNMPTDQLEWMVQLCGASVVKEPSSFTLGEDTHPVVVVQPDAWTEDGGFHA
IGQMCEAPVVTREWVLDSVALYQCQELNTYLIPQIS
NT seq 5511 nt   +upstreamnt  +downstreamnt
atggatttatgtgcggatcgtgttgaagaagtacaaaatgtccttaatgctatgcagaaa
atcttagagtgtccaatctgtctggagctgatcaaagagcctgtttccacaaaatgtgac
cacatattttgcaaattttgcatgctgaaacttctcaaccagaagaaagggccatcacag
tgtcctttgtgtaagaatgatataaccaaaagaagcctacaagaaagtacaagatttagt
caacttgttgaagagctattgaaaatcattcatgcttttgagcttgacacgggattgcag
tttgcaaacagttacaacttttcaaaaaaggaaaataactctcctgaacatctaaatgaa
gaagtttctatcatccaaagtttgggctaccgaaaccgtgccaaaagacttcgacagagt
gaacttgaaaattctaccttgcaggaaaccagtcttagcgtccaactctctaaccttgga
attgtgagatctctgaggacaaagcaacagatacaacctcagaataagtttgtctacatt
gaattgggatccgattcttctgaagaaacagttaataaagcaagttcttgcagtgtggga
gatcacgaattgttacagatcatccctcaaggagccaaggctgaagccagtttgaatcct
gcaaaaaaggataatgatgcttgtgagttttctgaggatataacgaatattgaacatcgt
aaatccagtaataacgatttgactaccactgagaagcatgcagctgagaagcatccagaa
aaatatcagggtagttctgtttcaaacttgcatgtggagccatgtggcacaaatgctcat
gccagctctttacagcatgagaacagtttattatacactaaagacagaatgaatgtagaa
aagactgacttctgtaataaaagcaaacagcctggcttagcaaggagccaacagaacaga
tgggttgaaactaaggaaacatgtaacgatatacagacttccagcacagagaaaaaggta
gttctgaatgctgatcccctgaatgggagaatagaactgaataagcagaaacctccatgc
tctgacagtcctagagattctcaagatatttcttggataacacggaatagtagcatacag
aaagttaatgagtggttttccagacgtgatgaaatattaacttctgatgtctcacctgat
gggaggtctgaatcaaatgtggtagaagttccaaatgaagtagatggatactctggtgct
tcagagaaaatagctttaaaggccaatgatcctcatggtgctttaatgtgcgaaagagtt
cactccaaactggtagaaagtaatattgaagataaaatatttgggaaaacatatcggagg
aaagcaagcctccctaacttgagccacataactgaaaatctaattacaggagcatctgct
atagaacctcagataacacaagagtatcccctcacaaataaactaaagcgtaaaaggaga
actacatcaggccttcatcctgaggattttatcaagaaaatagatttggcagttgttcag
aaaactccggaaaacataattgaggaaactgaccaaatagagcagaatggtcatgtgatg
aatagtactaataatggtcatgagaatgaaacaaaaggtgattatgttcagaagaagaaa
aatacaaacccaacagaatcattggaaaaagaatctactttcaaaactaaagctgaacct
atatgcagcagcataagcaatatggaactagaattaaatatccacagttcaaaagcagtt
aagaagaataggctgaggaggaagtcctctaccaggcatattcatgcacttgaactagta
gtcaatagaaatccaagcccacctaatcatactgaactacaaattgatagttgttctagc
agtgaagagctgaaggaaaaaaattctgaccaaatgccagtcagacacagcaaaaaactt
caattcatagaagataaagaatcttcaactggagccaagaagaataacaagccaaatgag
acaatcaataaaagacttgccagtgatgcttttccagaattaaatgtaacaaacatacct
ggtttttttactaatggttcaagttctaataaacttcaagagtttgtcaatcctagcctt
caaagagaagaaataaaagagaacctaggaacaattcaagtgtctaatagtaccaaggac
cccaaaattttgatcttcggtgaaggaagaggttcacaaactgatcgatctacagagagt
accagtattttattggtgcctgaaacagattatggcactcaagatagtatctcattactg
gaacctgacatcccagagagggtaaagacagcaccaaaccatcatgcagcaattaaaaac
cccagagaacttattcatggttgttctgaagatactagaaatgatgcagagggctttaaa
gatccattgagatgtgaagttaactacactcagaagacaaacattgaaatagaagagaat
gaacttgatacgcagtatttacagaatacattcaaggtttcaaagcgtcagtcatttgct
ttgttttcaaacccaggaaatctagaaaaggaatgtgcaacaggctatgcctactccaag
tccttgaggaaacaaagtccaaaagtcactcttgaatgtgaccgaaaagaaaatcaggga
aagaaagagtctaacgtcaagcatgtgcaggcagtttatacaactgtaggctttcctgtg
gtttgtgagaaagaaaaaaagccaggagattatgctaaatatggcataaaagaagtctct
aggctttgtcagtcatttcagttcagagaaaatgaaactgaactcactattgcaaataaa
cttggaatttcacaaaacccatatcatatgccatccatttctcccatcaagtcatctgtt
aaaactacatgtaagaaaaatctgtcagaggaaaagtttgaagaacattcaatatcccct
gaaagaacaataggaaatgagaccatcattcaaagtacagtgggcacaattagccaaaat
aacattagagaaagcacttttaaagaaggcagctcaagcagtatttatgaagcaggttcc
agtactaacgaactaggctctagtgtcaatgaagtaggttccagtggtgaaaacattcaa
gcagaactaagtagaaacagaggaccaaaattaaatgctgtgcttcagttgggtctcatg
cagcctgaagtctataagcaaagccttcctctaagtaattgtaaacatcctgaaataaaa
aggcaaggagaaaatgaaggagtagttcaggctgttaatgcagatgtctctctatgtcag
atttcagataacttagagcaacctatgggaaacagtaatgcttctcaggtttgttctgag
acaccggatgacctgttaaatgatgacaaaataaaagagaatatcggctttgatgaaagt
ggcattaaggaaagatctgctgtttttagcaaaagtgtccagaaaggagaattcaaaagg
agccctagtcccttagcccatacaagtttgtctcaaggtcgccgaagaggggctaggaaa
ttagagtcctcagaagaggatgtgtctagtgaggatgaagagcttccctgctttcaacac
ttattgtttggtaaagtcaccaaagtaccatcttcatctaccagatataatgctgttgcc
acagacggtctatctaagaaaacagaggagaacctggtatcactgaagaatagtttaaat
gacagcagtaaccggatagcatcagcaaaggcatcccaggaacatcacctcagtgaggaa
gcgagatgttctagtagcttattttcctcacaacacagtgcatcggaagacttgattgct
aatccgaacacccaggatcctttcttgatgtttgatcctccttccaaacaagtgaggcat
cagtctgaaaaccaggaagttctgagtgacaaggaattggtttcagatgatgatgaaagg
gaaactggcccagaagaatataatcaagaagagcagagtgtggattcaaacttagatgaa
gcagcatctgagtatgagaatgaaactagcctctctggagaatgttcaaggctgtcttct
cagagcgatattttaaccactcagcagagggataccatgcaagataatctgataaagctc
cagcaggaaatggccgaactggaagcggtgttagagcagcacgggagccagcctaacatg
tcccctcccctcatagctgattcttgtgcccctgaagagctgctaaatccggaacaaaac
acatcagaaaaagcagtattaacttcagagaaaagtagtgcatatcctgtaaggcagaat
ccggaaagcctttctgcaaacaagtctcaagaatctctgggtagatccaccaataaaaat
agagaaccaggagtggaaaggtcttccccttctaaatcccagttgttagatgataggtgg
tatgtgcacagccactcacagagtcttcagaacagaaactgcccgtctcaaaaggagctc
gataaagttgctaaagtgttggagcaacaactgataaagcctgaagcccaagagggaacc
ccttacctagagtctggagtcagcctcttctctgatgaccctcagtctgatccctctgaa
gacagagccccagagccggcttacgtttgcagcatgccagcttcaacctctgcattgaag
ttaccccaatttcaagttcaagaatctgccaagagtccagctgctgctcatactaatact
gttgggtataatgtgagagaagaaagtgtgagcaagaaaccagaagtgatatcttcaaca
aaaagagtaaacaaaagaatatctatggtggcatcaggcttgacccacaaagaatttatg
cttgtacacaagtttgccagaaaacaccacattactttaactaatctaattaccgaagag
actactcatgtcattatgaaaacagacaccgagtttgtatgtgaacggacactgaaatat
tttctgggaattgcaggaggaaagtgggtagttagctatttctgggtgacccagtctgtt
aaagaaagaaagattctagatgagcatgattttgaagtcagaggtgatgttgtcaatgga
aggaaccaccaaggtccaaagcgagcaagagaatcccaggacagaaagatcttcaggggc
ctagaaatctgttgctacggaccttttaccaacatgcccacagatcaactagaatggatg
gtgcagctctgtggggcttctgtggtgaaggagccttcatcattcaccctcggcgaggat
actcacccagttgtggttgtgcagccagatgcctggacagaggacggtggcttccatgcg
attgggcagatgtgtgaggcacctgtggtgacccgagaatgggtgttggacagcgtagcc
ctctaccagtgccaggagctgaacacctacctgataccccagatctcctag

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