Entry Name JAK-STAT signaling pathway - Acinonyx jubatus (cheetah)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Acinonyx jubatus (cheetah) [GN:
aju ]
Gene 113597168 LOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha [KO:K04737 ]
106982042 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X3 [KO:K05066 ]
106982043 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X3 [KO:K05066 ]
106985762 LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598 ]
106970920 oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
106973256 granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
106979712 signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
106986878 signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
106972608 signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
106979739 signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
106972566 signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
106972565 signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
106986653 induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
106984896 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
106984265 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
106976917 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
106973297 LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
106969150 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related aju04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
