Entry
Name
Prolactin signaling pathway - Acinonyx jubatus (cheetah)
Description
Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily. At the protein level, the long PRLR isoform (long-R) and several short PRLR isoforms (short-R) have been detected. Acting through the long-R, PRL activates many signaling cascades including Jak2/Stat, the major cascade, Src kinase, phosphatidylinositol-3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) pathways. PRL cannot activate Jak2/Stat5 through the short-R, but can activate pathways including MAPK and PI3K pathways.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Acinonyx jubatus (cheetah) [GN:
aju ]
Gene
106984896 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
106984265 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
106976917 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
106973297 LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
106969150 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
106979712 signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
106972608 signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
106972566 signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
106972565 signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
113602289 tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
106977188 lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248 ]
106990050 solute carrier family 2, facilitated glucose transporter member 2 isoform X2 [KO:K07593 ]
Compound
C00355 3,4-Dihydroxy-L-phenylalanine
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Binart N, Bachelot A, Bouilly J
Title
Impact of prolactin receptor isoforms on reproduction.
Journal
Reference
Authors
Bachelot A, Binart N
Title
Reproductive role of prolactin.
Journal
Reference
Authors
Hennighausen L, Robinson GW
Title
Information networks in the mammary gland.
Journal
Reference
Authors
Bouilly J, Sonigo C, Auffret J, Gibori G, Binart N
Title
Prolactin signaling mechanisms in ovary.
Journal
Reference
Authors
Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ
Title
Prolactin regulation of mammary gland development.
Journal
Reference
Authors
Frasor J, Gibori G
Title
Prolactin regulation of estrogen receptor expression.
Journal
Reference
Authors
Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA
Title
Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Journal
Reference
Authors
Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL
Title
Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy.
Journal
Reference
Authors
Grattan DR, Kokay IC
Title
Prolactin: a pleiotropic neuroendocrine hormone.
Journal
Reference
Authors
Yu-Lee LY, Luo G, Book ML, Morris SM
Title
Lactogenic hormone signal transduction.
Journal
Reference
Authors
Tam SP, Lau P, Djiane J, Hilton DJ, Waters MJ
Title
Tissue-specific induction of SOCS gene expression by PRL.
Journal
Reference
Authors
Halperin J, Devi SY, Elizur S, Stocco C, Shehu A, Rebourcet D, Unterman TG, Leslie ND, Le J, Binart N, Gibori G
Title
Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.
Journal
Reference
Authors
Sakamoto K, Creamer BA, Triplett AA, Wagner KU
Title
The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
Journal
Reference
Authors
Oakes SR, Hilton HN, Ormandy CJ
Title
The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.
Journal
Related pathway
KO pathway
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