KEGG   PATHWAY: bacu04010
Entry
bacu04010                   Pathway                                
Name
MAPK signaling pathway - Balaenoptera acutorostrata scammoni (minke whale)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
bacu04010  MAPK signaling pathway
bacu04010

Other DBs
GO: 0000165
Organism
Balaenoptera acutorostrata scammoni (minke whale) [GN:bacu]
Gene
103007483  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
103004988  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
103019389  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
103001906  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
103008378  CACNA1E; calcium channel, voltage-dependent, R type, alpha 1E subunit [KO:K04852]
102998540  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
103001651  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
103011359  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
102999494  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
103014409  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
103020121  CACNA2D1; calcium channel, voltage-dependent, alpha 2/delta subunit 1 [KO:K04858]
103003434  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
103004210  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
103019660  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
103017826  voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862]
103013626  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
103004138  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
103013367  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
103003619  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
103010602  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
103012821  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
103005857  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
103004251  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
103016995  CACNG6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
103017273  CACNG7; calcium voltage-gated channel auxiliary subunit gamma 7 [KO:K04872]
103002569  CACNG8; calcium voltage-gated channel auxiliary subunit gamma 8 [KO:K04873]
103000011  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103008319  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103004532  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103012542  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103017540  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103009974  GNA12; G protein subunit alpha 12 [KO:K04346]
103009446  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102997475  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103008480  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103009602  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
103020262  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
103019128  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
103019762  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
103000066  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
103011501  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
103019665  RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
103005459  rap guanine nucleotide exchange factor 2-like [KO:K08018]
103005314  NF1; neurofibromin 1 [KO:K08052]
102998210  RASA1; RAS p21 protein activator 1 [KO:K04352]
103013106  RASA2; RAS p21 protein activator 2 [KO:K08053]
103017880  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
103019004  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
103018737  ras-related protein Rap-1b-like [KO:K07836]
103004366  EGF; epidermal growth factor [KO:K04357]
103010563  TGFA; transforming growth factor alpha [KO:K08774]
103003402  EREG; epiregulin [KO:K09784]
103002922  AREG; amphiregulin [KO:K09782]
103018997  FGF1; fibroblast growth factor 1 [KO:K18496]
103015722  FGF2; fibroblast growth factor 2 [KO:K18497]
103012419  FGF5; fibroblast growth factor 5 [KO:K04358]
103004048  FGF9; fibroblast growth factor 9 [KO:K04358]
103001602  FGF8; fibroblast growth factor 8 [KO:K04358]
103009981  fibroblast growth factor 10-like [KO:K04358]
103002427  FGF6; fibroblast growth factor 6 [KO:K04358]
103013036  FGF20; fibroblast growth factor 20 [KO:K04358]
103020278  FGF7; fibroblast growth factor 7 [KO:K04358]
103018238  FGF17; fibroblast growth factor 17 [KO:K04358]
103012368  fibroblast growth factor 2-like [KO:K04358]
103017891  FGF18; fibroblast growth factor 18 [KO:K04358]
103020625  FGF16; fibroblast growth factor 16 [KO:K04358]
103018926  uncharacterized LOC103018926 [KO:K04358]
103012083  FGF19; fibroblast growth factor 19 [KO:K22603]
103016083  FGF21; fibroblast growth factor 21 [KO:K22429]
103017322  FGF23; fibroblast growth factor 23 [KO:K22428]
103002155  NGF; nerve growth factor [KO:K02582]
103017938  BDNF; brain derived neurotrophic factor [KO:K04355]
102997840  NTF3; neurotrophin 3 [KO:K04356]
103020826  NTF4; neurotrophin 4 [KO:K12457]
103021022  INS; insulin [KO:K04526]
103014780  IGF1; insulin like growth factor 1 [KO:K05459]
102997276  IGF2; insulin like growth factor 2 [KO:K13769]
103005337  PDGFA; platelet derived growth factor subunit A [KO:K04359]
103014878  PDGFB; platelet derived growth factor subunit B [KO:K17386]
103015925  PDGFD; platelet derived growth factor D [KO:K05450]
103019677  PDGFC; platelet derived growth factor C [KO:K05450]
103005966  CSF1; colony stimulating factor 1 [KO:K05453]
103001593  KITLG; KIT ligand [KO:K05461]
103003525  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
103008131  VEGFA; vascular endothelial growth factor A [KO:K05448]
103008905  VEGFB; vascular endothelial growth factor B [KO:K16858]
103017555  PGF; placental growth factor [KO:K16859]
103014140  VEGFC; vascular endothelial growth factor C [KO:K05449]
103007348  VEGFD; vascular endothelial growth factor D [KO:K05449]
102997605  hepatocyte growth factor-like [KO:K05460]
103009839  ANGPT1; angiopoietin 1 [KO:K05465]
103002510  ANGPT2; angiopoietin 2 [KO:K05466]
103002441  ANGPT4; angiopoietin 4 [KO:K05467]
103011308  EFNA5; ephrin A5 [KO:K05462]
103018674  EFNA3; ephrin A3 [KO:K05462]
103010861  EFNA1; ephrin A1 [KO:K05462]
103011343  EFNA4; ephrin A4 [KO:K05462]
103014464  uncharacterized LOC103014464 [KO:K05462]
103003079  GDNF; glial cell derived neurotrophic factor [KO:K05452]
103005875  NRTN; neurturin [KO:K25414]
103002762  ARTN; artemin [KO:K25415]
103013495  PSPN; persephin [KO:K25416]
103017029  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103002640  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
103015964  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
103004826  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
103017733  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103012184  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103002473  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103013305  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103015465  NGFR; nerve growth factor receptor [KO:K02583]
103003654  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
103020777  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
103018249  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103015537  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102998016  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103019883  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102999126  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102999027  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
103008462  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
103015874  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
103004554  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102999852  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
103002086  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
103016789  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
103009203  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
103006627  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
103010512  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102999196  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103019365  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103006545  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103015457  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103004931  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103010530  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
103008711  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
103016009  MRAS; muscle RAS oncogene homolog [KO:K07831]
103020975  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103002372  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103014337  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103017381  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103018627  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103018544  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102999619  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103002590  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103002216  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
103013251  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
103001596  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
103001540  RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6 [KO:K04373] [EC:2.7.11.1]
103013427  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102998068  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
103017770  ATF4; activating transcription factor 4 [KO:K04374]
102998249  ELK1; ELK1, ETS transcription factor [KO:K04375]
103004612  ELK4; ELK4, ETS transcription factor [KO:K04376]
103016933  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
103020044  SRF; serum response factor [KO:K04378]
102997242  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103009499  MAPT; microtubule associated protein tau [KO:K04380]
103006010  STMN1; stathmin 1 [KO:K04381]
103008898  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
103009192  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
103012091  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103012675  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
102999275  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
103005897  TNF; tumor necrosis factor [KO:K03156]
103008155  IL1A; interleukin 1 alpha [KO:K04383]
103008438  IL1B; interleukin 1 beta [KO:K04519]
103002687  TGFB1; transforming growth factor beta 1 [KO:K13375]
103001453  TGFB2; transforming growth factor beta 2 [KO:K13376]
103001029  TGFB3; transforming growth factor beta 3 [KO:K13377]
103016474  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102998234  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
103002906  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
102999446  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
103005777  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102999836  FASLG; Fas ligand [KO:K04389]
103020508  FAS; Fas cell surface death receptor [KO:K04390]
103003188  CD14; CD14 molecule [KO:K04391]
103007995  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103006132  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
103019253  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
103008817  CDC42; cell division cycle 42 [KO:K04393]
102999164  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103019939  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103013880  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103003048  DAXX; death domain associated protein [KO:K02308]
103011989  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102998365  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103013107  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103018592  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
103012188  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
103016967  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
103020367  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
103016005  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102997501  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
103001151  ECSIT; ECSIT signalling integrator [KO:K04405]
102997823  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
102999904  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
103019395  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
103010714  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
103006340  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
103005053  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
103007242  STK4; serine/threonine kinase 4 [KO:K04411]
103012811  STK3; serine/threonine kinase 3 [KO:K04412]
102999241  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
103010611  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103002185  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103004845  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
103017845  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102999255  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103019037  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
103005548  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
103001803  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
103011832  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
103020592  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
103018600  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
103015628  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
102999328  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103019299  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103006512  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
103008281  TAOK2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
103010904  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
103013371  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
103012105  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103011683  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103019100  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103012537  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103016156  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
103005927  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
103000025  FLNA; filamin A [KO:K04437]
103020871  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
103001411  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
103021082  ARRB2; arrestin beta 2 [KO:K04439]
103017343  ARRB1; arrestin beta 1 [KO:K04439]
102997603  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103007019  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103008728  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103009947  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102999798  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
103002378  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103008537  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103007521  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
102999332  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103001513  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102999918  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
103003842  RPS6KA4; ribosomal protein S6 kinase A4 [KO:K16510] [EC:2.7.11.1]
103012203  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
102999338  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
103017260  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
103001311  transcription factor AP-1-like [KO:K04448]
103014668  transcription factor AP-1-like [KO:K04448]
103008424  JUND; JunD proto-oncogene, AP-1 transcription factor subunit [KO:K04449]
102999133  ATF2; activating transcription factor 2 [KO:K04450]
103003426  TP53; tumor protein p53 [KO:K04451]
103018481  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102999653  MAX; MYC associated factor X [KO:K04453]
103010647  MEF2C; myocyte enhancer factor 2C [KO:K04454]
103010521  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
103002026  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103013147  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103004139  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103004855  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
103009977  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
103005705  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
103013076  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
103004641  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103020012  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103001364  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103007545  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103018532  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103009109  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103020779  DUSP2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103001134  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102998542  DUSP9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
103018451  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103015242  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103010488  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103019527  PPP5C; protein phosphatase 5 catalytic subunit [KO:K04460] [EC:3.1.3.16]
103010033  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
103008337  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
103019729  heat shock 70 kDa protein 1B-like [KO:K03283]
103020014  heat shock 70 kDa protein 1B-like [KO:K03283]
103020298  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
103008158  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
103019868  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
102999884  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
103020888  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103015859  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103015414  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103015119  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103017855  NF-kappa-B essential modulator-like [KO:K07210]
103002389  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
102999230  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103015507  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
103019614  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102999202  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Reference
PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Gene 320:3-21 (2003)
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
bacu04070  Phosphatidylinositol signaling system
bacu04110  Cell cycle
bacu04115  p53 signaling pathway
bacu04210  Apoptosis
bacu04310  Wnt signaling pathway
bacu04668  TNF signaling pathway
KO pathway
ko04010   
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