KEGG   PATHWAY: bacu05216
Entry
bacu05216                   Pathway                                

Name
Thyroid cancer - Balaenoptera acutorostrata scammoni (minke whale)
Description
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
Class
Human Diseases; Cancer: specific types
Pathway map
bacu05216  Thyroid cancer
bacu05216

Organism
Balaenoptera acutorostrata scammoni (minke whale) [GN:bacu]
Gene
103006627  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
103012560  CCDC6; coiled-coil domain containing 6 [KO:K09288]
103003756  NCOA4; nuclear receptor coactivator 4 [KO:K09289]
103003654  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
103000535  TPM3; tropomyosin 3 [KO:K09290]
103004609  tropomyosin alpha-3 chain-like [KO:K09290]
103002139  tropomyosin alpha-3 chain-like [KO:K09290]
102997907  TPR; translocated promoter region, nuclear basket protein [KO:K09291]
103019960  TFG; TRK-fused gene [KO:K09292]
103006545  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103004931  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103015457  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103002372  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103017381  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103018627  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102999619  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103002590  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103010950  PAX8; paired box 8 [KO:K09293]
103013413  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
103005517  RXRA; retinoid X receptor alpha [KO:K08524]
103006710  RXRB; retinoid X receptor beta [KO:K08525]
103017600  RXRG; retinoid X receptor gamma [KO:K08526]
103003426  TP53; tumor protein p53 [KO:K04451]
103005082  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
103012188  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
103016967  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
103020367  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
103019528  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102999845  putative Bcl-2 homologous antagonist/killer 2-like [KO:K14021]
103017537  DDB2; damage specific DNA binding protein 2 [KO:K10140]
103009875  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
102999370  CDH1; cadherin 1 [KO:K05689]
103019097  CTNNB1; catenin beta 1 [KO:K02105]
103018264  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
103010166  TCF7L1; transcription factor 7 like 1 [KO:K04490]
103010923  TCF7L2; transcription factor 7 like 2 [KO:K04491]
103020844  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
103016933  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
103013404  CCND1; cyclin D1 [KO:K04503]
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Related
pathway
bacu03320  PPAR signaling pathway
bacu04010  MAPK signaling pathway
bacu04115  p53 signaling pathway
bacu04310  Wnt signaling pathway
bacu04520  Adherens junction
KO pathway
ko05216   
LinkDB

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