KEGG   PATHWAY: bamb00020
Entry
bamb00020                   Pathway                                

Name
Citrate cycle (TCA cycle) - Bacillus velezensis NAU-B3
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
bamb00020  Citrate cycle (TCA cycle)
bamb00020

Module
bamb_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:bamb00020]
bamb_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:bamb00020]
bamb_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:bamb00020]
bamb_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:bamb00020]
bamb_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:bamb00020]
Other DBs
GO: 0006099
Organism
Bacillus velezensis NAU-B3 [GN:bamb]
Gene
BAPNAU_2832  citA; citrate synthase I [KO:K01647] [EC:2.3.3.1]
BAPNAU_0935  citZ; citrate synthase [KO:K01647] [EC:2.3.3.1]
BAPNAU_1343  mmgD; citrate synthase 3 [KO:K01647] [EC:2.3.3.1]
BAPNAU_1962  acnA; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
BAPNAU_0936  icd; isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
BAPNAU_1833  sucA; 2-oxoglutarate dehydrogenase E1 component [KO:K00164] [EC:1.2.4.2]
BAPNAU_1834  odhB; dihydrolipoamide succinyltransferase [KO:K00658] [EC:2.3.1.61]
BAPNAU_1351  bfmbC; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BAPNAU_2308  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BAPNAU_0764  acoL; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BAPNAU_2158  sucD; succinyl-CoA synthetase subunit alpha [KO:K01902] [EC:6.2.1.5]
BAPNAU_2159  sucC; succinyl-CoA synthetase subunit beta [KO:K01903] [EC:6.2.1.5]
BAPNAU_1002  sdhA1; succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1 1.3.5.4]
BAPNAU_1003  sdhB; succinate dehydrogenase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1 1.3.5.4]
BAPNAU_1001  sdhC; succinate dehydrogenase cytochrome b-556 subunit [KO:K00241]
BAPNAU_3196  fumC; fumarate hydratase [KO:K01679] [EC:4.2.1.2]
BAPNAU_0937  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
BAPNAU_2282  pycB; pyruvate carboxylase subunit A [KO:K01958] [EC:6.4.1.1]
BAPNAU_2921  pckA; phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
BAPNAU_2311  pdhA; pyruvate dehydrogenase E1 component subunit alpha [KO:K00161] [EC:1.2.4.1]
BAPNAU_2310  pdhB; pyruvate dehydrogenase E1 component subunit beta [KO:K00162] [EC:1.2.4.1]
BAPNAU_2309  pdhC; pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [KO:K00627] [EC:2.3.1.12]
BAPNAU_0763  acoC; branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 2)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 3)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
bamb00010  Glycolysis / Gluconeogenesis
bamb00053  Ascorbate and aldarate metabolism
bamb00061  Fatty acid biosynthesis
bamb00071  Fatty acid degradation
bamb00220  Arginine biosynthesis
bamb00250  Alanine, aspartate and glutamate metabolism
bamb00280  Valine, leucine and isoleucine degradation
bamb00350  Tyrosine metabolism
bamb00471  D-Glutamine and D-glutamate metabolism
bamb00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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