KEGG   PATHWAY: bcig03440
Entry
bcig03440                   Pathway                                

Name
Homologous recombination - Candidatus Baumannia cicadellinicola B-GSS
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
bcig03440  Homologous recombination
bcig03440

Other DBs
GO: 0000724
Organism
Candidatus Baumannia cicadellinicola B-GSS [GN:bcig]
Gene
AB162_129  recJ; Single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
AB162_086  ssB; Single-stranded DNA-binding protein [KO:K03111]
AB162_181  recA; RecA protein [KO:K03553]
AB162_092  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
AB162_258  ruvA; Holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
AB162_257  ruvB; Holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
AB162_259  ruvC; Crossover junction endodeoxyribonuclease [KO:K01159] [EC:3.1.22.4]
AB162_090  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
AB162_494  recB; Exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
AB162_493  recC; Exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
AB162_495  recD; Exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
AB162_487  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
AB162_110  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
AB162_093  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
AB162_195  holA; DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
AB162_379  holB; DNA polymerase III delta prime subunit [KO:K02341] [EC:2.7.7.7]
AB162_421  dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
AB162_233  holC; DNA polymerase III chi subunit [KO:K02339] [EC:2.7.7.7]
AB162_570  holD; DNA polymerase III psi subunit [KO:K02344] [EC:2.7.7.7]
AB162_143  priA; Helicase PriA essential for oriC/DnaA-independent DNA replication [KO:K04066] [EC:3.6.4.-]
AB162_520  priN; Primosomal replication protein N [KO:K02686]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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