KEGG   PATHWAY: biu05217
Entry
biu05217                    Pathway                                

Name
Basal cell carcinoma - Bos indicus (zebu cattle)
Description
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
Class
Human Diseases; Cancer: specific types
Pathway map
biu05217  Basal cell carcinoma
biu05217

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109574238  TP53; cellular tumor antigen p53 [KO:K04451]
109577247  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
109561788  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109556176  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109563283  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109571977  apoptosis regulator BAX [KO:K02159]
109571778  BAX; apoptosis regulator BAX [KO:K02159]
109577301  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
109569541  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
109564642  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
109563237  PTCH1; protein patched homolog 1 [KO:K06225]
109557614  SMO; smoothened homolog isoform X1 [KO:K06226]
109575162  KIF7; kinesin-like protein KIF7 [KO:K18806]
109579160  SUFU; suppressor of fused homolog isoform X1 [KO:K06229]
109559320  GLI1; zinc finger protein GLI1 [KO:K16797]
109568632  GLI2; zinc finger protein GLI2 [KO:K16798]
109557558  GLI3; transcriptional activator GLI3 [KO:K06230]
109567176  BMP2; bone morphogenetic protein 2 [KO:K21283]
109565174  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
109570862  HHIP; hedgehog-interacting protein [KO:K06231]
109556373  PTCH2; protein patched homolog 2 isoform X1 [KO:K11101]
109558697  WNT1; proto-oncogene Wnt-1 [KO:K03209]
109555924  WNT2B; protein Wnt-2b [KO:K00182]
109557407  WNT2; protein Wnt-2 [KO:K00182]
109561352  WNT3A; protein Wnt-3a [KO:K00312]
109573450  WNT3; proto-oncogene Wnt-3 [KO:K00312]
109576138  WNT4; protein Wnt-4 [KO:K00408]
109576252  WNT5A; protein Wnt-5a [KO:K00444]
109559776  WNT5B; protein Wnt-5b [KO:K00444]
109570782  WNT6; protein Wnt-6 [KO:K00445]
109558644  WNT7B; protein Wnt-7b [KO:K00572]
109576501  WNT7A; protein Wnt-7a [KO:K00572]
109578990  WNT8B; protein Wnt-8b [KO:K00714]
109561268  WNT8A; protein Wnt-8a [KO:K00714]
109560806  WNT9A; protein Wnt-9a [KO:K01064]
109570791  WNT10A; protein Wnt-10a [KO:K01357]
109559150  WNT10B; protein Wnt-10b [KO:K01357]
109569843  WNT11; protein Wnt-11 [KO:K01384]
109558182  FZD1; frizzled-1 [KO:K02432]
109569613  FZD7; frizzled-7 [KO:K02432]
109574394  FZD2; frizzled-2 [KO:K02235]
109575114  LOW QUALITY PROTEIN: frizzled-3-like [KO:K02329]
109562801  FZD3; frizzled-3 [KO:K02329]
109554353  FZD4; frizzled-4 [KO:K02354]
109570198  FZD5; frizzled-5 [KO:K02375]
109567602  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
109568539  FZD6; frizzled-6 [KO:K02376]
109571551  FZD10; frizzled-10 [KO:K02842]
109578168  FZD9; frizzled-9 [KO:K02842]
109573933  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
109570328  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
109562775  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
109578518  AXIN1; axin-1 isoform X1 [KO:K02157]
109561990  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
109564604  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
109576112  CTNNB1; catenin beta-1 [KO:K02105]
109562015  TCF7; transcription factor 7 isoform X1 [KO:K02620]
109565564  TCF7L1; transcription factor 7-like 1 [KO:K04490]
109553057  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
109560266  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
Compound
C00187  Cholesterol
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Wu F, Zhang Y, Sun B, McMahon AP, Wang Y
  Title
Hedgehog Signaling: From Basic Biology to Cancer Therapy.
  Journal
Cell Chem Biol 24:252-280 (2017)
DOI:10.1016/j.chembiol.2017.02.010
Reference
  Authors
Otsuka A, Levesque MP, Dummer R, Kabashima K
  Title
Hedgehog signaling in basal cell carcinoma.
  Journal
J Dermatol Sci 78:95-100 (2015)
DOI:10.1016/j.jdermsci.2015.02.007
Related
pathway
biu04110  Cell cycle
biu04115  p53 signaling pathway
biu04310  Wnt signaling pathway
biu04340  Hedgehog signaling pathway
biu04350  TGF-beta signaling pathway
KO pathway
ko05217   
LinkDB

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