KEGG   PATHWAY: bom04630
bom04630                    Pathway                                

JAK-STAT signaling pathway - Bos mutus (wild yak)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
bom04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Bos mutus (wild yak) [GN:bom]
102272426  IL2; interleukin 2 [KO:K05429]
102275760  IL3; interleukin-3 [KO:K04736]
102272045  IL4; interleukin 4 [KO:K05430]
102272910  IL5; interleukin 5 [KO:K05428]
102287919  IL6; interleukin 6 [KO:K05405]
102286767  IL7; interleukin 7 [KO:K05431]
102269055  IL9; interleukin 9 [KO:K05432]
102270457  IL10; interleukin 10 [KO:K05443]
102264800  IL11; interleukin 11 [KO:K05417]
102276398  IL12A; interleukin 12A [KO:K05406]
102283689  IL12B; interleukin 12B [KO:K05425]
102272332  IL13; interleukin 13 [KO:K05435]
102276455  IL15; interleukin 15 [KO:K05433]
102277364  IL17D; interleukin 17D [KO:K05492]
102274357  IL19; interleukin 19 [KO:K05444]
102274073  IL20; interleukin 20 [KO:K22667]
102285740  IL21; interleukin 21 [KO:K05434]
102266530  IL22; interleukin 22 [KO:K05445]
102277988  IL23A; interleukin 23 subunit alpha [KO:K05426]
102273503  IL24; interleukin 24 [KO:K22668]
102266354  interferon alpha-1 [KO:K05414]
102267307  interferon alpha-B [KO:K05414]
102270981  interferon alpha-H [KO:K05414]
102286313  interferon alpha-A [KO:K05414]
102281344  interferon alpha-2 [KO:K05414]
102267762  interferon alpha-F [KO:K05414]
102285417  interferon alpha-H-like [KO:K05414]
102284581  interferon beta-2 [KO:K05415]
102282466  interferon beta-2 [KO:K05415]
102281065  interferon beta-2 [KO:K05415]
102280497  interferon beta-2 [KO:K05415]
102267095  IFNG; interferon gamma [KO:K04687]
102284743  IFNE; interferon epsilon [KO:K05442]
102277434  IFNK; interferon kappa [KO:K05441]
102271031  IFNL1; interferon lambda 1 [KO:K05447]
102282896  interferon omega-1 [KO:K05440]
102284300  interferon omega-1 [KO:K05440]
102266753  interferon omega-1 [KO:K05440]
102270408  interferon omega-1-like [KO:K05440]
102272108  interferon omega-1 [KO:K05440]
102272591  interferon omega-1-like [KO:K05440]
102286595  interferon omega-1 [KO:K05440]
102285750  interferon omega-1 [KO:K05440]
102270705  interferon omega-1 [KO:K05440]
102271825  interferon omega-1 [KO:K05440]
102284869  interferon omega-1-like [KO:K05440]
102285705  interferon tau [KO:K05440]
102267486  interferon omega-1 [KO:K05440]
102282615  interferon omega-1 [KO:K05440]
106701613  interferon omega-1-like [KO:K05440]
102271854  OSM; oncostatin M [KO:K05418]
102271576  LIF; leukemia inhibitory factor [KO:K05419]
106701499  cardiotrophin-2-like [KO:K24382]
102275474  CSF2; colony stimulating factor 2 [KO:K05427]
102270631  CNTF; ciliary neurotrophic factor [KO:K05420]
102272188  CSF3; colony stimulating factor 3 [KO:K05423]
102279821  EPO; erythropoietin [KO:K05437]
102271788  somatotropin [KO:K05438]
102276736  LEP; leptin [KO:K05424]
102275287  THPO; thrombopoietin [KO:K06854]
102275031  PRL; prolactin [KO:K05439]
102274562  chorionic somatomammotropin hormone 1 [KO:K05439]
102272572  chorionic somatomammotropin hormone 2 [KO:K05439]
102273139  placental prolactin-related protein 4 [KO:K05439]
102271434  placental prolactin-related protein 1 [KO:K05439]
102272287  placental prolactin-related protein 4 [KO:K05439]
102271714  placental prolactin-related protein 3 [KO:K05439]
102272860  placental prolactin-related protein 1 [KO:K05439]
102276948  chorionic somatomammotropin hormone 2 [KO:K05439]
102276676  chorionic somatomammotropin hormone 2-like [KO:K05439]
102269208  placental prolactin-related protein 3 [KO:K05439]
106701660  placental prolactin-related protein 1-like [KO:K05439]
102285914  EGF; epidermal growth factor [KO:K04357]
102271219  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102266290  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102274858  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
102284639  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
106700824  interleukin-2 receptor subunit beta-like [KO:K05069]
102266681  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
102279846  interleukin-3 receptor subunit alpha [KO:K04737]
102273764  IL4R; interleukin 4 receptor [KO:K05071]
102273605  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
102287439  IL6R; interleukin 6 receptor [KO:K05055]
102284629  IL7R; interleukin 7 receptor [KO:K05072]
102284739  interleukin-9 receptor-like [KO:K05073]
102274768  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
102275508  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
102277908  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
102286576  IL12RB1; interleukin 12 receptor subunit beta 1 [KO:K05063]
102265420  IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
102274749  IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
102264417  IL13RA2; interleukin 13 receptor subunit alpha 2 [KO:K05077]
102276746  IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
102275814  IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
102279525  IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
102274052  IL21R; interleukin 21 receptor [KO:K05075]
102284614  IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
102281719  IL22RA2; interleukin 22 receptor subunit alpha 2 [KO:K05139]
102266368  IL23R; interleukin 23 receptor [KO:K05065]
102287947  IL27RA; interleukin 27 receptor subunit alpha [KO:K19598]
102280532  IL6ST; interleukin 6 signal transducer [KO:K05060]
102275793  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
102275218  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
102275527  IFNGR1; interferon gamma receptor 1 [KO:K05132]
102281523  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102284161  IFNLR1; interferon lambda receptor 1 [KO:K05140]
102277729  OSMR; oncostatin M receptor [KO:K05057]
102272060  LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
102279274  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
102283329  CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
102279567  CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
102279969  CSF2RB; colony stimulating factor 2 receptor beta common subunit [KO:K04738]
102274942  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
102265298  EPOR; erythropoietin receptor [KO:K05079]
102268311  GHR; growth hormone receptor [KO:K05080]
102269476  LEPR; leptin receptor [KO:K05062]
102286871  MPL; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
102269313  PRLR; prolactin receptor [KO:K05081]
102269868  epidermal growth factor receptor [KO:K04361] [EC:]
102282598  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:]
102270608  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:]
102286137  JAK1; Janus kinase 1 [KO:K11217] [EC:]
102278692  JAK2; Janus kinase 2 [KO:K04447] [EC:]
102286011  JAK3; Janus kinase 3 [KO:K11218] [EC:]
102287266  TYK2; tyrosine kinase 2 [KO:K11219] [EC:]
102283508  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
102277710  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102282282  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
102283979  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
102282927  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
102283211  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
102287830  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
102283657  CISH; cytokine inducible SH2 containing protein [KO:K04701]
102268022  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
102273017  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
102270424  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
102266089  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
102280213  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
102270492  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
102268592  BCL2; BCL2, apoptosis regulator [KO:K02161]
102283384  MCL1; BCL2 family apoptosis regulator [KO:K02539]
102277523  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
102277355  BCL2L1; BCL2 like 1 [KO:K04570]
102271380  bcl-2-like protein 1 [KO:K04570]
102287943  PIM1; Pim-1 proto-oncogene, serine/threonine kinase [KO:K04702] [EC:]
102274304  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102270546  CCND1; cyclin D1 [KO:K04503]
102272576  CCND2; cyclin D2 [KO:K10151]
102268077  CCND3; cyclin D3 [KO:K10152]
102268672  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102272565  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:]
102281032  aldehyde oxidase 4-like [KO:K00157] [EC:]
102283927  aldehyde oxidase 2 [KO:K00157] [EC:]
102274398  GFAP; glial fibrillary acidic protein [KO:K05640]
102283569  STAM; signal transducing adaptor molecule [KO:K04705]
102266275  STAM2; signal transducing adaptor molecule 2 [KO:K04705]
102281612  PTPN2; protein tyrosine phosphatase, non-receptor type 2 [KO:K18026] [EC:]
102283821  PTPN6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:]
102274031  IRF9; interferon regulatory factor 9 [KO:K04693]
102264880  CREBBP; CREB binding protein [KO:K04498] [EC:]
102273007  EP300; E1A binding protein p300 [KO:K04498] [EC:]
102284133  PIAS1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-]
102281021  PIAS2; protein inhibitor of activated STAT 2 [KO:K16063] [EC:2.3.2.-]
102286484  PIAS3; protein inhibitor of activated STAT 3 [KO:K16064] [EC:2.3.2.-]
102271432  PIAS4; protein inhibitor of activated STAT 4 [KO:K16065] [EC:]
102268388  FHL1; four and a half LIM domains 1 [KO:K14365]
102276389  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:]
102286241  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102286943  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102277585  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102278591  GTPase HRas [KO:K02833]
102277011  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102288216  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:]
102274553  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:]
102274461  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:]
102277548  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:]
102266922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102280296  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102286868  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102275199  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:]
102265427  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:]
102283212  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:]
102281727  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
bom04010  MAPK signaling pathway
bom04060  Cytokine-cytokine receptor interaction
bom04110  Cell cycle
bom04120  Ubiquitin mediated proteolysis
bom04151  PI3K-Akt signaling pathway
bom04210  Apoptosis
KO pathway

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