KEGG   PATHWAY: bom05225
Entry
bom05225                    Pathway                                
Name
Hepatocellular carcinoma - Bos mutus (wild yak)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
bom05225  Hepatocellular carcinoma
bom05225

Organism
Bos mutus (wild yak) [GN:bom]
Gene
102264981  TGFA; transforming growth factor alpha [KO:K08774]
102269868  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102274689  IGF2; insulin like growth factor 2 [KO:K13769]
102278105  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102265099  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102285300  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102278724  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102274116  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102265831  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102286114  ELK1; ELK1, ETS transcription factor [KO:K04375]
102265814  SHC1; SHC adaptor protein 1 [KO:K06279]
102281047  SHC2; SHC adaptor protein 2 [KO:K17447]
102268950  SHC3; SHC adaptor protein 3 [KO:K17448]
102284488  SHC4; SHC adaptor protein 4 [KO:K17449]
102286241  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102286943  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102277585  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102278591  GTPase HRas [KO:K02833]
102277011  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102286500  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102269203  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102285079  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102278631  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102288216  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102280670  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102271710  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102272368  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102284931  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102274553  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102274461  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102277548  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102266922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102280296  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102286868  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102268478  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102275199  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102265427  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102283212  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102281727  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102285710  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102271079  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102275975  BAD; BCL2 associated agonist of cell death [KO:K02158]
102277355  BCL2L1; BCL2 like 1 [KO:K04570]
102271380  bcl-2-like protein 1 [KO:K04570]
102274304  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102267169  RB1; RB transcriptional corepressor 1 [KO:K06618]
102274863  E2F1; E2F transcription factor 1 [KO:K17454]
102268181  E2F2; E2F transcription factor 2 [KO:K09389]
102270876  E2F3; E2F transcription factor 3 [KO:K06620]
102272370  TP53; tumor protein p53 [KO:K04451]
102268672  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102276116  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
102266978  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102288000  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102279740  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102266544  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102272760  DDB2; damage specific DNA binding protein 2 [KO:K10140]
102269608  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
102284461  CDKN2A; cyclin dependent kinase inhibitor 2A [KO:K06621]
102278545  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102264992  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102270546  CCND1; cyclin D1 [KO:K04503]
102283357  TGFB1; transforming growth factor beta 1 [KO:K13375]
102283491  TGFB2; transforming growth factor beta 2 [KO:K13376]
102265567  TGFB3; transforming growth factor beta 3 [KO:K13377]
102283685  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
102267018  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102286495  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
102282627  SMAD3; SMAD family member 3 [KO:K23605]
102265995  SMAD4; SMAD family member 4 [KO:K04501]
102268143  WNT1; Wnt family member 1 [KO:K03209]
102285570  WNT2B; Wnt family member 2B [KO:K00182]
102288008  WNT2; Wnt family member 2 [KO:K00182]
102275609  WNT3A; Wnt family member 3A [KO:K00312]
102281377  WNT3; Wnt family member 3 [KO:K00312]
102269858  WNT4; Wnt family member 4 [KO:K00408]
102269211  WNT5A; Wnt family member 5A [KO:K00444]
102276467  WNT5B; Wnt family member 5B [KO:K00444]
102286828  WNT6; Wnt family member 6 [KO:K00445]
102279575  WNT7A; Wnt family member 7A [KO:K00572]
102284700  protein Wnt-7b-like [KO:K00572]
102287042  protein Wnt-7b [KO:K00572]
102285959  WNT8B; Wnt family member 8B [KO:K00714]
102285045  WNT8A; Wnt family member 8A [KO:K00714]
102278321  WNT9A; Wnt family member 9A [KO:K01064]
102283149  WNT9B; Wnt family member 9B [KO:K01064]
102276805  WNT10A; Wnt family member 10A [KO:K01357]
102267865  WNT10B; Wnt family member 10B [KO:K01357]
102266913  WNT11; Wnt family member 11 [KO:K01384]
102274851  WNT16; Wnt family member 16 [KO:K01558]
102269934  FZD1; frizzled class receptor 1 [KO:K02432]
102275255  FZD7; frizzled class receptor 7 [KO:K02432]
102277539  FZD2; frizzled class receptor 2 [KO:K02235]
102273339  FZD3; frizzled class receptor 3 [KO:K02329]
102286685  FZD4; frizzled class receptor 4 [KO:K02354]
102282966  FZD5; frizzled class receptor 5 [KO:K02375]
102276331  FZD8; frizzled class receptor 8 [KO:K02375]
102265247  FZD6; frizzled class receptor 6 [KO:K02376]
102267470  FZD10; frizzled class receptor 10 [KO:K02842]
102272449  FZD9; frizzled class receptor 9 [KO:K02842]
102277840  LRP6; LDL receptor related protein 6 [KO:K03068]
102268590  LRP5; LDL receptor related protein 5 [KO:K03068]
102273776  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102287954  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102280462  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102269752  FRAT1; proto-oncogene FRAT1 [KO:K03069]
102275260  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102267637  AXIN1; axin 1 [KO:K02157]
102278168  AXIN2; axin 2 [KO:K04385]
102282143  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102272116  APC; APC, WNT signaling pathway regulator [KO:K02085]
102275011  CTNNB1; catenin beta 1 [KO:K02105]
102283373  casein kinase I isoform beta [KO:K08957] [EC:2.7.11.1]
102272853  CSNK1A1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
102287257  casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
102269709  casein kinase I isoform beta [KO:K08957] [EC:2.7.11.1]
102266633  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
102281039  TCF7L1; transcription factor 7 like 1 [KO:K04490]
102272230  TCF7L2; transcription factor 7 like 2 [KO:K04491]
102266946  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
102288117  KEAP1; kelch like ECH associated protein 1 [KO:K10456]
102283500  NFE2L2; nuclear factor, erythroid 2 like 2 [KO:K05638]
102281265  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
102280865  NQO1; NAD(P)H quinone dehydrogenase 1 [KO:K00355] [EC:1.6.5.2]
102287938  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
102268301  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
102282708  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102283655  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102283179  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102281969  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102282430  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
102281683  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
102264374  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
102276470  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
102276661  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102278818  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102288314  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
102264698  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
102288026  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
102280813  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
102271019  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
102274807  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
102288177  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
102276933  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102272205  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
102271929  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
102266756  TXNRD1; thioredoxin reductase 1 [KO:K22182] [EC:1.8.1.9]
102275449  TXNRD2; thioredoxin reductase 2 [KO:K22182] [EC:1.8.1.9]
102287013  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
102267837  HGF; hepatocyte growth factor [KO:K05460]
102285634  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102282859  GAB1; GRB2 associated binding protein 1 [KO:K09593]
102285564  ACTG1; actin gamma 1 [KO:K05692]
102286048  ACTB; actin beta [KO:K05692]
102275881  ACTL6A; actin like 6A [KO:K11340]
102272555  ACTL6B; actin like 6B [KO:K11652]
102266927  SMARCD1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 [KO:K11650]
102272545  SMARCD2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 [KO:K11650]
102265195  SMARCD3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 [KO:K11650]
102267478  PHF10; PHD finger protein 10 [KO:K22197]
102288341  DPF1; double PHD fingers 1 [KO:K22198]
102284138  DPF3; double PHD fingers 3 [KO:K22198]
102271998  ARID1A; AT-rich interaction domain 1A [KO:K11653]
102283441  ARID1B; AT-rich interaction domain 1B [KO:K11653]
102277209  SMARCE1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [KO:K11651]
102277219  SMARCB1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 [KO:K11648]
102286078  SMARCC1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 [KO:K11649]
102284345  SMARCC2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 [KO:K11649]
102278305  SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [KO:K11647] [EC:5.6.2.-]
102281271  SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [KO:K11647] [EC:5.6.2.-]
102286912  ARID2; AT-rich interaction domain 2 [KO:K11765]
102268710  PBRM1; polybromo 1 [KO:K11757]
102266489  BRD7; bromodomain containing 7 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
bom04010  MAPK signaling pathway
bom04020  Calcium signaling pathway
bom04110  Cell cycle
bom04115  p53 signaling pathway
bom04151  PI3K-Akt signaling pathway
bom04310  Wnt signaling pathway
bom04350  TGF-beta signaling pathway
bom04932  Non-alcoholic fatty liver disease
bom04936  Alcoholic liver disease
bom05160  Hepatitis C
bom05161  Hepatitis B
KO pathway
ko05225   
LinkDB

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