KEGG   PATHWAY: chx04151
Entry
chx04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Capra hircus (goat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
chx04151  PI3K-Akt signaling pathway
chx04151

Other DBs
GO: 0043491
Organism
Capra hircus (goat) [GN:chx]
Gene
106502173  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102185926  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102183226  EREG; proepiregulin isoform X1 [KO:K09784]
102180661  AREG; amphiregulin isoform X3 [KO:K09782]
102188850  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102186892  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
102171226  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
102179273  FGF16; fibroblast growth factor 16 [KO:K04358]
102178454  FGF7; fibroblast growth factor 7 [KO:K04358]
102171599  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
102169384  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102180381  FGF6; fibroblast growth factor 6 [KO:K04358]
102169602  FGF9; fibroblast growth factor 9 [KO:K04358]
102178396  FGF18; fibroblast growth factor 18 [KO:K04358]
102174339  FGF10; fibroblast growth factor 10 [KO:K04358]
102179261  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
108634211  FGF3; fibroblast growth factor 3 [KO:K04358]
102170206  FGF4; fibroblast growth factor 4 [KO:K04358]
102171403  FGF20; fibroblast growth factor 20 [KO:K04358]
102169942  FGF19; fibroblast growth factor 19 [KO:K22603]
102185860  FGF21; fibroblast growth factor 21 [KO:K22429]
102168896  FGF23; fibroblast growth factor 23 [KO:K22428]
100862660  NGF; beta-nerve growth factor precursor [KO:K02582]
102180782  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102178804  NTF3; neurotrophin-3 [KO:K04356]
102181070  NTF4; neurotrophin-4 [KO:K12457]
108634241  INS; insulin [KO:K04526]
100860838  IGF1; insulin-like growth factor I precursor [KO:K05459]
100861277  IGF2; insulin-like growth factor II isoform 2 precursor [KO:K13769]
102174268  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102184232  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
102168651  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102168934  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102185051  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100860807  KITLG; kit ligand precursor [KO:K05461]
102169895  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100860957  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
102189099  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102169297  PGF; placenta growth factor isoform X1 [KO:K16859]
102185645  VEGFD; vascular endothelial growth factor D [KO:K05449]
102189826  VEGFC; vascular endothelial growth factor C [KO:K05449]
102183288  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102189773  ANGPT1; angiopoietin-1 [KO:K05465]
102186656  ANGPT2; angiopoietin-2 [KO:K05466]
102180406  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
102184717  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102178126  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102177853  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102168502  EFNA1; ephrin-A1 [KO:K05462]
106502352  EFNA2; ephrin-A2 [KO:K05462]
102169798  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
108634739  neurturin [KO:K25414]
106501979  ARTN; artemin [KO:K25415]
102190215  PSPN; persephin [KO:K25416]
102172767  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102181989  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102173448  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102180167  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102180282  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102170938  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102183685  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102190168  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102172584  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102180223  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102168996  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100861165  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102174007  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102184426  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100861303  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100861386  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
102189319  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100860837  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
102180480  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100860836  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102181186  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
102169100  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102185411  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102172412  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102170356  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102185660  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102184154  SOS2; son of sevenless homolog 2 [KO:K03099]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102187180  NRAS; GTPase NRas [KO:K07828]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102184858  IRS1; insulin receptor substrate 1 [KO:K16172]
100860747  TLR2; toll-like receptor 2 precursor [KO:K10159]
100860955  TLR4; toll-like receptor 4 precursor [KO:K10160]
102173438  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102174120  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
102180277  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
102172864  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
100861230  GH1; somatotropin precursor [KO:K05438]
108638229  somatotropin-like [KO:K05438]
102190477  chorionic somatomammotropin hormone 2-like [KO:K05439]
100861397  PRP6; prolactin-related protein-6 precursor [KO:K05439]
100860766  PRP1; prolactin-related protein-1 precursor [KO:K05439]
102170569  placental prolactin-related protein 4-like [KO:K05439]
108638107  chorionic somatomammotropin hormone 2-like [KO:K05439]
102171116  placental prolactin-related protein 3-like [KO:K05439]
102184390  chorionic somatomammotropin hormone 2-like [KO:K05439]
102178616  placental prolactin-related protein 1-like [KO:K05439]
102180550  placental prolactin-related protein 3-like [KO:K05439]
102188790  OSM; oncostatin-M [KO:K05418]
102183089  IL2; interleukin-2 precursor [KO:K05429]
102190507  interleukin-3 isoform X2 [KO:K04736]
100860785  IL6; interleukin-6 precursor [KO:K05405]
100860814  IL4; interleukin-4 precursor [KO:K05430]
102182054  IL7; interleukin-7 [KO:K05431]
108635529  interferon alpha-H-like [KO:K05414]
108633160  interferon alpha-1-like [KO:K05414]
100860850  IFNA; interferon-alpha precursor [KO:K05414]
102174842  interferon alpha-1-like [KO:K05414]
102179943  interferon alpha-H-like [KO:K05414]
102180761  interferon alpha-H [KO:K05414]
102181299  interferon alpha-H-like [KO:K05414]
108636621  interferon alpha-H-like [KO:K05414]
108636627  interferon alpha-H-like [KO:K05414]
102181867  interferon beta-2 [KO:K05415]
102189208  LOW QUALITY PROTEIN: interferon beta-2 [KO:K05415]
102181595  interferon beta-2-like [KO:K05415]
108636544  interferon beta-2-like [KO:K05415]
108636629  interferon beta-2-like [KO:K05415]
108636632  interferon beta-2-like [KO:K05415]
108636634  interferon beta-2 [KO:K05415]
108633243  interferon beta-2-like [KO:K05415]
102180175  EPO; erythropoietin [KO:K05437]
102185602  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
100860790  GHR; growth hormone receptor precursor [KO:K05080]
100861318  PRLR; prolactin receptor precursor [KO:K05081]
102184003  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
102170059  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102169656  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102178527  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
102179824  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102176382  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102175248  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
102191552  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102175057  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102191790  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
102175546  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
102182846  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102180670  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102171504  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100860828  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
108634775  basic proline-rich protein-like [KO:K06236]
100860940  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100860743  COL2A1; collagen alpha-1(II) chain [KO:K19719]
102176677  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
102176947  COL4A5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
108633195  collagen alpha-6(IV) chain-like [KO:K06237]
102171347  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102171079  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102190083  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102190364  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102178669  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
102191085  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102191378  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102178401  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
102169643  COL6A3; collagen alpha-3(VI) chain isoform X5 [KO:K06238]
102185378  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
102188580  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102186825  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
102187050  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102176003  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
102171801  LAMA5; laminin subunit alpha-5 [KO:K06240]
102190835  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102177440  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102176661  LAMB1; laminin subunit beta-1 [KO:K05636]
102183372  laminin subunit beta-2 isoform X1 [KO:K06243]
102179246  laminin subunit beta-2 [KO:K06243]
102168376  LAMB3; laminin subunit beta-3 [KO:K06244]
102174902  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
102170256  LAMC1; laminin subunit gamma-1 [KO:K05635]
102170540  LAMC2; laminin subunit gamma-2 [KO:K06246]
102184914  LAMC3; laminin subunit gamma-3 [KO:K06247]
102176727  CHAD; chondroadherin [KO:K06248]
102172966  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100860971  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
102179675  THBS4; thrombospondin-4 [KO:K04659]
102179674  THBS2; thrombospondin-2 [KO:K04659]
102190652  THBS3; thrombospondin-3 [KO:K04659]
102190117  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
102182645  FN1; fibronectin isoform X1 [KO:K05717]
100860805  SPP1; osteopontin precursor [KO:K06250]
100861216  VTN; vitronectin [KO:K06251]
102181229  TNN; tenascin-N [KO:K06252]
102181525  TNR; tenascin-R [KO:K06252]
102174446  TNXB; tenascin-X isoform X1 [KO:K06252]
102179198  TNC; tenascin isoform X1 [KO:K06252]
102191119  VWF; von Willebrand factor [KO:K03900]
102175843  IBSP; bone sialoprotein 2 [KO:K06253]
102172761  ITGA1; integrin alpha-1 [KO:K06480]
102172198  ITGA2; integrin alpha-2 [KO:K06481]
102183451  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
102185499  ITGA3; integrin alpha-3 [KO:K06482]
102183190  ITGA4; integrin alpha-4 [KO:K06483]
102176587  ITGA5; integrin alpha-5 [KO:K06484]
102186530  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102169839  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
102181695  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102174073  ITGA9; integrin alpha-9 [KO:K06585]
102185415  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102171074  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
102187813  ITGAV; integrin alpha-V precursor [KO:K06487]
102178060  ITGB1; integrin beta-1 precursor [KO:K05719]
102169417  ITGB3; integrin beta-3 [KO:K06493]
102191175  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102173608  ITGB5; integrin beta-5 [KO:K06588]
102188539  ITGB6; integrin beta-6 precursor [KO:K06589]
102180190  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
102191301  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
102177814  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102187491  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
102187843  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102169456  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102189399  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102187119  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102186820  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102184511  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102189196  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102183611  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102187070  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102169841  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102191178  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102174574  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102189312  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
102184123  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102170665  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102190485  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102183232  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102189040  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106502450  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102186081  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102182581  uncharacterized LOC105372280 homolog [KO:K04347]
102175543  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102190190  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X2 [KO:K04547]
102185427  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
102190164  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102173256  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
102172758  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
102172481  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
102184966  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102188214  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
102171295  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102181338  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102176667  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102178739  TSC1; hamartin [KO:K07206]
100860943  TSC2; tuberin [KO:K07207]
100861308  RHEB; GTP-binding protein Rheb [KO:K07208]
100861036  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100860902  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102173122  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100861234  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102184413  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102177054  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102180441  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100861297  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
102169319  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
102182675  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102181269  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
102184058  RPS6; 40S ribosomal protein S6 [KO:K02991]
102180890  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102172617  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
102183285  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
102191148  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
102176607  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
102190431  SGK2; serine/threonine-protein kinase Sgk2 isoform X2 [KO:K13303] [EC:2.7.11.1]
102172279  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102178670  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9 [KO:K05631]
106502021  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
102185891  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102190188  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
102175016  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108637886  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102182013  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102170070  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102182533  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102181952  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102170971  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
102188298  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102177705  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
102191740  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102182916  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
102182878  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
102185489  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102169526  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
100861365  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
102171557  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100860851  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100861006  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102179454  HSP90B1; endoplasmin [KO:K09487]
102182400  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
102180907  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
102178032  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
102180148  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
102187352  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
102186807  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
102186099  MTCP1; protein p13 MTCP-1 [KO:K16837]
102185338  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
102173121  BRCA1; breast cancer type 1 susceptibility protein isoform X3 [KO:K10605] [EC:2.3.2.27]
102176363  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102189015  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
102188970  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
102179952  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
102168742  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
102174704  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
102179979  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
102170730  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
102171262  MYC; myc proto-oncogene protein [KO:K04377]
102169650  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102179898  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102175277  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100860751  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102171306  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102180182  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102180657  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102190470  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102185672  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
102184185  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102188676  FOXO3; forkhead box protein O3 [KO:K09408]
102181890  RBL2; retinoblastoma-like protein 2 [KO:K16332]
102178753  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102171716  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
102186877  YWHAQ; 14-3-3 protein theta [KO:K16197]
102175223  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
102172459  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
102177369  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
102174417  YWHAH; 14-3-3 protein eta [KO:K16198]
102182657  YWHAG; 14-3-3 protein gamma [KO:K16198]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102180684  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102183607  bcl-2-like protein 1 [KO:K04570]
100861254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102174681  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102186065  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102180634  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
102185072  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102180221  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102174829  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102183745  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102183893  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102170199  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102190378  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102171671  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
102185798  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
108634606  retinoic acid receptor RXR-alpha [KO:K08524]
102185438  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102174096  RELA; transcription factor p65 [KO:K04735]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102171339  MYB; transcriptional activator Myb isoform X2 [KO:K09420]
102173163  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
102169621  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
chx00010  Glycolysis / Gluconeogenesis
chx04010  MAPK signaling pathway
chx04012  ErbB signaling pathway
chx04062  Chemokine signaling pathway
chx04064  NF-kappa B signaling pathway
chx04068  FoxO signaling pathway
chx04110  Cell cycle
chx04115  p53 signaling pathway
chx04150  mTOR signaling pathway
chx04210  Apoptosis
chx04370  VEGF signaling pathway
chx04510  Focal adhesion
chx04620  Toll-like receptor signaling pathway
chx04630  JAK-STAT signaling pathway
chx04662  B cell receptor signaling pathway
chx04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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