KEGG   PATHWAY: cmy04530
Entry
cmy04530                    Pathway                                
Name
Tight junction - Chelonia mydas (green sea turtle)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
cmy04530  Tight junction
cmy04530

Other DBs
GO: 0005923
Organism
Chelonia mydas (green sea turtle) [GN:cmy]
Gene
102941318  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
102947753  claudin-34-like [KO:K06087]
102946962  claudin-9 [KO:K06087]
102935044  claudin-8-like [KO:K06087]
102938800  claudin-8-like [KO:K06087]
102944105  CLDN14; claudin-14 [KO:K06087]
102934722  claudin-4 [KO:K06087]
102948104  claudin-3 [KO:K06087]
102941767  CLDN11; claudin-11 [KO:K06087]
102944049  CLDN5; claudin-5 [KO:K06087]
102934946  claudin-4 [KO:K06087]
102935178  claudin-3-like [KO:K06087]
102938171  CLDN20; claudin-20 [KO:K06087]
102935741  CLDN16; claudin-16 [KO:K06087]
102940219  CLDN1; claudin-1 [KO:K06087]
102944952  CLDN18; claudin-18 [KO:K06087]
102932433  CLDN25; putative claudin-25 [KO:K06087]
102931399  claudin-23 [KO:K06087]
102940394  claudin-19-like isoform X1 [KO:K06087]
102935319  claudin-22 [KO:K06087]
102948210  CLDN2; claudin-2 [KO:K06087]
102929698  CLDN23; claudin-23 [KO:K06087]
102931935  CLDN19; claudin-19 isoform X2 [KO:K06087]
102946573  CLDN10; claudin-10 isoform X1 [KO:K06087]
114019565  claudin-34-like [KO:K06087]
102945782  CLDN12; LOW QUALITY PROTEIN: claudin-12 [KO:K06087]
102945690  CLDN15; claudin-15 isoform X1 [KO:K06087]
119566114  claudin-22-like [KO:K06087]
119566276  claudin-4 [KO:K06087]
114019562  LOW QUALITY PROTEIN: claudin-34-like [KO:K06087]
102938809  occludin isoform X1 [KO:K06088]
102940879  OCLN; occludin [KO:K06088]
102939532  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
102940123  JAM2; junctional adhesion molecule B [KO:K06735]
102940251  JAM3; junctional adhesion molecule C [KO:K06785]
102941742  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
102931327  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102937533  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102930784  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102946694  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
102935660  PALS1; protein PALS1 isoform X1 [KO:K06091]
102930683  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
102947764  TJP3; tight junction protein ZO-3 isoform X2 [KO:K06097]
102939647  PATJ; inaD-like protein isoform X2 [KO:K06092]
102938225  MPDZ; multiple PDZ domain protein isoform X9 [KO:K06095]
102936764  PRKCZ; protein kinase C zeta type isoform X5 [KO:K18952] [EC:2.7.11.13]
102942221  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
102945497  AMOT; angiomotin [KO:K16819]
102945951  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
102944058  AMOTL2; angiomotin-like protein 2 [KO:K06104]
102941856  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
102945867  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102939269  merlin isoform X1 [KO:K16684]
119563755  NF2; merlin isoform X1 [KO:K16684]
102944652  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
102946318  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
102946800  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
102936128  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
102945505  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
122461304  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102937853  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102938384  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
102931164  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102930979  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
102931325  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102936016  PARD3; partitioning defective 3 homolog isoform X2 [KO:K04237]
102934808  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
102946392  TJP1; tight junction protein ZO-1 isoform X4 [KO:K05701]
102941078  TJAP1; tight junction-associated protein 1 isoform X2 [KO:K06105]
102936277  DLG2; disks large homolog 2 isoform X4 [KO:K12075]
102940428  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
102941997  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
102934363  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
102931485  CGN; cingulin isoform X2 [KO:K06102]
102943031  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
102935687  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X2 [KO:K12791]
102933456  transforming protein RhoA isoform X2 [KO:K04513]
102939658  RHOA; transforming protein RhoA [KO:K04513]
102931342  GATA4; transcription factor GATA-4 [KO:K09183]
102932217  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
102947366  MARVEL domain-containing protein 3 isoform X2 [KO:K21099]
102938448  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
102935187  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102934812  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
102932835  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
102937264  JUN; transcription factor AP-1 [KO:K04448]
102935654  T-cell surface glycoprotein CD1b-3 [KO:K06448]
102933531  LOW QUALITY PROTEIN: antigen-presenting glycoprotein CD1d2 [KO:K06448]
119567606  antigen-presenting glycoprotein CD1d-like isoform X3 [KO:K06448]
119567607  antigen-presenting glycoprotein CD1d-like isoform X1 [KO:K06448]
119567767  antigen-presenting glycoprotein CD1d-like [KO:K06448]
114022627  antigen-presenting glycoprotein CD1d [KO:K06448]
119567357  antigen-presenting glycoprotein CD1d-like [KO:K06448]
119567358  antigen-presenting glycoprotein CD1d [KO:K06448]
119567359  antigen-presenting glycoprotein CD1d2-like isoform X1 [KO:K06448]
102936252  CFTR; cystic fibrosis transmembrane conductance regulator isoform X2 [KO:K05031] [EC:5.6.1.6]
102945436  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
102932249  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
102945453  SYMPK; symplekin isoform X1 [KO:K06100]
102945568  PCNA; proliferating cell nuclear antigen [KO:K04802]
102947923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102946701  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102944269  RUNX1; runt-related transcription factor 1 isoform X2 [KO:K08367]
102936364  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
102929514  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
102930116  EZR; ezrin [KO:K08007]
102934180  RDX; radixin [KO:K05762]
102932652  MSN; moesin [KO:K05763]
102936130  PRKCE; protein kinase C epsilon type isoform X3 [KO:K18050] [EC:2.7.11.13]
102941355  ACTL8; actin-like protein 8 isoform X2 [KO:K05692]
102930389  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102932532  actin, cytoplasmic type 5 [KO:K05692]
102937126  ACTB; actin, cytoplasmic 1 isoform X2 [KO:K05692]
102932311  actin, cytoplasmic type 5 [KO:K05692]
102934751  ACTBL2; LOW QUALITY PROTEIN: beta-actin-like protein 2 [KO:K05692]
102934282  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102936034  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X3 [KO:K04426] [EC:2.7.11.25]
102932325  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X9 [KO:K04431] [EC:2.7.12.2]
102939716  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102930885  CTTN; src substrate cortactin isoform X3 [KO:K06106]
102936302  HCLS1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
102930625  actin-related protein 2-B [KO:K17260]
102933572  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
102947890  ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
102943280  ACTR3; actin-related protein 3 [KO:K18584]
102938039  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102938264  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102934111  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
102931677  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102940324  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102931984  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102942455  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102930656  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
102938058  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
119564388  LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
102930962  cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
102943305  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102937534  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
102937758  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
119564816  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X2 [KO:K04345] [EC:2.7.11.11]
102947112  RAB13; ras-related protein Rab-13 [KO:K06109]
102933383  ARHGEF18; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 18 [KO:K21066]
102937514  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
102934710  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
102937866  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
102946997  EPB41L4B; band 4.1-like protein 4B isoform X2 [KO:K21111]
102947941  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
102944011  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102940952  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102931879  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X2 [KO:K07199]
119566970  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
102936816  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
102929680  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X2 [KO:K07200]
102943724  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
102930248  MYH10; myosin-10 isoform X2 [KO:K10352]
102939216  MYH9; myosin-9 [KO:K10352]
102936944  MYH11; myosin-11 isoform X2 [KO:K10352]
102930806  myosin light polypeptide 6 [KO:K12751]
102931032  myosin light polypeptide 6 [KO:K12751]
119563556  myosin light polypeptide 6 isoform X1 [KO:K12751]
119564289  myosin light polypeptide 6-like [KO:K12751]
102934098  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102937279  myosin regulatory light chain 12B isoform X1 [KO:K12757]
102938771  MYL12B; myosin regulatory light chain 12B [KO:K12757]
102938119  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
102939476  SYNPO; synaptopodin [KO:K21112]
102932714  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
102929632  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102941280  MICALL2; MICAL-like protein 2 isoform X8 [KO:K21068]
102930684  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
102940114  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
102934455  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X2 [KO:K08020]
102948045  RAP1A; ras-related protein Rap-1A [KO:K04353]
102946836  ITGB1; integrin beta-1 [KO:K05719]
102929950  AFDN; afadin isoform X1 [KO:K05702]
102946647  TJP2; tight junction protein ZO-2 isoform X6 [KO:K06098]
102941224  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102943257  RAP2C; ras-related protein Rap-2c [KO:K07839]
102944207  MARVELD2; MARVEL domain-containing protein 2 isoform X3 [KO:K17291]
102934360  tubulin alpha-1D chain [KO:K07374]
102933217  tubulin alpha-4A chain [KO:K07374]
102942563  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
102932498  tubulin alpha-3 chain isoform X1 [KO:K07374]
102932721  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
102934833  tubulin alpha-8 chain isoform X1 [KO:K07374]
102948258  tubulin alpha-3 chain isoform X1 [KO:K07374]
102937969  tubulin alpha-1B chain isoform X1 [KO:K07374]
102938196  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102938418  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102932947  tubulin alpha-3 chain isoform X1 [KO:K07374]
102942344  tubulin alpha-8 chain [KO:K07374]
102946649  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
cmy04520  Adherens junction
cmy04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

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