KEGG   PATHWAY: dme04013
Entry
dme04013                    Pathway                                

Name
MAPK signaling pathway - fly - Drosophila melanogaster (fruit fly)
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
dme04013  MAPK signaling pathway - fly
dme04013

Other DBs
GO: 0000165
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG6705  tsl; torso-like, isoform C [KO:K12377]
Dmel_CG5619  trk; trunk [KO:K20226]
Dmel_CG4790  fs(1)M3; female sterile (1) M3 [KO:K20227]
Dmel_CG11411  fs(1)N; female sterile (1) nasrat [KO:K20228]
Dmel_CG1389  tor; torso, isoform A [KO:K12378] [EC:2.7.10.1]
Dmel_CG4531  aos; argos [KO:K02104]
Dmel_CG10491  vn; vein, isoform A [KO:K16690]
Dmel_CG10334  spi; spitz, isoform G [KO:K20229]
Dmel_CG17610  grk; gurken [KO:K02447]
Dmel_CG32179  Krn; keren [KO:K16691]
Dmel_CG10079  Egfr; epidermal growth factor receptor, isoform B [KO:K04361] [EC:2.7.10.1]
Dmel_CG12283  kek1; kekkon 1, isoform C [KO:K20230]
Dmel_CG8285  boss; bride of sevenless [KO:K04623]
Dmel_CG18085  sev; sevenless [KO:K05088] [EC:2.7.10.1]
Dmel_CG3715  Shc; SHC-adaptor protein [KO:K06279]
Dmel_CG6033  drk; downstream of receptor kinase, isoform A [KO:K04364]
Dmel_CG1044  dos; daughter of sevenless, isoform A [KO:K20231]
Dmel_CG3954  csw; corkscrew, isoform A [KO:K07293] [EC:3.1.3.48]
Dmel_CG7793  Sos; Son of sevenless [KO:K03099]
Dmel_CG1921  sty; sprouty, isoform B [KO:K17383]
Dmel_CG9375  Ras85D; Ras oncogene at 85D [KO:K07827]
Dmel_CG9209  vap; vacuolar peduncle, isoform E [KO:K04352]
Dmel_CG6721  RasGAP1; Ras GTPase activating protein 1, isoform A [KO:K12380]
Dmel_CG2845  Raf; Raf oncogene, isoform E [KO:K04365] [EC:2.7.11.1]
Dmel_CG17870  14-3-3zeta; 14-3-3zeta, isoform J [KO:K16197]
Dmel_CG7109  mts; microtubule star, isoform B [KO:K04382] [EC:3.1.3.16]
Dmel_CG6556  cnk; connector enhancer of ksr, isoform B [KO:K17536]
Dmel_CG2899  ksr; kinase suppressor of ras, isoform B [KO:K18529] [EC:2.7.11.1]
Dmel_CG15793  Dsor1; downstream of raf1, isoform A [KO:K04368] [EC:2.7.12.2]
Dmel_CG12559  rl; rolled, isoform C [KO:K04371] [EC:2.7.11.24]
Dmel_CG9856  PTP-ER; protein tyrosine phosphatase-ERK/Enhancer of Ras1 [KO:K20220] [EC:3.1.3.48]
Dmel_CG7935  msk; moleskin [KO:K20223]
Dmel_CG43122  cic; capicua, isoform B [KO:K20225]
Dmel_CG1378  tll; tailless [KO:K08545]
Dmel_CG8384  gro; groucho, isoform E [KO:K04497]
Dmel_CG9768  hkb; huckebein [KO:K12379]
Dmel_CG17077  pnt; pointed, isoform B [KO:K02678]
Dmel_CG3166  aop; anterior open, isoform C [KO:K03211]
Dmel_CG15085  edl; ETS-domain lacking [KO:K20232]
Dmel_CG13387  emb; embargoed, isoform B [KO:K14290]
Dmel_CG1856  ttk; tramtrack, isoform G [KO:K09237]
Dmel_CG10108  phyl; phyllopod [KO:K20233]
Dmel_CG9949  sina; seven in absentia, isoform C [KO:K04506] [EC:2.3.2.27]
Dmel_CG13030  sinah; sina homologue [KO:K04506] [EC:2.3.2.27]
Dmel_CG4063  ebi; ebi [KO:K04508]
Dmel_CG7425  eff; effete, isoform B [KO:K06689] [EC:2.3.2.23]
Dmel_CG1689  lz; lozenge, isoform A [KO:K20214]
Dmel_CG17228  pros; prospero, isoform M [KO:K20211]
Dmel_CG12919  egr; eiger, isoform A [KO:K16678]
Dmel_CG6531  wgn; wengen, isoform A [KO:K16679]
Dmel_CG2079  Dok; downstream of kinase [KO:K20234]
Dmel_CG44128  Src42A; Src oncogene at 42A, isoform A [KO:K08892] [EC:2.7.10.2]
Dmel_CG7524  Src64B; Src oncogene at 64B, isoform D [KO:K05704] [EC:2.7.10.2]
Dmel_CG8049  Btk29A; Btk family kinase at 29A, isoform E [KO:K07364] [EC:2.7.10.2]
Dmel_CG18247  Shark; SH2 ankyrin repeat kinase [KO:K17512] [EC:2.7.10.2]
Dmel_CG16973  msn; misshapen, isoform F [KO:K08840] [EC:2.7.11.1]
Dmel_CG2248  Rac1; Rac1, isoform B [KO:K04392]
Dmel_CG9366  RhoL; Rho-like, isoform A [KO:K04392]
Dmel_CG5588  Mtl; Mig-2-like, isoform B [KO:K04392]
Dmel_CG8556  Rac2; Rac2, isoform B [KO:K04392]
Dmel_CG10961  Traf6; TNF-receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
Dmel_CG5603  CYLD; cylindromatosis, isoform E [KO:K08601] [EC:3.4.19.12]
Dmel_CG7417  Tab2; TAK1-associated binding protein 2, isoform B [KO:K04404]
Dmel_CG2272  slpr; slipper, isoform C [KO:K04417] [EC:2.7.11.25]
Dmel_CG18492  Tak1; TGF-beta activated kinase 1, isoform A [KO:K04427] [EC:2.7.11.25]
Dmel_CG4803  Takl2; Tak1-like 2 [KO:K04427] [EC:2.7.11.25]
Dmel_CG31421  Takl1; Tak1-like 1 [KO:K04427] [EC:2.7.11.25]
Dmel_CG6036  CG6036; uncharacterized protein [KO:K04461] [EC:3.1.3.16]
Dmel_CG1906  alph; alphabet, isoform F [KO:K04461] [EC:3.1.3.16]
Dmel_CG4353  hep; hemipterous, isoform A [KO:K04431] [EC:2.7.12.2]
Dmel_CG9738  Mkk4; MAP kinase kinase 4, isoform B [KO:K04430] [EC:2.7.12.2]
Dmel_CG5680  bsk; basket, isoform F [KO:K04440] [EC:2.7.11.24]
Dmel_CG7392  Cka; connector of kinase to AP-1, isoform E [KO:K17608]
Dmel_CG2275  Jra; Jun-related antigen, isoform A [KO:K04448]
Dmel_CG33956  kay; kayak, isoform F [KO:K09031]
Dmel_CG12212  peb; pebbled, isoform B [KO:K20210]
Dmel_CG12437  raw; raw, isoform C [KO:K20235]
Dmel_CG9885  dpp; decapentaplegic, isoform A [KO:K04662]
Dmel_CG9553  chic; chickadee, isoform E [KO:K05759]
Dmel_CG7850  puc; puckered, isoform B [KO:K20216] [EC:3.1.3.16 3.1.3.48]
Dmel_CG5123  hid; head involution defective, isoform B [KO:K20016]
Dmel_CG14026  tkv; thickveins, isoform A [KO:K13578] [EC:2.7.11.30]
Dmel_CG7717  Mekk1; Mekk1, isoform D [KO:K04428] [EC:2.7.11.25]
Dmel_CG4720  Ask1; apoptotic signal-regulating kinase 1, isoform C [KO:K04426] [EC:2.7.11.25]
Dmel_CG12244  lic; licorne [KO:K04432] [EC:2.7.12.2]
Dmel_CG7393  p38b; p38b MAP kinase [KO:K04441] [EC:2.7.11.24]
Dmel_CG5475  p38a; p38a MAP kinase, isoform C [KO:K04441] [EC:2.7.11.24]
Dmel_CG33338  p38c; p38c MAP kinase [KO:K04441] [EC:2.7.11.24]
Dmel_CG44246  Atf-2; activating transcription factor-2 [KO:K04450]
Dmel_CG3131  Duox; dual oxidase, isoform C [KO:K13411] [EC:1.6.3.1 1.11.1.-]
Dmel_CG3578  bi; bifid, isoform B [KO:K10176]
Dmel_CG1429  Mef2; myocyte enhancer factor 2, isoform D [KO:K09260]
Dmel_CG8905  Sod2; superoxide dismutase 2 (Mn), isoform B [KO:K04564] [EC:1.15.1.1]
Reference
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
dme04214  Apoptosis - fly
KO pathway
ko04013   
LinkDB

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