KEGG   PATHWAY: dmn04215
Entry
dmn04215                    Pathway                                

Name
Apoptosis - multiple species - Drosophila miranda
Description
Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The major players are caspases, caspase inhibitors, members of the Bcl-2 family of pro- and anti-apoptotic proteins and adaptors of the Ced-4/APAF-1 type. Mammals, by comparison with Caenorhabditis and Drosophila, exhibit highly complex extrinsic and intrinsic pathways for apoptosis induction. However, recent analyses of whole genome sequences from cnidarians (e.g. Hydra) suggest that the caspase and Bcl-2 families were already highly complex in cnidarians and that Caenorhabditis and Drosophila lost many of the genes involved in apoptosis.
Class
Cellular Processes; Cell growth and death
Pathway map
dmn04215  Apoptosis - multiple species
dmn04215

Other DBs
GO: 0006915
Organism
Drosophila miranda [GN:dmn]
Gene
108157384  fas-associated death domain protein [KO:K02373]
108153528  caspase-8 [KO:K04398] [EC:3.4.22.61]
108157734  caspase-3 [KO:K04397] [EC:3.4.22.60]
108156639  caspase [KO:K04397] [EC:3.4.22.60]
108158700  caspase-3 [KO:K02187] [EC:3.4.22.56]
108163300  cytochrome c-2 [KO:K08738]
108163565  cytochrome c-1 [KO:K08738]
108159879  uncharacterized protein LOC108159879 [KO:K02084]
108157255  serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
108164090  septin-5 isoform X1 [KO:K16943]
108159671  death-associated inhibitor of apoptosis 2 [KO:K16060]
117193609  death-associated inhibitor of apoptosis 2-like [KO:K16060]
117193610  death-associated inhibitor of apoptosis 2-like [KO:K16060]
117193611  death-associated inhibitor of apoptosis 2-like [KO:K16060]
108156367  baculoviral IAP repeat-containing protein 5 [KO:K08731]
108164595  tumor necrosis factor receptor superfamily member wengen isoform X1 [KO:K16679]
108161325  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
108151999  caspase Dronc [KO:K20009] [EC:3.4.22.-]
108158715  caspase-1 isoform X1 [KO:K20008] [EC:3.4.22.-]
117188200  caspase-1-like isoform X1 [KO:K20008] [EC:3.4.22.-]
108159904  caspase-1-like isoform X1 [KO:K20008] [EC:3.4.22.-]
108160519  bcl-2-related ovarian killer protein homolog B [KO:K02561]
117193672  bcl-2-related ovarian killer protein homolog B-like [KO:K02561]
108159850  bcl-2-related ovarian killer protein isoform X3 [KO:K20017]
117193850  bcl-2-related ovarian killer protein-like [KO:K20017]
108165515  cell death protein Grim [KO:K20018]
108165504  cell death protein rpr [KO:K20014]
108153017  cell death protein hid [KO:K20016]
108152426  death-associated inhibitor of apoptosis 1 isoform X1 [KO:K16061]
108154884  beclin-1-like protein [KO:K08334]
108154832  baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
Reference
  Authors
Fuchs Y, Steller H
  Title
Live to die another way: modes of programmed cell death and the signals emanating from dying cells.
  Journal
Nat Rev Mol Cell Biol 16:329-44 (2015)
DOI:10.1038/nrm3999
Reference
  Authors
Kumar S, Cakouros D
  Title
Transcriptional control of the core cell-death machinery.
  Journal
Trends Biochem Sci 29:193-9 (2004)
DOI:10.1016/j.tibs.2004.02.001
Reference
  Authors
Bergmann A, Steller H
  Title
Apoptosis, stem cells, and tissue regeneration.
  Journal
Sci Signal 3:re8 (2010)
DOI:10.1126/scisignal.3145re8
Reference
  Authors
Zmasek CM, Godzik A
  Title
Evolution of the animal apoptosis network.
  Journal
Cold Spring Harb Perspect Biol 5:a008649 (2013)
DOI:10.1101/cshperspect.a008649
Reference
  Authors
Twomey C, McCarthy JV
  Title
Pathways of apoptosis and importance in development.
  Journal
J Cell Mol Med 9:345-59 (2005)
DOI:10.1111/j.1582-4934.2005.tb00360.x
Reference
  Authors
Nicholson DW
  Title
Caspase structure, proteolytic substrates, and function during apoptotic cell death.
  Journal
Cell Death Differ 6:1028-42 (1999)
DOI:10.1038/sj.cdd.4400598
Reference
  Authors
Wang C, Youle RJ
  Title
The role of mitochondria in apoptosis*.
  Journal
Annu Rev Genet 43:95-118 (2009)
DOI:10.1146/annurev-genet-102108-134850
Reference
  Authors
Choi D, Woo M
  Title
Executioners of apoptosis in pancreatic {beta}-cells: not just for cell death.
  Journal
Am J Physiol Endocrinol Metab 298:E735-41 (2010)
DOI:10.1152/ajpendo.00696.2009
Reference
  Authors
Joza N, Kroemer G, Penninger JM
  Title
Genetic analysis of the mammalian cell death machinery.
  Journal
Trends Genet 18:142-9 (2002)
DOI:10.1016/S0168-9525(01)02618-X
Reference
  Authors
Yan N, Wu JW, Chai J, Li W, Shi Y
  Title
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
  Journal
Nat Struct Mol Biol 11:420-8 (2004)
DOI:10.1038/nsmb764
Reference
  Authors
Reiter S, Crescenzi M, Galliot B, Buzgariu W
  Title
Hydra, a versatile model to study the homeostatic and developmental functions of cell death.
  Journal
Int J Dev Biol 56:593-604 (2012)
DOI:10.1387/ijdb.123499sr
Reference
  Authors
Lasi M, Pauly B, Schmidt N, Cikala M, Stiening B, Kasbauer T, Zenner G, Popp T, Wagner A, Knapp RT, Huber AH, Grunert M, Soding J, David CN, Bottger A
  Title
The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins.
  Journal
Cell Res 20:812-25 (2010)
DOI:10.1038/cr.2010.66
Reference
  Authors
Lasi M, David CN, Bottger A
  Title
Apoptosis in pre-Bilaterians: Hydra as a model.
  Journal
Apoptosis 15:269-78 (2010)
DOI:10.1007/s10495-009-0442-7
Reference
  Authors
Romero A, Novoa B, Figueras A
  Title
The complexity of apoptotic cell death in mollusks: An update.
  Journal
Fish Shellfish Immunol 46:79-87 (2015)
DOI:10.1016/j.fsi.2015.03.038
Reference
  Authors
Potts MB, Cameron S
  Title
Cell lineage and cell death: Caenorhabditis elegans and cancer research.
  Journal
Nat Rev Cancer 11:50-8 (2011)
DOI:10.1038/nrc2984
Reference
  Authors
Lee EF, Young ND, Lim NT, Gasser RB, Fairlie WD
  Title
Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis.
  Journal
Trends Parasitol 30:75-84 (2014)
DOI:10.1016/j.pt.2013.12.005
Related
pathway
dmn04214  Apoptosis - fly
KO pathway
ko04215   
LinkDB

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