KEGG   PATHWAY: eai04010
Entry
eai04010                    Pathway                                
Name
MAPK signaling pathway - Equus asinus (ass)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
eai04010  MAPK signaling pathway
eai04010

Other DBs
GO: 0000165
Organism
Equus asinus (ass) [GN:eai]
Gene
106844288  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
106822757  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
106839455  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
106822066  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
106833978  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
106826963  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
106826471  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
106836269  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
106842428  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
106823553  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X3 [KO:K04857]
106840179  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3 [KO:K04858]
106830655  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
106848683  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
106839431  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
106826374  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
106834416  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X3 [KO:K04863]
106836823  CACNB3; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
106824678  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
106835563  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
106837570  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
106823836  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
106835565  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
106835564  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
106840861  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
106840860  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
106840954  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
106844316  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106824036  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106835567  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106823831  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106840859  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
106834780  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
106826929  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
106825068  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
106847712  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
106834431  PPP3CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
106842388  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
106828340  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
106831788  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
106840813  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
106841155  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
106835159  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
106833617  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
106839887  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
106836100  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
106823789  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
106844602  NF1; neurofibromin [KO:K08052]
106841206  RASA1; ras GTPase-activating protein 1 [KO:K04352]
106838119  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
106828599  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
106843586  RAP1B; ras-related protein Rap-1b [KO:K07836]
106829795  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
106828311  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
106846380  EREG; proepiregulin [KO:K09784]
106846382  AREG; amphiregulin [KO:K09782]
106836975  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
106838575  FGF7; fibroblast growth factor 7 [KO:K04358]
106831535  FGF6; fibroblast growth factor 6 [KO:K04358]
106847700  FGF17; fibroblast growth factor 17 isoform X3 [KO:K04358]
106828064  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
106834247  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
106828264  FGF20; fibroblast growth factor 20 [KO:K04358]
106844246  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
106844254  FGF3; fibroblast growth factor 3 [KO:K04358]
106846929  FGF16; fibroblast growth factor 16 [KO:K04358]
106837360  FGF18; fibroblast growth factor 18 [KO:K04358]
106828887  FGF8; fibroblast growth factor 8 [KO:K04358]
106824930  FGF10; fibroblast growth factor 10 [KO:K04358]
106828556  FGF9; fibroblast growth factor 9 [KO:K04358]
106844255  FGF19; fibroblast growth factor 19 [KO:K22603]
106838258  FGF21; fibroblast growth factor 21 [KO:K22429]
106831440  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
106835685  NGF; beta-nerve growth factor [KO:K02582]
106824927  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
106831487  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
106838275  NTF4; neurotrophin-4 [KO:K12457]
106827264  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
106824098  insulin-like growth factor II isoform X3 [KO:K13769]
106834748  PDGFA; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
106836855  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
106843123  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
106833032  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
106827389  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
106836514  KITLG; kit ligand isoform X1 [KO:K05461]
106828747  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
106833635  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
106827733  PGF; placenta growth factor isoform X1 [KO:K16859]
106841578  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
106843564  VEGFC; vascular endothelial growth factor C [KO:K05449]
106840178  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
106840095  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
106841411  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
106833695  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
106834223  EFNA2; ephrin-A2 [KO:K05462]
106838745  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
106828504  EFNA1; ephrin-A1 [KO:K05462]
106828508  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
106828509  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
106824793  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123278991  NRTN; LOW QUALITY PROTEIN: neurturin [KO:K25414]
106847895  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
106832783  PSPN; persephin [KO:K25416]
106824133  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
106826341  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
106832936  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
106837675  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
106824659  FGFR1; fibroblast growth factor receptor 1 isoform X6 [KO:K04362] [EC:2.7.10.1]
106846935  FGFR2; fibroblast growth factor receptor 2 isoform X6 [KO:K05093] [EC:2.7.10.1]
106830606  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
106827191  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
106826528  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
106828447  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
106822031  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
106844524  INSR; insulin receptor isoform X2 [KO:K04527] [EC:2.7.10.1]
106836604  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106839051  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
106838493  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
106838490  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
106839052  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
106832906  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
106832910  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
106843734  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
106836923  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
106829287  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
106838956  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
106827993  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
106831339  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
106830292  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
106825844  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
106839506  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
106824973  HRAS; GTPase HRas isoform X1 [KO:K02833]
106825548  KRAS; GTPase KRas isoform X2 [KO:K07827]
106829397  GTPase KRas-like [KO:K07827]
106835678  NRAS; GTPase NRas [KO:K07828]
106824177  RRAS; ras-related protein R-Ras [KO:K07829]
106833078  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
106838095  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
106847984  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
106842618  BRAF; serine/threonine-protein kinase B-raf isoform X8 [KO:K04365] [EC:2.7.11.1]
106829345  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106830991  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106840602  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
106832322  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106834441  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
106845632  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106848262  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106834166  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
106822602  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3 [KO:K04372] [EC:2.7.11.1]
106835507  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
106842063  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
106834323  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
106839915  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
106842437  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106847985  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
106823526  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
106824829  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
106828696  SRF; serum response factor [KO:K04378]
106827712  FOS; proto-oncogene c-Fos [KO:K04379]
106836496  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
106839936  STMN1; stathmin isoform X2 [KO:K04381]
106841342  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
106841343  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
106841344  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
106841348  PLA2G4B; cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
106846782  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
106825034  TNF; tumor necrosis factor isoform X1 [KO:K03156]
106838556  IL1A; interleukin-1 alpha [KO:K04383]
106838557  LOW QUALITY PROTEIN: interleukin-1 beta [KO:K04519]
123286234  interleukin-1 beta-like [KO:K04519]
123286693  interleukin-1 beta-like [KO:K04519]
106843812  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
106836714  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
106830938  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
106831483  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106839400  IL1R1; interleukin-1 receptor type 1 isoform X2 [KO:K04386]
106832560  interleukin-1 receptor accessory protein [KO:K04723]
106842924  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
106830994  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
106838669  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
106822180  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
106823774  CD14; monocyte differentiation antigen CD14 [KO:K04391]
106840518  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
106837585  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
106846070  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
106840004  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
106822449  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106830081  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
106845532  TRAF2; TNF receptor-associated factor 2 isoform X4 [KO:K03173] [EC:2.3.2.27]
106834593  DAXX; death domain-associated protein 6 [KO:K02308]
106834265  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
106825607  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
106828056  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
106837480  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106834158  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
106825069  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
106825118  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
106836857  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
106837218  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
106846598  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
106825862  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
106839392  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
106836065  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X2 [KO:K04408] [EC:2.7.11.1]
106842897  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
106848316  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
106843012  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
106835440  STK3; serine/threonine-protein kinase 3 [KO:K04412]
106833671  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
106837968  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
106843371  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
106833665  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
106834092  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
106835525  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
106824083  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
106843249  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
106839676  MAP3K21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
106835292  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
106834499  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
106834739  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
106839092  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
106837192  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106847421  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
106842047  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
106822000  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
106839774  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
106845621  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
106845730  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
106844503  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
106825518  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
106830236  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
106843928  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
106846024  MAPK8IP2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
106836211  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
106825616  FLNA; filamin-A isoform X1 [KO:K04437]
106822010  CRK; adapter molecule crk isoform X1 [KO:K04438]
106848274  CRKL; crk-like protein [KO:K04438]
106844136  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
106840410  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
106839421  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
106831384  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106843729  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106824547  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106824582  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
106846005  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
106846006  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
106842262  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
106823339  LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
106830742  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
106825387  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
106833673  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
106847689  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
106834926  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
106822461  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
106833477  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
106824999  JUND; transcription factor jun-D [KO:K04449]
106837905  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X2 [KO:K04450]
106844218  TP53; cellular tumor antigen p53 [KO:K04451]
106833003  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
106844892  MAX; protein max isoform X1 [KO:K04453]
106841211  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
106839277  HSPB1; heat shock protein beta-1 [KO:K04455]
106835457  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106839597  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106843289  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106846073  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
106842190  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
106845283  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
106832416  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
106837352  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
106826715  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106821751  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106837561  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106824571  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106825299  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123286716  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106845652  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
106826652  DUSP9; dual specificity protein phosphatase 9 isoform X1 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
106830447  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
106836436  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
106845172  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
106826237  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
106832775  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
106822285  heat shock 70 kDa protein 1 [KO:K03283]
106831112  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
106825061  heat shock 70 kDa protein 1-like [KO:K03283]
123282797  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
123288213  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
106834666  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
106840611  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X4 [KO:K04463] [EC:2.7.12.2]
106837912  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
106835239  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
106836478  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
106846705  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
106828957  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
106828814  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
106844594  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
106825951  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106837992  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
106833569  RELA; transcription factor p65 isoform X1 [KO:K04735]
106848418  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
eai04070  Phosphatidylinositol signaling system
eai04110  Cell cycle
eai04115  p53 signaling pathway
eai04210  Apoptosis
eai04310  Wnt signaling pathway
eai04668  TNF signaling pathway
KO pathway
ko04010   
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