KEGG   PATHWAY: elk05213
Entry
elk05213                    Pathway                                

Name
Endometrial cancer - Enhydra lutris kenyoni (northern sea otter)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
elk05213  Endometrial cancer
elk05213

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111156359  pro-epidermal growth factor isoform X1 [KO:K04357]
111157042  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111144778  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111156293  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
111159342  integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
111159383  integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111154673  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
111149975  bcl2-associated agonist of cell death [KO:K02158]
111158279  forkhead box protein O3 [KO:K09408]
111160411  growth factor receptor-bound protein 2 [KO:K04364]
111158354  son of sevenless homolog 1 isoform X1 [KO:K03099]
111160889  son of sevenless homolog 2 isoform X1 [KO:K03099]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111150582  serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
111151941  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111150586  ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
111159091  DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
111152800  LOW QUALITY PROTEIN: cadherin-1-like [KO:K05689]
111152817  cadherin-1 isoform X1 [KO:K05689]
111159001  catenin beta-1 [KO:K02105]
111140819  catenin alpha-1 [KO:K05691]
111144805  catenin alpha-3 [KO:K05691]
111148019  catenin alpha-2 isoform X1 [KO:K05691]
111156118  axin-1 isoform X1 [KO:K02157]
111158088  axin-2 isoform X1 [KO:K04385]
111161627  adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
111148270  adenomatous polyposis coli protein isoform X1 [KO:K02085]
111149921  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111141244  transcription factor 7 isoform X1 [KO:K02620]
111148131  transcription factor 7-like 1 isoform X1 [KO:K04490]
111145217  transcription factor 7-like 2 isoform X1 [KO:K04491]
111154120  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
111146783  myc proto-oncogene protein [KO:K04377]
111149458  G1/S-specific cyclin-D1 [KO:K04503]
111161133  cellular tumor antigen p53 [KO:K04451]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111143201  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
111161789  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111153625  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111160657  apoptosis regulator BAX isoform X1 [KO:K02159]
111152355  bcl-2 homologous antagonist/killer [KO:K14021]
111150113  DNA damage-binding protein 2 isoform X1 [KO:K10140]
111148313  DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
111151268  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
elk04010  MAPK signaling pathway
elk04012  ErbB signaling pathway
elk04060  Cytokine-cytokine receptor interaction
elk04110  Cell cycle
elk04115  p53 signaling pathway
elk04151  PI3K-Akt signaling pathway
elk04310  Wnt signaling pathway
elk04520  Adherens junction
KO pathway
ko05213   
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