KEGG   PATHWAY: etl04115
etl04115                    Pathway                                

p53 signaling pathway - Empidonax traillii (willow flycatcher)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
etl04115  p53 signaling pathway

Empidonax traillii (willow flycatcher) [GN:etl]
114066109  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:]
114061540  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:]
114069637  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:]
114064599  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:]
114063538  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
114062165  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:]
114069119  MDM4; protein Mdm4 [KO:K10127]
114064409  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114067926  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
114067087  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
114071008  G1/S-specific cyclin-D3-like [KO:K10152]
114067504  G1/S-specific cyclin-D3-like isoform X1 [KO:K10152]
114062117  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:]
114063486  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114060091  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
114070800  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:]
114068068  SFN; 14-3-3 protein sigma [KO:K06644]
114073337  protein reprimo-like [KO:K10128]
114056383  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
114063899  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:]
114061921  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114061072  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114072120  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
114069681  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
114055892  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
114068482  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
114066600  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
114069860  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
114055714  caspase-8-like isoform X1 [KO:K04398] [EC:]
114055715  caspase-8-like [KO:K04398] [EC:]
114069005  BID; BH3-interacting domain death agonist [KO:K04726]
114070069  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
114066726  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
114063044  BCL2L1; bcl-2-like protein 1 [KO:K04570]
114065315  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114064445  TP53I3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
114064605  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
114058748  SHISA5; protein shisa-5 [KO:K10135]
114059504  p53 apoptosis effector related to PMP-22-like [KO:K10136]
114059511  p53 apoptosis effector related to PMP-22-like [KO:K10136]
114062400  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
114067411  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:]
114064043  LOW QUALITY PROTEIN: cytochrome c, somatic A-like [KO:K08738]
114063690  cytochrome c [KO:K08738]
114065277  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114068717  CASP9; caspase-9 [KO:K04399] [EC:]
114055579  CASP3; caspase-3 [KO:K02187] [EC:]
114062209  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
114068393  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
114056148  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
114065893  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
114061633  CD82; CD82 antigen [KO:K06509]
114063733  THBS1; thrombospondin-1 [KO:K16857]
114065317  SERPINB5; serpin B5 [KO:K10139]
114058833  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
114058978  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:]
114057315  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:]
114067448  sestrin-3-like isoform X1 [KO:K10141]
114057246  SESN3; sestrin-3 isoform X1 [KO:K10141]
114063386  SESN1; sestrin-1 isoform X1 [KO:K10141]
114068397  SESN2; sestrin-2 [KO:K20394]
114069647  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:]
114064312  TSC2; tuberin isoform X1 [KO:K07207]
114063086  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
114068081  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:]
114067618  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:]
114067222  CCNG1; cyclin-G1 [KO:K10145]
114060027  CCNG2; cyclin-G2 [KO:K10146]
114068829  PPM1D; protein phosphatase 1D [KO:K10147] [EC:]
114069824  TP73; tumor protein p73 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
etl04110  Cell cycle
etl04210  Apoptosis
etl04218  Cellular senescence
KO pathway

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