KEGG   PATHWAY: etl04340
Entry
etl04340                    Pathway                                

Name
Hedgehog signaling pathway - Empidonax traillii (willow flycatcher)
Description
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Class
Environmental Information Processing; Signal transduction
Pathway map
etl04340  Hedgehog signaling pathway
etl04340

Organism
Empidonax traillii (willow flycatcher) [GN:etl]
Gene
114071695  protein patched homolog 1-like [KO:K06225]
114055235  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
114061960  PTCH2; LOW QUALITY PROTEIN: protein patched homolog 2 [KO:K11101]
114070065  SMO; smoothened homolog [KO:K06226]
114068363  GPR161; G-protein coupled receptor 161 [KO:K08439]
114064916  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114066728  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
114070721  CSNK1G2; casein kinase I [KO:K08958] [EC:2.7.11.1]
114055345  CSNK1G3; casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
114060268  CSNK1G1; casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
114060339  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
114055383  CSNK1E; casein kinase I [KO:K08960] [EC:2.7.11.1]
114055112  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114071280  GLI1; zinc finger protein GLI1 [KO:K16797]
114055514  GLI2; zinc finger protein GLI2 [KO:K16798]
114067160  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
114070282  SUFU; suppressor of fused homolog isoform X1 [KO:K06229]
114058007  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
114068542  HHIP; hedgehog-interacting protein [KO:K06231]
114067926  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
114067087  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
114065315  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114063866  CUL1; cullin-1 [KO:K03347]
114070460  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
114055534  SHH; sonic hedgehog protein [KO:K11988]
114055175  IHH; indian hedgehog protein [KO:K11989]
114071902  DHH; desert hedgehog protein [KO:K11990]
114055071  BOC; brother of CDO isoform X1 [KO:K20020]
114064593  CDON; cell adhesion molecule-related/down-regulated by oncogenes [KO:K20033]
114055999  GAS1; growth arrest-specific protein 1 [KO:K06232]
114073754  LRP2; low-density lipoprotein receptor-related protein 2 isoform X1 [KO:K06233]
114065933  MOSMO; modulator of smoothened protein [KO:K23663]
114057009  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
114060178  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
114065996  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
114067868  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
114066071  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
114061464  EVC; ellis-van Creveld syndrome protein isoform X1 [KO:K19605]
114061463  EVC2; limbin isoform X1 [KO:K19608]
114059625  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
114070741  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
114069335  CUL3; cullin-3 [KO:K03869]
114071494  SPOP; speckle-type POZ protein [KO:K10523]
114057681  SPOPL; speckle-type POZ protein-like isoform X1 [KO:K10523]
Compound
C00575  3',5'-Cyclic AMP
Reference
  Authors
Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
  Title
Hedgehog receptor function during craniofacial development.
  Journal
Dev Biol 415:198-215 (2016)
DOI:10.1016/j.ydbio.2016.02.009
Reference
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
  Authors
Alman BA
  Title
The role of hedgehog signalling in skeletal health and disease.
  Journal
Nat Rev Rheumatol 11:552-60 (2015)
DOI:10.1038/nrrheum.2015.84
Reference
  Authors
Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
  Title
Hedgehog and Resident Vascular Stem Cell Fate.
  Journal
Stem Cells Int 2015:468428 (2015)
DOI:10.1155/2015/468428
Reference
  Authors
Sasai N, Briscoe J
  Title
Primary cilia and graded Sonic Hedgehog signaling.
  Journal
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
DOI:10.1002/wdev.43
Reference
  Authors
Heretsch P, Tzagkaroulaki L, Giannis A
  Title
Modulators of the hedgehog signaling pathway.
  Journal
Bioorg Med Chem 18:6613-24 (2010)
DOI:10.1016/j.bmc.2010.07.038
Reference
  Authors
Anderson E, Peluso S, Lettice LA, Hill RE
  Title
Human limb abnormalities caused by disruption of hedgehog signaling.
  Journal
Trends Genet 28:364-73 (2012)
DOI:10.1016/j.tig.2012.03.012
Reference
  Authors
Rohatgi R, Scott MP
  Title
Cell biology. Arrestin' movement in cilia.
  Journal
Science 320:1726-7 (2008)
DOI:10.1126/science.1160448
Reference
  Authors
Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
  Title
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
  Journal
Elife 3:e02555 (2014)
DOI:10.7554/eLife.02555
Reference
  Authors
Ok CY, Singh RR, Vega F
  Title
Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
  Journal
Am J Pathol 180:2-11 (2012)
DOI:10.1016/j.ajpath.2011.09.009
Reference
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
  Authors
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
  Title
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
  Journal
Dev Cell 44:113-129.e8 (2018)
DOI:10.1016/j.devcel.2017.12.003
Related
pathway
etl04120  Ubiquitin mediated proteolysis
KO pathway
ko04340   
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