KEGG   PATHWAY: gfr04115
Entry
gfr04115                    Pathway                                

Name
p53 signaling pathway - Geospiza fortis (medium ground-finch)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
gfr04115  p53 signaling pathway
gfr04115

Organism
Geospiza fortis (medium ground-finch) [GN:gfr]
Gene
102038788  CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
102032229  ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
102039036  CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
102032732  GORAB; golgin, RAB6 interacting [KO:K19748]
102041787  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102031420  MDM4; MDM4, p53 regulator [KO:K10127]
102041135  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102042858  CCND1; cyclin D1 [KO:K04503]
102034688  CCND2; cyclin D2 [KO:K10151]
102033692  CCND3; cyclin D3 [KO:K10152]
102034159  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102043017  CCNE2; cyclin E2 [KO:K06626]
102040569  CCNE1; cyclin E1 [KO:K06626]
102038349  SFN; stratifin [KO:K06644]
102044449  CCNB2; cyclin B2 [KO:K21770]
102034239  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102034008  GTSE1; G2 and S-phase expressed 1 [KO:K10129]
102033034  FAS; Fas cell surface death receptor [KO:K04390]
102044448  PIDD1; p53-induced death domain protein 1 [KO:K10130]
102032130  tumor necrosis factor receptor superfamily member 26-like [KO:K04722]
102033914  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
102044546  caspase-8-like [KO:K04398] [EC:3.4.22.61]
102044717  caspase-8-like [KO:K04398] [EC:3.4.22.61]
102036429  BID; BH3 interacting domain death agonist [KO:K04726]
102043659  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
102036419  BCL2L1; BCL2 like 1 [KO:K04570]
102032008  BCL2; BCL2, apoptosis regulator [KO:K02161]
102032321  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
102035365  EI24; EI24, autophagy associated transmembrane protein [KO:K10134]
102040891  SHISA5; shisa family member 5 [KO:K10135]
102041213  p53 apoptosis effector related to PMP-22-like [KO:K10136]
102035332  p53 apoptosis effector related to PMP-22-like [KO:K10136]
102036629  ZMAT3; zinc finger matrin-type 3 [KO:K10137]
102040458  SIAH1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:2.3.2.27]
102033495  cytochrome c [KO:K08738]
102039129  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102039030  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102035830  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102031518  AIFM2; apoptosis inducing factor, mitochondria associated 2 [KO:K22745]
102040735  IGFBP3; insulin like growth factor binding protein 3 [KO:K10138]
102032215  IGF1; insulin like growth factor 1 [KO:K05459]
102033184  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
102040029  CD82; CD82 molecule [KO:K06509]
102031762  THBS1; thrombospondin 1 [KO:K16857]
102036717  SERPINB5; serpin family B member 5 [KO:K10139]
102035276  DDB2; damage specific DNA binding protein 2 [KO:K10140]
102033491  RRM2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
102036141  RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
102032819  SESN3; sestrin 3 [KO:K10141]
102032374  sestrin-3-like [KO:K10141]
102035838  SESN1; sestrin 1 [KO:K10141]
102037166  SESN2; sestrin-2 [KO:K20394]
102039901  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102039715  TSC2; tuberous sclerosis 2 [KO:K07207]
102043446  STEAP3; STEAP3 metalloreductase [KO:K10142] [EC:1.16.1.-]
102044323  RFWD2; ring finger and WD repeat domain 2 [KO:K10143] [EC:2.3.2.27]
102041363  RCHY1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:2.3.2.27]
102035379  CCNG1; cyclin G1 [KO:K10145]
102045099  CCNG2; cyclin G2 [KO:K10146]
102035924  PPM1D; protein phosphatase, Mg2+/Mn2+ dependent 1D [KO:K10147] [EC:3.1.3.16]
102034695  TP73; tumor protein p73 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
gfr04110  Cell cycle
gfr04210  Apoptosis
gfr04218  Cellular senescence
KO pathway
ko04115   
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