KEGG   PATHWAY: hgl04010
Entry
hgl04010                    Pathway                                
Name
MAPK signaling pathway - Heterocephalus glaber (naked mole-rat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
hgl04010  MAPK signaling pathway
hgl04010

Other DBs
GO: 0000165
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101725815  Cacna1a; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
101697609  Cacna1b; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
101717129  Cacna1c; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
101714832  Cacna1d; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
101701145  Cacna1e; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
101722090  Cacna1f; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
101709921  Cacna1g; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
101712631  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101723335  Cacna1i; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
101726232  Cacna1s; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
101708369  Cacna2d1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
101710707  Cacna2d2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
101712827  Cacna2d3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
101705589  Cacna2d4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
101714578  Cacnb1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
101713647  Cacnb2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
101696342  Cacnb3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
101723713  Cacnb4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
101714630  Cacng1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
101700752  Cacng2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
101723508  Cacng3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
101714984  Cacng4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
101715359  Cacng5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
101722990  Cacng6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
101697969  Cacng7; calcium voltage-gated channel auxiliary subunit gamma 7 [KO:K04872]
101723340  Cacng8; calcium voltage-gated channel auxiliary subunit gamma 8 [KO:K04873]
101707235  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101721558  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101716044  Prkca; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
101722702  Prkcb; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
101698346  Prkcg; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
101697421  Gna12; G protein subunit alpha 12 [KO:K04346]
101725110  Gng12; G protein subunit gamma 12 [KO:K04347]
101708178  Ppp3cb; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
101719947  Ppp3cc; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
101698959  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
101706255  Ppp3r1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
101710684  Ppp3r2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
101699491  Rasgrf1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
101698054  Rasgrf2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
101699646  Rasgrp1; RAS guanyl releasing protein 1 [KO:K04350]
101714183  Rasgrp2; RAS guanyl releasing protein 2 [KO:K12361]
101717811  Rasgrp3; RAS guanyl releasing protein 3 [KO:K12362]
101708596  Rasgrp4; RAS guanyl releasing protein 4 [KO:K12363]
101718791  Rapgef2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
101719382  Nf1; neurofibromin 1 [KO:K08052]
101713771  Rasa1; RAS p21 protein activator 1 [KO:K04352]
101725433  Rasa2; RAS p21 protein activator 2 [KO:K08053]
101698757  Rap1a; RAP1A, member of RAS oncogene family [KO:K04353]
101726671  Rap1b; RAP1B, member of RAS oncogene family [KO:K07836]
101714409  ras-related protein Rap-1b [KO:K07836]
106007527  Egf; epidermal growth factor [KO:K04357]
101723712  Tgfa; transforming growth factor alpha [KO:K08774]
101701158  Ereg; epiregulin [KO:K09784]
101700802  Areg; amphiregulin [KO:K09782]
101717777  Fgf1; fibroblast growth factor 1 [KO:K18496]
101720583  Fgf2; fibroblast growth factor 2 [KO:K18497]
101718946  Fgf18; fibroblast growth factor 18 [KO:K04358]
101714076  Fgf7; fibroblast growth factor 7 [KO:K04358]
101710458  Fgf3; fibroblast growth factor 3 [KO:K04358]
101707706  Fgf17; fibroblast growth factor 17 [KO:K04358]
101707578  Fgf10; fibroblast growth factor 10 [KO:K04358]
101700281  Fgf5; fibroblast growth factor 5 [KO:K04358]
101701734  Fgf20; fibroblast growth factor 20 [KO:K04358]
101711919  Fgf4; fibroblast growth factor 4 [KO:K04358]
101701530  Fgf9; fibroblast growth factor 9 [KO:K04358]
101720536  Fgf22; fibroblast growth factor 22 [KO:K04358]
101699438  Fgf8; fibroblast growth factor 8 [KO:K04358]
101716030  Fgf16; fibroblast growth factor 16 [KO:K04358]
101722884  Fgf6; fibroblast growth factor 6 [KO:K04358]
101710827  Fgf19; fibroblast growth factor 19 [KO:K22603]
101717974  Fgf21; fibroblast growth factor 21 [KO:K22429]
101713698  Fgf23; fibroblast growth factor 23 [KO:K22428]
101722226  Ngf; nerve growth factor [KO:K02582]
101704465  Bdnf; brain derived neurotrophic factor [KO:K04355]
101696620  Ntf3; neurotrophin 3 [KO:K04356]
101710673  Ntf4; neurotrophin 4 [KO:K12457]
101719971  Ins; insulin [KO:K04526]
101707684  Igf1; insulin like growth factor 1 [KO:K05459]
101720309  Igf2; insulin like growth factor 2 [KO:K13769]
101725739  Pdgfa; platelet derived growth factor subunit A [KO:K04359]
101698830  Pdgfb; platelet derived growth factor subunit B [KO:K17386]
101696768  Pdgfd; platelet derived growth factor D [KO:K05450]
101710927  Pdgfc; platelet derived growth factor C [KO:K05450]
101709756  Csf1; colony stimulating factor 1 [KO:K05453]
101697092  Kitlg; KIT ligand [KO:K05461]
101698597  Flt3lg; fms related tyrosine kinase 3 ligand [KO:K05454]
101702403  Vegfa; vascular endothelial growth factor A [KO:K05448]
101700074  Vegfb; vascular endothelial growth factor B [KO:K16858]
101725085  Pgf; placental growth factor [KO:K16859]
101719504  Vegfc; vascular endothelial growth factor C [KO:K05449]
101726005  Vegfd; vascular endothelial growth factor D [KO:K05449]
101707056  Hgf; hepatocyte growth factor [KO:K05460]
101725800  Angpt1; angiopoietin 1 [KO:K05465]
101710564  Angpt2; angiopoietin 2 [KO:K05466]
101717722  angiopoietin-4 [KO:K05467]
101718402  angiopoietin-4-like [KO:K05467]
101718756  angiopoietin-4-like [KO:K05467]
101706062  angiopoietin-4-like [KO:K05467]
101724262  Efna5; ephrin A5 [KO:K05462]
101711422  Efna4; ephrin A4 [KO:K05462]
101703816  Efna2; ephrin A2 [KO:K05462]
101710579  Efna3; ephrin A3 [KO:K05462]
101709969  Efna1; ephrin A1 [KO:K05462]
101700544  Gdnf; glial cell derived neurotrophic factor [KO:K05452]
101709125  Nrtn; neurturin [KO:K25414]
101717201  Artn; artemin [KO:K25415]
101720872  Pspn; persephin [KO:K25416]
101723771  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101705227  Erbb2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
101721671  Erbb3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
101725806  Erbb4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
101700324  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101709077  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101711651  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101700214  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101724251  Ngfr; nerve growth factor receptor [KO:K02583]
101724441  Ntrk1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
101720037  Ntrk2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
101722168  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101710224  Igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101697360  Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101721151  Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101719513  Csf1r; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101726400  Kit; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
101713724  Flt3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
101711333  Flt1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
101702013  Flt4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
101726029  Kdr; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
101725772  Met; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
101710501  Tek; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
101714513  Epha2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
101717565  Ret; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
101717035  Grb2; growth factor receptor bound protein 2 [KO:K04364]
101707893  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
101701753  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
101716053  Hras; HRas proto-oncogene, GTPase [KO:K02833]
101718997  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
101719269  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
101723449  Rras; related RAS viral (r-ras) oncogene homolog [KO:K07829]
101722671  Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
101709042  Mras; muscle RAS oncogene homolog [KO:K07831]
101723157  Araf; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
101702762  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
101721841  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
101715628  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101707562  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101702297  Lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
101706099  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101702687  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101716935  Mknk2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
101723982  Mknk1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
101712979  Rps6ka1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
101708473  Rps6ka2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
101722051  Rps6ka3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
101703020  Rps6ka6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
101724287  Atf4; activating transcription factor 4 [KO:K04374]
101725319  Elk1; ELK1, ETS transcription factor [KO:K04375]
101705607  Elk4; ELK4, ETS transcription factor [KO:K04376]
101704740  Myc; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
101719000  Srf; serum response factor [KO:K04378]
101718383  Fos; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
101719489  Mapt; microtubule associated protein tau [KO:K04380]
101702547  Stmn1; stathmin 1 [KO:K04381]
101705849  Pla2g4e; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
101706202  Pla2g4f; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
101703792  Pla2g4b; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
101717491  Pla2g4d; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
101713091  Pla2g4c; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
101704061  Pla2g4a; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
101718432  Tnf; tumor necrosis factor [KO:K03156]
101703933  Il1a; interleukin 1 alpha [KO:K04383]
101704309  Il1b; interleukin 1 beta [KO:K04519]
101704230  Tgfb1; transforming growth factor beta 1 [KO:K13375]
101707457  Tgfb2; transforming growth factor beta 2 [KO:K13376]
101712904  Tgfb3; transforming growth factor beta 3 [KO:K13377]
101698980  Tnfrsf1a; TNF receptor superfamily member 1A [KO:K03158]
101711273  Il1r1; interleukin 1 receptor type 1 [KO:K04386]
101707386  Il1rap; interleukin 1 receptor accessory protein [KO:K04723]
101718090  Tgfbr1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
101704397  Tgfbr2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
101698642  Faslg; Fas ligand [KO:K04389]
101704746  Fas; Fas cell surface death receptor [KO:K04390]
101708852  Cd14; CD14 molecule [KO:K04391]
101706434  Rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101725000  Rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
101723777  Rac3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
101701374  Cdc42; cell division cycle 42 [KO:K04393]
101711269  cell division control protein 42 homolog [KO:K04393]
101721567  Tradd; TNFRSF1A associated via death domain [KO:K03171]
101712867  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
101696390  caspase-3 [KO:K02187] [EC:3.4.22.56]
101723884  caspase-3-like [KO:K02187] [EC:3.4.22.56]
101705156  Traf2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
101717412  Daxx; death domain associated protein [KO:K02308]
101712637  Myd88; myeloid differentiation primary response 88 [KO:K04729]
101699021  Irak1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101698190  Irak4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101697126  Traf6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
101725746  Gadd45a; growth arrest and DNA damage inducible alpha [KO:K04402]
101711314  Gadd45g; growth arrest and DNA damage inducible gamma [KO:K04402]
101710909  Gadd45b; growth arrest and DNA damage inducible beta [KO:K04402]
101696480  Tab1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
101698406  Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
101716127  Ecsit; ECSIT signalling integrator [KO:K04405]
101709571  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
101707800  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
101709569  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
101713465  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
101710712  Pak2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
101704401  Stk4; serine/threonine kinase 4 [KO:K04411]
101715099  Stk3; serine/threonine kinase 3 [KO:K04412]
101710953  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
101710286  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101720769  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101718575  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101726195  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101704335  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101696673  Map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
101718471  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101704125  Map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
101702332  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
101700680  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101707762  Map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
101697616  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
101712051  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101718269  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
101701961  Map3k4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
101707041  Taok2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
101707795  Taok3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
101709784  Taok1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
101705822  Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101710666  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101718318  Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101703028  Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101705667  Mapk8ip1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
101712713  Mapk8ip2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
101716066  Mapk8ip3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
101702004  Flna; filamin A [KO:K04437]
101705695  Crkl; CRK like proto-oncogene, adaptor protein [KO:K04438]
101717585  Crk; CRK proto-oncogene, adaptor protein [KO:K04438]
101703451  Arrb1; arrestin beta 1 [KO:K04439]
101709908  Arrb2; arrestin beta 2 [KO:K04439]
101698286  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101715259  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101712980  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
101705370  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101706002  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101715692  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
106007524  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
101703557  Mapkapk5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
101708612  Mapkapk2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101717099  Mapkapk3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101712306  Rps6ka5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
101720436  Rps6ka4; ribosomal protein S6 kinase A4 [KO:K16510] [EC:2.7.11.1]
101701077  Cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
101697946  Nfatc1; nuclear factor of activated T-cells 1 [KO:K04446]
101696341  Nfatc3; nuclear factor of activated T-cells 3 [KO:K17333]
101722197  Jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
106008531  Jund; JunD proto-oncogene, AP-1 transcription factor subunit [KO:K04449]
101717365  Atf2; activating transcription factor 2 [KO:K04450]
101701769  Tp53; tumor protein p53 [KO:K04451]
101715873  Ddit3; DNA damage inducible transcript 3 [KO:K04452]
101699034  Max; MYC associated factor X [KO:K04453]
101716335  Mef2c; myocyte enhancer factor 2C [KO:K04454]
101716096  Hspb1; heat shock protein family B (small) member 1 [KO:K04455]
101700695  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101719164  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
101701289  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101720711  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101720052  Ptprr; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
101718223  Ptpn5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101715531  Ptpn7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101701425  Dusp1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101702046  Dusp2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101719827  Dusp4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101726329  Dusp5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101700389  Dusp16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101716391  Dusp8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101699953  Dusp7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101697963  Dusp6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101717115  Dusp9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101715205  Dusp10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101702703  Dusp3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101696971  Ppp5c; protein phosphatase 5 catalytic subunit [KO:K04460] [EC:3.1.3.16]
101724963  Ppm1b; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
101699805  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
101700637  heat shock 70 kDa protein 1B [KO:K03283]
101701238  Hspa6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
101708313  Hspa8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
101718355  Mecom; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
101711080  Map2k5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
101726391  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101707788  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101703313  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101719306  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
101711077  Ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101712077  Ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
101701893  Nlk; nemo like kinase [KO:K04468] [EC:2.7.11.24]
101696485  Nfkb1; nuclear factor kappa B subunit 1 [KO:K02580]
101714147  Nfkb2; nuclear factor kappa B subunit 2 [KO:K04469]
101716738  Rela; RELA proto-oncogene, NF-kB subunit [KO:K04735]
101719268  Relb; RELB proto-oncogene, NF-kB subunit [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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PMID:12676795
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PMID:11369511
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Genes Cells 7:1099-111 (2002)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
hgl04070  Phosphatidylinositol signaling system
hgl04110  Cell cycle
hgl04115  p53 signaling pathway
hgl04210  Apoptosis
hgl04310  Wnt signaling pathway
hgl04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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