Entry |
|
Name |
Calcium signaling pathway - Homo sapiens (human)
|
Description |
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
|
Class |
Environmental Information Processing; Signal transduction
|
Pathway map |

|
Network |
nt06120 Calcium signaling (viruses and bacteria) nt06124 Chemokine signaling (viruses) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06167 Human cytomegalovirus (HCMV) nt06220 Calcium signaling nt06263 Hepatocellular carcinoma nt06266 Non-small cell lung cancer nt06273 Glioma nt06410 Calcium signaling nt06460 Alzheimer disease |
Element |
N00023 | EGF-EGFR-PLCG-ERK signaling pathway |
N00026 | EGF-EGFR-PLCG-CAMK signaling pathway |
N00028 | PDGF-PDGFR-PLCG-CAMK signaling pathway |
N00147 | EGF-EGFR-PLCG-calcineurin signaling pathway |
N00227 | TGFA-EGFR-PLCG-PKC signaling pathway |
N00401 | CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway |
N01000 | mAChR-Ca2+ -apoptotic pathway |
|
Disease |
H00441 | Progressive osseous heteroplasia |
H00746 | Hypokalemic periodic paralysis (HypoPP) |
H00755 | Acrokeratosis verruciformis |
H00787 | Congenital stationary night blindness |
H00801 | Familial thoracic aortic aneurysm and dissection |
H01019 | Catecholaminergic polymorphic ventricular tachycardia |
H01307 | Nonsyndromic congenital nail disorder |
H02019 | Familial male-limited precocious puberty |
H02026 | Familial hypocalciuric hypercalcemia |
H02258 | Tubular aggregate myopathy |
H02281 | Isolated anhidrosis with normal sweat glands |
|
Drug |
D00059 | Levodopa (JP17/USP/INN) |
D00081 | Dinoprost (JP17/USAN/INN) |
D00176 | Protirelin (JP17/USAN/INN) |
D00180 | Alprostadil (JP17/USP/INN) |
D00227 | Aminophylline (USP/INN) |
D00255 | Carvedilol (JP17/USP/INN) |
D00295 | Cimetidine (JP17/USP/INN) |
D00300 | Diphenhydramine (JP17/INN) |
D00304 | Divalproex sodium (USP) |
D00318 | Famotidine (JP17/USP/INN) |
D00319 | Felodipine (JP17/USP/INN) |
D00356 | Latanoprost (JAN/USP/INN) |
D00397 | Tropicamide (JP17/USP/INN) |
D00411 | Zafirlukast (JAN/USAN/INN) |
D00437 | Nifedipine (JP17/USP/INN) |
D00440 | Nizatidine (JP17/USP/INN) |
D00480 | Promethazine hydrochloride (JP17/USP) |
D00481 | Propantheline bromide (JP17/USP/INN) |
D00511 | Phenylephrine hydrochloride (JP17/USP) |
D00520 | Dimenhydrinate (JP17/USP/INN) |
D00529 | Montelukast sodium (JP17/USP) |
D00537 | Topiramate (JAN/USP/INN) |
D00538 | Zonisamide (JP17/USP/INN) |
D00539 | Ethosuximide (JP17/USP/INN) |
D00598 | Betaxolol hydrochloride (JP17/USP) |
D00599 | Carteolol hydrochloride (JP17/USP) |
D00600 | Labetalol hydrochloride (JP17/USP) |
D00602 | Penbutolol sulfate (JP17/USP) |
D00603 | Timolol maleate (JP17/USP) |
D00607 | Guanadrel sulfate (USAN) |
D00613 | Fenoldopam mesylate (USP) |
D00615 | Amlodipine besylate (USP) |
D00617 | Nicardipine hydrochloride (JP17/USAN) |
D00618 | Nisoldipine (JAN/USAN/INN) |
D00619 | Verapamil hydrochloride (JP17/USP) |
D00629 | Nitrendipine (JP17/USAN/INN) |
D00631 | Bepridil hydrochloride (USAN) |
D00632 | Dobutamine hydrochloride (JP17/USP) |
D00633 | Dopamine hydrochloride (JP17/USP) |
D00634 | Bisoprolol fumarate (JP17/USP) |
D00636 | Amiodarone hydrochloride (JP17/USP) |
D00659 | Azelastine hydrochloride (JP17/USP) |
D00666 | Clemastine fumarate (JP17/USP) |
D00669 | Diphenhydramine hydrochloride (JP17/USP) |
D00672 | Hydroxyzine hydrochloride (JP17/USP) |
D00673 | Ranitidine hydrochloride (JP17/USP) |
D00679 | Ergotamine tartrate (JP17/USP) |
D00680 | Methylergonovine maleate (USP) |
D00682 | Carboprost tromethamine (USP) |
D00683 | Albuterol sulfate (USP) |
D00684 | Bitolterol mesylate (USAN) |
D00685 | Metaproterenol sulfate (USP) |
D00686 | Pirbuterol acetate (USAN) |
D00687 | Salmeterol xinafoate (JAN/USP) |
D00688 | Terbutaline sulfate (JP17/USP) |
D00710 | Valproate sodium (USAN) |
D00711 | Ketamine hydrochloride (JP17/USP) |
D00717 | Dicyclomine hydrochloride (JAN/USP) |
D00719 | Hyoscyamine sulfate (USP) |
D00720 | Mepenzolate bromide (JP17/INN) |
D00721 | Methanthelinium bromide (INN) |
D00722 | Oxybutynin chloride (USP) |
D00723 | Tridihexethyl chloride (BAN) |
D00774 | Orphenadrine citrate (USP) |
D00996 | Epinephrine hydrochloride (JAN) |
D00999 | Acetylcholine chloride (JP17/USP/INN) |
D01003 | Hexocyclium metilsulfate (INN) |
D01005 | Isopropamide iodide (JAN/USP/INN) |
D01007 | Propiverine hydrochloride (JP17) |
D01019 | Metaraminol bitartrate (JAN/USP) |
D01020 | Methoxamine hydrochloride (JAN) |
D01025 | Levobunolol hydrochloride (JAN/USP) |
D01026 | Sotalol hydrochloride (JAN/USP) |
D01077 | Methylatropine nitrate (USAN) |
D01096 | Hydroxyzine pamoate (JP17/USP) |
D01104 | Barnidipine hydrochloride (JAN) |
D01143 | Isothipendyl hydrochloride (JAN) |
D01145 | Azelnidipine (JP17/INN) |
D01148 | Tolterodine tartrate (JAN/USP) |
D01163 | Ergonovine maleate (USP) |
D01165 | Piperidolate hydrochloride (JAN) |
D01171 | Monatepil maleate (JAN/USAN) |
D01174 | Pheniramine maleate (JAN/USP) |
D01175 | Carpronium chloride (JAN/INN) |
D01192 | Olopatadine hydrochloride (JP17/USP) |
D01201 | Tiemonium iodide (JAN/INN) |
D01238 | Bucladesine sodium (JAN) |
D01242 | Promethazine teoclate (JAN/INN) |
D01263 | Ritodrine hydrochloride (JP17/USP) |
D01269 | Solifenacin succinate (JAN/USAN/INN) |
D01295 | Cinnarizine (JAN/USAN/INN) |
D01297 | Pirenzepine hydrochloride (USAN) |
D01303 | Flunarizine hydrochloride (JAN/USAN) |
D01307 | Midodrine hydrochloride (JAN/USP) |
D01343 | Dimethindene maleate (USAN) |
D01347 | Tramazoline hydrochloride (JAN/USAN) |
D01349 | Pirbuterol hydrochloride (JAN/USAN) |
D01352 | Dinoprost tromethamine (JAN/USP) |
D01360 | Clenbuterol hydrochloride (JAN/USP) |
D01362 | Tulobuterol hydrochloride (JP17) |
D01369 | Bevantolol hydrochloride (JAN/USAN) |
D01373 | Formoterol fumarate (USP) |
D01377 | Prifinium bromide (JAN/INN) |
D01386 | Ephedrine hydrochloride (JP17/USP) |
D01390 | Isoproterenol hydrochloride (USP) |
D01428 | Fenoterol hydrobromide (JAN) |
D01444 | Bunitrolol hydrochloride (JAN) |
D01451 | Scopolamine butylbromide (JP17) |
D01452 | Isopropyl unoprostone (JAN) |
D01453 | Caffeine hydrate (JP17) |
D01454 | Bupranolol hydrochloride (JP17) |
D01467 | Roxatidine acetate hydrochloride (JP17/USAN) |
D01469 | Amosulalol hydrochloride (JP17) |
D01491 | Butropium bromide (JP17/INN) |
D01504 | Bufetolol hydrochloride (JP17) |
D01512 | Befunolol hydrochloride (JAN) |
D01538 | Valethamate bromide (JAN) |
D01553 | Manidipine hydrochloride (JP17) |
D01573 | Etilefrine hydrochloride (JP17) |
D01589 | Mabuterol hydrochloride (JAN) |
D01592 | Betahistine mesilate (JP17) |
D01604 | Efonidipine hydrochloride ethanolate (JAN) |
D01635 | Methoxyphenamine hydrochloride (JAN) |
D01648 | Hyoscyamine methylbromide (JAN) |
D01654 | Bepotastine besylate (USAN) |
D01697 | Colforsin daropate hydrochloride (JAN) |
D01712 | Theophylline sodium acetate (JAN) |
D01717 | Levocabastine hydrochloride (JAN/USP) |
D01771 | Proxyphylline (JAN/INN) |
D01794 | Bopindolol malonate (JAN) |
D01801 | Thonzylamine hydrochloride (JAN/USAN) |
D01830 | Arotinolol hydrochloride (JP17) |
D01835 | Clorprenaline hydrochloride (JAN/USAN) |
D01849 | Lercanidipine hydrochloride (JAN/USAN) |
D01887 | Bunazosin hydrochloride (JP17) |
D01902 | Fonazine mesylate (USAN) |
D01908 | Nilvadipine (JP17/USAN/INN) |
D01925 | Taltirelin hydrate (JP17) |
D01929 | Tiotropium bromide hydrate (JAN) |
D01933 | Vatanidipine hydrochloride (JAN) |
D01946 | Oxitropium bromide (JAN/INN) |
D01955 | Aclatonium napadisilate (JAN) |
D01958 | Indenolol hydrochloride (JP17) |
D01964 | Travoprost (JAN/USP/INN) |
D01969 | Gallopamil hydrochloride (JAN) |
D01976 | N-Methylscopolamine methylsulfate (JAN) |
D01978 | Trimetoquinol hydrochloride |
D02007 | Protirelin tartrate hydrate (JP17) |
D02045 | Benidipine hydrochloride (JP17) |
D02066 | Isoproterenol sulfate (USP) |
D02069 | Atropine sulfate (JP17/USP) |
D02073 | Gemeprost (JAN/USAN/INN) |
D02081 | Metipranolol hydrochloride |
D02091 | Tripelennamine hydrochloride (USP) |
D02093 | Isoetharine hydrochloride (USP) |
D02109 | dl-Methylephedrine hydrochloride (JP17) |
D02149 | Epinephrine bitartrate (JAN/USP) |
D02150 | l-Isoprenaline hydrochloride (JP17) |
D02218 | Papaverine hydrochloride (JP17/USP) |
D02281 | Levalbuterol hydrochloride (USP) |
D02342 | Bisoprolol (JAN/USAN/INN) |
D02372 | Perospirone hydrochloride hydrate (JAN) |
D02374 | Metipranolol (USAN/INN) |
D02396 | Hexoprenaline sulfate (USAN) |
D02404 | Procaterol hydrochloride (USAN) |
D02419 | Diphenhydramine salicylate (JAN) |
D02535 | Timepidium bromide hydrate (JP17) |
D02599 | Orphenadrine hydrochloride |
D02633 | Lomerizine hydrochloride (JAN) |
D02641 | Butaclamol hydrochloride (USAN) |
D02702 | Talibegron hydrochloride (USAN) |
D02705 | Alprostadil alfadex (JP17) |
D02724 | Bimatoprost (JAN/USAN/INN) |
D02732 | Pranlukast hydrate (JP17) |
D02765 | Adaprolol maleate (USAN) |
D02767 | Adatanserin hydrochloride (USAN) |
D02834 | Alprenoxime hydrochloride (USAN) |
D02860 | Limaprost alfadex (JP17) |
D02914 | Amlodipine maleate (USAN) |
D02939 | Angiotensin amide (USAN) |
D02950 | Antazoline phosphate (USP) |
D02976 | Arbutamine hydrochloride (USAN) |
D02981 | Arformoterol tartrate (USAN) |
D02983 | Argipressin tannate (USAN) |
D03088 | Benzilonium bromide (USAN/INN) |
D03102 | Betahistine hydrochloride (USP) |
D03198 | Butoxamine hydrochloride (USAN) |
D03285 | Diphenhydramine tannate (JP17) |
D03290 | Promethazine methylenedisalicylate (JAN) |
D03350 | Canertinib dihydrochloride (USAN) |
D03360 | Diphenhydramine laurylsulfate (JAN) |
D03399 | Carboprost methyl (USAN) |
D03402 | Carbuterol hydrochloride (USAN) |
D03415 | Carvedilol phosphate (USAN) |
D03478 | Choriogonadotropin alfa (USAN/INN) |
D03503 | Cimetidine hydrochloride (USP) |
D03506 | Cinanserin hydrochloride (USAN) |
D03536 | Clentiazem maleate (JAN/USAN) |
D03729 | Dexpropranolol hydrochloride (USAN) |
D03814 | Atropine methylbromide (JAN) |
D03854 | Diphenhydramine citrate (USP) |
D03880 | Dobutamine lactobionate (USAN) |
D03881 | Dobutamine tartrate (USAN) |
D03914 | Dronedarone hydrochloride (USP) |
D04018 | Ephedrine sulfate (USP) |
D04057 | Esoxybutynin chloride (USAN) |
D04072 | Etafedrine hydrochloride (USAN) |
D04479 | Hyoscyamine hydrobromide (USP) |
D04626 | Isoetharine mesylate (USP) |
D04701 | Levalbuterol sulfate (USAN) |
D04703 | Levalbuterol tartrate (USAN) |
D04708 | Levdobutamine lactobionate (USAN) |
D04710 | Levobetaxolol hydrochloride (USAN) |
D04868 | Mebeverine hydrochloride (USAN) |
D04970 | Methacholine chloride (JAN/USP/INN) |
D05024 | Mibefradil dihydrochloride (USAN) |
D05037 | Trimetoquinol hydrochloride hydrate (JP17) |
D05206 | Norepinephrine bitartrate (USP) |
D05276 | Pirenzepine hydrochloride hydrate (JP17) |
D05277 | Formoterol fumarate hydrate (JP17) |
D05345 | Pamatolol sulfate (USAN) |
D05366 | Procaterol hydrochloride hydrate (JP17) |
D05429 | Aminophylline hydrate (JP17) |
D05442 | Perhexiline maleate (USAN) |
D05479 | Pimagedine hydrochloride (USAN) |
D05660 | Pyrilamine maleate (USP) |
D05699 | Ranitidine bismuth citrate (USAN) |
D05714 | Remacemide hydrochloride (USAN) |
D05718 | Reproterol hydrochloride (USAN) |
D06104 | Theophylline sodium glycinate (USP) |
D06129 | Tiapamil hydrochloride (USAN) |
D06274 | Tafluprost (JAN/USAN/INN) |
D06633 | Pruvanserin hydrochloride (USAN) |
D06672 | Terlipressin (USAN/INN) |
D06877 | Oxyphenonium bromide (INN) |
D07083 | Otilonium bromide (INN) |
D07094 | Pinaverium bromide (INN) |
D07097 | Isometheptene mucate (USP) |
D07099 | Cimetropium bromide (JAN/INN) |
D07459 | Antazoline hydrochloride |
D07489 | Bambuterol hydrochloride |
D07492 | Bamipine dihydrochloride |
D07679 | Chloropyramine hydrochloride |
D07684 | Chlorphenoxamine hydrochloride |
D07734 | Cinnarizine dihydrochloride |
D07943 | Fendiline hydrochloride |
D07951 | Fentonium bromide (INN) |
D08057 | Ibopamine hydrochloride |
D08207 | Methylergometrine (INN) |
D08238 | Moxaverine hydrochloride |
D08284 | Norepinephrine hydrochoride |
D08495 | Roxatidine acetate (BAN) |
D08571 | Terlipressin acetate (JAN) |
D08595 | Tiemonium methylsulfate |
D08837 | Aclidinium bromide (JAN/USAN/INN) |
D08864 | Azilsartan (JAN/USAN/INN) |
D08923 | Fesoterodine fumarate (JAN/USAN) |
D08945 | Milveterol hydrochloride (USAN) |
D08966 | Phenylephrine bitartrate (USP) |
D09319 | Indacaterol maleate (JAN/USAN) |
D09402 | Darotropium bromide (USAN/INN) |
D09645 | Nelotanserin (USAN/INN) |
D09694 | Velusetrag hydrochloride (USAN) |
D09697 | Vilanterol trifenatate (JAN/USAN) |
D09732 | Ritobegron ethyl hydrochloride (JAN) |
D09752 | Carpronium chloride hydrate (JAN) |
D09766 | Vorapaxar sulfate (JAN/USAN) |
D09774 | Imitrodast sodium (JAN) |
D09784 | Garomefrine hydrochloride (JAN) |
D09789 | Kirenidipine hydrochloride (JAN) |
D09794 | Norepinephrine hydrochloride (JAN) |
D09820 | Vasopressin tannate (JAN) |
D09867 | Atopaxar hydrobromide (USAN) |
D09934 | Naronapride dihydrochloride (USAN) |
D09977 | Temanogrel hydrochloride (USAN) |
D10006 | Eplivanserin (USAN/INN) |
D10020 | Olodaterol hydrochloride (JAN/USAN) |
D10100 | Cerlapirdine hydrochloride (USAN) |
D10118 | Epelsiban besylate (USAN) |
D10181 | Umeclidinium bromide (JAN/USAN) |
D10220 | Abediterol napadisylate (USAN) |
D10546 | Batefenterol succinate (USAN) |
D11009 | Indacaterol acetate (JAN) |
D11102 | Tamolarizine hydrochloride (JAN) |
D11142 | Angiotensin II acetate (USAN) |
D11630 | Aminophylline dihydrate |
D11901 | Navafenterol saccharinate (USAN) |
|
Other DBs |
|
Organism |
Homo sapiens (human) [GN: hsa]
|
Gene |
6546 | SLC8A1; solute carrier family 8 member A1 [KO:K05849] |
6543 | SLC8A2; solute carrier family 8 member A2 [KO:K05849] |
6547 | SLC8A3; solute carrier family 8 member A3 [KO:K05849] |
1128 | CHRM1; cholinergic receptor muscarinic 1 [KO:K04129] |
1131 | CHRM3; cholinergic receptor muscarinic 3 [KO:K04131] |
1133 | CHRM5; cholinergic receptor muscarinic 5 [KO:K04133] |
135 | ADORA2A; adenosine A2a receptor [KO:K04266] |
136 | ADORA2B; adenosine A2b receptor [KO:K04267] |
3360 | HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160] |
3361 | HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161] |
3362 | HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162] |
3363 | HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163] |
487 | ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10] |
489 | ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10] |
488 | ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10] |
3270 | HRC; histidine rich calcium binding protein [KO:K23450] |
6786 | STIM1; stromal interaction molecule 1 [KO:K16059] |
57620 | STIM2; stromal interaction molecule 2 [KO:K18196] |
84876 | ORAI1; ORAI calcium release-activated calcium modulator 1 [KO:K16056] |
80228 | ORAI2; ORAI calcium release-activated calcium modulator 2 [KO:K16057] |
93129 | ORAI3; ORAI calcium release-activated calcium modulator 3 [KO:K16058] |
775 | CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850] |
776 | CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851] |
778 | CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853] |
779 | CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857] |
773 | CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344] |
774 | CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849] |
777 | CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852] |
8913 | CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854] |
8912 | CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855] |
8911 | CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856] |
1139 | CHRNA7; cholinergic receptor nicotinic alpha 7 subunit [KO:K04809] |
2902 | GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208] |
2903 | GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209] |
2905 | GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211] |
2906 | GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212] |
10800 | CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322] |
57105 | CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323] |
1129 | CHRM2; cholinergic receptor muscarinic 2 [KO:K04130] |
148 | ADRA1A; adrenoceptor alpha 1A [KO:K04135] |
147 | ADRA1B; adrenoceptor alpha 1B [KO:K04136] |
146 | ADRA1D; adrenoceptor alpha 1D [KO:K04137] |
185 | AGTR1; angiotensin II receptor type 1 [KO:K04166] |
1909 | EDNRA; endothelin receptor type A [KO:K04197] |
1910 | EDNRB; endothelin receptor type B [KO:K04198] |
2149 | F2R; coagulation factor II thrombin receptor [KO:K03914] |
2911 | GRM1; glutamate metabotropic receptor 1 [KO:K04603] |
2915 | GRM5; glutamate metabotropic receptor 5 [KO:K04604] |
2925 | GRPR; gastrin releasing peptide receptor [KO:K04169] |
3356 | HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157] |
3357 | HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157] |
3358 | HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157] |
3973 | LHCGR; luteinizing hormone/choriogonadotropin receptor [KO:K04248] |
552 | AVPR1A; arginine vasopressin receptor 1A [KO:K04226] |
553 | AVPR1B; arginine vasopressin receptor 1B [KO:K04227] |
5724 | PTAFR; platelet activating factor receptor [KO:K04279] |
5731 | PTGER1; prostaglandin E receptor 1 [KO:K04258] |
5733 | PTGER3; prostaglandin E receptor 3 [KO:K04260] |
623 | BDKRB1; bradykinin receptor B1 [KO:K03915] |
624 | BDKRB2; bradykinin receptor B2 [KO:K03916] |
7201 | TRHR; thyrotropin releasing hormone receptor [KO:K04282] |
886 | CCKAR; cholecystokinin A receptor [KO:K04194] |
887 | CCKBR; cholecystokinin B receptor [KO:K04195] |
7852 | CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189] |
2767 | GNA11; G protein subunit alpha 11 [KO:K04635] |
9630 | GNA14; G protein subunit alpha 14 [KO:K04636] |
2769 | GNA15; G protein subunit alpha 15 [KO:K04637] |
5154 | PDGFA; platelet derived growth factor subunit A [KO:K04359] |
5155 | PDGFB; platelet derived growth factor subunit B [KO:K17386] |
56034 | PDGFC; platelet derived growth factor C [KO:K05450] |
80310 | PDGFD; platelet derived growth factor D [KO:K05450] |
8822 | FGF17; fibroblast growth factor 17 [KO:K04358] |
2255 | FGF10; fibroblast growth factor 10 [KO:K04358] |
8823 | FGF16; fibroblast growth factor 16 [KO:K04358] |
8817 | FGF18; fibroblast growth factor 18 [KO:K04358] |
9965 | FGF19; fibroblast growth factor 19 [KO:K22603] |
8074 | FGF23; fibroblast growth factor 23 [KO:K22428] |
7422 | VEGFA; vascular endothelial growth factor A [KO:K05448] |
7423 | VEGFB; vascular endothelial growth factor B [KO:K16858] |
7424 | VEGFC; vascular endothelial growth factor C [KO:K05449] |
2277 | VEGFD; vascular endothelial growth factor D [KO:K05449] |
2668 | GDNF; glial cell derived neurotrophic factor [KO:K05452] |
3708 | ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958] |
3709 | ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959] |
3710 | ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960] |
57192 | MCOLN1; mucolipin TRP cation channel 1 [KO:K04992] |
55283 | MCOLN3; mucolipin TRP cation channel 3 [KO:K04994] |
7416 | VDAC1; voltage dependent anion channel 1 [KO:K05862] |
7417 | VDAC2; voltage dependent anion channel 2 [KO:K15040] |
7419 | VDAC3; voltage dependent anion channel 3 [KO:K15041] |
291 | SLC25A4; solute carrier family 25 member 4 [KO:K05863] |
292 | SLC25A5; solute carrier family 25 member 5 [KO:K05863] |
293 | SLC25A6; solute carrier family 25 member 6 [KO:K05863] |
83447 | SLC25A31; solute carrier family 25 member 31 [KO:K05863] |
7134 | TNNC1; troponin C1, slow skeletal and cardiac type [KO:K05865] |
7125 | TNNC2; troponin C2, fast skeletal type [KO:K12042] |
5257 | PHKB; phosphorylase kinase regulatory subunit beta [KO:K07190] |
5256 | PHKA2; phosphorylase kinase regulatory subunit alpha 2 [KO:K07190] |
5255 | PHKA1; phosphorylase kinase regulatory subunit alpha 1 [KO:K07190] |
815 | CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17] |
817 | CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17] |
816 | CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17] |
818 | CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17] |
5534 | PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268] |
5535 | PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268] |
|
Compound |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
C06124 | Sphingosine 1-phosphate |
C11556 | 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate |
C13051 | Nicotinic acid adenine dinucleotide phosphate |
|
Reference |
|
Authors |
Berridge MJ, Bootman MD, Roderick HL. |
Title |
Calcium signalling: dynamics, homeostasis and remodelling. |
Journal |
|
Reference |
|
Authors |
Berridge MJ, Lipp P, Bootman MD. |
Title |
The versatility and universality of calcium signalling. |
Journal |
|
Reference |
|
Authors |
Wang MC, Dolphin A, Kitmitto A. |
Title |
L-type voltage-gated calcium channels: understanding function through structure. |
Journal |
|
Reference |
|
Authors |
Ferrier GR, Howlett SE. |
Title |
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction. |
Journal |
|
Reference |
|
Authors |
Keef KD, Hume JR, Zhong J. |
Title |
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases. |
Journal |
|
Reference |
|
Authors |
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA. |
Title |
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini. |
Journal |
J Biol Chem 269:7390-6 (1994) |
Reference |
|
Authors |
Yunker AM. |
Title |
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels. |
Journal |
|
Reference |
|
Authors |
Yakel JL. |
Title |
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription. |
Journal |
|
Reference |
|
Authors |
Fukunaga K, Miyamoto E. |
Title |
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory. |
Journal |
|
Reference |
|
Authors |
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ. |
Title |
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. |
Journal |
|
Reference |
|
Authors |
Furuichi T, Mikoshiba K. |
Title |
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain. |
Journal |
|
Reference |
|
Authors |
Bruce JI, Straub SV, Yule DI. |
Title |
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells. |
Journal |
|
Reference |
|
Authors |
Lee HC, Munshi C, Graeff R. |
Title |
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes. |
Journal |
|
Reference |
|
Authors |
Crompton M. |
Title |
Mitochondrial intermembrane junctional complexes and their role in cell death. |
Journal |
|
Reference |
|
Authors |
Grewal SS, York RD, Stork PJ. |
Title |
Extracellular-signal-regulated kinase signalling in neurons. |
Journal |
|
Reference |
|
Authors |
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV. |
Title |
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. |
Journal |
|
Reference |
|
Authors |
Hutchins JR, Dikovskaya D, Clarke PR. |
Title |
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II. |
Journal |
|
Reference |
|
Authors |
Tornquist K |
Title |
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells. |
Journal |
|
Reference |
|
Authors |
Feske S |
Title |
Immunodeficiency due to defects in store-operated calcium entry. |
Journal |
|
Reference |
|
Authors |
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC |
Title |
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg. |
Journal |
|
Reference |
|
Authors |
Baba Y, Kurosaki T |
Title |
[Regulation of store-operated calcium entry by STIM1]. |
Journal |
Seikagaku 80:1123-8 (2008) |
Reference |
|
Authors |
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX |
Title |
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. |
Journal |
|
Reference |
|
Authors |
Beard NA, Wei L, Dulhunty AF |
Title |
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin. |
Journal |
|
Reference |
|
Authors |
Marty I |
Title |
Triadin regulation of the ryanodine receptor complex. |
Journal |
|
Reference |
|
Authors |
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG |
Title |
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling. |
Journal |
|
Related pathway |
hsa04070 | Phosphatidylinositol signaling system |
|
KO pathway |
|
LinkDB |
|