Entry |
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Name |
RIG-I-like receptor signaling pathway - Homo sapiens (human)
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Description |
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
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Class |
Organismal Systems; Immune system
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Pathway map |
hsa04622 | RIG-I-like receptor signaling pathway |

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Network |
nt06133 RLR signaling (viruses) nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06165 Epstein-Barr virus (EBV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nt06263 Hepatocellular carcinoma |
Element |
N00469 | RIG-I-IRF7/3 signaling pathway |
N00688 | RIG-I-NFKB signaling pathway |
N01308 | MDA5-IRF7/3 signaling pathway |
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Disease |
H00290 | Aicardi-Goutieres syndrome |
H00827 | Brooke-Spiegler syndrome |
H01746 | STING-associated vasculopathy with onset in infancy |
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Organism |
Homo sapiens (human) [GN: hsa]
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Gene |
57506 | MAVS; mitochondrial antiviral signaling protein [KO:K12648] |
7187 | TRAF3; TNF receptor associated factor 3 [KO:K03174] |
10010 | TANK; TRAF family member associated NFKB activator [KO:K12650] |
8517 | IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [KO:K07210] |
9641 | IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10] |
3661 | IRF3; interferon regulatory factor 3 [KO:K05411] |
3665 | IRF7; interferon regulatory factor 7 [KO:K09447] |
8717 | TRADD; TNFRSF1A associated via death domain [KO:K03171] |
8772 | FADD; Fas associated via death domain [KO:K02373] |
1147 | CHUK; component of inhibitor of nuclear factor kappa B kinase complex [KO:K04467] [EC:2.7.11.10] |
4790 | NFKB1; nuclear factor kappa B subunit 1 [KO:K02580] |
5970 | RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735] |
3576 | CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030] |
3627 | CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671] |
9636 | ISG15; ISG15 ubiquitin like modifier [KO:K12159] |
340061 | STING1; stimulator of interferon response cGAMP interactor 1 [KO:K12654] |
5300 | PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8] |
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Reference |
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Authors |
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T |
Title |
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. |
Journal |
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Reference |
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Authors |
Takeuchi O, Akira S |
Title |
MDA5/RIG-I and virus recognition. |
Journal |
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Reference |
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Authors |
Yoneyama M, Fujita T |
Title |
RNA recognition and signal transduction by RIG-I-like receptors. |
Journal |
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Reference |
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Authors |
Nakhaei P, Genin P, Civas A, Hiscott J |
Title |
RIG-I-like receptors: sensing and responding to RNA virus infection. |
Journal |
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Reference |
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Authors |
Moore CB, Ting JP |
Title |
Regulation of mitochondrial antiviral signaling pathways. |
Journal |
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Reference |
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Authors |
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB |
Title |
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity. |
Journal |
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Reference |
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Authors |
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G |
Title |
Approaching the RNA ligand for RIG-I? |
Journal |
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Reference |
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Authors |
Saito T, Gale M Jr |
Title |
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity. |
Journal |
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Reference |
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Authors |
Kawai T, Akira S |
Title |
Toll-like receptor and RIG-I-like receptor signaling. |
Journal |
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Reference |
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Authors |
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J |
Title |
TRADD protein is an essential component of the RIG-like helicase antiviral pathway. |
Journal |
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Reference |
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Authors |
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T |
Title |
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. |
Journal |
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Reference |
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Authors |
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR |
Title |
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. |
Journal |
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Related pathway |
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KO pathway |
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LinkDB |
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