KEGG   PATHWAY: ko02060
ko02060                     Pathway                                

Phosphotransferase system (PTS)
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Environmental Information Processing; Membrane transport
Pathway map
ko02060  Phosphotransferase system (PTS)

Other DBs
GO: 0009401
TC: 4.A
K08483  phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:]
K02784  phosphocarrier protein HPr
K20118  glucose PTS system EIICBA or EIICB component [EC:]
K02777  sugar PTS system EIIA component [EC:2.7.1.-]
K02779  glucose PTS system EIICB or EIICBA component [EC:]
K02804  N-acetylglucosamine PTS system EIICBA or EIICB component [EC:]
K02791  maltose/glucose PTS system EIICB component [EC:]
K20108  maltose PTS system EIICB or EIICBA component [EC:]
K02765  D-glucosamine PTS system EIICBA component [EC:2.7.1.-]
K02810  sucrose PTS system EIIBCA or EIIBC component [EC:]
K02757  beta-glucoside PTS system EIICBA component [EC:2.7.1.-]
K02753  beta-glucoside (arbutin/salicin/cellobiose) PTS system EIICB component [EC:2.7.1.-]
K02750  alpha-glucoside PTS system EIICB component [EC: 2.7.1.-]
K02819  trehalose PTS system EIIBC or EIIBCA component [EC:]
K11192  N-acetylmuramic acid PTS system EIICB component [EC:]
K02798  mannitol PTS system EIIA component [EC:]
K02800  mannitol PTS system EIICBA or EIICB component [EC:]
K11200  2-O-A-mannosyl-D-glycerate PTS system EIIABC component [EC:]
K02786  lactose PTS system EIIA component [EC:]
K02788  lactose PTS system EIICB component [EC:]
K02759  cellobiose PTS system EIIA component [EC:]
K02760  cellobiose PTS system EIIB component [EC:]
K02761  cellobiose PTS system EIIC component
K02793  mannose PTS system EIIA component [EC:]
K02794  mannose PTS system EIIAB component [EC:]
K02795  mannose PTS system EIIC component
K02796  mannose PTS system EIID component
K19506  fructoselysine/glucoselysine PTS system EIIA component [EC:2.7.1.-]
K19507  fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-]
K19508  fructoselysine/glucoselysine PTS system EIIC component
K19509  fructoselysine/glucoselysine PTS system EIID component
K11194  fructose PTS system EIIA component [EC:]
K11195  fructose PTS system EIIB component [EC:]
K11196  fructose PTS system EIIC component
K02771  fructose PTS system EIID component
K02812  sorbose PTS system EIIA component [EC:]
K02813  sorbose PTS system EIIB component [EC:]
K02814  sorbose PTS system EIIC component
K02815  sorbose PTS system EIID component
K02744  N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-]
K02745  N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
K02746  N-acetylgalactosamine PTS system EIIC component
K02747  N-acetylgalactosamine PTS system EIID component
K10984  galactosamine PTS system EIIB component [EC:2.7.1.-]
K10985  galactosamine PTS system EIIC component
K10986  galactosamine PTS system EIID component
K17464  D-glucosaminate PTS system EIIA component [EC:]
K17465  D-glucosaminate PTS system EIIB component [EC:]
K17466  D-glucosaminate PTS system EIIC component
K17467  D-glucosaminate PTS system EIID component
K02781  glucitol/sorbitol PTS system EIIA component [EC:]
K02782  glucitol/sorbitol PTS system EIIB component [EC:]
K02783  glucitol/sorbitol PTS system EIIC component
K02773  galactitol PTS system EIIA component [EC:]
K02774  galactitol PTS system EIIB component [EC:]
K02775  galactitol PTS system EIIC component
K20112  galactose PTS system EIIA component [EC:]
K20113  galactose PTS system EIIB component [EC:]
K20114  galactose PTS system EIIC component
K02821  ascorbate PTS system EIIA or EIIAB component [EC:]
K02822  ascorbate PTS system EIIB component [EC:]
K03475  ascorbate PTS system EIIC component
K11183  multiphosphoryl transfer protein [EC:]
K23993  multiphosphoryl transfer protein [EC:]
K02770  fructose PTS system EIIBC or EIIC component [EC:]
K02769  fructose PTS system EIIB component [EC:]
K02768  fructose PTS system EIIA component [EC:]
K00882  1-phosphofructokinase [EC:]
K08484  phosphotransferase system, enzyme I, PtsP [EC:]
K08485  phosphocarrier protein NPr
K02806  nitrogen PTS system EIIA component [EC:2.7.1.-]
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05378  beta-D-Fructose 1,6-bisphosphate
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Darbon E, Galinier A, Le Coq D, Deutscher J.
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
J Mol Microbiol Biotechnol 3:439-44 (2001)
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
J Bacteriol 186:2385-92 (2004)
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
J Mol Biol 214:657-71 (1990)
Kristich CJ, Glekas GD, Ordal GW.
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
Mol Microbiol 47:1353-66 (2003)
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
J Biol Chem 279:5537-48 (2004)
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
EcoCyc: a comprehensive database resource for Escherichia coli.
Nucleic Acids Res 33:D334-7 (2005)
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
J Bacteriol 190:1710-7 (2008)
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
Mol Microbiol 37:125-35 (2000)
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
The complete phosphotranferase system in Escherichia coli.
J Mol Microbiol Biotechnol 3:329-46 (2001)
Kotrba P, Inui M, Yukawa H.
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
J Biosci Bioeng 92:502-17 (2001)
ko00051  Fructose and mannose metabolism

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