Entry Name Spliceosome
Description After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class Genetic Information Processing; TranscriptionBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K12813 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [EC:5.6.2.6 ]
K12814 pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 [EC:5.6.2.6 ]
K12815 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 [EC:5.6.2.6 ]
K12816 pre-mRNA-processing factor 17
K12817 pre-mRNA-splicing factor 18
K12819 pre-mRNA-processing factor SLU7
K12820 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 [EC:5.6.2.6 ]
K11086 small nuclear ribonucleoprotein B and B'
K11087 small nuclear ribonucleoprotein D1
K11096 small nuclear ribonucleoprotein D2
K11088 small nuclear ribonucleoprotein D3
K11097 small nuclear ribonucleoprotein E
K11098 small nuclear ribonucleoprotein F
K11099 small nuclear ribonucleoprotein G
K11093 U1 small nuclear ribonucleoprotein 70kDa
K11091 U1 small nuclear ribonucleoprotein A
K11095 U1 small nuclear ribonucleoprotein C
K12821 pre-mRNA-processing factor 40
K12824 transcription elongation regulator 1
K13098 RNA-binding protein FUS
K11092 U2 small nuclear ribonucleoprotein A'
K11094 U2 small nuclear ribonucleoprotein B''
K12825 splicing factor 3A subunit 1
K12826 splicing factor 3A subunit 2
K12827 splicing factor 3A subunit 3
K12828 splicing factor 3B subunit 1
K12829 splicing factor 3B subunit 2
K12830 splicing factor 3B subunit 3
K12831 splicing factor 3B subunit 4
K12832 splicing factor 3B subunit 5
K12833 pre-mRNA branch site protein p14
K12834 PHD finger-like domain-containing protein 5A
K12836 splicing factor U2AF 35 kDa subunit
K12837 splicing factor U2AF 65 kDa subunit
K12838 poly(U)-binding-splicing factor PUF60
K12839 survival of motor neuron-related-splicing factor 30
K12841 calcium homeostasis endoplasmic reticulum protein
K12842 U2-associated protein SR140
K19604 retinitis pigmentosa 9 protein
K12621 U6 snRNA-associated Sm-like protein LSm2
K12622 U6 snRNA-associated Sm-like protein LSm3
K12623 U6 snRNA-associated Sm-like protein LSm4
K12624 U6 snRNA-associated Sm-like protein LSm5
K12625 U6 snRNA-associated Sm-like protein LSm6
K12626 U6 snRNA-associated Sm-like protein LSm7
K12627 U6 snRNA-associated Sm-like protein LSm8
K12843 U4/U6 small nuclear ribonucleoprotein PRP3
K12662 U4/U6 small nuclear ribonucleoprotein PRP4
K12844 U4/U6 small nuclear ribonucleoprotein PRP31
K12845 U4/U6 small nuclear ribonucleoprotein SNU13
K12846 U4/U6.U5 tri-snRNP-associated protein 3
K12847 U4/U6.U5 tri-snRNP-associated protein 2
K11984 U4/U6.U5 tri-snRNP-associated protein 1
K12848 U4/U6.U5 tri-snRNP component SNU23
K12849 pre-mRNA-splicing factor 38A
K12850 pre-mRNA-splicing factor 38B
K12851 pre-mRNA-splicing factor 38
K12852 116 kDa U5 small nuclear ribonucleoprotein component
K12853 114 kDa U5 small nuclear ribonucleoprotein component
K12855 pre-mRNA-processing factor 6
K12856 pre-mRNA-processing factor 8
K12859 U5 snRNP protein, DIM1 family
K12860 pre-mRNA-splicing factor CDC5/CEF1
K12861 pre-mRNA-splicing factor SPF27
K12862 pleiotropic regulator 1
K12864 beta-catenin-like protein 1
K03283 heat shock 70kDa protein 1/6/8
K12865 polyglutamine-binding protein 1
K12866 WW domain-binding protein 11
K06063 SNW domain-containing protein 1
K12867 pre-mRNA-splicing factor SYF1
K12868 pre-mRNA-splicing factor SYF2
K12870 pre-mRNA-splicing factor ISY1
K12871 coiled-coil domain-containing protein 12
K12872 pre-mRNA-splicing factor RBM22/SLT11
K12873 bud site selection protein 31
K12874 intron-binding protein aquarius
K12875 apoptotic chromatin condensation inducer in the nucleus
K12882 nuclear cap-binding protein subunit 1
K12883 nuclear cap-binding protein subunit 2
K12741 heterogeneous nuclear ribonucleoprotein A1/A3
K12884 heterogeneous nuclear ribonucleoprotein C1/C2
K12885 heterogeneous nuclear ribonucleoprotein G
K12886 heterogeneous nuclear ribonucleoprotein K
K12887 heterogeneous nuclear ribonucleoprotein M
K12888 heterogeneous nuclear ribonucleoprotein U
K12889 poly(rC)-binding protein 1
K12890 serine/arginine-rich splicing factor 1
K12891 serine/arginine-rich splicing factor 2/8
K12892 serine/arginine-rich splicing factor 3
K12893 serine/arginine-rich splicing factor 4/5/6
K12896 serine/arginine-rich splicing factor 7
K21123 serine/arginine-rich splicing factor 9
K12900 serine/arginine-rich splicing factor 10
Reference Authors Wahl MC, Will CL, Luhrmann R
Title The spliceosome: design principles of a dynamic RNP machine.
Journal Reference Authors Morris DP, Greenleaf AL
Title The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal Reference Authors Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal Reference Authors Ritchie DB, Schellenberg MJ, MacMillan AM
Title Spliceosome structure: piece by piece.
Journal LinkDB All DBs
