KEGG   PATHWAY: lav04923
Entry
lav04923                    Pathway                                

Name
Regulation of lipolysis in adipocytes - Loxodonta africana (African savanna elephant)
Description
Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding to Gs-coupled-adrenergic receptors (-AR), activate adenylate cyclase (AC) to increase cAMP and activate protein kinase A (PKA). PKA phosphorylates target protein such as hormone-sensitive lipase (HSL) and perilipin 1 (PLIN). PLIN phosphorylation is a key event in the sequential activation of TAG hydrolysis involving adipose triglyceride lipase (ATGL), HSL, and monoglyceride lipase (MGL). During the fed state, insulin, through activation of phosphodiesterase-3B (PDE-3B), inhibits catecholamine-induced lipolysis via the degradation of cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
lav04923  Regulation of lipolysis in adipocytes
lav04923

Other DBs
GO: 0016042
Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100660279  TSHB; thyrotropin subunit beta [KO:K05251]
100673911  CGA; glycoprotein hormones alpha chain [KO:K08522]
100659046  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
100654973  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
100664615  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100674524  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100655206  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100669226  neuroendocrine secretory protein 55-like [KO:K04632]
100671072  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100673570  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100674724  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100675525  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100670244  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100653532  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100653771  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100661616  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100663448  ADCY9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100656966  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100674245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100660875  NPPA; natriuretic peptides A [KO:K12334]
100671961  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100662471  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
100657163  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
100675020  PLIN1; LOW QUALITY PROTEIN: perilipin-1 [KO:K08768]
100670874  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
100657987  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
100664173  ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [KO:K13699] [EC:2.3.1.51]
100671842  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
100660274  FABP4; fatty acid-binding protein, adipocyte [KO:K08753]
100659041  FABP9; fatty acid-binding protein 9 [KO:K08753]
100676974  AQP7; aquaporin-7 [KO:K08771]
100661112  INS; insulin [KO:K04526]
100668116  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
100664968  IRS1; insulin receptor substrate 1 [KO:K16172]
100676904  IRS2; insulin receptor substrate 2 isoform X3 [KO:K07187]
100660353  LOW QUALITY PROTEIN: insulin receptor substrate 1-like [KO:K17445]
100667324  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
100657948  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100658340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100666266  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100653731  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100665045  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100675496  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100660871  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
100666679  HRAS-like suppressor 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100667251  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100653633  PTGS1; prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
100666359  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100676506  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
100675292  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100658837  NPY; pro-neuropeptide Y [KO:K05232]
100668572  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
100666344  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100670234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100667957  GNAI3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
Compound
C00020  AMP
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00788  L-Adrenaline
C00942  3',5'-Cyclic GMP
C01885  1-Acylglycerol
C02140  Corticosterone
Reference
  Authors
Ahmadian M, Wang Y, Sul HS
  Title
Lipolysis in adipocytes.
  Journal
Int J Biochem Cell Biol 42:555-9 (2010)
DOI:10.1016/j.biocel.2009.12.009
Reference
  Authors
Ahmadian M, Duncan RE, Sul HS
  Title
The skinny on fat: lipolysis and fatty acid utilization in adipocytes.
  Journal
Trends Endocrinol Metab 20:424-8 (2009)
DOI:10.1016/j.tem.2009.06.002
Reference
  Authors
Wang S, Soni KG, Semache M, Casavant S, Fortier M, Pan L, Mitchell GA
  Title
Lipolysis and the integrated physiology of lipid energy metabolism.
  Journal
Mol Genet Metab 95:117-26 (2008)
DOI:10.1016/j.ymgme.2008.06.012
Reference
  Authors
Lafontan M
  Title
Historical perspectives in fat cell biology: the fat cell as a model for the investigation of hormonal and metabolic pathways.
  Journal
Am J Physiol Cell Physiol 302:C327-59 (2012)
DOI:10.1152/ajpcell.00168.2011
Reference
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
  Authors
Proenca AR, Sertie RA, Oliveira AC, Campana AB, Caminhotto RO, Chimin P, Lima FB
  Title
New concepts in white adipose tissue physiology.
  Journal
Braz J Med Biol Res 47:192-205 (2014)
DOI:10.1590/1414-431X20132911
Reference
  Authors
Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS
  Title
Regulation of lipolysis in adipocytes.
  Journal
Annu Rev Nutr 27:79-101 (2007)
DOI:10.1146/annurev.nutr.27.061406.093734
Reference
  Authors
Lafontan M
  Title
Advances in adipose tissue metabolism.
  Journal
Int J Obes (Lond) 32 Suppl 7:S39-51 (2008)
DOI:10.1038/ijo.2008.237
Reference
  Authors
Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS
  Title
Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
  Journal
Am J Physiol Gastrointest Liver Physiol 293:G1-4 (2007)
DOI:10.1152/ajpgi.00554.2006
Reference
  Authors
Thompson D, Karpe F, Lafontan M, Frayn K
  Title
Physical activity and exercise in the regulation of human adipose tissue physiology.
  Journal
Physiol Rev 92:157-91 (2012)
DOI:10.1152/physrev.00012.2011
Reference
  Authors
Lafontan M, Langin D
  Title
Lipolysis and lipid mobilization in human adipose tissue.
  Journal
Prog Lipid Res 48:275-97 (2009)
DOI:10.1016/j.plipres.2009.05.001
Reference
  Authors
Arner P, Langin D
  Title
Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.
  Journal
Trends Endocrinol Metab 25:255-62 (2014)
DOI:10.1016/j.tem.2014.03.002
Reference
  Authors
Brasaemle DL
  Title
Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis.
  Journal
J Lipid Res 48:2547-59 (2007)
DOI:10.1194/jlr.R700014-JLR200
Reference
  Authors
Lampidonis AD, Rogdakis E, Voutsinas GE, Stravopodis DJ
  Title
The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis.
  Journal
Gene 477:1-11 (2011)
DOI:10.1016/j.gene.2011.01.007
Reference
  Authors
Bickel PE, Tansey JT, Welte MA
  Title
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
  Journal
Biochim Biophys Acta 1791:419-40 (2009)
DOI:10.1016/j.bbalip.2009.04.002
Related
pathway
lav00561  Glycerolipid metabolism
lav00590  Arachidonic acid metabolism
lav04022  cGMP-PKG signaling pathway
lav04024  cAMP signaling pathway
lav04910  Insulin signaling pathway
KO pathway
ko04923   
LinkDB

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