KEGG   PATHWAY: lav04923
lav04923                    Pathway                                

Regulation of lipolysis in adipocytes - Loxodonta africana (African savanna elephant)
Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding to Gs-coupled-adrenergic receptors (-AR), activate adenylate cyclase (AC) to increase cAMP and activate protein kinase A (PKA). PKA phosphorylates target protein such as hormone-sensitive lipase (HSL) and perilipin 1 (PLIN). PLIN phosphorylation is a key event in the sequential activation of TAG hydrolysis involving adipose triglyceride lipase (ATGL), HSL, and monoglyceride lipase (MGL). During the fed state, insulin, through activation of phosphodiesterase-3B (PDE-3B), inhibits catecholamine-induced lipolysis via the degradation of cAMP.
Organismal Systems; Endocrine system
Pathway map
lav04923  Regulation of lipolysis in adipocytes

Other DBs
GO: 0016042
Loxodonta africana (African savanna elephant) [GN:lav]
100660279  TSHB; thyrotropin subunit beta [KO:K05251]
100673911  CGA; glycoprotein hormones alpha chain [KO:K08522]
100659046  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
100654973  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
100664615  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100674524  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100655206  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100669226  neuroendocrine secretory protein 55-like [KO:K04632]
100671072  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:]
100673570  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:]
100674724  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:]
100675525  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:]
100670244  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:]
100653532  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:]
100653771  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:]
100661616  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:]
100663448  ADCY9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:]
100656966  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:]
100674245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
100660875  NPPA; natriuretic peptides A [KO:K12334]
100671961  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:]
100662471  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:]
100657163  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:]
100675020  PLIN1; LOW QUALITY PROTEIN: perilipin-1 [KO:K08768]
100670874  LIPE; hormone-sensitive lipase [KO:K07188] [EC:]
100657987  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:]
100664173  ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [KO:K13699] [EC:]
100671842  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:]
100660274  FABP4; fatty acid-binding protein, adipocyte [KO:K08753]
100659041  FABP9; fatty acid-binding protein 9 [KO:K08753]
100676974  AQP7; aquaporin-7 [KO:K08771]
100661112  INS; insulin [KO:K04526]
100668116  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:]
100664968  IRS1; insulin receptor substrate 1 [KO:K16172]
100676904  IRS2; insulin receptor substrate 2 isoform X3 [KO:K07187]
100660353  LOW QUALITY PROTEIN: insulin receptor substrate 1-like [KO:K17445]
100667324  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
100657948  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
100658340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:]
100666266  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:]
100653731  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100665045  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100675496  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:]
100660871  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:]
100666679  HRAS-like suppressor 3 isoform X1 [KO:K16817] [EC:]
100667251  HRAS-like suppressor 3 [KO:K16817] [EC:]
100653633  PTGS1; prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:]
100666359  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:]
100676506  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
100675292  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100658837  NPY; pro-neuropeptide Y [KO:K05232]
100668572  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
100666344  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100670234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100667957  GNAI3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
C00020  AMP
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00788  L-Adrenaline
C00942  3',5'-Cyclic GMP
C01885  1-Acylglycerol
C02140  Corticosterone
Ahmadian M, Wang Y, Sul HS
Lipolysis in adipocytes.
Int J Biochem Cell Biol 42:555-9 (2010)
Ahmadian M, Duncan RE, Sul HS
The skinny on fat: lipolysis and fatty acid utilization in adipocytes.
Trends Endocrinol Metab 20:424-8 (2009)
Wang S, Soni KG, Semache M, Casavant S, Fortier M, Pan L, Mitchell GA
Lipolysis and the integrated physiology of lipid energy metabolism.
Mol Genet Metab 95:117-26 (2008)
Lafontan M
Historical perspectives in fat cell biology: the fat cell as a model for the investigation of hormonal and metabolic pathways.
Am J Physiol Cell Physiol 302:C327-59 (2012)
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
Regulation of adipocyte lipolysis.
Nutr Res Rev 27:63-93 (2014)
Proenca AR, Sertie RA, Oliveira AC, Campana AB, Caminhotto RO, Chimin P, Lima FB
New concepts in white adipose tissue physiology.
Braz J Med Biol Res 47:192-205 (2014)
Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS
Regulation of lipolysis in adipocytes.
Annu Rev Nutr 27:79-101 (2007)
Lafontan M
Advances in adipose tissue metabolism.
Int J Obes (Lond) 32 Suppl 7:S39-51 (2008)
Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS
Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
Am J Physiol Gastrointest Liver Physiol 293:G1-4 (2007)
Thompson D, Karpe F, Lafontan M, Frayn K
Physical activity and exercise in the regulation of human adipose tissue physiology.
Physiol Rev 92:157-91 (2012)
Lafontan M, Langin D
Lipolysis and lipid mobilization in human adipose tissue.
Prog Lipid Res 48:275-97 (2009)
Arner P, Langin D
Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.
Trends Endocrinol Metab 25:255-62 (2014)
Brasaemle DL
Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis.
J Lipid Res 48:2547-59 (2007)
Lampidonis AD, Rogdakis E, Voutsinas GE, Stravopodis DJ
The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis.
Gene 477:1-11 (2011)
Bickel PE, Tansey JT, Welte MA
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
Biochim Biophys Acta 1791:419-40 (2009)
lav00561  Glycerolipid metabolism
lav00590  Arachidonic acid metabolism
lav04022  cGMP-PKG signaling pathway
lav04024  cAMP signaling pathway
lav04910  Insulin signaling pathway
KO pathway

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