KEGG   PATHWAY: lcm04115
lcm04115                    Pathway                                

p53 signaling pathway - Latimeria chalumnae (coelacanth)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
lcm04115  p53 signaling pathway

Latimeria chalumnae (coelacanth) [GN:lcm]
102347668  ATM; ATM serine/threonine kinase [KO:K04728] [EC:]
102362683  CHEK2; checkpoint kinase 2 [KO:K06641] [EC:]
102354343  ATR; ATR serine/threonine kinase [KO:K06640] [EC:]
102357495  CHEK1; checkpoint kinase 1 [KO:K02216] [EC:]
102348269  GORAB; golgin, RAB6 interacting [KO:K19748]
102353921  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:]
102358918  MDM4; MDM4, p53 regulator [KO:K10127]
102366539  TP53; tumor protein p53 [KO:K04451]
102361382  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102361167  CCND1; cyclin D1 [KO:K04503]
102367471  G1/S-specific cyclin-D1-like [KO:K04503]
102351286  CCND2; cyclin D2 [KO:K10151]
102345953  G1/S-specific cyclin-D2-like [KO:K10151]
102363370  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:]
102366718  cyclin-dependent kinase 6-like [KO:K02091] [EC:]
102353660  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:]
102366176  CCNE1; cyclin E1 [KO:K06626]
102363290  CCNE2; cyclin E2 [KO:K06626]
102366560  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:]
102367189  cyclin-dependent kinase 2-like [KO:K02206] [EC:]
106702484  protein reprimo A-like [KO:K10128]
102363451  RPRM; reprimo, TP53 dependent G2 arrest mediator candidate [KO:K10128]
102360112  G2/mitotic-specific cyclin-B1-like [KO:K05868]
102359547  CCNB1; cyclin B1 [KO:K05868]
102349107  CCNB2; cyclin B2 [KO:K21770]
102364653  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:]
102353479  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
102361538  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102349018  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102347366  GTSE1; G2 and S-phase expressed 1 [KO:K10129]
102349412  FAS; Fas cell surface death receptor [KO:K04390]
102349614  PIDD1; p53-induced death domain protein 1 [KO:K10130]
102366259  uncharacterized LOC102366259 [KO:K04722]
102366681  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
102361530  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
102355925  caspase-8-like [KO:K04398] [EC:]
102356202  caspase-8-like [KO:K04398] [EC:]
102349989  caspase-8-like [KO:K04398] [EC:]
102360597  BID; BH3-interacting domain death agonist [KO:K04726]
102359041  apoptosis regulator BAX-like [KO:K02159]
102352490  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102362452  apoptosis regulatory protein Siva-like [KO:K22744]
102358360  SIVA1; SIVA1 apoptosis inducing factor [KO:K22744]
102358181  BCL2L1; BCL2 like 1 [KO:K04570]
102361889  TP53I3; tumor protein p53 inducible protein 3 [KO:K10133] [EC:1.-.-.-]
102356381  EI24; EI24, autophagy associated transmembrane protein [KO:K10134]
102352894  SHISA5; shisa family member 5 [KO:K10135]
102361707  p53 apoptosis effector related to PMP-22-like [KO:K10136]
102361982  p53 apoptosis effector related to PMP-22-like [KO:K10136]
102347863  ZMAT3; zinc finger matrin-type 3 [KO:K10137]
102361177  SIAH1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:]
102363280  cytochrome c [KO:K08738]
102345199  cytochrome c-like [KO:K08738]
102354670  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102362720  CASP9; caspase 9 [KO:K04399] [EC:]
106705928  CASP3; caspase 3 [KO:K02187] [EC:]
102358055  AIFM2; apoptosis inducing factor, mitochondria associated 2 [KO:K22745]
102347870  IGFBP3; insulin like growth factor binding protein 3 [KO:K10138]
102365620  insulin-like growth factor I [KO:K05459]
102361051  IGF1; insulin like growth factor 1 [KO:K05459]
102360184  SERPINE1; serpin family E member 1 [KO:K03982]
102364066  CD82; CD82 molecule [KO:K06509]
102358103  THBS1; thrombospondin 1 [KO:K16857]
102361010  RRM2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:]
102361950  SESN1; sestrin 1 [KO:K10141]
102356692  SESN3; sestrin-3 [KO:K10141]
102348720  SESN2; sestrin-2 [KO:K20394]
102348548  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:]
102365821  TSC2; tuberous sclerosis 2 [KO:K07207]
102356275  STEAP3; STEAP3 metalloreductase [KO:K10142] [EC:1.16.1.-]
102363850  RFWD2; ring finger and WD repeat domain 2 [KO:K10143] [EC:]
102350333  RCHY1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:]
102346817  CCNG1; cyclin G1 [KO:K10145]
102365710  CCNG2; cyclin G2 [KO:K10146]
102359801  PPM1D; protein phosphatase, Mg2+/Mn2+ dependent 1D [KO:K10147] [EC:]
102364155  TP73; tumor protein p73 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
lcm04110  Cell cycle
lcm04210  Apoptosis
lcm04218  Cellular senescence
KO pathway

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